Tyrosine-protein phosphatase non-receptor type 12

A tyrosine-protein phosphatase non-receptor type 12 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05209]

EC 3.1.3.48;
PTP-PEST;
Protein-tyrosine phosphatase G1;
PTPG1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
morusin	Homo sapiens (human)	IC50	100.0000	1	1
trans-2,3',4,5'-tetrahydroxystilbene	Homo sapiens (human)	IC50	100.0000	1	1
Norartocarpetin	Homo sapiens (human)	IC50	20.9400	1	1
cudraflavanone a	Homo sapiens (human)	IC50	18.6100	1	1

This protein enables 5 target(s):

Target	Category	Definition
phosphoprotein phosphatase activity	molecular function	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. [ISBN:0198547684]
protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]
non-membrane spanning protein tyrosine phosphatase activity	molecular function	Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
SH3 domain binding	molecular function	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]

This protein is located in 5 target(s):

Target	Category	Definition
podosome	cellular component	An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. [PMID:12837608, PMID:15890982]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
focal adhesion	cellular component	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002]
cell projection	cellular component	A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 7 target(s):

Target	Category	Definition
protein dephosphorylation	biological process	The process of removing one or more phosphoric residues from a protein. [GOC:hb]
peptidyl-tyrosine dephosphorylation	biological process	The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. [GOC:bf]
regulation of epidermal growth factor receptor signaling pathway	biological process	Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators]
tissue regeneration	biological process	The regrowth of lost or destroyed tissues. [GOC:curators]
cellular response to epidermal growth factor stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. [GOC:mah]
negative regulation of ERBB signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway. [GOC:BHF, GOC:TermGenie]
negative regulation of platelet-derived growth factor receptor-beta signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway. [GOC:obol]