o-acetyl-adp-ribose

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

O-Acetyl-ADP-Ribose: An acetyl ester of ADENOSINE DIPHOSPHATE RIBOSE formed during NAD-dependent deacetylation of proteins by SIRTUINS. The acetate group resides on the ribose ring where nicotinamide was cleaved from NAD during the reaction. Several isomers of O-acetyl-ADP-ribose have been isolated from the reaction. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2''-O-acetyl-ADP-D-ribose : A nucleotide-sugar having ADP as the nucleotide fragment and 2-O-acetyl-D-ribofuranos-5-yl as the sugar component. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	72193709
CHEBI ID	76279
MeSH ID	M0384443

Synonyms (15)

Synonym
AC1MMT9E ,
2''-o-acetyl-adp-ribose
C20658
aadpr
o-acetyl-adp-ribose
gtpl6333
[(3r,4r,5r)-5-[[[[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxymethyl]-2,4-dihydroxyoxolan-3-yl] acetate
adenosine 5'-[3-(2-o-acetyl-d-ribofuranos-5-o-yl) dihydrogen diphosphate]
2'-o-acetyl-adp-ribose
oaadpr
2''-o-acetyl-adp-d-ribose
CHEBI:76279
2'-oaadpr
BFNOPXRXIQJDHO-YDKGJHSESA-N
o-acetyl-adp ribose

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
nucleotide-sugar
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (33)

Pathway	Proteins	Compounds
Organelle biogenesis and maintenance	232	16
Mitochondrial biogenesis	66	8
Transcriptional activation of mitochondrial biogenesis	35	7
DNA Repair	255	47
DNA Double-Strand Break Repair	103	13
Homology Directed Repair	83	9
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	79	9
Processing of DNA double-strand break ends	51	8
Signaling Pathways	1269	117
Signaling by NOTCH	113	14
Pre-NOTCH Expression and Processing	24	13
Pre-NOTCH Transcription and Translation	17	4
Cellular responses to stimuli	483	56
Cellular responses to stress	469	54
Cellular response to heat stress	70	9
Regulation of HSF1-mediated heat shock response	57	7
Cell Cycle	538	31
Cell Cycle, Mitotic	410	31
M Phase	279	21
Mitotic Metaphase and Anaphase	158	12
FOXO-mediated transcription	60	7
Regulation of FOXO transcriptional activity by acetylation	8	5
Mitotic Anaphase	157	12
Nuclear Envelope (NE) Reassembly	51	10
Initiation of Nuclear Envelope (NE) Reformation	14	7
Gene expression (Transcription)	902	49
RNA Polymerase II Transcription	728	42
Generic Transcription Pathway	608	39
Epigenetic regulation of gene expression	117	17
Negative epigenetic regulation of rRNA expression	45	6
SIRT1 negatively regulates rRNA expression	9	5
NAD+ Signalling Pathway (Cancer)	10	12
The impact of Nsp14 on metabolism (COVID-19 Disease Map)	0	84

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID1346628	Human TRPM2 (Transient Receptor Potential channels)	2006	The Journal of biological chemistry, May-19, Volume: 281, Issue:20	Metabolite of SIR2 reaction modulates TRPM2 ion channel.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (39)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	22 (56.41)	29.6817
2010's	16 (41.03)	24.3611
2020's	1 (2.56)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.72 (24.57)
Research Supply Index	3.69 (2.92)
Research Growth Index	6.11 (4.65)
Search Engine Demand Index	18.60 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (21.72)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	7 (17.95%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	32 (82.05%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
niacinamide nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.	4.34	3	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.72	3	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	3.51	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
isonicotinamide isonicotinamide : A pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid.	3.15	1	pyridinecarboxamide
carbonates Carbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed). carbonates : Organooxygen compounds that are salts or esters of carbonic acid, H2CO3.	2.08	1	carbon oxoanion
deuterium oxide Deuterium Oxide: The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.	2	1	deuterated compound; water	NMR solvent
adenosine diphosphate ribose Adenosine Diphosphate Ribose: An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.	5.34	10	ADP-sugar	Escherichia coli metabolite; mouse metabolite
arabinose [no description available]	2	1	L-arabinose	Escherichia coli metabolite; mouse metabolite
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	3.15	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
chalcone trans-chalcone : The trans-isomer of chalcone.	2.02	1	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	3.15	1	stilbene
bilirubin [no description available]	2.02	1	biladienes; dicarboxylic acid	antioxidant; human metabolite; mouse metabolite
3',4',5',3,4,5-hexamethoxy-chalcone [no description available]	2.02	1
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	6.62	17	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
srt1720 [no description available]	3.15	1

Condition	Relationship Strength	Studies
Fatty Liver, Nonalcoholic [description not available]	2.1	1
Liver Steatosis [description not available]	2.1	1
Fatty Liver Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.	2.1	1
Non-alcoholic Fatty Liver Disease Fatty liver finding without excessive ALCOHOL CONSUMPTION.	2.1	1
Insulin Sensitivity [description not available]	2.97	1
Benign Neoplasms [description not available]	2.97	1
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	2.97	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.97	1
Genome Instability [description not available]	2.07	1
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2.94	1

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