pd 98059 has been researched along with Insulin Resistance in 14 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Insulin resistance was then induced in adipocytes using dexamethasone, and DHM was shown to dose and time dependently promote glucose uptake in the dexamethasone-treated adipocytes." | 1.48 | Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPARγ in 3T3-L1 cells. ( Lang, H; Liu, L; Mi, M; Zhou, M; Zhou, Y, 2018) |
| "Hepatic insulin resistance is a major contributor to fasting hyperglycemia in patients with metabolic syndrome and type 2 diabetes." | 1.35 | Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes. ( Henkel, J; Neuschäfer-Rube, F; Pathe-Neuschäfer-Rube, A; Püschel, GP, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 9 (64.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, L | 1 |
| Zhou, M | 1 |
| Lang, H | 1 |
| Zhou, Y | 1 |
| Mi, M | 1 |
| Zhang, R | 1 |
| Liu, S | 1 |
| Guo, B | 1 |
| Chang, L | 1 |
| Li, Y | 1 |
| Okazaki, M | 1 |
| Iwasaki, Y | 1 |
| Jing, H | 1 |
| Nishiyama, M | 1 |
| Taguchi, T | 1 |
| Tsugita, M | 1 |
| Taniguchi, Y | 1 |
| Kambayashi, M | 1 |
| Hashimoto, K | 1 |
| Henkel, J | 1 |
| Neuschäfer-Rube, F | 1 |
| Pathe-Neuschäfer-Rube, A | 1 |
| Püschel, GP | 1 |
| Madonna, R | 1 |
| Salerni, S | 1 |
| Schiavone, D | 1 |
| Glatz, JF | 1 |
| Geng, YJ | 1 |
| De Caterina, R | 1 |
| Nohara, A | 1 |
| Okada, S | 1 |
| Ohshima, K | 1 |
| Pessin, JE | 1 |
| Mori, M | 1 |
| Nadeau, KJ | 1 |
| Leitner, JW | 1 |
| Gurerich, I | 1 |
| Draznin, B | 1 |
| Hori, Y | 1 |
| Nakatani, K | 1 |
| Morioka, K | 1 |
| Katsuki, A | 1 |
| Gabazza, EC | 1 |
| Yano, Y | 1 |
| Nobori, T | 1 |
| Adachi, Y | 1 |
| Sumida, Y | 1 |
| He, Z | 1 |
| Opland, DM | 1 |
| Way, KJ | 1 |
| Ueki, K | 1 |
| Bodyak, N | 1 |
| Kang, PM | 1 |
| Izumo, S | 1 |
| Kulkarni, RN | 1 |
| Wang, B | 1 |
| Liao, R | 1 |
| Kahn, CR | 1 |
| King, GL | 1 |
| Fischoeder, A | 1 |
| Meyborg, H | 1 |
| Stibenz, D | 1 |
| Fleck, E | 1 |
| Graf, K | 1 |
| Stawowy, P | 1 |
| Dardevet, D | 1 |
| Sornet, C | 1 |
| Grizard, J | 1 |
| Begum, N | 1 |
| Ragolia, L | 1 |
| Engelman, JA | 1 |
| Berg, AH | 1 |
| Lewis, RY | 1 |
| Lisanti, MP | 1 |
| Scherer, PE | 1 |
| Naitoh, T | 1 |
| Kitahara, M | 1 |
| Tsuruzoe, N | 1 |
14 other studies available for pd 98059 and Insulin Resistance
| Article | Year |
|---|---|
Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPARγ in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adiponectin; Anilides; Animals; Cell Survival; Dexamethasone | 2018 |
Chemerin induces insulin resistance in rat cardiomyocytes in part through the ERK1/2 signaling pathway.
Topics: Animals; Animals, Newborn; Cells, Cultured; Chemokines; Flavonoids; Glucose; Insulin; Insulin Resist | 2014 |
Insulin enhancement of cytokine-induced coagulation/inflammation-related gene transcription in hepatocytes.
Topics: Blood Coagulation; Cytokines; Drug Combinations; Flavonoids; Hepatocytes; Humans; Inflammation; Infl | 2008 |
Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes.
Topics: Animals; Cell Line; Cells, Cultured; Dinoprostone; Flavonoids; Hepatocytes; Humans; Insulin Receptor | 2009 |
Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells.
Topics: Androstadienes; Anilides; Calcium-Calmodulin-Dependent Protein Kinases; CD36 Antigens; Cell Line; De | 2011 |
Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α-induced insulin resistance.
Topics: 3T3-L1 Cells; Actins; Animals; Cyclin-Dependent Kinase 5; Flavonoids; Glucose Transporter Type 4; Gu | 2011 |
Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Androstadienes; Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein | 2004 |
Insulin enhanced thrombin-activable fibrinolysis inhibitor expression through PI3 kinase/Akt pathway.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Androstadienes; Animals; Carboxypeptidase B2; Dose-Respons | 2005 |
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia.
Topics: Androstadienes; Animals; Cells, Cultured; Coronary Vessels; Flavonoids; Humans; Insulin; Insulin Res | 2006 |
Insulin augments matrix metalloproteinase-9 expression in monocytes.
Topics: Androstadienes; Antibodies, Blocking; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell | 2007 |
Glucocorticoid-induced insulin resistance of protein synthesis is independent of the rapamycin-sensitive pathways in rat skeletal muscle.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Dexamethasone; Enzyme Inhibitors; Flavonoids; | 1999 |
High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.
Topics: Animals; Aorta; Cell Cycle Proteins; Cell Division; Cells, Cultured; Dual Specificity Phosphatase 1; | 2000 |
Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Anisomycin; Cell Differentiation; Enzyme Inhibitors; Epidermal Growt | 2000 |
Tumor necrosis factor-alpha is induced through phorbol ester--and glycated human albumin-dependent pathway in THP-1 cells.
Topics: Carcinogens; Catalase; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relatio | 2001 |