hydrogen carbonate has been researched along with Insulin Resistance in 17 studies
Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.
hydrogencarbonate : The carbon oxoanion resulting from the removal of a proton from carbonic acid.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For each test, glucose constant decay (K), immunoreactive insulin (IRI) area and C-peptide (C-p) area response, insulinogenic index (IGI) and insulin resistance index (RI) were calculated." | 3.68 | Glucose-induced insulin secretion in uremia: relation with acid-base balance and effects of bicarbonate administration. ( Allegra, V; Martimbianco, L; Mengozzi, G; Vasile, A, 1993) |
| "Insulin resistance is closely associated with obesity and precedes the development of type 2 diabetes." | 2.53 | The role of dietary acid load and mild metabolic acidosis in insulin resistance in humans. ( Kozan, P; Samocha-Bonet, D; Williams, RS, 2016) |
| "Hypocitraturia and hypercalciuria are risk factors for calcium stone disease." | 2.47 | Diet-induced metabolic acidosis. ( Adeva, MM; Souto, G, 2011) |
| "Insulin sensitivity was measured by hyperinsulinemic euglycemic clamp." | 1.43 | Dietary Acid Load is Associated With Serum Bicarbonate but not Insulin Sensitivity in Chronic Kidney Disease. ( Curtin, L; de Boer, IH; Himmelfarb, J; Ikizler, HO; Kestenbaum, B; Ruzinski, J; Utzschneider, KM; Zelnick, L, 2016) |
| "Insulin sensitivity was estimated by an index based on fasting insulin and triglyceride levels (MFFM)." | 1.35 | Serum bicarbonate, anion gap and insulin resistance in the National Health and Nutrition Examination Survey. ( Farwell, WR; Taylor, EN, 2008) |
| "Insulin resistance is frequently associated with hypertension, but the mechanism underlying this association remains speculative." | 1.33 | Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption. ( Endo, Y; Fujita, T; Horita, S; Kadowaki, T; Kunimi, M; Li, Y; Sakamoto, K; Seki, G; Terauchi, Y; Tobe, K; Yamada, H; Zheng, Y, 2005) |
| "Insulin resistance was examined in 19 non-diabetic patients with end-stage renal disease (ESRD) before and after dialysis therapy (HD, n=10; CAPD, n=9), as well as in 10 healthy controls using the hyperinsulinaemic euglycaemic glucose clamp technique." | 1.31 | Impact of dialysis therapy on insulin resistance in end-stage renal disease: comparison of haemodialysis and continuous ambulatory peritoneal dialysis. ( Ikeda, T; Kobayashi, S; Maejima, S; Nagase, M, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (41.18) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Williams, RS | 1 |
| Kozan, P | 1 |
| Samocha-Bonet, D | 1 |
| Ikizler, HO | 1 |
| Zelnick, L | 1 |
| Ruzinski, J | 1 |
| Curtin, L | 1 |
| Utzschneider, KM | 1 |
| Kestenbaum, B | 1 |
| Himmelfarb, J | 1 |
| de Boer, IH | 1 |
| Bellasi, A | 1 |
| Di Micco, L | 1 |
| Santoro, D | 1 |
| Marzocco, S | 1 |
| De Simone, E | 1 |
| Cozzolino, M | 1 |
| Di Lullo, L | 1 |
| Guastaferro, P | 1 |
| Di Iorio, B | 1 |
| Farwell, WR | 1 |
| Taylor, EN | 1 |
| Das, S | 1 |
| Misra, B | 1 |
| Roul, L | 1 |
| Minz, NT | 1 |
| Pattnaik, M | 1 |
| Baig, MA | 1 |
| Adeva, MM | 1 |
| Souto, G | 1 |
| Zheng, Y | 1 |
| Yamada, H | 1 |
| Sakamoto, K | 1 |
| Horita, S | 1 |
| Kunimi, M | 1 |
| Endo, Y | 1 |
| Li, Y | 1 |
| Tobe, K | 1 |
| Terauchi, Y | 1 |
| Kadowaki, T | 1 |
| Seki, G | 1 |
| Fujita, T | 1 |
| Foster, DW | 1 |
| McGarry, JD | 1 |
| Barrett, EJ | 1 |
| DeFronzo, RA | 2 |
| Allegra, V | 1 |
| Mengozzi, G | 1 |
| Martimbianco, L | 1 |
| Vasile, A | 1 |
| Vettor, R | 1 |
| Lombardi, AM | 1 |
| Fabris, R | 1 |
| Pagano, C | 1 |
| Cusin, I | 1 |
| Rohner-Jeanrenaud, F | 1 |
| Federspil, G | 1 |
| Jeanrenaud, B | 1 |
| Kobayashi, S | 1 |
| Maejima, S | 1 |
| Ikeda, T | 1 |
| Nagase, M | 1 |
| Alberti, KG | 1 |
| Nattrass, M | 1 |
| Jaspan, JB | 1 |
| Bratusch-Marrain, PR | 1 |
| Beigelman, PM | 1 |
| Martin, HE | 1 |
| Miller, LV | 1 |
| Grant, WJ | 1 |
| Cryer, PE | 1 |
| Daughaday, WH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Is There Any Effect of Maternal Dietary Acid Load During Pregnancy on Arising Gestational Diabetes Mellitus?[NCT03790579] | 80 participants (Actual) | Observational | 2014-01-05 | Completed | |||
| A Prospective, Controlled, Randomized, Multicentric Study: Correction of Metabolic Acidosis With Use of Bicarbonate in Chronic Renal Insufficiency (CKD3b-4)[NCT01640119] | Phase 3 | 728 participants (Anticipated) | Interventional | 2014-07-31 | Recruiting | ||
| Alkaline Diet for Insulin Sensitivity[NCT02501343] | 32 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for hydrogen carbonate and Insulin Resistance
| Article | Year |
|---|---|
The role of dietary acid load and mild metabolic acidosis in insulin resistance in humans.
Topics: Acidosis; Bicarbonates; Diabetes Mellitus, Type 2; Diet; Female; Humans; Insulin Resistance; Male | 2016 |
Diet-induced metabolic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Biomarkers; Cardiovascular Diseases; Citric Acid; Die | 2011 |
The metabolic derangements and treatment of diabetic ketoacidosis.
Topics: Bicarbonates; Brain Edema; Diabetic Ketoacidosis; Fluid Therapy; Glucose; Humans; Infections; Insuli | 1983 |
1 trial available for hydrogen carbonate and Insulin Resistance
| Article | Year |
|---|---|
Correction of metabolic acidosis improves insulin resistance in chronic kidney disease.
Topics: Acidosis; Aged; Bicarbonates; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Hypoglycemic Age | 2016 |
13 other studies available for hydrogen carbonate and Insulin Resistance
| Article | Year |
|---|---|
Dietary Acid Load is Associated With Serum Bicarbonate but not Insulin Sensitivity in Chronic Kidney Disease.
Topics: Acidosis; Aged; Bicarbonates; Blood Glucose; Body Mass Index; Cross-Sectional Studies; Diet; Female; | 2016 |
Serum bicarbonate, anion gap and insulin resistance in the National Health and Nutrition Examination Survey.
Topics: Acid-Base Imbalance; Adult; Bicarbonates; Blood Glucose; Fasting; Female; Humans; Insulin Resistance | 2008 |
Insulin resistance and beta cell function as prognostic indicator in multi-organ dysfunction syndrome.
Topics: Adolescent; Adult; Aged; APACHE; Bicarbonates; Blood Glucose; Critical Illness; Disease Progression; | 2009 |
Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.
Topics: Absorption; Androstadienes; Animals; Bicarbonates; Chromones; Crosses, Genetic; Dose-Response Relati | 2005 |
Diabetic ketoacidosis: diagnosis and treatment.
Topics: Bicarbonates; Blood Glucose; Diabetic Ketoacidosis; Electrocardiography; Glucose; Heart; Humans; Hyp | 1984 |
Glucose-induced insulin secretion in uremia: relation with acid-base balance and effects of bicarbonate administration.
Topics: Acid-Base Equilibrium; Administration, Oral; Adult; Aged; Bicarbonates; Blood Glucose; C-Peptide; Fe | 1993 |
Lactate infusion in anesthetized rats produces insulin resistance in heart and skeletal muscles.
Topics: Adipose Tissue; Anesthesia, General; Animals; Bicarbonates; Blood Glucose; Deoxyglucose; Glucose; Gl | 1997 |
Impact of dialysis therapy on insulin resistance in end-stage renal disease: comparison of haemodialysis and continuous ambulatory peritoneal dialysis.
Topics: Adult; Aged; Bicarbonates; Blood Glucose; Blood Urea Nitrogen; Female; Glucose Clamp Technique; Hema | 2000 |
Severe diabetic ketoacidosis.
Topics: Bicarbonates; Diabetic Ketoacidosis; Glucagon; Humans; Infusions, Parenteral; Injections, Intramuscu | 1978 |
Treatment of diabetic coma with low-dose hourly intramuscular insulin.
Topics: Adult; Aged; Bicarbonates; Blood Glucose; Diabetic Coma; Diabetic Ketoacidosis; Female; Humans; Hypo | 1975 |
Failure of hyperketonemia to alter basal and insulin-mediated glucose metabolism in man.
Topics: 3-Hydroxybutyric Acid; Adult; Bicarbonates; Blood Glucose; Glucose; Humans; Hydrogen-Ion Concentrati | 1986 |
Severe diabetic ketoacidosis.
Topics: Adolescent; Adult; Aged; Bicarbonates; Blood Glucose; Diabetic Coma; Diabetic Ketoacidosis; Female; | 1969 |
Diabetic ketosis. Serial plasma growth hormone concentrations during therapy.
Topics: Adolescent; Adult; Bicarbonates; Blood Glucose; Diabetic Ketoacidosis; Female; Growth Hormone; Human | 1970 |