amitriptyline has been researched along with Insulin Resistance in 8 studies
Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
amitriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eighty inpatients with an episode of major depressive disorder (DSM-IV criteria) were treated in a double-blind, randomized protocol with either amitriptyline or paroxetine over a period of 5 weeks." | 6.72 | Improved insulin sensitivity in 80 nondiabetic patients with MDD after clinical remission in a double-blind, randomized trial of amitriptyline and paroxetine. ( Deuschle, M; Gilles, M; Heuser, I; Lederbogen, F; Weber-Hamann, B, 2006) |
| "Since macrophages are vital players in nonalcoholic steatohepatitis (NASH) and atherosclerosis, we assessed the effect of ASMase inhibition on NASH and atherosclerosis cooperatively induced by high-PA-containing high-fat diet (HP-HFD) and LPS in LDL receptor-deficient (LDLR-/-) mice." | 5.56 | Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism. ( Huang, Y; Li, Y; Lopes-Virella, MF; Lu, Z; Lyons, TJ; Syn, WK; Wang, Z, 2020) |
| " We studied lipoprotein composition, insulin sensitivity (quantitative insulin sensitivity check index), and saliva cortisol in 78 depressed patients before and after 35 days of amitriptyline or paroxetin treatment." | 3.72 | Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment. ( Deuschle, M; Gilles, M; Henn, FA; Heuser, I; Kopf, D; Lederbogen, F; Lehnert, H; Luley, CW; Ritter, S; Weber-Hamann, B; Westphal, S, 2004) |
| "Eighty inpatients with an episode of major depressive disorder (DSM-IV criteria) were treated in a double-blind, randomized protocol with either amitriptyline or paroxetine over a period of 5 weeks." | 2.72 | Improved insulin sensitivity in 80 nondiabetic patients with MDD after clinical remission in a double-blind, randomized trial of amitriptyline and paroxetine. ( Deuschle, M; Gilles, M; Heuser, I; Lederbogen, F; Weber-Hamann, B, 2006) |
| "Since macrophages are vital players in nonalcoholic steatohepatitis (NASH) and atherosclerosis, we assessed the effect of ASMase inhibition on NASH and atherosclerosis cooperatively induced by high-PA-containing high-fat diet (HP-HFD) and LPS in LDL receptor-deficient (LDLR-/-) mice." | 1.56 | Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism. ( Huang, Y; Li, Y; Lopes-Virella, MF; Lu, Z; Lyons, TJ; Syn, WK; Wang, Z, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, Z | 1 |
| Li, Y | 1 |
| Syn, WK | 1 |
| Wang, Z | 1 |
| Lopes-Virella, MF | 1 |
| Lyons, TJ | 1 |
| Huang, Y | 1 |
| Li, X | 1 |
| Jin, SJ | 1 |
| Su, J | 1 |
| Li, XX | 1 |
| Xu, M | 1 |
| Kopf, D | 1 |
| Westphal, S | 1 |
| Luley, CW | 1 |
| Ritter, S | 1 |
| Gilles, M | 2 |
| Weber-Hamann, B | 2 |
| Lederbogen, F | 2 |
| Lehnert, H | 1 |
| Henn, FA | 1 |
| Heuser, I | 2 |
| Deuschle, M | 2 |
| Chadwick, W | 1 |
| Wilson, G | 1 |
| van de Venter, M | 1 |
| Oelofsen, W | 1 |
| Roux, S | 1 |
| Paykel, ES | 1 |
| Mueller, PS | 3 |
| De la Vergne, PM | 1 |
| Heninger, GR | 2 |
| McDonald, RK | 2 |
2 trials available for amitriptyline and Insulin Resistance
| Article | Year |
|---|---|
Improved insulin sensitivity in 80 nondiabetic patients with MDD after clinical remission in a double-blind, randomized trial of amitriptyline and paroxetine.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Di | 2006 |
Amitriptyline, weight gain and carbohydrate craving: a side effect.
Topics: Adult; Amitriptyline; Appetite; Blood Glucose; Body Weight; Clinical Trials as Topic; Depression; Di | 1973 |
6 other studies available for amitriptyline and Insulin Resistance
| Article | Year |
|---|---|
Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism.
Topics: Amitriptyline; Aniline Compounds; Animals; Atherosclerosis; Benzylidene Compounds; Blood Glucose; Cy | 2020 |
Acid Sphingomyelinase Down-regulation Alleviates Vascular Endothelial Insulin Resistance in Diabetic Rats.
Topics: Amitriptyline; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Down-Regulation; End | 2018 |
Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Analysis of Variance; Antidepressive Agents; Blood Gl | 2004 |
Shifts in metabolic parameters surrounding glucose homoeostasis resulting from tricyclic antidepressant therapy: implications of insulin resistance?
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Cell Line; Glucose; Glyburi | 2007 |
Intravenous glucose tolerance test in depression.
Topics: Adult; Age Factors; Aged; Amitriptyline; Bipolar Disorder; Blood Glucose; Body Weight; Depression; F | 1969 |
Insulin tolerance test in depression.
Topics: Adult; Amitriptyline; Bipolar Disorder; Blood Glucose; Depression; Female; Growth Hormone; Humans; I | 1969 |