trimethyloxamine has been researched along with Insulin Resistance in 17 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our findings underscore the importance of changes in TMAO, choline and L-carnitine in improving insulin sensitivity during a weight-loss intervention for obese patients." | 5.30 | Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial. ( Bray, GA; DiDonato, JA; Heianza, Y; Li, X; Qi, L; Sacks, FM; Sun, D, 2019) |
| "Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD)." | 4.02 | Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. ( Aguilar-Salinas, C; Campos-Pérez, F; Canizales-Quinteros, S; Gómez-Pérez, F; González-González, I; Grandini-Rosales, P; Hazen, SL; Hernández-Pando, R; Huertas-Vazquez, A; Hui, ST; Larrieta-Carrasco, E; León-Mimila, P; Li, XS; López-Contreras, B; Lusis, AJ; Macías-Kauffer, L; Morán-Ramos, S; Ocampo-Medina, E; Olivares-Arevalo, M; Shih, DM; Villamil-Ramírez, H; Villarreal-Molina, T; Wang, Z, 2021) |
| " Trimethylamine-N-oxide (TMAO), dimethylamine, and dimethyl sulfone are identified and display significant dose-response with intake (p < 0." | 2.94 | The Relationship between Fish Intake and Urinary Trimethylamine-N-Oxide. ( Brennan, L; Flynn, A; Frost, G; Gibbons, H; McNulty, BA; Nugent, AP; Rundle, M; Walton, J; Yin, X, 2020) |
| "Obesity is a main contributing factor for the development of glucose intolerance and type 2 diabetes mellitus (T2D)." | 1.62 | Roux-en-Y Gastric Bypass Improved Insulin Resistance via Alteration of the Human Gut Microbiome and Alleviation of Endotoxemia. ( Li, D; Shi, Q; Wang, C; Wang, Q; Yang, H; Yin, Z; Yu, S; Zhong, H, 2021) |
| "Insulin resistance was defined using HOMA-IR." | 1.56 | Plasma Trimethylamine-N-oxide and impaired glucose regulation: Results from The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS). ( Colombo, PC; Demmer, RT; Nandakumar, R; Roy, S; Yuzefpolskaya, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 8 (47.06) | 2.80 |
| Authors | Studies |
|---|---|
| Lanz, M | 1 |
| Janeiro, MH | 1 |
| Milagro, FI | 1 |
| Puerta, E | 1 |
| Ludwig, IA | 1 |
| Pineda-Lucena, A | 1 |
| Ramírez, MJ | 1 |
| Solas, M | 1 |
| Chen, S | 1 |
| Henderson, A | 1 |
| Petriello, MC | 1 |
| Romano, KA | 1 |
| Gearing, M | 1 |
| Miao, J | 1 |
| Schell, M | 1 |
| Sandoval-Espinola, WJ | 1 |
| Tao, J | 1 |
| Sha, B | 1 |
| Graham, M | 1 |
| Crooke, R | 1 |
| Kleinridders, A | 1 |
| Balskus, EP | 1 |
| Rey, FE | 1 |
| Morris, AJ | 1 |
| Biddinger, SB | 1 |
| Mitchell, SM | 1 |
| Milan, AM | 1 |
| Mitchell, CJ | 1 |
| Gillies, NA | 1 |
| D'Souza, RF | 1 |
| Zeng, N | 1 |
| Ramzan, F | 1 |
| Sharma, P | 1 |
| Knowles, SO | 1 |
| Roy, NC | 1 |
| Sjödin, A | 1 |
| Wagner, KH | 1 |
| Zeisel, SH | 1 |
| Cameron-Smith, D | 1 |
| Yin, X | 1 |
| Gibbons, H | 1 |
| Rundle, M | 1 |
| Frost, G | 1 |
| McNulty, BA | 1 |
| Nugent, AP | 1 |
| Walton, J | 1 |
| Flynn, A | 1 |
| Brennan, L | 1 |
| Huang, J | 1 |
| Liu, L | 1 |
| Chen, C | 1 |
| Gao, Y | 1 |
| Roy, S | 1 |
| Yuzefpolskaya, M | 1 |
| Nandakumar, R | 1 |
| Colombo, PC | 1 |
| Demmer, RT | 1 |
| Zhu, T | 1 |
| Goodarzi, MO | 1 |
| León-Mimila, P | 1 |
| Villamil-Ramírez, H | 1 |
| Li, XS | 1 |
| Shih, DM | 1 |
| Hui, ST | 1 |
| Ocampo-Medina, E | 1 |
| López-Contreras, B | 1 |
| Morán-Ramos, S | 1 |
| Olivares-Arevalo, M | 1 |
| Grandini-Rosales, P | 1 |
| Macías-Kauffer, L | 1 |
| González-González, I | 1 |
| Hernández-Pando, R | 1 |
| Gómez-Pérez, F | 1 |
| Campos-Pérez, F | 1 |
| Aguilar-Salinas, C | 1 |
| Larrieta-Carrasco, E | 1 |
| Villarreal-Molina, T | 1 |
| Wang, Z | 3 |
| Lusis, AJ | 1 |
| Hazen, SL | 3 |
| Huertas-Vazquez, A | 1 |
| Canizales-Quinteros, S | 1 |
| Duttaroy, AK | 1 |
| Shi, Q | 1 |
| Wang, Q | 1 |
| Zhong, H | 1 |
| Li, D | 1 |
| Yu, S | 1 |
| Yang, H | 1 |
| Wang, C | 1 |
| Yin, Z | 1 |
| Oellgaard, J | 1 |
| Winther, SA | 1 |
| Hansen, TS | 1 |
| Rossing, P | 1 |
| von Scholten, BJ | 1 |
| Heianza, Y | 1 |
| Sun, D | 1 |
| Li, X | 2 |
| DiDonato, JA | 1 |
| Bray, GA | 1 |
| Sacks, FM | 1 |
| Qi, L | 1 |
| Erickson, ML | 1 |
| Malin, SK | 1 |
| Brown, JM | 1 |
| Kirwan, JP | 1 |
| Ussher, JR | 1 |
| Lopaschuk, GD | 1 |
| Arduini, A | 1 |
| Gao, X | 1 |
| Liu, X | 1 |
| Xu, J | 1 |
| Xue, C | 1 |
| Xue, Y | 1 |
| Wang, Y | 1 |
| Randrianarisoa, E | 1 |
| Lehn-Stefan, A | 1 |
| Wang, X | 1 |
| Hoene, M | 1 |
| Peter, A | 1 |
| Heinzmann, SS | 1 |
| Zhao, X | 1 |
| Königsrainer, I | 1 |
| Königsrainer, A | 1 |
| Balletshofer, B | 1 |
| Machann, J | 1 |
| Schick, F | 1 |
| Fritsche, A | 1 |
| Häring, HU | 1 |
| Xu, G | 1 |
| Lehmann, R | 1 |
| Stefan, N | 1 |
| Bergeron, N | 1 |
| Williams, PT | 1 |
| Lamendella, R | 1 |
| Faghihnia, N | 1 |
| Grube, A | 1 |
| Knight, R | 1 |
| Jansson, JK | 1 |
| Krauss, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)[NCT00072995] | 811 participants | Interventional | 2003-09-30 | Completed | |||
| A Randomised, Double-blinded, Cross-over, Placebo- Controlled Pilot Study to Investigate the Effect of Tomato Extract on TMAO in Overweight or Obese Adults[NCT04160481] | 37 participants (Actual) | Interventional | 2019-11-12 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for trimethyloxamine and Insulin Resistance
| Article | Year |
|---|---|
Metabolites Linking the Gut Microbiome with Risk for Type 2 Diabetes.
Topics: Amino Acids, Branched-Chain; Animals; Bile Acids and Salts; Diabetes Mellitus, Type 2; Diet Therapy; | 2020 |
Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review.
Topics: Animals; Atherosclerosis; Blood Platelets; Cardiovascular Diseases; Fatty Acids, Volatile; Gastroint | 2021 |
Trimethylamine N-oxide (TMAO) as a New Potential Therapeutic Target for Insulin Resistance and Cancer.
Topics: Animals; Antineoplastic Agents; Diabetes Mellitus; Drug Delivery Systems; Gastrointestinal Microbiom | 2017 |
Gut microbiota metabolism of L-carnitine and cardiovascular risk.
Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Diet; Dietary Supplements; Humans; Ins | 2013 |
6 trials available for trimethyloxamine and Insulin Resistance
| Article | Year |
|---|---|
Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).
Topics: Aged; Biomarkers; Cardiovascular Diseases; Cholesterol, LDL; Diet, High-Protein; Dietary Proteins; F | 2019 |
The Relationship between Fish Intake and Urinary Trimethylamine-N-Oxide.
Topics: Biomarkers; Cross-Sectional Studies; Diet, Vegetarian; Dietary Fats; Dimethylamines; Eating; Female; | 2020 |
Gut microbiota metabolites, amino acid metabolites and improvements in insulin sensitivity and glucose metabolism: the POUNDS Lost trial.
Topics: Adult; Amino Acids; Carnitine; Choline; Diet, Reducing; Female; Gastrointestinal Microbiome; Glucose | 2019 |
Effects of Lifestyle Intervention on Plasma Trimethylamine N-Oxide in Obese Adults.
Topics: Adiposity; Aged; Blood Glucose; Body Composition; Body Mass Index; Caloric Restriction; Diet, Reduci | 2019 |
Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans.
Topics: Adiposity; Adult; Atherosclerosis; Female; Humans; Insulin Resistance; Intra-Abdominal Fat; Male; Me | 2016 |
Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk.
Topics: Adult; Biomarkers; Body Mass Index; California; Cardiovascular Diseases; Cross-Over Studies; Diet, C | 2016 |
7 other studies available for trimethyloxamine and Insulin Resistance
| Article | Year |
|---|---|
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model.
Topics: Animals; Cognition; Dementia; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Insuli | 2022 |
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Topics: Animals; eIF-2 Kinase; Gastrointestinal Microbiome; HEK293 Cells; Hep G2 Cells; Humans; Indoles; Ins | 2019 |
PCOS without hyperandrogenism is associated with higher plasma Trimethylamine N-oxide levels.
Topics: Adult; Biomarkers; Body Mass Index; Case-Control Studies; China; Female; Follow-Up Studies; Humans; | 2020 |
Plasma Trimethylamine-N-oxide and impaired glucose regulation: Results from The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS).
Topics: Adult; Biomarkers; Blood Glucose; Cross-Sectional Studies; Female; Glucose Intolerance; Glycated Hem | 2020 |
Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
Topics: Adult; Betaine; Bile Acids and Salts; Biomarkers; Biopsy; Choline; Diabetes Mellitus, Type 2; Female | 2021 |
Roux-en-Y Gastric Bypass Improved Insulin Resistance via Alteration of the Human Gut Microbiome and Alleviation of Endotoxemia.
Topics: Acute-Phase Proteins; Carrier Proteins; Down-Regulation; Endotoxemia; Gastric Bypass; Gastrointestin | 2021 |
Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet.
Topics: Adipose Tissue; Animals; Blood Glucose; Chemokine CCL2; Diet, High-Fat; Dietary Fats; Fasting; Gluco | 2014 |