Page last updated: 2024-12-07

14-fluoro-6-thiaheptadecanoic acid

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Description

## 14-Fluoro-6-thiaheptadecanoic acid: A Research Tool for Studying Fatty Acid Metabolism

**14-Fluoro-6-thiaheptadecanoic acid** is a synthetic analog of palmitic acid, a common saturated fatty acid found in animals and plants. It has several key structural features that make it a useful tool in research:

* **Fluorine substitution:** The presence of fluorine at the 14th carbon position makes the molecule more stable and resistant to metabolic breakdown. This allows it to persist in the body longer, providing a more sustained effect for research purposes.
* **Sulfur substitution:** The sulfur atom at the 6th carbon position introduces a unique chemical property that can be exploited in various research applications.
* **Chain length:** The 17-carbon chain length makes it comparable to naturally occurring fatty acids, ensuring relevant interactions with cellular pathways.

**Here's why this molecule is important for research:**

**1. Studying Fatty Acid Metabolism:**

* **Inhibition of Fatty Acid Synthesis:** 14-fluoro-6-thiaheptadecanoic acid has been shown to inhibit the enzyme fatty acid synthase (FAS), a key enzyme responsible for the synthesis of fatty acids in the body. By inhibiting FAS, researchers can study the effects of reduced fatty acid synthesis on various cellular processes and disease models.
* **Modulation of Lipid Metabolism:** This molecule can also be used to study the transport, storage, and breakdown of lipids. It can interact with various proteins involved in lipid metabolism, providing insights into their function and potential targets for drug development.

**2. Development of Anti-Cancer Agents:**

* **Cancer Cell Growth Inhibition:** The inhibition of fatty acid synthesis by 14-fluoro-6-thiaheptadecanoic acid has shown potential in reducing the growth of certain types of cancer cells.
* **Increased Sensitivity to Chemotherapy:** Research suggests that this compound might increase the effectiveness of chemotherapy drugs in treating some cancers.

**3. Studying Mitochondrial Function:**

* **Mitochondrial Metabolism:** 14-fluoro-6-thiaheptadecanoic acid can affect the function of mitochondria, the powerhouses of cells, by interfering with fatty acid oxidation. This allows for studying the role of mitochondria in various cellular processes and diseases.

**4. Understanding the Role of Fatty Acids in Health and Disease:**

* **Metabolic Disorders:** The effects of 14-fluoro-6-thiaheptadecanoic acid on lipid metabolism can provide insights into the development and progression of metabolic disorders such as obesity, diabetes, and cardiovascular disease.
* **Neurological Disorders:** Studies using this molecule have explored its potential role in neurological conditions, demonstrating its influence on brain function and neuronal health.

**Overall, 14-fluoro-6-thiaheptadecanoic acid is a versatile research tool that provides valuable information about fatty acid metabolism and its impact on various cellular processes and disease states.**

It's important to note that research with this molecule is ongoing, and its full therapeutic potential is still being investigated.

14-fluoro-6-thiaheptadecanoic acid: structure given in first source; RN given is for 18F labelled cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID132136
MeSH IDM0193462

Synonyms (10)

Synonym
138225-06-6
14-fluoro-6-thiaheptadecanoic acid
pentanoic acid, 5-((8-(fluoro-18f)undecyl)thio)-, (+-)-
ftha
5-(8-fluoroundecylsulfanyl)pentanoic acid
137564-72-8
14-fluoro-6-thia-heptadecanoic acid
14(r,s)-fluoro-6-thiaheptadecanoic acid
5-[(8-fluoroundecyl)sulfanyl]pentanoic acid
DTXSID70930027
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's9 (34.62)18.2507
2000's6 (23.08)29.6817
2010's8 (30.77)24.3611
2020's3 (11.54)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.19 (24.57)
Research Supply Index3.40 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (7.41%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (3.70%)4.05%
Observational0 (0.00%)0.25%
Other24 (88.89%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]