propofol has been researched along with Insulin Resistance in 4 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown." | 7.81 | Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking. ( Affolter, A; Clanachan, AS; Gandhi, M; Hersberger, M; Hornemann, T; Lou, PH; Lucchinetti, E; Zaugg, M; Zhakupova, A; Zhang, L, 2015) |
| " Moreover, the effects of propofol, a clinically relevant intravenous anesthetic, also used in the intensive care unit for sedation, on insulin sensitivity have not yet been investigated." | 7.79 | Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats. ( Fukushima, Y; Kaneki, M; Martyn, JA; Yasuda, Y, 2013) |
| "Propofol was administered as an intravenous bolus (3mg/kg) to initiate anesthesia, which was then maintained with inhaled sevoflurane or isoflurane (2-3%) for the duration of the procedure." | 5.43 | Isoflurane and Sevoflurane Induce Severe Hepatic Insulin Resistance in a Canine Model. ( Broussard, JL; Kim, SP; Kolka, CM, 2016) |
| "The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown." | 3.81 | Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking. ( Affolter, A; Clanachan, AS; Gandhi, M; Hersberger, M; Hornemann, T; Lou, PH; Lucchinetti, E; Zaugg, M; Zhakupova, A; Zhang, L, 2015) |
| " Moreover, the effects of propofol, a clinically relevant intravenous anesthetic, also used in the intensive care unit for sedation, on insulin sensitivity have not yet been investigated." | 3.79 | Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats. ( Fukushima, Y; Kaneki, M; Martyn, JA; Yasuda, Y, 2013) |
| "Propofol was administered as an intravenous bolus (3mg/kg) to initiate anesthesia, which was then maintained with inhaled sevoflurane or isoflurane (2-3%) for the duration of the procedure." | 1.43 | Isoflurane and Sevoflurane Induce Severe Hepatic Insulin Resistance in a Canine Model. ( Broussard, JL; Kim, SP; Kolka, CM, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Kitamura, T | 1 |
| Kawamura, G | 1 |
| Mori, Y | 1 |
| Sato, K | 1 |
| Araki, Y | 1 |
| Sato, R | 1 |
| Yamada, Y | 1 |
| Lou, PH | 1 |
| Lucchinetti, E | 1 |
| Zhang, L | 1 |
| Affolter, A | 1 |
| Gandhi, M | 1 |
| Zhakupova, A | 1 |
| Hersberger, M | 1 |
| Hornemann, T | 1 |
| Clanachan, AS | 1 |
| Zaugg, M | 1 |
| Kim, SP | 1 |
| Broussard, JL | 1 |
| Kolka, CM | 1 |
| Yasuda, Y | 1 |
| Fukushima, Y | 1 |
| Kaneki, M | 1 |
| Martyn, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Optimierung Der Kardioprotektion Durch Inhalative Anästhetika Eine Untersuchung Bei Patienten Mit Diabetes Mellitus während Off-pump Herzchirurgie[NCT02407626] | 2 participants (Actual) | Interventional | 2015-09-30 | Terminated (stopped due to Very low patient recruitment, changed insurance requirements) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for propofol and Insulin Resistance
| Article | Year |
|---|---|
Comparison of mechanisms underlying changes in glucose utilization in fasted rats anesthetized with propofol or sevoflurane: Hyperinsulinemia is exaggerated by propofol with concomitant insulin resistance induced by an acute lipid load.
Topics: Animals; Fasting; Glucose; Hyperinsulinism; Insulin Resistance; Male; Methyl Ethers; Propofol; Rats; | 2014 |
Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking.
Topics: Anesthetics, Intravenous; Animals; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; Emulsions; Fat | 2015 |
Isoflurane and Sevoflurane Induce Severe Hepatic Insulin Resistance in a Canine Model.
Topics: Anesthesia, Inhalation; Animals; Blood Glucose; Dietary Fats; Dogs; Glucose; Glucose Clamp Technique | 2016 |
Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Glucose; Glucose Clamp Technique; Insuli | 2013 |