Page last updated: 2024-08-21

adamantane and Insulin Resistance

adamantane has been researched along with Insulin Resistance in 67 studies

Research

Studies (67)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (14.93)	29.6817
2010's	54 (80.60)	24.3611
2020's	3 (4.48)	2.80

Authors

Authors	Studies
Coskun, ZM	1
Abdel-Aal, RA; Abdel-Rahman, MS; Al Bayoumi, S; Ali, LA	1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Chunchai, T; Jaiwongkam, T; Kerdphoo, S; Pratchayasakul, W; Saiyasit, N; Sripetchwandee, J	1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Jiang, C; Li, X; Liang, G; Sa-Nguanmoo, P; Tanajak, P; Wang, X	1
Chen, Q; Huang, L; Kong, L; Wang, J; Wang, Z; Xu, D; Zhang, T; Zhou, X	1
Chattipakorn, N; Chattipakorn, SC; Jaiwongkam, T; Kerdphoo, S; Pratchayasakul, W; Sa-Nguanmoo, P; Tanajak, P	1
Attia, A; El-Shenawy, S; Gomaa, N; Hassan, A; Hegazy, R; Kenawy, S; Zaki, H	1
Li, M; Ping, F; Wang, T; Wang, X; Xiao, X; Yu, M; Zhang, Q; Zheng, J	1
Apaijai, N; Chattipakorn, N; Chattipakorn, S; Ittichaicharoen, J; Sa-Nguanmoo, P; Tanajak, P	1
Bolkent, S; Coskun, ZM; Nephan, G	1
Chattipakorn, N; Chattipakorn, SC; Jaiwongkam, T; Jiang, C; Kerdphoo, S; Li, X; Liang, G; Pratchayasakul, W; Sa-Nguanmoo, P; Tanajak, P; Wang, X	1
Chen, K; Mei, Q; Wang, J; Zhuo, T	1
Bi, Y; Cheng, J; Gu, T; Li, D; Ma, J; Shao, J; Shi, B; Sun, Z; Xu, L; Zhang, H; Zhang, Q; Zhong, S; Zhu, D; Zhu, L	1
Fan, B; Guo, XL; Li, JJ; Zhang, P; Zheng, ZS	1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Pintana, H	3
Bhatt, DL; Braunwald, E; Davidson, J; Frederich, B; Hirshberg, B; Mosenzon, O; Ohman, P; Price, DL; Raz, I; Scirica, BM; Stahre, CI; Steg, PG; Udell, JA	1
Carbone, A; Cicero, AF; D'Angelo, A; Derosa, G; Fogari, E; Maffioli, P; Ragonesi, PD	2
Bae, JH; Cho, YM; Jung, HS; Kim, SY; Kim, YG; Oh, TJ; Park, KS	1
Araki, E; Goto, R; Igata, M; Kawasaki, S; Kawashima, J; Kitano, S; Kondo, T; Matsumura, T; Matsuyama, R; Miyagawa, K; Motoshima, H; Ono, K	1
Bianchi, L; Bonaventura, A; D'Angelo, A; Derosa, G; Fogari, E; Maffioli, P; Romano, D	2
Hirshberg, B; Iqbal, N; Lu, J; Sjöstrand, M	1
Chen, H; Chen, R; Liu, Y; Sun, J; Zhang, Z	1
Horie, A; Ide, K; Ishizuka, T; Kanatsuka, A; Marumo, K; Oshikiri, K; Sunaga, M; Suzuki, Y; Tokuyama, Y	1
Choi, SA; Jang, JY; Jung, HS; Kim, HC; Kim, JH; Kim, MJ; Kim, SW; Lee, HM; Lee, KB; Ohn, JH; Park, KS; Yoon, JW	1
Apaijai, N; Chattipakorn, N; Chattipakorn, S; Chinda, K; Palee, S	1
Iwamura, T; Kainoh, M; Kawai, K; Kumagai, H; Nakaki, J; Nitta, A; Okazaki, S; Sakami, S; Sato, M; Sekiya, Y; Takahashi, T; Yagi, M	1
Chattipakorn, N; Chattipakorn, SC; Pipatpiboon, N; Pratchayasakul, W; Sripetchwandee, J	1
Chattipakorn, N; Chattipakorn, SC; Pintana, H; Pongkan, W; Pratchayasakul, W	1
Fan, X; Fan, Y; Li, X; Ren, F; Ren, G; Shen, C; Shen, J; Song, Y; Yang, J; Zhang, N; Zhang, Y; Zheng, H	1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC	1
Choi, CS; Han, HY; Jeong, KH; Jun, HS; Kim, S; Kim, SS; Lee, HJ; Oh, H; Ryu, JH; Sa, JH; Son, HJ	1
Brückner, J; Eckel, J; Röhrborn, D; Sell, H	1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Inthachai, T; Lekawanvijit, S	1
Amblee, A; Fogelfeld, L; Lious, D	1
Abiru, N; Ando, T; Horie, I; Kawakami, A; Shigeno, R	1
Chattipakorn, N; Chattipakorn, SC; Pongkan, W; Pratchayasakul, W; Sa-Nguanmoo, P; Sivasinprasasn, S	1
Chattipakorn, N; Chattipakorn, SC; Jaiwongkam, T; Kredphoo, S; Pintana, H; Pongkan, W; Sivasinprasasn, S	1
Apaijai, N; Chattipakorn, N; Chattipakorn, SC; Khamseekaew, J; Pintana, H; Siri-Angkul, N; Tanajak, P	1
Abdallah, DM; Al-Shorbagy, MY; Aldakinah, AA; El-Abhar, HS	1
Chattipakorn, N; Chattipakorn, SC; Pongkan, W; Pratchayasakul, W; Sivasinprasasn, S; Tanajak, P	1
Dejager, S; Foley, J; Halimi, S; Minic, B; Schweizer, A	1
Barnett, AH; Piya, MK; Tahrani, AA	1
Aerts, JM; Arbeeny, C; Aten, J; Bijl, N; Dubbelhuis, PF; Ghauharali-van der Vlugt, K; Groen, AK; Ottenhoff, R; Overkleeft, HS; Seeman, I; van Eijk, M; van Roomen, CP	1
Aerts, JM; Aten, J; Bijl, N; Boot, RG; Claessen, N; Groen, AK; Langeveld, M; Moerland, PD; Ottenhoff, R; Sokolović, M; van Eijk, M; van Roomen, CP; Vrins, C	1
Ciccarelli, L; D'Angelo, A; Derosa, G; Ferrari, I; Franzetti, IG; Gadaleta, G; Maffioli, P; Mereu, R; Piccinni, MN; Querci, F; Ragonesi, PD; Salvadeo, SA	1
Foley, JE; Jordan, J	1
Campbell, RK; Cobble, ME; Reid, TS; Shomali, ME	3
Ito, H; Mimori, N; Sekiguchi, K; Wajima, T; Yamaguchi, M	1
Aavula, BR; Anandan, SK; Cases, S; Chen, D; Cheng, Y; Do, ZN; Gless, R; Hammock, BD; Jones, PD; MacIntyre, DE; Mehra, U; Patel, DV; Sabry, J; Tran, V; Vincelette, J; Wang, YX; Waszczuk, J; Webb, HK; Whitcomb, R; White, K; Wong, KR; Zhang, LN	1
Aerts, JM; Aten, J; Bietrix, FM; Bijl, N; Boot, RG; Dekker, N; Groen, AK; Groener, J; Langeveld, M; Lombardo, E; Ottenhoff, R; Overkleeft, HS; Serlie, M; van Eijk, M; van Roomen, C; Wennekes, T	1
Dotta, F; Fondelli, C; Guarino, E; Nigi, L; Patti, A	1
Bianchi, L; Bonaventura, A; Carbone, A; Cicero, AF; Derosa, G; Fogari, E; Maffioli, P; Ragonesi, PD; Romano, D	1
Ahn, JH; Jung, WH; Kang, NS; Kang, SK; Kim, HY; Kim, KY; Park, JS; Rhee, SD	1
Nakamura, A; Terauchi, Y	1
Chattipakorn, N; Chattipakorn, SC; Pintana, H; Pipatpiboon, N; Pratchayasakul, W	1
Balkan, B; Bolognese, L; Burkey, BF; Hughes, TE; Li, X; Mone, M; Russell, M; Wang, PR	1
Balkovec, JM; Chen, HY; Cheng, K; Hermanowski-Vosatka, A; Hernandez, M; Koo, GC; Le Grand, CB; Li, Z; Metzger, JM; Mundt, SS; Noonan, H; Nunes, CN; Olson, SH; Pikounis, B; Ren, N; Robertson, N; Schaeffer, JM; Shah, K; Springer, MS; Strack, AM; Strowski, M; Thieringer, R; Wright, SD; Wu, K; Wu, T; Xiao, J; Zhang, BB	1
Winkler, G	1
Göke, B	1
Ahrén, B; Foley, JE	1

Reviews

7 review(s) available for adamantane and Insulin Resistance

Article	Year
Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet. Vascular health and risk management, 2008, Volume: 4, Issue:3 Topics: Adamantane; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Drug Combinations; Humans; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Metformin; Nitriles; Pyrrolidines; Tablets; Treatment Outcome; Vildagliptin	2008
Drug evaluation: vildagliptin-metformin single-tablet combination. Advances in therapy, 2009, Volume: 26, Issue:2 Topics: Adamantane; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin Resistance; Lipids; Metformin; Nitriles; Practice Guidelines as Topic; Pyrrolidines; Safety; Treatment Outcome; Vildagliptin	2009
Weight neutrality with the DPP-4 inhibitor, vildagliptin: mechanistic basis and clinical experience. Vascular health and risk management, 2010, Aug-09, Volume: 6 Topics: Adamantane; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucose; Humans; Hypoglycemic Agents; Insulin Resistance; Nitriles; Pyrrolidines; Vildagliptin; Weight Gain	2010
Glycosphingolipids and insulin resistance. Advances in experimental medicine and biology, 2011, Volume: 721 Topics: 1-Deoxynojirimycin; Adamantane; Animals; Cardiovascular Diseases; Ceramides; Diabetes Mellitus, Type 2; Dioxanes; Disease Models, Animal; Fatty Acids; Fatty Liver; Gaucher Disease; Glucosyltransferases; Glycosphingolipids; Humans; Insulin Resistance; Metabolic Syndrome; Mice; Mice, Obese; Non-alcoholic Fatty Liver Disease; Obesity; Pyrrolidines; Receptor, Insulin; Signal Transduction	2011
Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus. Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:9 Topics: Adamantane; Administration, Oral; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Combinations; Evidence-Based Medicine; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Metformin; Nitriles; Pyrrolidines; Tablets; Treatment Outcome; Vildagliptin	2012
[Incretin enhancers, incretin mimetics: from therapeutic concept to clinical application]. Orvosi hetilap, 2007, Apr-01, Volume: 148, Issue:13 Topics: Adamantane; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon-Like Peptide 1; Glycoproteins; Humans; Hypoglycemic Agents; Insulin Resistance; Intestinal Mucosa; Nitriles; Peptide Hormones; Peptides; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin	2007
The islet enhancer vildagliptin: mechanisms of improved glucose metabolism. International journal of clinical practice. Supplement, 2008, Issue:159 Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Gastric Emptying; Glucagon-Like Peptide 1; Glucose; Humans; Insulin Resistance; Islets of Langerhans; Lipid Metabolism; Liver; Nitriles; Pyrrolidines; Vildagliptin	2008

Trials

13 trial(s) available for adamantane and Insulin Resistance

Article	Year
Effects of saxagliptin on glucose homeostasis and body composition of obese patients with newly diagnosed pre-diabetes. Diabetes research and clinical practice, 2017, Volume: 130 Topics: Adamantane; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Diet; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Female; Glucose Intolerance; Homeostasis; Humans; Insulin Resistance; Life Style; Male; Metformin; Middle Aged; Obesity; Postprandial Period; Prediabetic State; Treatment Outcome	2017
Saxagliptin Upregulates Nesfatin-1 Secretion and Ameliorates Insulin Resistance and Metabolic Profiles in Type 2 Diabetes Mellitus. Metabolic syndrome and related disorders, 2018, Volume: 16, Issue:7 Topics: Acarbose; Adamantane; Aged; Blood Glucose; Calcium-Binding Proteins; Diabetes Mellitus, Type 2; Dipeptides; DNA-Binding Proteins; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Male; Metabolome; Metformin; Middle Aged; Nerve Tissue Proteins; Nucleobindins; Up-Regulation	2018
Comparative effect of saxagliptin and glimepiride with a composite endpoint of adequate glycaemic control without hypoglycaemia and without weight gain in patients uncontrolled with metformin therapy: Results from the SPECIFY study, a 48-week, multi-centr Diabetes, obesity & metabolism, 2019, Volume: 21, Issue:4 Topics: Adamantane; Adult; Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dipeptides; Female; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Postprandial Period; Sulfonylurea Compounds; Weight Gain	2019
Baseline characteristics of the patient population in the Saxagliptin Assessment of Vascular Outcomes Recorded in patients with diabetes mellitus (SAVOR)-TIMI 53 trial. Diabetes/metabolism research and reviews, 2013, Volume: 29, Issue:5 Topics: Adamantane; Aged; Biomarkers; Body Mass Index; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Male; Middle Aged; Overweight; Prevalence; Risk Factors; Severity of Illness Index	2013
RETRACTED: Evaluation of the positive effects on insulin-resistance and β-cell measurements of vildagliptin in addition to metformin in type 2 diabetic patients. Pharmacological research, 2013, Volume: 73 Topics: Adamantane; Cytokines; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; GPI-Linked Proteins; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Lectins; Male; Metformin; Middle Aged; Nicotinamide Phosphoribosyltransferase; Nitriles; Pyrrolidines; Serpins; Vildagliptin	2013
Comparison of vildagliptin and glimepiride: effects on glycaemic control, fat tolerance and inflammatory markers in people with type 2 diabetes. Diabetic medicine : a journal of the British Diabetic Association, 2014, Volume: 31, Issue:12 Topics: Adamantane; Adiponectin; Aged; Biomarkers; Blood Glucose; C-Reactive Protein; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Dietary Fats; Double-Blind Method; Drug Therapy, Combination; Female; Glucagon; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipid Metabolism; Male; Metformin; Middle Aged; Nitriles; Proinsulin; Pyrrolidines; Sulfonylurea Compounds; Treatment Outcome; Triglycerides; Tumor Necrosis Factor-alpha; Vildagliptin	2014
Vildagliptin compared to glimepiride on post-prandial lipemia and on insulin resistance in type 2 diabetic patients. Metabolism: clinical and experimental, 2014, Volume: 63, Issue:7 Topics: Adamantane; Aged; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemia; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Intention to Treat Analysis; Male; Metformin; Middle Aged; Nitriles; Postprandial Period; Pyrrolidines; Sulfonylurea Compounds; Vildagliptin; Weight Gain; Weight Loss	2014
Saxagliptin improves glycemic control by modulating postprandial glucagon and C-peptide levels in Chinese patients with type 2 diabetes. Diabetes research and clinical practice, 2014, Volume: 105, Issue:2 Topics: Adamantane; Asian People; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Glucagon; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Postprandial Period	2014
Improved Insulin Secretion by Autologous Islet Transplantation, Compared to Oral Antidiabetic Agents, After Distal Pancreatectomy. Cell transplantation, 2015, Volume: 24, Issue:8 Topics: Adamantane; Administration, Oral; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; HMGB1 Protein; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans Transplantation; Male; Metformin; Middle Aged; Nitriles; Pancreatectomy; Pancreatic Neoplasms; Pyrrolidines; Transplantation, Autologous; Vascular Endothelial Growth Factor A; Vildagliptin	2015
Combination of Saxagliptin and Metformin Is Effective as Initial Therapy in New-Onset Type 2 Diabetes Mellitus With Severe Hyperglycemia. The Journal of clinical endocrinology and metabolism, 2016, Volume: 101, Issue:6 Topics: Adamantane; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Treatment Outcome	2016
Effects of one year treatment of vildagliptin added to pioglitazone or glimepiride in poorly controlled type 2 diabetic patients. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2010, Volume: 42, Issue:9 Topics: Adamantane; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Humans; Hypoglycemic Agents; Inflammation; Insulin Resistance; Insulin-Secreting Cells; Male; Middle Aged; Nitriles; Pioglitazone; Pyrrolidines; Sulfonylurea Compounds; Thiazolidinediones; Time Factors; Treatment Outcome; Tumor Necrosis Factor-alpha; Vildagliptin	2010
Vildagliptin added to metformin on β-cell function after a euglycemic hyperinsulinemic and hyperglycemic clamp in type 2 diabetes patients. Diabetes technology & therapeutics, 2012, Volume: 14, Issue:6 Topics: Adamantane; Blood Glucose; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Nitriles; Pyrrolidines; Vildagliptin; Weight Loss	2012
Vildagliptin action on some adipocytokine levels in type 2 diabetic patients: a 12-month, placebo-controlled study. Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:18 Topics: Adamantane; Adult; Chemokines; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Down-Regulation; Drug Therapy, Combination; Female; Humans; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Intention to Treat Analysis; Intercellular Signaling Peptides and Proteins; Male; Metformin; Middle Aged; Nitriles; Pyrrolidines; Resistin; Retinol-Binding Proteins, Plasma; Vildagliptin	2012

Other Studies

47 other study(ies) available for adamantane and Insulin Resistance

Article	Year
ER Stress Amelioration by Saxagliptin Protects the Liver Against Fructose-induced Insulin Resistance. Archives of medical research, 2020, Volume: 51, Issue:4 Topics: Adamantane; Animals; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fructose; Humans; Insulin Resistance; Liver; Male; Rats	2020
Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats. Journal of ethnopharmacology, 2021, Jan-30, Volume: 265 Topics: Adamantane; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptides; Herb-Drug Interactions; Hypoglycemic Agents; Hypolipidemic Agents; Insulin Resistance; Male; Niacinamide; Plant Extracts; Rats; Rats, Wistar; Stevia; Streptozocin	2021
Neurotensin receptor 1 agonist provides neuroprotection in pre-diabetic rats. The Journal of endocrinology, 2021, Volume: 248, Issue:1 Topics: Adamantane; Animals; Cognitive Dysfunction; Diet, High-Fat; Drug Evaluation, Preclinical; Drug Therapy, Combination; Hippocampus; Ileum; Imidazoles; Insulin Resistance; Male; Neuronal Plasticity; Obesity; Oligopeptides; Oxidative Stress; Prediabetic State; Random Allocation; Rats, Wistar; Receptors, Neurotensin	2021
Comparisons of cardioprotective efficacy between fibroblast growth factor 21 and dipeptidyl peptidase-4 inhibitor in prediabetic rats. Cardiovascular therapeutics, 2017, Volume: 35, Issue:4 Topics: Adamantane; Animals; Cardiotonic Agents; Diabetic Cardiomyopathies; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Fibroblast Growth Factors; Gene Expression Regulation; Heart Rate; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Mitochondria, Heart; Nitriles; Obesity; Prediabetic State; Pyrrolidines; Rats; Rats, Wistar; Recombinant Proteins; Tumor Necrosis Factor-alpha; Ventricular Dysfunction, Left; Vildagliptin	2017
SGLT2-inhibitor and DPP-4 inhibitor improve brain function via attenuating mitochondrial dysfunction, insulin resistance, inflammation, and apoptosis in HFD-induced obese rats. Toxicology and applied pharmacology, 2017, 10-15, Volume: 333 Topics: Adamantane; Animals; Anti-Inflammatory Agents; Apoptosis; Benzhydryl Compounds; Brain; Cognition Disorders; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Glucosides; Insulin; Insulin Resistance; Long-Term Potentiation; Male; Malondialdehyde; Maze Learning; Membrane Potential, Mitochondrial; Memory; Mitochondria; Neuroprotective Agents; Nitriles; Obesity; Oxidative Stress; Pyrrolidines; Rats, Wistar; Reactive Oxygen Species; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Vildagliptin	2017
Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin. PloS one, 2017, Volume: 12, Issue:8 Topics: Adamantane; Aging; Animals; Biomarkers; Body Weight; Brain; Dementia; Dipeptides; Galactose; Glycated Hemoglobin; Hypoglycemic Agents; Insulin Resistance; Locomotion; Male; Metformin; Nerve Tissue Proteins; Oxidative Stress; Rats; Rats, Wistar; Reaction Time	2017
Vildagliptin increases butyrate-producing bacteria in the gut of diabetic rats. PloS one, 2017, Volume: 12, Issue:10 Topics: Adamantane; Administration, Oral; Animals; Blood Glucose; Butyrates; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Gastrointestinal Microbiome; Glucagon-Like Peptide 1; Insulin Resistance; Interleukin-6; Male; Nitriles; Pyrrolidines; Random Allocation; Rats, Sprague-Dawley; RNA, Ribosomal, 16S; Vildagliptin	2017
Dipeptidyl peptidase-4 inhibitor enhances restoration of salivary glands impaired by obese-insulin resistance. Archives of oral biology, 2018, Volume: 85 Topics: Adamantane; Animals; Apoptosis; Blotting, Western; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Inflammation; Insulin Resistance; Male; Mitochondria; Nitriles; Obesity; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Salivary Glands; Vildagliptin	2018
Dipeptidyl peptidase-4 inhibition prevents cell death via extrinsic and intrinsic apoptotic pathways in rat pancreas with insulin resistance. Cell biochemistry and function, 2018, Volume: 36, Issue:4 Topics: Adamantane; Animals; Apoptosis; Dietary Carbohydrates; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Insulin Resistance; Male; Pancreas; Rats; Rats, Sprague-Dawley	2018
FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97 Topics: Adamantane; Animals; Apoptosis; Cognitive Dysfunction; Dipeptidyl-Peptidase IV Inhibitors; Fibroblast Growth Factors; Hippocampus; Humans; Insulin Resistance; Male; Malondialdehyde; Mitochondria; Neuronal Plasticity; Nitriles; Obesity; Oxidative Stress; Pyrrolidines; Rats, Wistar; Signal Transduction; Vildagliptin	2018
The efficacy of saxagliptin in T2DM patients with non-alcoholic fatty liver disease: preliminary data. Revista da Associacao Medica Brasileira (1992), 2019, Volume: 65, Issue:1 Topics: Adamantane; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Dipeptides; Female; Humans; Hypoglycemic Agents; Insulin Resistance; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Phosphatidylcholines; Sulfonylurea Compounds; Treatment Outcome	2019
Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats. British journal of pharmacology, 2013, Volume: 169, Issue:5 Topics: Adamantane; Animals; Blood Glucose; Blood Pressure; Body Weight; Cardiotonic Agents; Cholesterol; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Heart; Heart Rate; Insulin; Insulin Resistance; Male; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria, Heart; Nitriles; Obesity; Oxidative Stress; Pyrazines; Pyrrolidines; Rats, Wistar; Reactive Oxygen Species; Sitagliptin Phosphate; Triazoles; Vildagliptin	2013
DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats. The Journal of endocrinology, 2013, Volume: 218, Issue:1 Topics: Adamantane; Animals; Behavior, Animal; Brain; Cognition Disorders; Diabetes Mellitus, Type 2; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Hippocampus; Insulin Resistance; Male; Maze Learning; Memory; Memory Disorders; Mitochondria; Nitriles; Obesity; Oxidative Stress; Pyrazines; Pyrrolidines; Rats; Rats, Wistar; Sitagliptin Phosphate; Triazoles; Vildagliptin	2013
Clinical characteristics of the responders to dipeptidyl peptidase-4 inhibitors in Korean subjects with type 2 diabetes. Journal of Korean medical science, 2013, Volume: 28, Issue:6 Topics: Adamantane; Blood Glucose; Body Mass Index; C-Peptide; Creatinine; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glycated Hemoglobin; Humans; Insulin Resistance; Male; Middle Aged; Multivariate Analysis; Nitriles; Pyrazines; Pyrrolidines; Retrospective Studies; Sitagliptin Phosphate; Triazoles; Vildagliptin	2013
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes. Cardiovascular diabetology, 2013, Nov-04, Volume: 12 Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin	2013
[Therapeutic effect of saxagliptin in rat models of nonalcoholic fatty liver and type 2 diabetes]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014, Volume: 34, Issue:6 Topics: Adamantane; Animals; bcl-2-Associated X Protein; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Disease Models, Animal; Hepatocytes; Insulin Resistance; Lipids; Liver; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley	2014
The dipeptidyl peptidase-4 inhibitor vildagliptin has the capacity to repair β-cell dysfunction and insulin resistance. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2014, Volume: 46, Issue:11 Topics: Adamantane; Area Under Curve; C-Reactive Protein; Dipeptidyl-Peptidase IV Inhibitors; Fasting; Female; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Middle Aged; Nitriles; Pyrrolidines; Vildagliptin	2014
Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats. PloS one, 2014, Volume: 9, Issue:7 Topics: Adamantane; Animals; Arrhythmias, Cardiac; Calcium; Cardiotonic Agents; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Heart Rate; Insulin Resistance; Intracellular Space; Male; Metformin; Mitochondria; Myocardial Ischemia; Myocardial Reperfusion Injury; Nitriles; Obesity; Pyrrolidines; Rats; Rats, Wistar; Ventricular Dysfunction, Left; Vildagliptin	2014
HIS-388, a novel orally active and long-acting 11β-hydroxysteroid dehydrogenase type 1 inhibitor, ameliorates insulin sensitivity and glucose intolerance in diet-induced obesity and nongenetic type 2 diabetic murine models. The Journal of pharmacology and experimental therapeutics, 2014, Volume: 351, Issue:1 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Administration, Oral; Animals; Azepines; Carbenoxolone; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Female; Glucose Intolerance; Humans; Hypoglycemic Agents; Insulin Resistance; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Obesity; Pioglitazone; Thiazolidinediones; Triazoles	2014
DPP-4 inhibitor and PPARγ agonist restore the loss of CA1 dendritic spines in obese insulin-resistant rats. Archives of medical research, 2014, Volume: 45, Issue:7 Topics: Adamantane; Animals; Blood Glucose; Cholesterol; Dendritic Spines; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Hippocampus; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Neuroprotective Agents; Nitriles; Obesity; Pioglitazone; PPAR gamma; Pyrrolidines; Rats; Rats, Wistar; Receptor, Insulin; Thiazolidinediones; Vildagliptin	2014
Dipeptidyl peptidase 4 inhibitor improves brain insulin sensitivity, but fails to prevent cognitive impairment in orchiectomy obese rats. The Journal of endocrinology, 2015, Volume: 226, Issue:2 Topics: Adamantane; Animals; Brain; Cognition; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Insulin Resistance; Male; Maze Learning; Mitochondria; Neuronal Plasticity; Nitriles; Obesity; Orchiectomy; Pyrrolidines; Rats; Rats, Wistar; Vildagliptin	2015
Treatment with metformin and a dipeptidyl peptidase-4 inhibitor elevates apelin levels in patients with type 2 diabetes mellitus. Drug design, development and therapy, 2015, Volume: 9 Topics: Adamantane; Adult; Apelin; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Male; Metformin; Middle Aged; Nitriles; Pyrrolidines; Time Factors; Treatment Outcome; Up-Regulation; Vildagliptin	2015
Dipeptidyl peptidase-4 inhibitors and the ischemic heart: Additional benefits beyond glycemic control. International journal of cardiology, 2016, Jan-01, Volume: 202 Topics: Adamantane; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Humans; Hypoglycemic Agents; Insulin Resistance; Myocardial Ischemia; Nitriles; Obesity; Oxidative Stress; Pyrrolidines; Rats; Sitagliptin Phosphate; Ventricular Function, Left; Vildagliptin	2016
A potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, SKI2852, ameliorates metabolic syndrome in diabetic mice models. European journal of pharmacology, 2015, Dec-05, Volume: 768 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Adipose Tissue; Animals; Body Weight; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glycated Hemoglobin; Insulin Resistance; Lipids; Liver; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Pyrimidines	2015
Reduced DPP4 activity improves insulin signaling in primary human adipocytes. Biochemical and biophysical research communications, 2016, Mar-11, Volume: 471, Issue:3 Topics: Adamantane; Adipocytes; Cell Differentiation; Cells, Cultured; Dipeptides; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Enzyme Activation; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Signal Transduction; Sitagliptin Phosphate	2016
Effects of dipeptidyl peptidase-4 inhibitor in insulin-resistant rats with myocardial infarction. The Journal of endocrinology, 2016, Volume: 229, Issue:3 Topics: Adamantane; Animals; Cardiotonic Agents; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Enalapril; Heart Rate; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Myocardial Infarction; Nitriles; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Ventricular Remodeling; Vildagliptin	2016
Low-carbohydrate diet combined with SGLT2 inhibitor for refractory hyperglycemia caused by insulin antibodies. Diabetes research and clinical practice, 2016, Volume: 116 Topics: Adamantane; Aged; Benzhydryl Compounds; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Diet, Carbohydrate-Restricted; Drug Therapy, Combination; Glucosides; Humans; Hypoglycemic Agents; Insulin; Insulin Antibodies; Insulin Resistance; Male; Metformin; Nitriles; Pyrrolidines; Sodium-Glucose Transporter 2 Inhibitors; Vildagliptin	2016
Estrogen and DPP4 inhibitor, but not metformin, exert cardioprotection via attenuating cardiac mitochondrial dysfunction in obese insulin-resistant and estrogen-deprived female rats. Menopause (New York, N.Y.), 2016, Volume: 23, Issue:8 Topics: Adamantane; Animals; Cardiotonic Agents; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Estrogens; Female; Heart Rate; Hypoglycemic Agents; Insulin Resistance; Menopause, Premature; Metformin; Mitochondria, Heart; Nitriles; Obesity; Ovariectomy; Oxidative Stress; Pyrrolidines; Rats; Rats, Wistar; Vildagliptin	2016
Vildagliptin reduces cardiac ischemic-reperfusion injury in obese orchiectomized rats. The Journal of endocrinology, 2016, Volume: 231, Issue:1 Topics: Adamantane; Androgens; Animals; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Heart; Heart Rate; Insulin Resistance; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Nitriles; Obesity; Orchiectomy; Pyrrolidines; Rats; Rats, Wistar; Testosterone; Ventricular Function, Left; Vildagliptin	2016
Vildagliptin and caloric restriction for cardioprotection in pre-diabetic rats. The Journal of endocrinology, 2017, Volume: 232, Issue:2 Topics: Adamantane; Animals; Blood Glucose; Body Weight; Caloric Restriction; Cardiotonic Agents; Diet, High-Fat; Fibroblast Growth Factors; Heart Rate; Insulin Resistance; Intra-Abdominal Fat; Male; Mitochondria, Heart; Nitriles; Oxidative Stress; Prediabetic State; Pyrrolidines; Rats; Rats, Wistar; Ventricular Function, Left; Vildagliptin	2017
Trigonelline and vildagliptin antidiabetic effect: improvement of insulin signalling pathway. The Journal of pharmacy and pharmacology, 2017, Volume: 69, Issue:7 Topics: Adamantane; Alkaloids; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hypoglycemic Agents; Hypolipidemic Agents; Insulin; Insulin Resistance; Lipids; Male; Nitriles; Pyrrolidines; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction; Vildagliptin	2017
DPP-4 Inhibitor and Estrogen Share Similar Efficacy Against Cardiac Ischemic-Reperfusion Injury in Obese-Insulin Resistant and Estrogen-Deprived Female Rats. Scientific reports, 2017, 03-10, Volume: 7 Topics: Adamantane; Animals; Apoptosis; Blood Glucose; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Estradiol; Fasting; Female; Heart Rate; Insulin Resistance; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Nitriles; Obesity; Ovariectomy; Pyrrolidines; Rats; Rats, Wistar; Stroke Volume; Ventricular Function, Left; Vildagliptin	2017
Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. PloS one, 2009, Volume: 4, Issue:3 Topics: 1-Deoxynojirimycin; Adamantane; Adipogenesis; Adiponectin; Adipose Tissue; Animals; Chemokine CCL2; Glucose; Glycosphingolipids; Homeostasis; Inflammation; Insulin Resistance; Macrophages; Mice; Mice, Inbred C57BL; Mice, Obese; Signal Transduction	2009
Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice. Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:5 Topics: 1-Deoxynojirimycin; Adamantane; Animals; Disease Models, Animal; Fatty Liver; Glucose; Glycosphingolipids; Homeostasis; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Triglycerides	2009
Distinguishing among incretin-based therapies. Glucose-lowering effects of incretin-based therapies. The Journal of family practice, 2010, Volume: 59, Issue:9 Suppl 1 Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Liraglutide; Male; Metformin; Middle Aged; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms	2010
Distinguishing among incretin-based therapies. Patient education and self-management. The Journal of family practice, 2010, Volume: 59, Issue:9 Suppl 1 Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Liraglutide; Male; Metformin; Middle Aged; Patient Education as Topic; Peptides; Pyrazines; Receptors, Glucagon; Self Care; Sitagliptin Phosphate; Triazoles; Venoms	2010
Distinguishing among incretin-based therapies. Introduction. The Journal of family practice, 2010, Volume: 59, Issue:9 Suppl 1 Topics: Adamantane; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Administration Schedule; Exenatide; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Insulin-Secreting Cells; Liraglutide; Metformin; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms	2010
[Preclinical and clinical findings of the dipeptidyl peptidase-4 inhibitor vildagliptin]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2010, Volume: 136, Issue:5 Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucose Intolerance; Humans; Hypoglycemic Agents; Incretins; Insulin Resistance; Islets of Langerhans; Nitriles; Pyrrolidines; Vildagliptin	2010
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. Bioorganic & medicinal chemistry letters, 2011, Feb-01, Volume: 21, Issue:3 Topics: Adamantane; Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Blood Glucose; Disease Models, Animal; Enzyme Inhibitors; Epoxide Hydrolases; Hypertension; Insulin Resistance; Mice; Obesity; Rats; Urea	2011
Cardioprotective effects of metformin and vildagliptin in adult rats with insulin resistance induced by a high-fat diet. Endocrinology, 2012, Volume: 153, Issue:8 Topics: Adamantane; Animals; Blood Glucose; Body Weight; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Heart Diseases; Heart Rate; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Metformin; Nitriles; Pyrrolidines; Rats; Rats, Wistar; Vildagliptin	2012
Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor in the diet-induced obese mice. European journal of pharmacology, 2012, Sep-15, Volume: 691, Issue:1-3 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 3T3-L1 Cells; Adamantane; Adipocytes; Adipogenesis; Adrenal Glands; Animals; Biomarkers; CHO Cells; Cricetinae; Cricetulus; Diet; Enzyme Inhibitors; Gene Expression Regulation; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Hypothalamo-Hypophyseal System; Insulin Resistance; Mice; Molecular Docking Simulation; Obesity; Protein Conformation; Thiadiazines	2012
Factors associated with the glucose-lowering effect of vildagliptin identified from the results of the oral glucose tolerance test in Japanese patients with type 2 diabetes. Endocrine journal, 2013, Volume: 60, Issue:1 Topics: Adamantane; Aged; Asian People; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Japan; Male; Middle Aged; Nitriles; Pyrrolidines; Treatment Outcome; Vildagliptin	2013
DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption. The European journal of neuroscience, 2013, Volume: 37, Issue:5 Topics: Adamantane; Animals; Brain; Cognition; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Gene Expression; Glucagon-Like Peptide 1; Insulin Receptor Substrate Proteins; Insulin Resistance; Long-Term Synaptic Depression; Male; Maze Learning; Membrane Potential, Mitochondrial; Memory; Mitochondria; Neurons; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrrolidines; Rats; Rats, Wistar; Receptor, Insulin; Vildagliptin	2013
Acute and chronic effects of the incretin enhancer vildagliptin in insulin-resistant rats. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 315, Issue:2 Topics: Adamantane; Animals; Area Under Curve; Blood Glucose; Dietary Fats; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Glucagon-Like Peptide 1; Glucose Intolerance; Glucose Oxidase; Glucose Tolerance Test; Insulin Resistance; Male; Nitriles; Pyrrolidines; Rats; Rats, Zucker; Tachyphylaxis; Time Factors; Vildagliptin; Weight Gain	2005
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. The Journal of experimental medicine, 2005, Aug-15, Volume: 202, Issue:4 Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adamantane; Animals; Aorta; Arteriosclerosis; Azepines; Blood Glucose; Cortisone; Diet, Atherogenic; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Fatty Acids; Hydrocortisone; Insulin; Insulin Resistance; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Syndrome; Triazoles; Triglycerides	2005
Molecule of the month. Vildagilptin. Drug news & perspectives, 2006, Volume: 19, Issue:4 Topics: Adamantane; Diabetes Mellitus; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin Resistance; Nitriles; Pyrrolidines; Randomized Controlled Trials as Topic; Vildagliptin	2006
Islet cell function is as interesting as insulin resistance for T2DM treatment options. International journal of clinical practice. Supplement, 2008, Issue:159 Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Humans; Insulin Resistance; Islets of Langerhans; Nitriles; Pyrrolidines; Vildagliptin	2008