dironyl and Insulin-Resistance

dironyl has been researched along with Insulin-Resistance* in 2 studies

Other Studies

2 other study(ies) available for dironyl and Insulin-Resistance

Article	Year
Inhibition of growth hormone excess reduces insulin resistance and ovarian dysfunction in a lean case of polycystic ovary syndrome with a growth-hormone-producing pituitary adenoma. Hormone research, 2003, Volume: 59, Issue:3 A 23-year-old female with polycystic ovary syndrome (PCOS) and a growth-hormone (GH)-producing pituitary adenoma is described. A reduction in the elevated GH levels to normal levels following the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dysfunction. Menstrual cycles were therefore restored and the number of ovarian cysts reduced, suggesting that insulin and/or IGF-1, stimulators of theca cell proliferation, may be pathogenetic factors in PCOS. Topics: Acanthosis Nigricans; Acromegaly; Adenoma; Adult; Bromocriptine; Dopamine Agents; Female; Glucose Tolerance Test; Human Growth Hormone; Humans; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Lisuride; Magnetic Resonance Imaging; Menstrual Cycle; Ovary; Pancreatic Function Tests; Pituitary Function Tests; Pituitary Neoplasms; Polycystic Ovary Syndrome; Theca Cells	2003
Terguride attenuates prolactin levels and ameliorates insulin sensitivity and insulin binding in obese spontaneously hypertensive rats. Physiological research, 2001, Volume: 50, Issue:2 Glucose tolerance, serum insulin, insulin receptors in epididymal fat tissue, circulating total cholesterol and triglyceride concentrations as well as serum prolactin were studied in obese and lean spontaneously hypertensive rats (SHR) of both sexes. Obese animals displayed insulin resistance and elevated insulin and triglyceride concentrations. Moreover, in obese rats the increased mass of epididymal fat tissue was accompanied with decreased capacity of high affinity binding sites of insulin receptors in the tissue plasma membranes. Terguride treatment lowered prolactin serum levels which was accompanied by ameliorated insulin sensitivity in obese animals of both sexes. In addition, terguride treatment decreased serum insulin and triglyceride concentrations in obese females and at the same time enhanced the affinity of high affinity insulin binding sites. Our results show that obesity in SHR is associated with a decreased capacity of insulin receptors and that prolactin may play a role in obesity-induced insulin resistance, particularly in female rats. Topics: Adipose Tissue; Animals; Blood Glucose; Dopamine Agonists; Female; Hypertension; Insulin; Insulin Resistance; Lisuride; Male; Obesity; Prolactin; Rats; Rats, Inbred SHR	2001

Article

Year

Inhibition of growth hormone excess reduces insulin resistance and ovarian dysfunction in a lean case of polycystic ovary syndrome with a growth-hormone-producing pituitary adenoma.

Hormone research, 2003, Volume: 59, Issue:3

A 23-year-old female with polycystic ovary syndrome (PCOS) and a growth-hormone (GH)-producing pituitary adenoma is described. A reduction in the elevated GH levels to normal levels following the administration of dopaminergic agents decreased plasma insulin-like growth factor (IGF)-1 and ovarian dysfunction. Menstrual cycles were therefore restored and the number of ovarian cysts reduced, suggesting that insulin and/or IGF-1, stimulators of theca cell proliferation, may be pathogenetic factors in PCOS.

Topics: Acanthosis Nigricans; Acromegaly; Adenoma; Adult; Bromocriptine; Dopamine Agents; Female; Glucose Tolerance Test; Human Growth Hormone; Humans; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Lisuride; Magnetic Resonance Imaging; Menstrual Cycle; Ovary; Pancreatic Function Tests; Pituitary Function Tests; Pituitary Neoplasms; Polycystic Ovary Syndrome; Theca Cells

2003

Terguride attenuates prolactin levels and ameliorates insulin sensitivity and insulin binding in obese spontaneously hypertensive rats.

Physiological research, 2001, Volume: 50, Issue:2

Glucose tolerance, serum insulin, insulin receptors in epididymal fat tissue, circulating total cholesterol and triglyceride concentrations as well as serum prolactin were studied in obese and lean spontaneously hypertensive rats (SHR) of both sexes. Obese animals displayed insulin resistance and elevated insulin and triglyceride concentrations. Moreover, in obese rats the increased mass of epididymal fat tissue was accompanied with decreased capacity of high affinity binding sites of insulin receptors in the tissue plasma membranes. Terguride treatment lowered prolactin serum levels which was accompanied by ameliorated insulin sensitivity in obese animals of both sexes. In addition, terguride treatment decreased serum insulin and triglyceride concentrations in obese females and at the same time enhanced the affinity of high affinity insulin binding sites. Our results show that obesity in SHR is associated with a decreased capacity of insulin receptors and that prolactin may play a role in obesity-induced insulin resistance, particularly in female rats.

Topics: Adipose Tissue; Animals; Blood Glucose; Dopamine Agonists; Female; Hypertension; Insulin; Insulin Resistance; Lisuride; Male; Obesity; Prolactin; Rats; Rats, Inbred SHR

2001