Page last updated: 2024-10-28

glyburide and Insulin Resistance

glyburide has been researched along with Insulin Resistance in 87 studies

Glyburide: An antidiabetic sulfonylurea derivative with actions like those of chlorpropamide
glyburide : An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.

Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.

Research Excerpts

ExcerptRelevanceReference
"Several studies have demonstrated the decreased insulin resistance (IR) in persons with type 2 diabetes mellitus (T2DM) treated with glimepiride."9.30The differential influence of glimepiride and glibenclamide on insulin resistance and adiponectin levels in patients with type 2 diabetes. ( Bahtiri, E; Begolli, L; Blaslov, K; Car, N; Emini-Sadiku, M; Haliti, E, 2019)
"Measures of β-cell function and insulin sensitivity from an OGTT showed more favorable changes over time with rosiglitazone versus metformin or glyburide."9.15Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT. ( Aftring, RP; Haffner, SM; Herman, WH; Holman, RR; Kahn, SE; Kravitz, BG; Lachin, JM; Paul, G; Viberti, G; Zinman, B, 2011)
"Glimepiride appears to improve insulin resistance and atherosclerotic disorders."9.12Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis. ( Ito, S; Koshiba, K; Nakaya, Y; Nomura, M, 2006)
"This study compared the effects of 52 weeks' treatment with pioglitazone, a thiazolidinedione that reduces insulin resistance, and glibenclamide, on insulin sensitivity, glycaemic control, and lipids in patients with Type 2 diabetes."9.11Sustained effects of pioglitazone vs. glibenclamide on insulin sensitivity, glycaemic control, and lipid profiles in patients with Type 2 diabetes. ( Clausen, J; Eriksson, JW; Halse, J; Herz, M; Johns, D; Konkoy, CS; Madsbad, S; Strand, J; Tan, MH, 2004)
"The aim of the present study was to investigate the effect of bezafibrate on insulin sensitivity and insulin secretion in 30 non-obese Japanese type 2 diabetic patients with hypertriglyceridemia (serum triglycerides > 150 mg/dL)."9.09Effects of bezafibrate on insulin sensitivity and insulin secretion in non-obese Japanese type 2 diabetic patients. ( Doi, K; Fukunaga, A; Fukushima, M; Kishimoto, H; Kitatani, N; Matsuura, T; Nagasaka, S; Nagata, I; Nakai, Y; Nakaishi, S; Okumura, T; Sakai, M; Taniguchi, A; Tokuyama, K; Yamashita, Y, 2001)
"Both doses of olanzapine caused pronounced glucose dysregulation and insulin resistance, which were significantly reduced by treatment with metformin and rosiglitazone; however, glucose tolerance did not fully return to control levels."7.78Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats. ( Barr, AM; Boyda, HN; Hawkes, E; Honer, WG; Jin, CH; Pang, CC; Procyshyn, RM; Tse, L, 2012)
"To observe and compare the effect of taurine on contractions of aortic rings isolated from normal (NC) and insulin resistance (IR) Sprague-Dawley rats, and to explore its underlying mechanism(s)."7.74Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. ( Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M, 2008)
"Here we investigate the effect of rosiglitazone (RSG), metformin (MET) and glyburide (GLIB) on plasma glucose levels, beta-cell mass, function and insulin sensitivity in 10-week-old diabetic male Zucker diabetic fatty (mZDF) rats using quantitative morphometry and a mathematical model beta-cell mass, insulin and glucose kinetics (betaIG)."7.74Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats. ( Atkinson, LL; Benkoczi, C; Finegood, DT; McDonald-Dyck, C, 2008)
"Pioglitazone is an insulin-sensitizing agent that has been reported to have anti-arteriosclerotic effects."6.71Effect of pioglitazone on arteriosclerosis in comparison with that of glibenclamide. ( Anazawa, T; Kanmatsuse, K; Kushiro, T; Tani, S; Watanabe, I, 2005)
"Several studies have demonstrated the decreased insulin resistance (IR) in persons with type 2 diabetes mellitus (T2DM) treated with glimepiride."5.30The differential influence of glimepiride and glibenclamide on insulin resistance and adiponectin levels in patients with type 2 diabetes. ( Bahtiri, E; Begolli, L; Blaslov, K; Car, N; Emini-Sadiku, M; Haliti, E, 2019)
"Measures of β-cell function and insulin sensitivity from an OGTT showed more favorable changes over time with rosiglitazone versus metformin or glyburide."5.15Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT. ( Aftring, RP; Haffner, SM; Herman, WH; Holman, RR; Kahn, SE; Kravitz, BG; Lachin, JM; Paul, G; Viberti, G; Zinman, B, 2011)
"Both exenatide and glibenclamide gave a similar improvement of glycemic control, but only exenatide gave improvements of insulin resistance and beta-cell function, giving also a decrease of body weight and of inflammatory state."5.14Exenatide versus glibenclamide in patients with diabetes. ( Ciccarelli, L; Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Franzetti, IG; Gadaleta, G; Maffioli, P; Piccinni, MN; Querci, F; Ragonesi, PD; Salvadeo, SA, 2010)
"Glimepiride appears to improve insulin resistance and atherosclerotic disorders."5.12Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis. ( Ito, S; Koshiba, K; Nakaya, Y; Nomura, M, 2006)
"To investigate the relationship between insulin resistance, postprandial hyperglycemia, postprandial hyperlipidemia, and oxidative stress in type 2 diabetes, changes in postprandial glucose, triglyceride, and nitrotyrosine levels vs baseline after diet loading were examined in type 2 diabetic patients given pioglitazone (PG) or glibenclamide (GB)."5.12Effects of pioglitazone vs glibenclamide on postprandial increases in glucose and triglyceride levels and on oxidative stress in Japanese patients with type 2 diabetes. ( Itoh, Y; Mori, Y; Obata, T; Tajima, N, 2006)
"This study compared the effects of 52 weeks' treatment with pioglitazone, a thiazolidinedione that reduces insulin resistance, and glibenclamide, on insulin sensitivity, glycaemic control, and lipids in patients with Type 2 diabetes."5.11Sustained effects of pioglitazone vs. glibenclamide on insulin sensitivity, glycaemic control, and lipid profiles in patients with Type 2 diabetes. ( Clausen, J; Eriksson, JW; Halse, J; Herz, M; Johns, D; Konkoy, CS; Madsbad, S; Strand, J; Tan, MH, 2004)
"The aim of the present study was to investigate the effect of bezafibrate on insulin sensitivity and insulin secretion in 30 non-obese Japanese type 2 diabetic patients with hypertriglyceridemia (serum triglycerides > 150 mg/dL)."5.09Effects of bezafibrate on insulin sensitivity and insulin secretion in non-obese Japanese type 2 diabetic patients. ( Doi, K; Fukunaga, A; Fukushima, M; Kishimoto, H; Kitatani, N; Matsuura, T; Nagasaka, S; Nagata, I; Nakai, Y; Nakaishi, S; Okumura, T; Sakai, M; Taniguchi, A; Tokuyama, K; Yamashita, Y, 2001)
"Both doses of olanzapine caused pronounced glucose dysregulation and insulin resistance, which were significantly reduced by treatment with metformin and rosiglitazone; however, glucose tolerance did not fully return to control levels."3.78Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats. ( Barr, AM; Boyda, HN; Hawkes, E; Honer, WG; Jin, CH; Pang, CC; Procyshyn, RM; Tse, L, 2012)
"Glimepiride can rapidly and stably improve glycemic control and lipoprotein metabolism, significantly alleviate insulin resistance and enhance fibrinolytic activity."3.76Effects of Glimepiride on metabolic parameters and cardiovascular risk factors in patients with newly diagnosed type 2 diabetes mellitus. ( Du, W; Huang, QX; Liu, L; Liu, YH; Xie, XM; Xu, DY; Zhao, SP, 2010)
"To observe and compare the effect of taurine on contractions of aortic rings isolated from normal (NC) and insulin resistance (IR) Sprague-Dawley rats, and to explore its underlying mechanism(s)."3.74Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. ( Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M, 2008)
"Here we investigate the effect of rosiglitazone (RSG), metformin (MET) and glyburide (GLIB) on plasma glucose levels, beta-cell mass, function and insulin sensitivity in 10-week-old diabetic male Zucker diabetic fatty (mZDF) rats using quantitative morphometry and a mathematical model beta-cell mass, insulin and glucose kinetics (betaIG)."3.74Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats. ( Atkinson, LL; Benkoczi, C; Finegood, DT; McDonald-Dyck, C, 2008)
"Although the role of insulin sensitivity is not negligible, insulin secretion appears to be the major determinant of diabetic control in overt type 2 diabetic patients who are treated with metformin alone or with a two-drug therapy combining metformin and glyburide."3.73Insulin secretion and sensitivity as determinants of HbA1c in type 2 diabetes. ( Colette, C; Lapinski, H; Monnier, L; Thuan, JF, 2006)
"To determine whether hypoglycemic agents such as sulfonylureas, biguanides and the newly developed insulin sensitizers such as troglitazone, have hypotensive effects in an animal model of non-insulin-dependent diabetes mellitus associated with insulin resistance, male Otsuka Long Evans Tokushima Fatty (OLETF) rats aged 12 weeks were administered following hypoglycemic agents or vehicle by gavage for 26 weeks; glibenclamide (5 mg/kg/day), metformin (100 mg/kg/day) and troglitazone (70 mg/kg/day)."3.70Troglitazone and metformin, but not glibenclamide, decrease blood pressure in Otsuka Long Evans Tokushima Fatty rats. ( Awata, T; Chen, S; Katayama, S; Kosegawa, I; Negishi, K, 1999)
"Insulin tolerance test was done to assess the insulin sensitivity in a group of untreated non insulin dependent diabetic subjects before and after sulfonylurea (tolbutamide, glibenclamide, glipizide) therapy."3.68Effect of sulphonylurea therapy on insulin sensitivity in non insulin dependent diabetics. ( Dash, RJ; Khandekar, S; Sethi, BK, 1990)
"Glyburide and other sulfonylureas consistently enhance receptor binding in cells from patients with non-insulin-dependent diabetes mellitus, whereas no effects and mixed effects have been demonstrated in cells from patients with insulin-dependent diabetes mellitus and in normal cells, respectively."3.67Dual actions of sulfonylureas and glyburide. Receptor and post-receptor effects. ( Gavin, JR, 1985)
" Data are limited regarding the pharmacodynamic effects of metformin and glyburide during pregnancy."2.94Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus. ( Ahmed, MS; Brown, LM; Brown, Z; Caritis, S; Clark, S; Easterling, TR; Flood Nichols, SK; Haas, DM; Haneline, LS; Hebert, MF; Ma, X; Manuck, TA; Quinney, SK; Ren, Z; Shen, DD; Shireman, LM; Shuster, DL; Thummel, KE; Tita, AT; Venkataramanan, R, 2020)
"Pioglitazone was better than glibenclamide in decreasing HbA (1c), FPG, FPI, lipid profile, and in improving inflammatory parameters such as Hs-CRP, and ADN."2.76Pioglitazone compared to glibenclamide on lipid profile and inflammation markers in type 2 diabetic patients during an oral fat load. ( Bianchi, L; Cicero, AF; D'Angelo, A; Derosa, G; Fogari, E; Maffioli, P, 2011)
" Women with GDM in whom glyburide treatment has failed may benefit from alternative medication or dosage escalation; however, fetal safety should be kept in mind."2.74Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice. ( Ahmed, MS; Blough, D; Caritis, SN; Carr, DB; Cobelli, C; Easterling, TR; Hankins, GD; Hebert, MF; Kelly, EJ; Krudys, KM; Ma, X; Mattison, DR; Miodovnik, M; Naraharisetti, SB; Snodgrass, WR; Umans, JG; Unadkat, JD; Vicini, P, 2009)
"Pioglitazone treatment resulted in a significant reduction in fasting levels of PI and SPI compared to those of the controls."2.73Reduced postprandial proinsulinaemia and 32-33 split proinsulinaemia after a mixed meal in type 2 diabetic patients following sensitization to insulin with pioglitazone. ( Al Majali, K; Bailey, CJ; Betteridge, DJ; Cooper, MB, 2008)
"No weight gain was observed in patients treated with nateglinide."2.72Nateglinide with glibenclamide examination using the respiratory quotient (RQ). ( Harada, S; Ito, S; Nakaya, Y; Nomura, M, 2006)
"Metabolic syndrome was more frequent and microalbuminuria less frequent in NAC."2.72A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe. ( Freed, MI; Haffner, S; Heise, MA; Herman, WH; Holman, R; Jones, NP; Kahn, SE; Kravitz, B; Lachin, J; O'Neill, MC; Viberti, G; Zinman, B, 2006)
"Type 2 diabetes mellitus is characterized by both insulin deficiency and insulin resistance."2.71Beneficial effects of a glyburide/metformin combination preparation in type 2 diabetes mellitus. ( Bokhari, SU; Duckworth, WC; Gopal, UM, 2003)
"Pioglitazone is an insulin-sensitizing agent that has been reported to have anti-arteriosclerotic effects."2.71Effect of pioglitazone on arteriosclerosis in comparison with that of glibenclamide. ( Anazawa, T; Kanmatsuse, K; Kushiro, T; Tani, S; Watanabe, I, 2005)
"Glyburide treatment of diabetes decreased CRP and did so even though body weight increased."2.71Adiponectin and C-reactive protein in obesity, type 2 diabetes, and monodrug therapy. ( Bar, RS; Goldner, WS; Haynes, WG; Putz, DM; Sivitz, WI, 2004)
" In conclusion, combination treatment with metformin and sulfonylurea is more effective than these drugs alone in improving glycemic control in type 2 diabetes, while also allowing a reduction of the dosage of each drug."2.71Combination treatment with metformin and glibenclamide versus single-drug therapies in type 2 diabetes mellitus: a randomized, double-blind, comparative study. ( Brun, E; Coppini, A; Gori, M; Moghetti, P; Muggeo, M; Perobelli, L; Spiazzi, G; Tosi, F; Zanolin, E, 2003)
" The dosage of hypoglycemic drugs was maintained at a constant level throughout the study."2.67A high-monounsaturated-fat/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients. ( Capaldo, B; Ciardullo, AV; Genovese, S; Giacco, A; Parillo, M; Riccardi, G; Rivellese, AA, 1992)
"The usual choice of therapy in NIDDM diabetes, using oral anti-diabetic compounds, insulin or associated treatments, is based on the results of treatment evaluated empirically using glycemic profiles."2.67[Model of therapeutic programming in NIDDM diabetes]. ( Cortinovis, A; Crippa, A; Romano, E, 1992)
"Insulin sensitivity was increased by glibenclamide but not by glipizide."2.66Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics. ( Fyhrqvist, F; Groop, L; Groop, PH; Melander, A; Tolppanen, EM; Tötterman, KJ; Wåhlin-Boll, E, 1985)
"Insulin resistance is the key in this process because of the inability of insulin to suppress hepatic glucose production, thereby allowing an unopposed glucagon effect."2.38Effects of glyburide on carbohydrate metabolism and insulin action in the liver. ( Caro, JF, 1990)
"to investigate possible beneficial effects of hydroalcoholic extract of SecurigeraSecuridaca seed (HESS) on antioxidant capacity, fibroblast growth factor 21 (FGF21) and insulin resistance in Streptozotocin (STZ)-induced diabetic rats, alone and in combination with glibenclamide."1.56Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats. ( Alizadeh-Fanalou, S; Azadi, N; Babaei, M; Bahreini, E; Borji, M; Hosseini, A; Malekinejad, H; Nazarizadeh, A; Shojaii, A, 2020)
" Meanwhile, in co-treated group, elimination rate constant (Ke) of glibenclamide was reduced while peak plasma concentration (C(max)), area under the plasma concentration vs time curve (AUC(0-14 h)) and elimination half-life (T(1/2Ke)) were increased significantly vs glibenclamide alone administered rats."1.35Effects of 18alpha-glycyrrhizin on the pharmacodynamics and pharmacokinetics of glibenclamide in alloxan-induced diabetic rats. ( Ao, Y; Chen, J; Peng, RX; Yue, J, 2008)
"One hundred and twenty-four consecutive type 2 diabetes patients (mean age, 57."1.32Beneficial effects of triple drug combination of pioglitazone with glibenclamide and metformin in type 2 diabetes mellitus patients on insulin therapy. ( Chandalia, HB; Fafadia, A; Joshi, SR; Panikar, V; Santvana, C, 2003)
"Insulin resistance was produced when the hypoglycemic action of glibenclamide at a dose of 10 mg/kg was almost abolished in rats that received daily injections of long-acting insulin for 15 days."1.31Less of insulin desensitization in sympathetic nerve terminals from wistar rats with insulin resistance. ( Cheng, JT; Chi, TC; Liu, IM, 2000)
"Seventy-five patients with type 2 diabetes participated (mean age (+/- SD), 67 +/- 8 years; body mass index, 25."1.30Prognostic factors for successful insulin therapy in subjects with type 2 diabetes. ( Menheere, PP; Rondas-Colbers, GJ; Sels, JP; Wolffenbuttel, BH, 1999)
"A 60-year-old obese woman with type II diabetes mellitus and hepatomegaly exhibited progression of steatosis to hepatitis and cirrhosis."1.29Remission of active diabetic hepatitis after correction of hyperglycemia. ( Tak, PP; ten Kate, FJ, 1993)
"Insulin sensitivity has been determined in primary nonobese diabetics and subjects with borderline glucose intolerance by a newly devised technique using glucose, insulin, and somatostatin infusion."1.26Clinical significance of altered insulin sensitivity in diabetes mellitus assessed by glucose, insulin, and somatostatin infusion. ( Harano, Y; Hidaka, H; Izumi, K; Kashiwagi, A; Kobayashi, M; Kosugi, K; Nakano, T; Ohgaku, S; Shigeta, Y; Yasuda, H, 1981)

Research

Studies (87)

TimeframeStudies, this research(%)All Research%
pre-199012 (13.79)18.7374
1990's11 (12.64)18.2507
2000's35 (40.23)29.6817
2010's26 (29.89)24.3611
2020's3 (3.45)2.80

Authors

AuthorsStudies
Yu, J1
Ahn, S2
Kim, HJ1
Lee, M1
Kim, J1
Jin, SH1
Lee, E1
Kim, G1
Cheong, JH1
Jacobson, KA1
Jeong, LS1
Noh, M1
Alizadeh-Fanalou, S1
Babaei, M1
Hosseini, A1
Azadi, N1
Nazarizadeh, A1
Shojaii, A1
Borji, M1
Malekinejad, H1
Bahreini, E1
Shuster, DL1
Shireman, LM1
Ma, X2
Shen, DD1
Flood Nichols, SK1
Ahmed, MS2
Clark, S1
Caritis, S1
Venkataramanan, R1
Haas, DM1
Quinney, SK1
Haneline, LS1
Tita, AT1
Manuck, TA1
Thummel, KE1
Brown, LM1
Ren, Z1
Brown, Z1
Easterling, TR2
Hebert, MF2
Pires Mendes, C1
Postal, BG1
Silva Frederico, MJ1
Gonçalves Marques Elias, R1
Aiceles de Medeiros Pinto, V1
da Fonte Ramos, C1
Devantier Neuenfeldt, P1
Nunes, RJ1
Mena Barreto Silva, FR1
Sadri, H1
Larki, NN1
Kolahian, S1
Gao, H1
Ho, E1
Balakrishnan, M1
Yechoor, V1
Yallampalli, C1
Su, WJ1
Peng, W1
Gong, H1
Liu, YZ1
Zhang, Y1
Lian, YJ1
Cao, ZY1
Wu, R1
Liu, LL1
Wang, B1
Wang, YX1
Jiang, CL1
Yildiz, M1
Akcay, T1
Aydin, B1
Akgun, A1
Dogan, BB1
De Franco, E1
Ellard, S1
Onal, H1
Emfinger, CH1
Yan, Z1
Welscher, A1
Hung, P1
McAllister, W1
Hruz, PW2
Nichols, CG2
Remedi, MS2
Emini-Sadiku, M1
Car, N1
Begolli, L1
Blaslov, K1
Haliti, E1
Bahtiri, E1
Derosa, G4
Cicero, AF4
Franzetti, IG3
Querci, F3
Carbone, A2
Piccinni, MN3
D'Angelo, A4
Fogari, E3
Maffioli, P4
Henriksbo, BD1
Lau, TC1
Cavallari, JF1
Denou, E1
Chi, W1
Lally, JS1
Crane, JD1
Duggan, BM1
Foley, KP1
Fullerton, MD1
Tarnopolsky, MA1
Steinberg, GR1
Schertzer, JD1
Honda, H1
Nagai, Y1
Matsunaga, T1
Okamoto, N1
Watanabe, Y1
Tsuneyama, K1
Hayashi, H1
Fujii, I1
Ikutani, M1
Hirai, Y1
Muraguchi, A1
Takatsu, K1
Roche, C1
Besnier, M1
Cassel, R1
Harouki, N1
Coquerel, D1
Guerrot, D1
Nicol, L1
Loizon, E1
Remy-Jouet, I1
Morisseau, C1
Mulder, P1
Ouvrard-Pascaud, A1
Madec, AM1
Richard, V1
Bellien, J1
Koupý, D1
Kotolová, H1
Rudá Kučerová, J1
Seino, Y1
Kuwata, H1
Yabe, D1
Choudhary, S1
Mourya, A1
Ahuja, S1
Sah, SP1
Kumar, A1
Stephen Irudayaraj, S1
Christudas, S1
Antony, S1
Duraipandiyan, V1
Naif Abdullah, AD1
Ignacimuthu, S1
Franco, CCS1
Prates, KV1
Previate, C1
Moraes, AMP1
Matiusso, CCI1
Miranda, RA1
de Oliveira, JC1
Tófolo, LP1
Martins, IP1
Barella, LF1
Ribeiro, TA1
Malta, A1
Pavanello, A1
Francisco, FA1
Gomes, RM1
Alves, VS1
Moreira, VM1
Rigo, KP1
Almeida, DL1
de Sant Anna, JR1
Prado, MAAC1
Mathias, PCF1
Xue, W1
Zhang, M1
Li, J1
Wu, D1
Niu, L1
Liang, Y1
Naraharisetti, SB1
Krudys, KM1
Umans, JG1
Hankins, GD1
Caritis, SN1
Miodovnik, M1
Mattison, DR1
Unadkat, JD1
Kelly, EJ1
Blough, D1
Cobelli, C1
Snodgrass, WR1
Carr, DB1
Vicini, P1
Xu, DY1
Zhao, SP1
Huang, QX1
Du, W1
Liu, YH1
Liu, L1
Xie, XM1
Konya, H1
Hasegawa, Y1
Hamaguchi, T1
Satani, K1
Umehara, A1
Katsuno, T1
Ishikawa, T1
Miuchi, M1
Kohri, K1
Suehiro, A1
Kakishita, E1
Miyagawa, J1
Namba, M1
Salvadeo, SA1
Ferrari, I1
Ragonesi, PD1
Gadaleta, G1
Ciccarelli, L1
Kirana, H1
Srinivasan, BP1
Kahn, SE2
Lachin, JM1
Zinman, B2
Haffner, SM1
Aftring, RP1
Paul, G1
Kravitz, BG1
Herman, WH2
Viberti, G2
Holman, RR1
Bianchi, L1
Adeneye, AA1
Agbaje, EO1
Olagunju, JA1
Agapova, SE1
Vyas, AK1
Boyda, HN1
Procyshyn, RM1
Tse, L1
Hawkes, E1
Jin, CH1
Pang, CC1
Honer, WG1
Barr, AM1
Nakamura, N1
Fischer, S1
Patzak, A1
Rietzsch, H1
Schwanebeck, U1
Köhler, C1
Wildbrett, J1
Fuecker, K1
Temelkova-Kurktschiev, T1
Hanefeld, M2
Bokhari, SU1
Gopal, UM1
Duckworth, WC1
Tamás, G1
Kerényi, Z1
Tosi, F1
Muggeo, M1
Brun, E1
Spiazzi, G1
Perobelli, L1
Zanolin, E1
Gori, M1
Coppini, A1
Moghetti, P1
Scheen, AJ1
Yosefy, C1
Magen, E1
Kiselevich, A1
Priluk, R1
London, D1
Volchek, L1
Viskoper, RJ1
Panikar, V1
Chandalia, HB1
Joshi, SR1
Fafadia, A1
Santvana, C1
Tan, MH1
Johns, D1
Strand, J1
Halse, J1
Madsbad, S1
Eriksson, JW1
Clausen, J1
Konkoy, CS1
Herz, M1
Putz, DM1
Goldner, WS1
Bar, RS1
Haynes, WG1
Sivitz, WI1
Watanabe, I1
Tani, S1
Anazawa, T1
Kushiro, T1
Kanmatsuse, K1
Inukai, K1
Watanabe, M1
Nakashima, Y1
Sawa, T1
Takata, N1
Tanaka, M1
Kashiwabara, H1
Yokota, K1
Suzuki, M1
Kurihara, S1
Awata, T2
Katayama, S2
Satoh, J1
Takahashi, K1
Takizawa, Y1
Ishihara, H1
Hirai, M1
Katagiri, H1
Hinokio, Y1
Suzuki, S1
Tsuji, I1
Oka, Y1
Chen, J2
Jeppesen, PB1
Abudula, R1
Dyrskog, SE1
Colombo, M1
Hermansen, K1
Koshiba, K1
Nomura, M2
Nakaya, Y2
Ito, S2
Monnier, L1
Colette, C1
Thuan, JF1
Lapinski, H1
Mori, Y1
Itoh, Y1
Obata, T1
Tajima, N1
Scollan-Koliopoulos, M1
Guadagno, S1
Walker, EA1
Pfützner, A1
Forst, T1
Lübben, G1
Taniguchi, Y1
Ooie, T1
Takahashi, N1
Shinohara, T1
Nakagawa, M1
Yonemochi, H1
Hara, M1
Yoshimatsu, H1
Saikawa, T1
Harada, S1
Lachin, J1
Holman, R1
Haffner, S1
Kravitz, B1
Heise, MA1
Jones, NP1
O'Neill, MC1
Freed, MI1
Chadwick, W1
Wilson, G1
van de Venter, M1
Oelofsen, W1
Roux, S1
Atkinson, LL1
McDonald-Dyck, C1
Benkoczi, C1
Finegood, DT1
Cooper, MB1
Al Majali, K1
Bailey, CJ1
Betteridge, DJ1
Standl, E1
Schnell, O1
Kamgang, R1
Mboumi, RY1
Fondjo, AF1
Tagne, MA1
N'dillé, GP1
Yonkeu, JN1
Ao, Y1
Yue, J1
Peng, RX1
Harano, Y1
Ohgaku, S1
Kosugi, K1
Yasuda, H1
Nakano, T1
Kobayashi, M1
Hidaka, H1
Izumi, K1
Kashiwagi, A1
Shigeta, Y1
Kolterman, OG1
Prince, MJ1
Olefsky, JM2
Tattersall, RB1
Birkeland, KI1
Hanssen, KF1
Urdal, P1
Berg, K1
Vaaler, S1
Kumar, S1
Boulton, AJ1
Tak, PP1
ten Kate, FJ1
Jones, TW1
Boulware, SD1
Caprio, S1
Merkel, P1
Amiel, SA1
Pearson, HA1
Sherwin, RS1
Tamborlane, WV1
Wolffenbuttel, BH1
Sels, JP1
Rondas-Colbers, GJ1
Menheere, PP1
Kosegawa, I1
Chen, S1
Negishi, K1
Chi, TC1
Liu, IM1
Cheng, JT1
Taniguchi, A1
Fukushima, M1
Sakai, M1
Tokuyama, K1
Nagata, I1
Fukunaga, A1
Kishimoto, H1
Doi, K1
Yamashita, Y1
Matsuura, T1
Kitatani, N1
Okumura, T1
Nagasaka, S1
Nakaishi, S1
Nakai, Y1
Sekiya, M1
Suzuki, J1
Watanabe, K1
Funada, J1
Otani, T1
Akutsu, H1
Miller, AW1
Tulbert, C1
Puskar, M1
Busija, DW1
Boyd, K1
Rogers, C1
Boreham, C1
Andrews, WJ1
Hadden, DR1
Parillo, M1
Rivellese, AA1
Ciardullo, AV1
Capaldo, B1
Giacco, A1
Genovese, S1
Riccardi, G1
Cortinovis, A1
Crippa, A1
Romano, E1
Caro, JF1
Khandekar, S1
Sethi, BK1
Dash, RJ1
Chen, QM1
Shank, WA1
Morrison, AD1
Draznin, B1
Sussman, KE1
Eckel, RH1
Kao, M1
Yost, T1
Sherman, NA1
Bolinder, J1
Ostman, J1
Arner, P1
Owens, DR1
Gavin, JR1
Groop, L1
Wåhlin-Boll, E1
Groop, PH1
Tötterman, KJ1
Melander, A1
Tolppanen, EM1
Fyhrqvist, F1
Hosker, JP1
Burnett, MA1
Davies, EG1
Harris, EA1
Turner, RC1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT01947699]Phase 40 participants (Actual)Interventional2013-09-30Withdrawn (stopped due to PI decided to withdrawal study before recruitment started)
The Impact of Glucose Lowering Therapies Including Dipeptidyl Peptidase-4 Inhibitor on Circulating Endothelial Progenitor Cells (EPCs) and Its Mobilising Factor Stromal Derived Factor-1α (SDF-1α) in Patients With Type 2 Diabetes[NCT02694575]241 participants (Actual)Observational2015-03-01Completed
A Randomized, Double-Blind Study to Compare the Durability of Glucose Lowering and Preservation of Pancreatic Beta-Cell Function of Rosiglitazone Monotherapy Compared to Metformin or Glyburide/Glibenclamide in Patients With Drug-Naive, Recently Diagnosed [NCT00279045]Phase 34,426 participants (Actual)Interventional2000-01-03Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for glyburide and Insulin Resistance

ArticleYear
[Effectiveness of phytotherapy in supportive treatment of type 2 diabetes mellitus II. Fenugreek (Trigonella foenum-graecum)].
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2015, Volume: 64, Issue:3

    Topics: Diabetes Mellitus, Type 2; Glucose; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Resista

2015
Incretin-based drugs for type 2 diabetes: Focus on East Asian perspectives.
    Journal of diabetes investigation, 2016, Volume: 7 Suppl 1

    Topics: Animals; Asian People; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like

2016
[Glimepiride].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9

    Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Clinical Trials as Topic; Diabet

2002
Current controversies in the mechanisms and treatment of gestational diabetes.
    Current diabetes reports, 2002, Volume: 2, Issue:4

    Topics: Autoimmune Diseases; Blood Glucose; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic A

2002
[Medication of the month. Glucovance in type 2 diabetes, a fixed combination of metformin-glibenclamide for the treatment of a bipolar metabolic disease].
    Revue medicale de Liege, 2003, Volume: 58, Issue:6

    Topics: Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; In

2003
Gestational diabetes management: guidelines to a healthy pregnancy.
    The Nurse practitioner, 2006, Volume: 31, Issue:6

    Topics: Diabetes Mellitus, Type 2; Diabetes, Gestational; Diet, Diabetic; Estrogens; Exercise; Female; Fetal

2006
Insulin resistance in noninsulin-dependent diabetes mellitus: impact of sulfonylurea agents in vivo and in vitro.
    The American journal of medicine, 1983, Jan-17, Volume: 74, Issue:1A

    Topics: Diabetes Mellitus; Glucose; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Rec

1983
[25 years of diabetic treatment by oral hypoglycemic agents: successes and failures].
    Journees annuelles de diabetologie de l'Hotel-Dieu, 1984

    Topics: Aged; Aging; Blood Glucose; Cardiovascular Diseases; Chlorpropamide; Diabetes Complications; Diabete

1984
Effects of glyburide on carbohydrate metabolism and insulin action in the liver.
    The American journal of medicine, 1990, Aug-20, Volume: 89, Issue:2A

    Topics: Carbohydrate Metabolism; Diabetes Mellitus, Type 2; Glucose; Glyburide; Glycolysis; Humans; Insulin;

1990
Oral sulfonylureas for the treatment of type II diabetes: an update.
    Southern medical journal, 1986, Volume: 79, Issue:3

    Topics: Administration, Oral; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Hypersensitivity; Glipizide; G

1986
Effects of oral sulfonylureas on the spectrum of defects in non-insulin-dependent diabetes mellitus.
    The American journal of medicine, 1985, Aug-23, Volume: 79, Issue:2B

    Topics: Adult; Aged; Blood Glucose; Chlorpropamide; Clinical Trials as Topic; Combined Modality Therapy; Dia

1985

Trials

31 trials available for glyburide and Insulin Resistance

ArticleYear
Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.
    Clinical pharmacology and therapeutics, 2020, Volume: 107, Issue:6

    Topics: Adolescent; Adult; Blood Glucose; Diabetes, Gestational; Drug Therapy, Combination; Female; Glyburid

2020
The differential influence of glimepiride and glibenclamide on insulin resistance and adiponectin levels in patients with type 2 diabetes.
    Endocrine journal, 2019, Oct-28, Volume: 66, Issue:10

    Topics: Adiponectin; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemic Agent

2019
A comparison between sitagliptin or glibenclamide in addition to metformin + pioglitazone on glycaemic control and β-cell function: the triple oral therapy.
    Diabetic medicine : a journal of the British Diabetic Association, 2013, Volume: 30, Issue:7

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; F

2013
A randomized, double-blind, comparative therapy evaluating sitagliptin versus glibenclamide in type 2 diabetes patients already treated with pioglitazone and metformin: a 3-year study.
    Diabetes technology & therapeutics, 2013, Volume: 15, Issue:3

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; F

2013
Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice.
    Clinical pharmacology and therapeutics, 2009, Volume: 85, Issue:6

    Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Cytochrome P-450 CYP2C9; Diab

2009
Exenatide versus glibenclamide in patients with diabetes.
    Diabetes technology & therapeutics, 2010, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Body Mass Index; Body Weight; C-Reactive

2010
Effects of rosiglitazone, glyburide, and metformin on β-cell function and insulin sensitivity in ADOPT.
    Diabetes, 2011, Volume: 60, Issue:5

    Topics: Aged; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin Resistance;

2011
Pioglitazone compared to glibenclamide on lipid profile and inflammation markers in type 2 diabetic patients during an oral fat load.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2011, Volume: 43, Issue:7

    Topics: Administration, Oral; Biomarkers; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Female; G

2011
Influence of treatment with acarbose or glibenclamide on insulin sensitivity in type 2 diabetic patients.
    Diabetes, obesity & metabolism, 2003, Volume: 5, Issue:1

    Topics: Acarbose; Adult; Aged; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Doubl

2003
Beneficial effects of a glyburide/metformin combination preparation in type 2 diabetes mellitus.
    The American journal of the medical sciences, 2003, Volume: 325, Issue:2

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Drug Combinations; Glyburide; Hemoglobin A; Humans; Hypogl

2003
Combination treatment with metformin and glibenclamide versus single-drug therapies in type 2 diabetes mellitus: a randomized, double-blind, comparative study.
    Metabolism: clinical and experimental, 2003, Volume: 52, Issue:7

    Topics: Blood Glucose; Body Mass Index; Cholesterol; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Bli

2003
Rosiglitazone improves, while Glibenclamide worsens blood pressure control in treated hypertensive diabetic and dyslipidemic subjects via modulation of insulin resistance and sympathetic activity.
    Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:2

    Topics: Administration, Oral; Albuminuria; Blood Glucose; Blood Pressure; Body Mass Index; Brachial Artery;

2004
Sustained effects of pioglitazone vs. glibenclamide on insulin sensitivity, glycaemic control, and lipid profiles in patients with Type 2 diabetes.
    Diabetic medicine : a journal of the British Diabetic Association, 2004, Volume: 21, Issue:8

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin Re

2004
Adiponectin and C-reactive protein in obesity, type 2 diabetes, and monodrug therapy.
    Metabolism: clinical and experimental, 2004, Volume: 53, Issue:11

    Topics: Adiponectin; Blood Glucose; Body Composition; C-Reactive Protein; Cross-Over Studies; Diabetes Melli

2004
Effect of pioglitazone on arteriosclerosis in comparison with that of glibenclamide.
    Diabetes research and clinical practice, 2005, Volume: 68, Issue:2

    Topics: Arteriosclerosis; Blood Glucose; Cholesterol, LDL; Diabetes Mellitus, Type 2; Drug Administration Sc

2005
Efficacy of glimepiride in Japanese type 2 diabetic subjects.
    Diabetes research and clinical practice, 2005, Volume: 68, Issue:3

    Topics: Aged; Asian People; Body Mass Index; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fe

2005
Secondary sulfonylurea failure: comparison of period until insulin treatment between diabetic patients treated with gliclazide and glibenclamide.
    Diabetes research and clinical practice, 2005, Volume: 70, Issue:3

    Topics: Age of Onset; Databases, Factual; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glic

2005
Efficacy of glimepiride on insulin resistance, adipocytokines, and atherosclerosis.
    The journal of medical investigation : JMI, 2006, Volume: 53, Issue:1-2

    Topics: Adipocytes; Aged; Atherosclerosis; Cytokines; Diabetes Mellitus, Type 2; Female; Glyburide; Humans;

2006
Effects of pioglitazone vs glibenclamide on postprandial increases in glucose and triglyceride levels and on oxidative stress in Japanese patients with type 2 diabetes.
    Endocrine, 2006, Volume: 29, Issue:1

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fatty Acids, Nones

2006
Glycemic control and treatment failure with pioglitazone versus glibenclamide in type 2 diabetes mellitus: a 42-month, open-label, observational, primary care study.
    Current medical research and opinion, 2006, Volume: 22, Issue:6

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glyburide; Glycated Hemoglobin; Humans; Hypo

2006
Nateglinide with glibenclamide examination using the respiratory quotient (RQ).
    The journal of medical investigation : JMI, 2006, Volume: 53, Issue:3-4

    Topics: Aged; Blood Glucose; Body Weight; Cyclohexanes; Diabetes Mellitus, Type 2; Female; Glyburide; Humans

2006
A Diabetes Outcome Progression Trial (ADOPT): baseline characteristics of Type 2 diabetic patients in North America and Europe.
    Diabetic medicine : a journal of the British Diabetic Association, 2006, Volume: 23, Issue:12

    Topics: Adult; Age Distribution; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Europe; Female; Glyburide;

2006
Reduced postprandial proinsulinaemia and 32-33 split proinsulinaemia after a mixed meal in type 2 diabetic patients following sensitization to insulin with pioglitazone.
    Clinical endocrinology, 2008, Volume: 68, Issue:5

    Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glyburide; Humans; Hyp

2008
A long-term, randomized, comparative study of insulin versus sulfonylurea therapy in type 2 diabetes.
    Journal of internal medicine, 1994, Volume: 236, Issue:3

    Topics: Aged; Blood Pressure; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glyburide; Glycate

1994
Effects of bezafibrate on insulin sensitivity and insulin secretion in non-obese Japanese type 2 diabetic patients.
    Metabolism: clinical and experimental, 2001, Volume: 50, Issue:4

    Topics: Adult; Aged; Bezafibrate; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypog

2001
Beneficial effect of troglitazone, an insulin-sensitizing antidiabetic agent, on coronary circulation in patients with non-insulin-dependent diabetes mellitus.
    Japanese circulation journal, 2001, Volume: 65, Issue:6

    Topics: Adenosine Triphosphate; Aged; Blood Glucose; Case-Control Studies; Chromans; Coronary Circulation; D

2001
Insulin, glibenclamide or metformin treatment for non insulin dependent diabetes: heterogenous responses of standard measures of insulin action and insulin secretion before and after differing hypoglycaemic therapy.
    Diabetes research (Edinburgh, Scotland), 1992, Volume: 19, Issue:2

    Topics: Blood Glucose; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glybu

1992
A high-monounsaturated-fat/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients.
    Metabolism: clinical and experimental, 1992, Volume: 41, Issue:12

    Topics: Adult; Blood Glucose; Body Mass Index; Combined Modality Therapy; Diabetes Mellitus, Type 2; Dietary

1992
[Model of therapeutic programming in NIDDM diabetes].
    Minerva medica, 1992, Volume: 83, Issue:3

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin R

1992
Effects of oral sulfonylureas on the spectrum of defects in non-insulin-dependent diabetes mellitus.
    The American journal of medicine, 1985, Aug-23, Volume: 79, Issue:2B

    Topics: Adult; Aged; Blood Glucose; Chlorpropamide; Clinical Trials as Topic; Combined Modality Therapy; Dia

1985
Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics.
    European journal of clinical pharmacology, 1985, Volume: 28, Issue:6

    Topics: Aged; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus, Type 2; Double-Blind Method; Erythro

1985

Other Studies

46 other studies available for glyburide and Insulin Resistance

ArticleYear
Polypharmacology of N
    Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17

    Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine A3 Receptor Antagonists; Adiponectin; Animals;

2017
Effects of Securigera Securidaca seed extract in combination with glibenclamide on antioxidant capacity, fibroblast growth factor 21 and insulin resistance in hyperglycemic rats.
    Journal of ethnopharmacology, 2020, Feb-10, Volume: 248

    Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Drug Therapy, Com

2020
Synthesis of a novel glibenclamide-pioglitazone hybrid compound and its effects on glucose homeostasis in normal and insulin-resistant rats.
    Bioorganic chemistry, 2021, Volume: 114

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glyburide; Home

2021
Hypoglycemic and Hypolipidemic Effects of Leucine, Zinc, and Chromium, Alone and in Combination, in Rats with Type 2 Diabetes.
    Biological trace element research, 2017, Volume: 180, Issue:2

    Topics: Animals; Blood Glucose; Chromium; Combined Modality Therapy; Diabetes Mellitus, Type 2; Dietary Supp

2017
Decreased insulin secretion in pregnant rats fed a low protein diet.
    Biology of reproduction, 2017, Oct-01, Volume: 97, Issue:4

    Topics: Animals; Arginine; Blood Glucose; Diet, Protein-Restricted; Dietary Proteins; Female; Glucose; Gluco

2017
Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance.
    Journal of neuroinflammation, 2017, Oct-30, Volume: 14, Issue:1

    Topics: Animals; Comorbidity; Depressive Disorder; Glyburide; Hypoglycemic Agents; Insulin Resistance; Male;

2017
Emergence of insulin resistance following empirical glibenclamide therapy: a case report of neonatal diabetes with a recessive INS gene mutation.
    Journal of pediatric endocrinology & metabolism : JPEM, 2018, Mar-28, Volume: 31, Issue:3

    Topics: Blood Glucose; Consanguinity; Diabetes Mellitus; Glyburide; Homozygote; Humans; Infant, Newborn; Inf

2018
Contribution of systemic inflammation to permanence of K
    American journal of physiology. Endocrinology and metabolism, 2018, 12-01, Volume: 315, Issue:6

    Topics: Animals; Blood Glucose; Cytokines; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glyburide;

2018
Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance.
    Diabetes, 2014, Volume: 63, Issue:11

    Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Carrier Proteins; Caspase 1; Fatty Acids, Monounsaturated; Fl

2014
Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation.
    Journal of leukocyte biology, 2014, Volume: 96, Issue:6

    Topics: Adipose Tissue, White; Animals; Anti-Inflammatory Agents; Carrier Proteins; Cell Line, Tumor; Chalco

2014
Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice.
    American journal of physiology. Heart and circulatory physiology, 2015, May-01, Volume: 308, Issue:9

    Topics: Animals; Benzoates; Blood Glucose; Coronary Vessels; Disease Models, Animal; Dose-Response Relations

2015
Plausible anti-inflammatory mechanism of resveratrol and caffeic acid against chronic stress-induced insulin resistance in mice.
    Inflammopharmacology, 2016, Volume: 24, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Caffeic Acids; Corticosterone; Cytokines; Drug The

2016
Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats.
    Pharmaceutical biology, 2017, Volume: 55, Issue:1

    Topics: Acetates; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty

2017
Glibenclamide treatment blocks metabolic dysfunctions and improves vagal activity in monosodium glutamate-obese male rats.
    Endocrine, 2017, Volume: 56, Issue:2

    Topics: Adipose Tissue; Animals; Autonomic Nervous System; Blood Glucose; Body Weight; Eating; Glyburide; Hy

2017
Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed.
    Cardiovascular drugs and therapy, 2008, Volume: 22, Issue:6

    Topics: 4-Aminopyridine; Acetylcholine; Administration, Oral; Animals; Aorta; Blood Glucose; Blood Pressure;

2008
Effects of Glimepiride on metabolic parameters and cardiovascular risk factors in patients with newly diagnosed type 2 diabetes mellitus.
    Diabetes research and clinical practice, 2010, Volume: 88, Issue:1

    Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glyburide; Glycated Hemoglobin; Human

2010
Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:9

    Topics: Aged; alpha-2-Antiplasmin; Antithrombin III; Azides; Blood Glucose; Body Mass Index; Deoxyuracil Nuc

2010
Effect of Cyclea peltata Lam. roots aqueous extract on glucose levels, lipid profile, insulin, TNF-alpha and skeletal muscle glycogen in type 2 diabetic rats.
    Indian journal of experimental biology, 2010, Volume: 48, Issue:5

    Topics: Animals; Blood Glucose; Cyclea; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Eva

2010
Metformin: an effective attenuator of risperidone-induced insulin resistance hyperglycemia and dyslipidemia in rats.
    Indian journal of experimental biology, 2011, Volume: 49, Issue:5

    Topics: Animals; Antipsychotic Agents; Blood Glucose; Disease Models, Animal; Dyslipidemias; Glyburide; Huma

2011
Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.
    Diabetes, 2011, Volume: 60, Issue:10

    Topics: Animals; Blood Glucose; Diabetes Mellitus; Glucose; Glyburide; Humans; Hypoglycemic Agents; Insulin

2011
Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats.
    Journal of psychiatry & neuroscience : JPN, 2012, Volume: 37, Issue:6

    Topics: Animals; Antipsychotic Agents; Benzodiazepines; Female; Glucose Intolerance; Glyburide; Hypoglycemic

2012
Beneficial effects of triple drug combination of pioglitazone with glibenclamide and metformin in type 2 diabetes mellitus patients on insulin therapy.
    The Journal of the Association of Physicians of India, 2003, Volume: 51

    Topics: Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Glycated Hemoglobin; Humans

2003
Stevioside does not cause increased basal insulin secretion or beta-cell desensitization as does the sulphonylurea, glibenclamide: studies in vitro.
    Life sciences, 2006, Mar-06, Volume: 78, Issue:15

    Topics: Animals; Diterpenes, Kaurane; Female; Glucose; Glucosides; Glyburide; Hypoglycemic Agents; In Vitro

2006
[Hardly any hypoglycemias, constant weight--and still cost effective].
    MMW Fortschritte der Medizin, 2005, Nov-24, Volume: 147, Issue:47

    Topics: Body Weight; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Drugs, Generic; Glyburide; Humans; Hy

2005
Insulin secretion and sensitivity as determinants of HbA1c in type 2 diabetes.
    European journal of clinical investigation, 2006, Volume: 36, Issue:4

    Topics: Biomarkers; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Glycated Hemogl

2006
Pioglitazone but not glibenclamide improves cardiac expression of heat shock protein 72 and tolerance against ischemia/reperfusion injury in the heredity insulin-resistant rat.
    Diabetes, 2006, Volume: 55, Issue:8

    Topics: Animals; Blotting, Western; Diabetes Mellitus, Type 2; Fever; Glucose Tolerance Test; Glyburide; HSP

2006
Shifts in metabolic parameters surrounding glucose homoeostasis resulting from tricyclic antidepressant therapy: implications of insulin resistance?
    The Journal of pharmacy and pharmacology, 2007, Volume: 59, Issue:1

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Blood Glucose; Cell Line; Glucose; Glyburi

2007
Effect of chronic rosiglitazone, metformin and glyburide treatment on beta-cell mass, function and insulin sensitivity in mZDF rats.
    Diabetes, obesity & metabolism, 2008, Volume: 10, Issue:9

    Topics: Animals; Apoptosis; Blood Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Resistance; Insu

2008
Insulin as a first-line therapy in type 2 diabetes: should the use of sulfonylureas be halted?
    Diabetes care, 2008, Volume: 31 Suppl 2

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Glyburide; Humans; Hypogl

2008
Antihyperglycaemic potential of the water-ethanol extract of Kalanchoe crenata (Crassulaceae).
    Journal of natural medicines, 2008, Volume: 62, Issue:1

    Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty

2008
Effects of 18alpha-glycyrrhizin on the pharmacodynamics and pharmacokinetics of glibenclamide in alloxan-induced diabetic rats.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Animals; Cytochrome P-450 CYP3A; Diabetes Mellitus, Experimental; Drug Interactions; Glyburide; Glyc

2008
Clinical significance of altered insulin sensitivity in diabetes mellitus assessed by glucose, insulin, and somatostatin infusion.
    The Journal of clinical endocrinology and metabolism, 1981, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Aged; Blood Glucose; Diabetes Mellitus; Diet, Diabetic; Fasting; Glucose; Glyburi

1981
Serious, prolonged hypoglycaemia with glibenclamide in a patient with Mendenhall's syndrome.
    Clinical endocrinology, 1993, Volume: 39, Issue:1

    Topics: Abnormalities, Multiple; Adult; Diabetes Mellitus; Glyburide; Humans; Hyperplasia; Hypoglycemia; Hyp

1993
Remission of active diabetic hepatitis after correction of hyperglycemia.
    Liver, 1993, Volume: 13, Issue:4

    Topics: Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glyburide; Hepatitis; Humans; Hypergly

1993
Correction of hyperinsulinemia by glyburide treatment in nondiabetic patients with thalassemia major.
    Pediatric research, 1993, Volume: 33, Issue:5

    Topics: Adolescent; Adult; beta-Thalassemia; Child; Diabetes Mellitus; Female; Glucose Tolerance Test; Glybu

1993
Prognostic factors for successful insulin therapy in subjects with type 2 diabetes.
    The Netherlands journal of medicine, 1999, Volume: 54, Issue:2

    Topics: Aged; Biomarkers; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Drug Therapy, Combinati

1999
Troglitazone and metformin, but not glibenclamide, decrease blood pressure in Otsuka Long Evans Tokushima Fatty rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1999, Volume: 21, Issue:3

    Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Chromans; Diabetes Mellitus, Type 2; Glucose

1999
Less of insulin desensitization in sympathetic nerve terminals from wistar rats with insulin resistance.
    Journal of the autonomic nervous system, 2000, Apr-12, Volume: 80, Issue:1-2

    Topics: Adipocytes; Adrenergic Fibers; Animals; Aorta; Blood Glucose; Carbon Radioisotopes; Deoxyglucose; Gl

2000
Enhanced endothelin activity prevents vasodilation to insulin in insulin resistance.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:1

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dose-Response Relationship, Drug; Endothelin Receptor Antagon

2002
Effect of sulphonylurea therapy on insulin sensitivity in non insulin dependent diabetics.
    The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:7

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glipizide; Glyburide; Humans; Insulin Resistance; Middle A

1990
[Study on biological characteristics of spontaneous diabetic KK mice].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1988, Volume: 10, Issue:6

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Glucose Tolerance Test; Glyburide;

1988
Possible role of cytosolic free calcium concentrations in mediating insulin resistance of obesity and hyperinsulinemia.
    The Journal of clinical investigation, 1988, Volume: 82, Issue:6

    Topics: Adipose Tissue; Adult; Biopsy; Calcium; Cytosol; Deoxyglucose; Female; Glyburide; Humans; Hyperinsul

1988
Reversal of insulin resistance in adipose tissue of non-insulin-dependent diabetics by treatment with diet and sulphonylurea.
    Acta endocrinologica, 1985, Volume: 108, Issue:1

    Topics: Adipose Tissue; Diabetes Mellitus, Type 2; Female; Glipizide; Glucose; Glyburide; Humans; Insulin; I

1985
Clinical, cellular, and physiologic effects of glyburide in non-insulin-dependent diabetes mellitus.
    The American journal of medicine, 1985, Sep-20, Volume: 79, Issue:3B

    Topics: Biological Transport; Diabetes Mellitus, Type 2; Drug Administration Schedule; Glucose; Glyburide; H

1985
Dual actions of sulfonylureas and glyburide. Receptor and post-receptor effects.
    The American journal of medicine, 1985, Sep-20, Volume: 79, Issue:3B

    Topics: Adipose Tissue; Animals; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mel

1985
Sulphonylurea therapy doubles B-cell response to glucose in type 2 diabetic patients.
    Diabetologia, 1985, Volume: 28, Issue:11

    Topics: Aged; Blood Glucose; C-Peptide; Chlorpropamide; Diabetes Mellitus, Type 2; Glucose; Glyburide; Human

1985