| Assay ID | Title | Year | Journal | Article |
|---|
| AID313754 | Agonist activity at human PPARgamma assessed as receptor activation by cell based assay relative to rosiglitazone | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID277180 | Agonist potency at mouse PPARalpha | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277178 | Plasma concentration in Beagle dog at 3 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID313751 | Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID277170 | Volume of distribution in Wistar rat at 2.7 mg/kg, iv | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277175 | Volume of distribution in Beagle dog at 2 mg/kg, iv | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID410083 | Agonist activity at human PPARgamma receptor by cell based transient transfection assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| The discovery of equipotent PPARalpha/gamma dual activators. |
| AID1547181 | Agonist activity at human PPARalpha expressed in nonhuman mammalian cells assessed as increase in receptor transcriptional activity incubated for 22 to 24 hrs by luciferase reporter gene assay | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. |
| AID277151 | Agonist potency at PPARalpha expressed in CV1 cells relative to GW-590735 | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID677052 | Selectivity ratio for EC50 for human PPARgamma to EC50 for human PPARalpha | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. |
| AID277159 | Decrease in VLDL cholesterol in human Apo-A-I transgenic C57BL/6 mouse at 1 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277152 | Agonist potency at PPARdelta in CV1 cells relative to GW-501516 | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277171 | Plasma clearance in Wistar rat at 2.7 mg/kg, iv | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID677054 | Agonist activity at human PPARalpha | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. |
| AID277166 | Increase in HDL cholesterol level in human Apo-A-I transgenic C57BL/6 mouse at 5 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277150 | Agonist potency at PPARgamma in CV1 cells by cell based transient transfection assay | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID313749 | Agonist activity at human PPARdelta assessed as receptor activation by cell based assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID1547189 | Binding affinity to His-tagged PPARalpha LBD (unknown origin) expressed in Escherichia coli Rosetta (DE3) assessed as change in Gibbs free energy at 25 degree C by isothermal titration calorimetry | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. |
| AID313750 | Agonist activity at human PPARdelta assessed as receptor activation by cell based assay relative to GW516 | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID277169 | Decrease in plasma TG level in human Apo-A-I transgenic C57BL/6 mouse at 5 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277164 | Increase in HDL cholesterol level in human Apo-A-I transgenic C57BL/6 mouse at 0.5 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID313748 | Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID677053 | Selectivity ratio for EC50 for human PPARbeta/gamma to EC50 for human PPARalpha | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. |
| AID597760 | Agonist activity at human PPARalpha-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists. |
| AID597761 | Agonist activity at human PPARgamma-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists. |
| AID313755 | Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID410081 | Agonist activity at human PPARalpha receptor by cell based transient transfection assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| The discovery of equipotent PPARalpha/gamma dual activators. |
| AID1395948 | Agonist activity at human PPARgamma after 22 to 24 hrs by luciferase reporter gene assay | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16
| Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARα selective agonists: New leads for oculovascular conditions. |
| AID551966 | Transactivation of Gal4-fused human PPARgamma DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation. |
| AID277176 | Plasma clearance in Beagle dog at 2 mg/kg, iv | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID313747 | Agonist activity at human PPARalpha assessed as receptor activation by cell based assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID277172 | Half life in Wistar rat plasma at 2.7 mg/kg, iv | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID313752 | Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assay relative to GW516 | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID313756 | Agonist activity at mouse PPARgamma assessed as receptor activation by cell based assay relative to rosiglitazone | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID1547188 | Binding affinity to His-tagged PPARalpha LBD (unknown origin) expressed in Escherichia coli Rosetta (DE3) at 25 degree C by isothermal titration calorimetry | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. |
| AID1547200 | Ratio of agonist activity at human PPARalpha expressed in nonhuman mammalian cells assessed as increase in receptor transcriptional activity by measuring relative light units at 5 uM to agonist activity at human PPARalpha expressed in nonhuman mammalian c | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. |
| AID410082 | Agonist activity at human PPARdelta receptor by cell based transient transfection assay | 2008 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue:23
| The discovery of equipotent PPARalpha/gamma dual activators. |
| AID277174 | Bioavailability in Wistar rat at 3 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID1395947 | Agonist activity at human PPARdelta after 22 to 24 hrs by luciferase reporter gene assay | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16
| Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARα selective agonists: New leads for oculovascular conditions. |
| AID277177 | Half life in Beagle dog plasma at 2 mg/kg, iv | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID597762 | Agonist activity at human PPARdelta-LBD expressed in CV1 cells co-transfected with Gal4 after 40 hrs by luciferase based transactivation assay | 2011 | Bioorganic & medicinal chemistry, May-15, Volume: 19, Issue:10
| Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists. |
| AID277162 | Decrease in LDL cholesterol level in human Apo-A-I transgenic C57BL/6 mouse at 1 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277167 | Decrease in plasma TG level in human Apo-A-I transgenic C57BL/6 mouse at 0.5 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277149 | Agonist potency at PPARdelta in CV1 cells by cell based transient transfection assay | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID1547199 | Agonist activity at human PPARalpha expressed in nonhuman mammalian cells assessed as maximal increase in receptor transcriptional activity incubated for 22 to 24 hrs by luciferase reporter gene assay relative to GW590735 | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. |
| AID551967 | Transactivation of Gal4-fused human PPARdelta DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation. |
| AID551965 | Transactivation of Gal4-fused human PPARalpha DNA binding domain expressed in african green monkey CV1 cells by luciferase reporter gene assay | 2011 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
| Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation. |
| AID277163 | Decrease in LDL cholesterol level in human Apo-A-I transgenic C57BL/6 mouse at 5 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277161 | Decrease in LDL cholesterol level in human Apo-A-I transgenic C57BL/6 mouse at 0.5 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277173 | Plasma concentration in Wistar rat at 3 mg/kg, po after 1.5 hrs | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277160 | Decrease in VLDL cholesterol in human Apo-A-I transgenic C57BL/6 mouse at 5 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID1547191 | Binding affinity to His tagged PPARalpha LBD (unknown origin) expressed in Escherichia coli Rosetta (DE3) assessed as change in entropy at 25 degree C by isothermal titration calorimetry | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. |
| AID277179 | Bioavailability in Beagle dog at 3 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277165 | Increase in HDL cholesterol level in human Apo-A-I transgenic C57BL/6 mouse at 1 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277181 | Agonist potency at mouse PPARdelta | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277168 | Decrease in plasma TG level in human Apo-A-I transgenic C57BL/6 mouse at 1 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID313753 | Agonist activity at human PPARgamma assessed as receptor activation by cell based assay | 2008 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 18, Issue:2
| Design, synthesis and evaluation of trifluoromethane sulfonamide derivatives as new potent and selective peroxisome proliferator-activated receptor alpha agonists. |
| AID1395945 | Agonist activity at human PPARalpha after 22 to 24 hrs by luciferase reporter gene assay | 2018 | Bioorganic & medicinal chemistry letters, 09-01, Volume: 28, Issue:16
| Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARα selective agonists: New leads for oculovascular conditions. |
| AID277158 | Decrease in VLDL cholesterol in human Apo-A-I transgenic C57BL/6 mouse at 0.5 mg/kg, po | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID1547190 | Binding affinity to His-tagged PPARalpha LBD (unknown origin) expressed in Escherichia coli Rosetta (DE3) assessed as change in enthalpy at 25 degree C by isothermal titration calorimetry | 2020 | Journal of medicinal chemistry, 03-26, Volume: 63, Issue:6
| Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. |
| AID277148 | Agonist potency at PPARalpha in CV1 cells by cell based transient transfection assay | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID277182 | Agonist potency at mouse PPARgamma | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| AID1798916 | Cell-Based Transcription Assay from Article 10.1021/jm058056x: \\Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents.\\ | 2007 | Journal of medicinal chemistry, Feb-22, Volume: 50, Issue:4
| Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARalpha agonists. 1. Discovery of a novel series of potent HDLc raising agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |