n(1)-methylnicotinamide has been researched along with Insulin Resistance in 6 studies
N(1)-methylnicotinamide: RN given refers to parent cpd
1-methylnicotinamide : A pyridinium ion comprising nicotinamide having a methyl group at the 1-position. It is a metabolite of nicotinamide which was initially considered to be biologically inactive but has emerged as an anti-thrombotic and anti-inflammatory agent.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ecological evidence suggests that niacin (nicotinamide and nicotinic acid) fortification may be involved in the increased prevalence of obesity and type 2 diabetes, both of which are associated with insulin resistance and epigenetic changes." | 3.79 | Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats. ( Cao, JM; Cao, Y; Gong, XJ; Guo, J; Guo, M; Li, D; Lun, YZ; Luo, N; Sun, WP; Tian, YJ; Zhou, SS, 2013) |
| "Patients with manifest type 2 diabetes have a significantly (approximately twofold) higher NNMT expression both in omental and subcutaneous WAT compared with controls." | 2.80 | Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance. ( Blüher, M; Dietrich, A; Kannt, A; Klöting, N; Pfenninger, A; Schön, MR; Teichert, L; Tönjes, A, 2015) |
| " At the same dosage (2 g/kg), in comparison with nicotinamide, nicotinic acid was weaker in raising plasma N(1)-methylnicotinamide levels (0." | 1.39 | Excessive nicotinic acid increases methyl consumption and hydrogen peroxide generation in rats. ( Cao, Y; Li, D; Li, SZ; Luo, N; Ma, Q; Shi, Q; Zhou, SS, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 2 |
| Chen, Y | 2 |
| Liu, C | 2 |
| Li, L | 2 |
| Li, P | 2 |
| Li, D | 3 |
| Tian, YJ | 2 |
| Guo, J | 1 |
| Sun, WP | 1 |
| Lun, YZ | 1 |
| Guo, M | 2 |
| Luo, N | 2 |
| Cao, Y | 3 |
| Cao, JM | 1 |
| Gong, XJ | 1 |
| Zhou, SS | 3 |
| Kannt, A | 1 |
| Pfenninger, A | 1 |
| Teichert, L | 1 |
| Tönjes, A | 1 |
| Dietrich, A | 1 |
| Schön, MR | 1 |
| Klöting, N | 1 |
| Blüher, M | 1 |
| Liu, XX | 1 |
| Sun, CB | 1 |
| Yang, TT | 1 |
| Li, CY | 1 |
| Ma, Q | 1 |
| Li, SZ | 1 |
| Shi, Q | 1 |
1 trial available for n(1)-methylnicotinamide and Insulin Resistance
| Article | Year |
|---|---|
Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance.
Topics: Adult; Aged; Bariatric Surgery; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Diabetes | 2015 |
5 other studies available for n(1)-methylnicotinamide and Insulin Resistance
| Article | Year |
|---|---|
N
Topics: Acetylation; Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; | 2020 |
N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Receptor Sub | 2021 |
Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.
Topics: Animals; Betaine; Choline; CpG Islands; Dietary Supplements; DNA; DNA Damage; DNA Methylation; Epige | 2013 |
Decreased skin-mediated detoxification contributes to oxidative stress and insulin resistance.
Topics: Animals; Antioxidants; Blood Glucose; Burns; Glycogen; Hydrogen Peroxide; Insulin; Insulin Resistanc | 2012 |
Excessive nicotinic acid increases methyl consumption and hydrogen peroxide generation in rats.
Topics: Animals; Dose-Response Relationship, Drug; Glucose; Glucose Tolerance Test; Glycogen; Hydrogen Perox | 2013 |