alloxan has been researched along with Insulin Resistance in 22 studies
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carnitine deficiency and impaired glucose tolerance (IGT) exacerbate liver steatosis." | 8.12 | High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. ( Matsuura, T; Mekada, K; Nakamura, SI; Ozaki, K; Terayama, Y, 2022) |
| "Alloxan treatment, however, does not alter lymph insulin kinetics, indicating that insulin resistance of Type 1 (insulin-dependent) diabetes mellitus reflects direct impairment at the cellular level." | 5.30 | Evidence for direct action of alloxan to induce insulin resistance at the cellular level. ( Ader, M; Bergman, RN; Richey, JM, 1998) |
| "Carnitine deficiency and impaired glucose tolerance (IGT) exacerbate liver steatosis." | 4.12 | High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. ( Matsuura, T; Mekada, K; Nakamura, SI; Ozaki, K; Terayama, Y, 2022) |
| " This study aimed to investigate the effect of AZ on glucose and lipid metabolism disorders in alloxan-induced diabetic mice and also explored the effect of AZ on insulin resistance in 3T3-L1 adipocytes." | 3.91 | Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice. ( Kang, W; Liu, Z; Saadeldeen, FS; Wei, J; Xing, M; Xu, L; Xu, X, 2019) |
| "At 28 days, the alloxan animals exhibited higher insulin resistance as measured by the disappearance of glucose serum (% Kitt/min) during the ITT." | 3.78 | Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan. ( Botezelli, JD; Cambri, LT; da Silva Sponton, AC; Dalia, RA; de Araújo, MB; de Mello, MA; Ribeiro, C, 2012) |
| "This study was designed to investigate the hypoglycaemic and anti-oxidant effects of Zingiber officinale on experimentally induced diabetes mellitus using alloxan and insulin resistance." | 3.77 | Anti-diabetic and anti-oxidant effects of Zingiber officinale on alloxan-induced and insulin-resistant diabetic male rats. ( Arikawe, AP; Iranloye, BO; Rotimi, G; Sogbade, AO, 2011) |
| "Alloxan was then intraperitoneally administered, and blood glucose, glucose tolerance and the insulin level in mouse blood were examined." | 1.39 | Effect of vitamin E on alloxan-induced mouse diabetes. ( Doi, W; Ishihara, K; Kamimura, W; Masuoka, N; Oda, S; Sugiyama, H; Takemoto, K; Wang, DH, 2013) |
| "Alloxan treatment, however, does not alter lymph insulin kinetics, indicating that insulin resistance of Type 1 (insulin-dependent) diabetes mellitus reflects direct impairment at the cellular level." | 1.30 | Evidence for direct action of alloxan to induce insulin resistance at the cellular level. ( Ader, M; Bergman, RN; Richey, JM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 10 (45.45) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Terayama, Y | 1 |
| Nakamura, SI | 1 |
| Mekada, K | 1 |
| Matsuura, T | 1 |
| Ozaki, K | 1 |
| Ojo, OA | 1 |
| Amanze, JC | 1 |
| Oni, AI | 1 |
| Grant, S | 1 |
| Iyobhebhe, M | 1 |
| Elebiyo, TC | 1 |
| Rotimi, D | 1 |
| Asogwa, NT | 1 |
| Oyinloye, BE | 1 |
| Ajiboye, BO | 1 |
| Ojo, AB | 1 |
| Xu, L | 1 |
| Xing, M | 1 |
| Xu, X | 1 |
| Saadeldeen, FS | 1 |
| Liu, Z | 1 |
| Wei, J | 1 |
| Kang, W | 1 |
| Badin, JK | 1 |
| Progar, V | 1 |
| Pareddy, A | 1 |
| Cagle, J | 1 |
| Alloosh, M | 1 |
| Sturek, M | 1 |
| Kamimura, W | 1 |
| Doi, W | 1 |
| Takemoto, K | 1 |
| Ishihara, K | 1 |
| Wang, DH | 1 |
| Sugiyama, H | 1 |
| Oda, S | 1 |
| Masuoka, N | 1 |
| Tang, RQ | 1 |
| Zhang, XL | 1 |
| Tian, JY | 1 |
| Kong, SM | 1 |
| Zhou, Y | 1 |
| Zhang, P | 1 |
| Yang, HK | 1 |
| Wu, S | 1 |
| Zhang, Y | 1 |
| Ye, F | 1 |
| Panveloski-Costa, AC | 1 |
| Silva Teixeira, S | 1 |
| Ribeiro, IM | 1 |
| Serrano-Nascimento, C | 1 |
| das Neves, RX | 1 |
| Favaro, RR | 1 |
| Seelaender, M | 1 |
| Antunes, VR | 1 |
| Nunes, MT | 1 |
| Okamoto, MM | 1 |
| Anhê, GF | 1 |
| Sabino-Silva, R | 1 |
| Marques, MF | 1 |
| Freitas, HS | 1 |
| Mori, RC | 1 |
| Melo, KF | 1 |
| Machado, UF | 1 |
| Dool, CJ | 1 |
| Mashhedi, H | 1 |
| Zakikhani, M | 1 |
| David, S | 1 |
| Zhao, Y | 1 |
| Birman, E | 1 |
| Carboni, JM | 1 |
| Gottardis, M | 1 |
| Blouin, MJ | 1 |
| Pollak, M | 1 |
| Iranloye, BO | 1 |
| Arikawe, AP | 3 |
| Rotimi, G | 1 |
| Sogbade, AO | 1 |
| Ivanov, VV | 1 |
| Shakhristova, EV | 1 |
| Stepovaya, EA | 1 |
| Zhavoronok, TV | 1 |
| Novitsky, VV | 1 |
| Ribeiro, C | 1 |
| Cambri, LT | 1 |
| Dalia, RA | 1 |
| de Araújo, MB | 1 |
| Botezelli, JD | 1 |
| da Silva Sponton, AC | 1 |
| de Mello, MA | 2 |
| de Oliveira, CA | 1 |
| Luciano, E | 1 |
| Ettarh, RR | 1 |
| Daramola, AO | 1 |
| Odofin, AO | 1 |
| Obika, LF | 1 |
| Mahler, RJ | 3 |
| Rasschaert, J | 1 |
| Malaisse, WJ | 1 |
| Ader, M | 1 |
| Richey, JM | 1 |
| Bergman, RN | 1 |
| Das, SN | 1 |
| Sadhu, DP | 1 |
| Solomon, J | 1 |
| Bulkley, RJ | 1 |
| Mayer, J | 1 |
| Szabo, O | 1 |
1 review available for alloxan and Insulin Resistance
| Article | Year |
|---|---|
The relationship between the hyperplastic pancreatic islet and insulin insensitivity in obesity.
Topics: Adipose Tissue; Alloxan; Animals; Glucagon; Glucose; Humans; Hyperplasia; Insulin; Insulin Resistanc | 1981 |
21 other studies available for alloxan and Insulin Resistance
| Article | Year |
|---|---|
High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models.
Topics: Alloxan; Animals; Carcinogenesis; Carnitine; Diet, High-Fat; Disease Models, Animal; Glucose Intoler | 2022 |
Antidiabetic activity of avocado seeds (Persea americana Mill.) in diabetic rats via activation of PI3K/AKT signaling pathway.
Topics: Alloxan; Animals; Cell Death; Diabetes Mellitus, Experimental; Glycolipids; Hypoglycemic Agents; Ins | 2022 |
Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice.
Topics: 3T3-L1 Cells; Adipocytes; Alloxan; Animals; Anthraquinones; Diabetes Mellitus, Experimental; Glucose | 2019 |
Effect of Age on Diabetogenicity of Alloxan in Ossabaw Miniature Swine.
Topics: Age Factors; Alloxan; Animals; Diabetes Mellitus, Experimental; Insulin Resistance; Swine; Swine, Mi | 2019 |
Effect of vitamin E on alloxan-induced mouse diabetes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Alloxan; alpha-Tocopherol; Animals; Antioxidants; | 2013 |
[The effects of compound CX09040 on the inhibition of PTP1B and protection of pancreatic β cells].
Topics: Alloxan; Animals; Benzoates; Biological Assay; Disease Models, Animal; Glucose; Glucose Tolerance Te | 2015 |
Thyroid hormone reduces inflammatory cytokines improving glycaemia control in alloxan-induced diabetic wistar rats.
Topics: Adipose Tissue; Alloxan; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Inflamm | 2016 |
Intensive insulin treatment induces insulin resistance in diabetic rats by impairing glucose metabolism-related mechanisms in muscle and liver.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationshi | 2011 |
IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer.
Topics: Alloxan; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell | 2011 |
Anti-diabetic and anti-oxidant effects of Zingiber officinale on alloxan-induced and insulin-resistant diabetic male rats.
Topics: Administration, Oral; Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental | 2011 |
Effect of alloxan on spontaneous lipolysis and glutathione system in isolated rat adipocytes.
Topics: Adipocytes; Alloxan; Animals; Cells, Cultured; Diabetes Mellitus; Glutathione; Glutathione Disulfide | 2011 |
Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Energy | 2012 |
The role of exercise on long-term effects of alloxan administered in neonatal rats.
Topics: Adaptation, Physiological; Alloxan; Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabetes | 2005 |
Effects of diabetes and insulin resistance in pregnant rats on ex vivo vascular reaction to magnesium.
Topics: Alloxan; Animals; Aorta; Blood Glucose; Diabetes Mellitus, Experimental; Female; In Vitro Techniques | 2004 |
Alloxan-induced and insulin-resistant diabetes mellitus affect semen parameters and impair spermatogenesis in male rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Insulin Resistance; Luteinizing Hormone; Male; Ra | 2006 |
Streptozotocin-induced FAD-glycerophosphate dehydrogenase suppression in pancreatic islets. Relationship with the severity and duration of hyperglycaemia and resistance to insulin or riboflavin treatment.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Flavin-Adenine Dinucleotid | 1993 |
Evidence for direct action of alloxan to induce insulin resistance at the cellular level.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucose Clamp Technique; Glu | 1998 |
Effect of fat meal & heparin on insulin sensitivity in dogs with alloxan diabetes.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Fats; Dogs; Female; Hepari | 1979 |
The hyperplastic pancreatic islet as the cause of insulin resistance in obesity.
Topics: Alloxan; Animals; Blood Glucose; Diet; Humans; Hyperplasia; Insulin; Insulin Resistance; Islets of L | 1974 |
Effect of a low dose of alloxan on blood glucose, islet beta cell granulation, body weight, and insulin resistance of ob/ob mice.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fasting; Female; Gluc | 1974 |
Amelioration of insulin resistance in obese mice.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Fasting; Fatty Acids, Nonesterified; Hyperplasia; Inje | 1971 |