Page last updated: 2024-11-08

n(1)-guanyl-1,7-diaminoheptane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N(1)-guanyl-1,7-diaminoheptane: inhibits deoxyhypusine synthase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-(7-aminoheptyl)guanidine : A member of the class of guanidines in which the imino hydrogen of guanidine itself has been replaced by a 7-aminoheptyl group. It is an inhibitor of deoxyhypusine synthase activity (GO:0034038). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID448393
CHEMBL ID229457
CHEBI ID133366
SCHEMBL ID433609
MeSH IDM0264145

Synonyms (16)

Synonym
GC7 ,
n-(7-aminoheptyl)guanidine
CHEBI:133366
1-(7-aminoheptyl)guanidine
n(1)-guanyl-1,7-diaminoheptane
n-guanyl-1,7-diaminoheptane
2-(7-aminoheptyl)guanidine
CHEMBL229457 ,
bdbm50216786
n-(7-amino-heptyl)-guanidine
SCHEMBL433609
150333-69-0
mfcd20667694
deoxyhypusine synthase inhibitor, gc-7
n1-guanyl-1,7-diaminoheptane (gc7)
1,7-diaminoheptane, n-amidino-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
EC 2.5.1.46 (deoxyhypusine synthase) inhibitorAn EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of deoxyhypusine synthase (EC 2.5.1.46).
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
guanidinesAny organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas.
primary amino compoundA compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Deoxyhypusine synthaseHomo sapiens (human)IC50 (µMol)0.78670.14000.78671.7200AID1561253; AID1561254; AID1820366
Deoxyhypusine synthaseRattus norvegicus (Norway rat)IC50 (µMol)0.03000.03001.76503.5000AID56588
Deoxyhypusine synthasePlasmodium falciparum (malaria parasite P. falciparum)Ki0.10000.10000.10000.1000AID289237
NischarinHomo sapiens (human)IC50 (µMol)0.50000.09702.99936.4000AID1561254
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (12)

Processvia Protein(s)Taxonomy
translationDeoxyhypusine synthaseHomo sapiens (human)
spermidine metabolic processDeoxyhypusine synthaseHomo sapiens (human)
positive regulation of cell population proliferationDeoxyhypusine synthaseHomo sapiens (human)
peptidyl-lysine modification to peptidyl-hypusineDeoxyhypusine synthaseHomo sapiens (human)
positive regulation of T cell proliferationDeoxyhypusine synthaseHomo sapiens (human)
glucose homeostasisDeoxyhypusine synthaseHomo sapiens (human)
spermidine catabolic processDeoxyhypusine synthaseHomo sapiens (human)
apoptotic processNischarinHomo sapiens (human)
Rac protein signal transductionNischarinHomo sapiens (human)
actin cytoskeleton organizationNischarinHomo sapiens (human)
negative regulation of cell migrationNischarinHomo sapiens (human)
outer dynein arm assemblyNischarinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (7)

Processvia Protein(s)Taxonomy
protein bindingDeoxyhypusine synthaseHomo sapiens (human)
deoxyhypusine synthase activityDeoxyhypusine synthaseHomo sapiens (human)
identical protein bindingDeoxyhypusine synthaseHomo sapiens (human)
integrin bindingNischarinHomo sapiens (human)
protein bindingNischarinHomo sapiens (human)
phosphatidylinositol bindingNischarinHomo sapiens (human)
identical protein bindingNischarinHomo sapiens (human)
dynein heavy chain bindingNischarinHomo sapiens (human)
alpha-tubulin bindingNischarinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (10)

Processvia Protein(s)Taxonomy
cytosolDeoxyhypusine synthaseHomo sapiens (human)
cytoplasmDeoxyhypusine synthaseHomo sapiens (human)
nucleoplasmNischarinHomo sapiens (human)
early endosomeNischarinHomo sapiens (human)
cytosolNischarinHomo sapiens (human)
plasma membraneNischarinHomo sapiens (human)
microtubule cytoskeletonNischarinHomo sapiens (human)
membraneNischarinHomo sapiens (human)
intracellular membrane-bounded organelleNischarinHomo sapiens (human)
intercellular bridgeNischarinHomo sapiens (human)
recycling endosomeNischarinHomo sapiens (human)
cytoplasmNischarinHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID47706Effect on hypusine synthesis in CHO cells at concentration 3 uM.1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
AID1561253Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabelled amino-butylidene incorporation in eIF5A using [3H]Spermidine trichloride as substrate after 90 to 120 2020Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
AID1820366Inhibition of DHPS (unknown origin ) incubated for 30 mins by NAD/NADH-Glow assay2021Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
AID1820368Cytotoxicity against mouse B16 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay2021Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
AID44878Growth inhibition was measured against CHO cell line; ++++ indicates <0.5 uM1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
AID56588In vitro IC50 value by measuring the inhibition of deoxyhypusine synthase.1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
AID289237Inhibition of recombinant deoxyhypusine synthase in Plasmodium falciparum NF542007Bioorganic & medicinal chemistry, Sep-15, Volume: 15, Issue:18
Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic properties.
AID1820369Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay2021Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
AID44873Effect on spermidine uptake in CHO cells at concentration 3 uM.1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
AID47705Effect on hypusine synthesis in CHO cells at concentration 10 uM.1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
AID47704Effect on Hypusine formation in CHO cells at concentration 3 uM.1995Journal of medicinal chemistry, Aug-04, Volume: 38, Issue:16
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
AID1561254Competitive inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabelled amino-butylidene incorporation in eIF5A using 2 uM of [3H]Spermidine trichloride as substr2020Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.
AID1820371Cytotoxicity against human HaCaT cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay2021Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
AID1820370Cytotoxicity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 24 hrs by CCK-8 assay2021Journal of medicinal chemistry, 09-23, Volume: 64, Issue:18
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (37)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (10.81)18.2507
2000's10 (27.03)29.6817
2010's20 (54.05)24.3611
2020's3 (8.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.16 (24.57)
Research Supply Index3.66 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.63%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other37 (97.37%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]