Compounds > poliothrysoside

Page last updated: 2024-11-10

poliothrysoside

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

poliothrysoside: isolated from Laxocalyx urticifolius; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	3084295
CHEMBL ID	512419
MeSH ID	M0454868

Synonyms (15)

Synonym
beta-d-glucopyranoside, 4-hydroxy-2-(hydroxymethyl)phenyl, 6-benzoate
xylosmoside
glucopyranoside, alpha,4-dihydroxy-o-tolyl, 6-benzoate
18463-25-7
poliothrysoside
poliothyrsoside
CHEMBL512419
tributyltinchloroacetate
ncgc00385097-01_c20h22o9_beta-d-glucopyranoside, 4-hydroxy-2-(hydroxymethyl)phenyl, 6-benzoate
NCGC00385097-01
AKOS032948709
((2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(4-hydroxy-2-(hydroxymethyl)phenoxy)tetrahydro-2h-pyran-2-yl)methyl benzoate
DTXSID10939852
4-hydroxy-2-(hydroxymethyl)phenyl 6-o-benzoylhexopyranoside
FS-10508

Research Excerpts

Bioavailability

Excerpt	Reference	Relevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."	( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)	0.51

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID1296008	Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening	2020	SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1	Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347159	Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1346986	P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987	P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen	2019	Molecular pharmacology, 11, Volume: 96, Issue:5	A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID722960	Antimalarial activity against Plasmodium yoelii infected in Swiss mouse assessed as inhibition of beta-hematin formation in plasma after 16 hrs by spectrophotometric analysis	2013	European journal of medicinal chemistry, Feb, Volume: 60	Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents.
AID1163840	Induction of [3H] 2-deoxyglucose uptake in chronic insulin resistant mouse 3T3L1 cells assessed as maximum uptake at 10 uM by liquid scintillation counting	2014	European journal of medicinal chemistry, Oct-30, Volume: 86	Poliothrysoside and its derivatives as novel insulin sensitizers potentially driving AMPK activation and inhibiting adipogenesis.
AID385238	Inhibition of COX2 at 10 uM	2008	Journal of natural products, May, Volume: 71, Issue:5	Itosides J-N from Itoa orientalis and structure - anti-COX-2 activity relationship of phenolic glycosides.
AID722963	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	2013	European journal of medicinal chemistry, Feb, Volume: 60	Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents.
AID722961	Selectivity index, ratio of CC50 for african green monkey Vero cells to IC50 for Plasmodium falciparum 3D7	2013	European journal of medicinal chemistry, Feb, Volume: 60	Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents.
AID663478	Inhibition of Dengue virus NS5 polymerase assessed as inhibition of radiolabeled guanosine incorporation into homopolymeric cytosine RNA template by liquid scintillation counting	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi.
AID722964	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 72 hrs by SYBR green assay	2013	European journal of medicinal chemistry, Feb, Volume: 60	Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents.
AID722962	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	2013	European journal of medicinal chemistry, Feb, Volume: 60	Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (22.22)	29.6817
2010's	5 (55.56)	24.3611
2020's	2 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.43 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.73 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
catechol [no description available]	2.05	1	0	catechols	allelochemical; genotoxin; plant metabolite
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	2	1	0	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2.47	2	0	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
metformin Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289). metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.	2.1	1	0	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic
n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide: structure given in first source. NS-398 : A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.	2.04	1	0	aromatic ether; C-nitro compound; sulfonamide	antineoplastic agent; cyclooxygenase 2 inhibitor
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.73	3	0	D-glucopyranose	epitope; mouse metabolite
salicin [no description available]	2.04	1	0	aromatic primary alcohol; aryl beta-D-glucoside; benzyl alcohols	antipyretic; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; prodrug
tremulacin tremulacin: extracted from Folia Populus tomentosa Carr; structure given in first source	2.04	1	0	glycoside
pyracrenic acid pyracrenic acid: a lupane from bark of Pyracantha crenulata; structure given in first source	2.07	1	0	triterpenoid	metabolite
phytosterols Phytosterols: A class of organic compounds known as sterols or STEROIDS derived from plants.. phytosterols : Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond.	2	1	0
salirepin salirepin: isolated from Symplocos racemosa; structure in first source	2.04	1	0	glycoside
vanilloloside [no description available]	2.04	1	0	glycoside	metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Insulin Sensitivity [description not available]	0	2.1	1	0
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	0	2.1	1	0
Congenital Zika Syndrome [description not available]	0	2.25	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	2.25	1	0
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	0	2.25	1	0