atenolol has been researched along with Insulin Resistance in 20 studies
Atenolol: A cardioselective beta-1 adrenergic blocker possessing properties and potency similar to PROPRANOLOL, but without a negative inotropic effect.
atenolol : An ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Combination therapy of nitrendipine and atenolol may significantly increase BW and fasting BG in overweight or obese patients with hypertension." | 9.14 | Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients. ( Qin, YW; Qiu, JL; Zhang, JL; Zhao, XX; Zheng, X; Zou, DJ, 2009) |
| " We investigated the influence of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension." | 9.12 | Effect of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension. ( Chenevard, R; Flammer, AJ; Gay, S; Hermann, F; Hürlimann, D; Lehmann, R; Lüscher, TF; Neidhart, M; Noll, G; Riesen, W; Ruschitzka, F; Schwegler, B; Sudano, I; Wiesli, P, 2007) |
| " We hypothesized that treatment with losartan as compared to atenolol would improve insulin sensitivity through regression of peripheral vascular hypertrophy/rarefaction." | 9.11 | Long-term treatment with losartan versus atenolol improves insulin sensitivity in hypertension: ICARUS, a LIFE substudy. ( Andersen, UB; Fossum, E; Gaboury, CL; Hjerkinn, E; Høieggen, A; Ibsen, H; Julius, S; Kjeldsen, SE; Nesbitt, SD; Olsen, MH; Phillips, RA; Wachtell, K, 2005) |
| "The effects on glucose metabolism by the beta-blocker atenolol and the angiotensin-converting enzyme (ACE)-inhibitor trandolapril were investigated in a randomised double-blind parallel group study of patients with primary hypertension." | 9.09 | Induction of insulin resistance by beta-blockade but not ACE-inhibition: long-term treatment with atenolol or trandolapril. ( Alvarez, E; Andersson, PE; Byberg, L; Haenni, A; Lithell, H; Reneland, R, 2000) |
| "These results indicate that insulin sensitivity was not modified significantly by nebivolol, whereas it was reduced by atenolol, although blood pressure was decreased to the same extent by both drugs." | 9.09 | Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients. ( Cléroux, J; Lacourcière, Y; Nadeau, A; Poirier, L, 2001) |
| "The aim of this double-blind, parallel group study was to compare the effects of nebivolol and atenolol on blood pressure (BP) and insulin sensitivity in hypertensive patients with type II, non-insulin dependent diabetes mellitus (NIDDM)." | 9.08 | Comparative effects of nebivolol and atenolol on blood pressure and insulin sensitivity in hypertensive subjects with type II diabetes. ( Fogari, R; Lazzari, P; Lusardi, P; Mugellini, A; Preti, P; Van Nueten, L; Vertommen, C; Zoppi, A, 1997) |
| "Fifty patients with mild to moderate essential hypertension were randomized to receive either 20 mg fosinopril daily for 16 weeks or placebo for 4 weeks followed by 12 weeks of 50 mg atenolol daily." | 9.07 | Metabolic effects of long-term angiotensin-converting enzyme inhibition with fosinopril in patients with essential hypertension: relationship to angiotensin-converting enzyme inhibition. ( Andersson, PE; Haenni, A; Lithell, H; Reneland, R, 1994) |
| "The short-term effects of two sympatholytic antihypertensive drug treatments, β-blocking agent atenolol and imidazoline receptor-1 agonist moxonidine, on postmenopausal symptoms and their relationship to antihypertensive and insulin sensitivity effect were studied." | 5.19 | Effects of sympatholytic therapy on postmenopausal symptoms in hypertensive postmenopausal women. ( Kaaja, RJ; Kujala, SM; Pöyhönen-Alho, M, 2014) |
| "Combination therapy of nitrendipine and atenolol may significantly increase BW and fasting BG in overweight or obese patients with hypertension." | 5.14 | Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients. ( Qin, YW; Qiu, JL; Zhang, JL; Zhao, XX; Zheng, X; Zou, DJ, 2009) |
| " We compared the effect of two sympatholytic antihypertensive drug treatments, the centrally acting imidazoline receptor-1 agonist moxonidine and peripherally acting beta-blocking agent atenolol on sensitive inflammatory markers in overweight postmenopausal women with diastolic hypertension." | 5.13 | Central sympatholytic therapy has anti-inflammatory properties in hypertensive postmenopausal women. ( Antikainen, RL; Ebeling, PE; Erkkola, RU; Kaaja, RJ; Katzman, P; Kibarskis, A; Manhem, K; Pöyhönen-Alho, MK; Tuomilehto, JO, 2008) |
| " We investigated the influence of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension." | 5.12 | Effect of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension. ( Chenevard, R; Flammer, AJ; Gay, S; Hermann, F; Hürlimann, D; Lehmann, R; Lüscher, TF; Neidhart, M; Noll, G; Riesen, W; Ruschitzka, F; Schwegler, B; Sudano, I; Wiesli, P, 2007) |
| " We hypothesized that treatment with losartan as compared to atenolol would improve insulin sensitivity through regression of peripheral vascular hypertrophy/rarefaction." | 5.11 | Long-term treatment with losartan versus atenolol improves insulin sensitivity in hypertension: ICARUS, a LIFE substudy. ( Andersen, UB; Fossum, E; Gaboury, CL; Hjerkinn, E; Høieggen, A; Ibsen, H; Julius, S; Kjeldsen, SE; Nesbitt, SD; Olsen, MH; Phillips, RA; Wachtell, K, 2005) |
| "The effects on glucose metabolism by the beta-blocker atenolol and the angiotensin-converting enzyme (ACE)-inhibitor trandolapril were investigated in a randomised double-blind parallel group study of patients with primary hypertension." | 5.09 | Induction of insulin resistance by beta-blockade but not ACE-inhibition: long-term treatment with atenolol or trandolapril. ( Alvarez, E; Andersson, PE; Byberg, L; Haenni, A; Lithell, H; Reneland, R, 2000) |
| "These results indicate that insulin sensitivity was not modified significantly by nebivolol, whereas it was reduced by atenolol, although blood pressure was decreased to the same extent by both drugs." | 5.09 | Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients. ( Cléroux, J; Lacourcière, Y; Nadeau, A; Poirier, L, 2001) |
| "The aim of this double-blind, parallel group study was to compare the effects of nebivolol and atenolol on blood pressure (BP) and insulin sensitivity in hypertensive patients with type II, non-insulin dependent diabetes mellitus (NIDDM)." | 5.08 | Comparative effects of nebivolol and atenolol on blood pressure and insulin sensitivity in hypertensive subjects with type II diabetes. ( Fogari, R; Lazzari, P; Lusardi, P; Mugellini, A; Preti, P; Van Nueten, L; Vertommen, C; Zoppi, A, 1997) |
| "Fifty patients with mild to moderate essential hypertension were randomized to receive either 20 mg fosinopril daily for 16 weeks or placebo for 4 weeks followed by 12 weeks of 50 mg atenolol daily." | 5.07 | Metabolic effects of long-term angiotensin-converting enzyme inhibition with fosinopril in patients with essential hypertension: relationship to angiotensin-converting enzyme inhibition. ( Andersson, PE; Haenni, A; Lithell, H; Reneland, R, 1994) |
| "60 Patients with primary hypertension (diastolic blood pressure when resting supine 95-119 mm Hg on at least two occasions during four to six weeks of treatment with placebo) randomised to receive either metoprolol (n = 30) or atenolol (n = 30) during the first treatment period." | 5.06 | Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. ( Berne, C; Lithell, H; Pollare, T; Selinus, I, 1989) |
| "Previous studies in fetuses with intrauterine growth restriction (IUGR) have shown that adrenergic dysregulation was associated with low insulin concentrations and greater insulin sensitivity." | 1.51 | Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle. ( Allen, RE; Anderson, MJ; Antolic, AT; Camacho, LE; Davis, MA; Goyal, R; Hay, WW; Kelly, AC; Limesand, SW; Papas, KK; Steyn, LV; Yates, DT, 2019) |
| "Only clonidine treatment totally prevented the development of insulin resistance, and high-dose aspirin, known to prevent insulin resistance by inhibition of the activity of IkappaB kinase-beta, decreased the degree of insulin resistance by almost 70%." | 1.32 | Hypertension and insulin resistance are not directly related in obese dogs. ( Gokee, A; Rocchini, AP; Yang, JQ, 2004) |
| "Propranolol was also able to ameliorate the hepatic insulin resistance produced by TNF." | 1.29 | Beta-adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor. ( Lang, CH, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 10 (50.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yates, DT | 1 |
| Camacho, LE | 1 |
| Kelly, AC | 1 |
| Steyn, LV | 1 |
| Davis, MA | 1 |
| Antolic, AT | 1 |
| Anderson, MJ | 1 |
| Goyal, R | 1 |
| Allen, RE | 1 |
| Papas, KK | 1 |
| Hay, WW | 1 |
| Limesand, SW | 1 |
| Kujala, SM | 1 |
| Pöyhönen-Alho, M | 1 |
| Kaaja, RJ | 2 |
| Oh, PC | 1 |
| Kang, WC | 1 |
| Moon, J | 1 |
| Park, YM | 1 |
| Kim, S | 1 |
| Kim, MG | 1 |
| Lee, K | 1 |
| Ahn, T | 1 |
| Shin, EK | 1 |
| Hausberg, M | 1 |
| Hillebrand, U | 1 |
| Kisters, K | 1 |
| Pöyhönen-Alho, MK | 1 |
| Manhem, K | 2 |
| Katzman, P | 2 |
| Kibarskis, A | 2 |
| Antikainen, RL | 1 |
| Erkkola, RU | 1 |
| Tuomilehto, JO | 1 |
| Ebeling, PE | 1 |
| Zhang, JL | 1 |
| Zheng, X | 1 |
| Zou, DJ | 1 |
| Qiu, JL | 1 |
| Zhao, XX | 1 |
| Qin, YW | 1 |
| Rocchini, AP | 1 |
| Yang, JQ | 1 |
| Gokee, A | 1 |
| Olsen, MH | 1 |
| Fossum, E | 1 |
| Høieggen, A | 1 |
| Wachtell, K | 1 |
| Hjerkinn, E | 1 |
| Nesbitt, SD | 1 |
| Andersen, UB | 1 |
| Phillips, RA | 1 |
| Gaboury, CL | 1 |
| Ibsen, H | 1 |
| Kjeldsen, SE | 1 |
| Julius, S | 1 |
| Flammer, AJ | 1 |
| Hermann, F | 1 |
| Wiesli, P | 1 |
| Schwegler, B | 1 |
| Chenevard, R | 1 |
| Hürlimann, D | 1 |
| Sudano, I | 1 |
| Gay, S | 1 |
| Neidhart, M | 1 |
| Riesen, W | 1 |
| Ruschitzka, F | 1 |
| Lüscher, TF | 1 |
| Noll, G | 1 |
| Lehmann, R | 1 |
| Kaaja, R | 1 |
| Kujala, S | 1 |
| Antikainen, R | 1 |
| Ylihärsilä, H | 1 |
| Erkkola, R | 1 |
| Tuomilehto, J | 1 |
| Reneland, R | 2 |
| Andersson, PE | 2 |
| Haenni, A | 2 |
| Lithell, H | 3 |
| Lang, CH | 2 |
| Fogari, R | 1 |
| Zoppi, A | 1 |
| Lazzari, P | 1 |
| Mugellini, A | 1 |
| Lusardi, P | 1 |
| Preti, P | 1 |
| Van Nueten, L | 1 |
| Vertommen, C | 1 |
| Fragasso, G | 1 |
| Cattaneo, N | 1 |
| Locatelli, M | 1 |
| Caumo, A | 1 |
| Pagnotta, P | 1 |
| Piatti, P | 1 |
| Bonini, P | 1 |
| Chierchia, SL | 1 |
| Alvarez, E | 1 |
| Byberg, L | 1 |
| Kuperstein, R | 1 |
| Sasson, Z | 1 |
| Poirier, L | 1 |
| Cléroux, J | 1 |
| Nadeau, A | 1 |
| Lacourcière, Y | 1 |
| Lithell, HO | 1 |
| Pollare, T | 1 |
| Selinus, I | 1 |
| Berne, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Carvedilol and Atenolol on Anti-anginal and Metabolic Effects in Patients With Stable Angina Pectoris[NCT02547597] | Phase 4 | 99 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| A Triple-Blind, Parallel Study to Investigate the Effect of Losartan Versus Atenolol on the Reduction of Morbidity and Mortality in Hypertensive Patients With Left Ventricular Hypertrophy[NCT00338260] | Phase 3 | 496 participants (Actual) | Interventional | 1995-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for atenolol and Insulin Resistance
| Article | Year |
|---|---|
Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Double-Blind Method; Glucose; Humans; | 1991 |
15 trials available for atenolol and Insulin Resistance
| Article | Year |
|---|---|
Effects of sympatholytic therapy on postmenopausal symptoms in hypertensive postmenopausal women.
Topics: Atenolol; Blood Pressure; Body Mass Index; Double-Blind Method; Drug Monitoring; Female; Hot Flashes | 2014 |
Anti-Anginal and Metabolic Effects of Carvedilol and Atenolol in Patients with Stable Angina Pectoris: A Prospective, Randomized, Parallel, Open-Label Study.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Angina, Stable; Atenolol; Carbazoles; Cardiotonic Agen | 2016 |
Central sympatholytic therapy has anti-inflammatory properties in hypertensive postmenopausal women.
Topics: Adiponectin; Antihypertensive Agents; Atenolol; C-Reactive Protein; Double-Blind Method; Female; Fin | 2008 |
Effect of metformin on weight gain during antihypertensive treatment with a beta-blocker in Chinese patients.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Body Mass Index | 2009 |
Long-term treatment with losartan versus atenolol improves insulin sensitivity in hypertension: ICARUS, a LIFE substudy.
Topics: Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; F | 2005 |
Effect of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Brachial Artery; Cross-Over Studies; Diabetes Mel | 2007 |
Effects of sympatholytic therapy on insulin sensitivity indices in hypertensive postmenopausal women.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Double-Blind Method; Female; Finland | 2007 |
Metabolic effects of long-term angiotensin-converting enzyme inhibition with fosinopril in patients with essential hypertension: relationship to angiotensin-converting enzyme inhibition.
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Atenolol; Blood Pressure; Female; | 1994 |
Comparative effects of nebivolol and atenolol on blood pressure and insulin sensitivity in hypertensive subjects with type II diabetes.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Benzopyrans; Blood Pres | 1997 |
Differential effects of selective beta-adrenergic blockade on insulin sensitivity and release in control subjects and in patients with angina and normal coronary arteries (syndrome X).
Topics: Administration, Oral; Adrenergic beta-Antagonists; Atenolol; Blood Glucose; Cross-Over Studies; Doub | 1998 |
Induction of insulin resistance by beta-blockade but not ACE-inhibition: long-term treatment with atenolol or trandolapril.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Atenolol; Blood Pressur | 2000 |
Effects of antihypertensive therapy on glucose and insulin metabolism and on left ventricular mass: A randomized, double-blind, controlled study of 21 obese hypertensives.
Topics: Antihypertensive Agents; Atenolol; Double-Blind Method; Female; Glucose; Heart Ventricles; Humans; H | 2000 |
Effects of nebivolol and atenolol on insulin sensitivity and haemodynamics in hypertensive patients.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Atenolol; Benzopyrans; Cross-Over Studies; Dou | 2001 |
Effect of antihypertensive drugs on insulin, glucose, and lipid metabolism.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Double-Blind Method; Glucose; Humans; | 1991 |
Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients.
Topics: Atenolol; Blood Glucose; Cholesterol; Clinical Trials as Topic; Double-Blind Method; Female; Glucose | 1989 |
5 other studies available for atenolol and Insulin Resistance
| Article | Year |
|---|---|
Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Animals; Atenolol; Cell | 2019 |
Addressing the relationship between sympathetic activity and inflammation.
Topics: Antihypertensive Agents; Atenolol; C-Reactive Protein; Female; Humans; Hypertension; Imidazoles; Inf | 2008 |
Hypertension and insulin resistance are not directly related in obese dogs.
Topics: Adrenergic beta-Antagonists; Animals; Aspirin; Atenolol; Blood Glucose; Clonidine; Diet, Sodium-Rest | 2004 |
Beta-adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Glucose; Glucose Clamp Technique; Insulin; Insulin R | 1993 |
Sepsis-induced insulin resistance in rats is mediated by a beta-adrenergic mechanism.
Topics: Animals; Atenolol; Deoxyglucose; Escherichia coli Infections; Glucose; Glucose Clamp Technique; Insu | 1992 |