17-hydroxypregnanolone profile

## 17-Hydroxypregnanolone: A Neurosteroid with a Complex Role

**17-Hydroxypregnanolone (17OHP)** is a naturally occurring neurosteroid, meaning it's produced in the brain and acts as a neurotransmitter. Its chemical structure is similar to that of progesterone, a hormone produced in the ovaries and adrenal glands.

**Here's why 17OHP is important for research:**

* **Neuromodulatory effects:** 17OHP acts as a positive allosteric modulator of the GABA-A receptor, the primary inhibitory neurotransmitter receptor in the brain. This means it enhances the activity of GABA, leading to a calming and sedative effect.
* **Potential therapeutic implications:** Research suggests 17OHP could have potential in treating various conditions:
* **Anxiety and depression:** 17OHP's calming effect makes it a potential therapeutic target for these disorders.
* **Epilepsy:** Studies show that 17OHP can suppress epileptic seizures.
* **Neurodegenerative diseases:** There's growing interest in 17OHP's potential role in treating neurodegenerative conditions like Alzheimer's disease, due to its neuroprotective effects.
* **Role in neurodevelopment:** 17OHP is involved in brain development and maturation, particularly in the hippocampus and amygdala, regions involved in memory and emotion.
* **Interplay with other neurochemicals:** 17OHP interacts with other neurochemicals, including serotonin and dopamine, further complicating its effects and adding to its potential in various neurological conditions.
* **Impact on sleep:** 17OHP levels fluctuate throughout the day and are particularly high during sleep, suggesting a role in regulating sleep cycles.

**However, research is still ongoing, and more studies are needed to fully understand the complex role of 17OHP and its potential for therapeutic applications. Some of the challenges researchers face include:**

* **Variability in levels:** 17OHP levels can fluctuate significantly depending on individual factors like age, sex, and stress levels.
* **Limited understanding of mechanisms:** The exact mechanisms through which 17OHP exerts its effects are not fully understood.
* **Potential side effects:** Like any drug, 17OHP may have potential side effects, requiring further investigation before clinical use.

Overall, 17-hydroxypregnanolone is a fascinating neurosteroid with significant potential for understanding and treating neurological conditions. Research continues to explore its mechanisms of action, potential therapeutic applications, and its role in brain function.

17-hydroxypregnanolone: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	162411
SCHEMBL ID	5449875
MeSH ID	M0060496

Synonym
17-hydroxypregnanolone
40248-23-5
pregnan-20-one, 3,17-dihydroxy-
17-oh-polone
17-(1-ketoethyl)androstane-3,17-diol
5beta-pregnane-3alpha,17alpha-diol-20-one
SCHEMBL5449875
3,17-dihydroxypregnan-20-one

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	13 (81.25)	18.7374
1990's	1 (6.25)	18.2507
2000's	2 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (11.76%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (88.24%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
thalidomide Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.. thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.. 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.	1.97	1	phthalimides; piperidones
tetrahydrocortisol [no description available]	1.97	1	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3alpha-hydroxy steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone
tetrahydrocortisone [no description available]	7.35	2	21-hydroxy steroid
etiocholanolone Etiocholanolone: The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.. 3alpha-hydroxy-5beta-androstan-17-one : An androstanoid that is 5beta-androstane substituted by an alpha-hydroxy group at position 3 and an oxo group at position 17. It is a metabolite of testosterone in mammals.	1.97	1	17-oxo steroid; 3alpha-hydroxy steroid; androstanoid	human metabolite; mouse metabolite
dehydroepiandrosterone Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	2.01	1	17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid	androgen; human metabolite; mouse metabolite
17-alpha-hydroxyprogesterone 17alpha-hydroxyprogesterone : A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.	2.4	2	17alpha-hydroxy-C21-steroid; 17alpha-hydroxy steroid; tertiary alpha-hydroxy ketone	human metabolite; metabolite; mouse metabolite; progestin
pregnenolone [no description available]	2.01	1	20-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; C21-steroid	human metabolite; mouse metabolite
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	1.97	1	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
pregnanolone Pregnanolone: A pregnane found in the urine of pregnant women and sows. It has anesthetic, hypnotic, and sedative properties.. 3alpha-hydroxy-5beta-pregnan-20-one : The 3alpha-stereoisomer of 3-hydroxy-5beta-pregnan-20-one.	4.1	16	3-hydroxy-5beta-pregnan-20-one; 3alpha-hydroxy steroid	human metabolite; intravenous anaesthetic; sedative
androstane-3,17-diol Androstane-3,17-diol: The unspecified form of the steroid, normally a major metabolite of TESTOSTERONE with androgenic activity. It has been implicated as a regulator of gonadotropin secretion.	1.97	1	17-hydroxy steroid; 3-hydroxy steroid; androstanoid
pregnanetriol Pregnanetriol: A metabolite of 17-ALPHA-HYDROXYPROGESTERONE, normally produced in small quantities by the GONADS and the ADRENAL GLANDS, found in URINE. An elevated urinary pregnanetriol is associated with CONGENITAL ADRENAL HYPERPLASIA with a deficiency of STEROID 21-HYDROXYLASE.	8.05	5	corticosteroid hormone
cortisone [no description available]	6.93	1	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
pregnanetriolone pregnanetriolone: structure	2.37	2	corticosteroid hormone
17-ketosteroids 17-Ketosteroids: Steroids that contain a ketone group at position 17.. 17-oxo steroid : Any oxo steroid carrying the oxo group at position 17.	1.96	1
11-ketotestosterone 11-ketotestosterone: RN given refers to cpd without isomeric designation. 11-oxotestosterone : A 3-oxo Delta(4)-steroid that is testosterone carrying an additional oxo substituent at position 11.	1.99	1	11-oxo steroid; 17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; androstanoid	androgen; human metabolite; marine xenobiotic metabolite
pregnanediol [no description available]	2.63	3
cortisol succinate, sodium salt hydrocortisone hemisuccinate: RN given refers to (11beta)-isomer; Synonyms Solu-Cortef & sopolcort H refer to Na salt	1.96	1	organic molecular entity

Condition	Relationship Strength	Studies
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	3.22	6
Congenital Adrenal Hyperplasia [description not available]	7.64	3
Adrenal Hyperplasia, Congenital A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.	2.64	3
Birth Weight The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.	2.03	1
Insulin Sensitivity [description not available]	2.03	1
Familial Precocious Puberty [description not available]	2.4	2
Acanthosis Nigricans A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.	2.03	1
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	2.03	1
Puberty, Precocious Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.	2.4	2
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1
Chorioadenoma [description not available]	1.96	1
Hydatid Mole [description not available]	1.96	1
Cancer of the Uterus [description not available]	2.37	2
Hydatidiform Mole Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype.	1.96	1
Uterine Neoplasms Tumors or cancer of the UTERUS.	2.37	2
Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.	2.36	2
Adrenal Gland Hyperfunction [description not available]	1.95	1
Adrenocortical Hyperfunction Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.	1.95	1
Corpus Luteum Cyst [description not available]	1.96	1
Neoplasms, Trophoblastic [description not available]	1.96	1
Ovarian Cysts General term for CYSTS and cystic diseases of the OVARY.	1.96	1
Androgenization [description not available]	1.97	1

17-hydroxypregnanolone

Description

Cross-References

Synonyms (8)

Research

Studies (16)

Market Indicators

Research Demand Index: 11.48

Study Types