Compounds > nad
Page last updated: 2024-08-17

nad and Insulin Resistance

nad has been researched along with Insulin Resistance in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.89)18.7374
1990's2 (3.77)18.2507
2000's4 (7.55)29.6817
2010's28 (52.83)24.3611
2020's18 (33.96)2.80

Authors

AuthorsStudies
Jin, X; Lian, H; Liu, K; Ye, J; Zhang, X1
Garcia-Arroyo, FE; Johnson, RJ; Lanaspa, MA; Nakagawa, T; Rodriguez-Iturbe, B; Sánchez-Lozada, LG1
Aflatounian, A; Bertoldo, MJ; Cochran, BJ; Edwards, MC; Gilchrist, RB; Ledger, WL; Paris, VR; Richani, D; Walters, KA; Wu, LE1
Ban, J; Chen, S; Chen, X; Jia, Z; Li, Z; Niu, S; Pan, X; Ren, Q; Yue, L; Zhen, R; Zhu, R1
Apte, RS; Bhargava, A; Bhasin, S; Cheng, M; Ghattas-Puylara, C; Latham, N; Lavu, S; Lawney, B; Lin, AP; Livingston, D; Memish-Beleva, Y; Merugumala, S; Orkaby, AR; Ozimek, NE; Pencina, KM; Reid, KF; Sinclair, DA; Storer, T; Swain, PM; Valderrabano, R; Wilson, L; Wipper, B1
Muralidaran, V; Patel, K; Ryan, CE; Sunny, NE; Surugihalli, C; Zhao, D1
Dong, M; Pei, Z; Wang, S1
Chen, L; Chuang, YH; Du, L; Guo, LZ; Ho, JA; Li, M; Li, Y; Liu, TM; Liu, Y; Qin, G; Wang, TD; Wang, X; Wu, PC; Zheng, W1
Hyeon, J; Kim, E; Kim, KP; Lee, HM; Lee, J; Lee, YI; Nam, CH; Park, HS; Shin, J1
Bae, HR; Han, Y; Kim, S; Kwon, EY; Shin, SK; Yoo, JH; Young, HA1
Boutant, M; Canto, C; Cercillieux, A; Giner, MP; Giroud-Gerbetant, J; Joffraud, M; Kulkarni, SS; Moco, S; Ratajczak, J; Sambeat, A; Sanchez-Garcia, JL; Valera-Alberni, M; Valsesia, A1
Agerholm, M; Altıntaş, A; Barrès, R; Chubanava, S; Dollerup, OL; Høyer, KF; Jessen, N; Larsen, S; Lavery, GG; Møller, AB; Prats, C; Ringgaard, S; Stødkilde-Jørgensen, H; Søndergård, SD; Treebak, JT1
Lee, AY; Lin, F; Ngo, K; Nguyen, HP; Shin, G; Sul, HS; Tabuchi, C; Viscarra, JA; Wang, Y; Yi, D1
Boriek, AM; Pardo, PS1
Fernández, AF; Fraga, MF; Roberti, A1
Franczyk, MP; Imai, SI; Kayser, BD; Klein, S; Mills, KF; Patterson, BW; Patti, GJ; Pietka, T; Sindelar, M; Yoshino, J; Yoshino, M1
Abel, ED; Karwi, QG; Lopaschuk, GD; Tian, R; Wende, AR1
Chen, D; Montllor-Albalate, C; Song, Z1
Fischer-Posovszky, P; Roos, J; Zinngrebe, J1
Adler, GK; Hamid, AAA; Homma, M; Homma, T; Huang, Y; Hurwitz, S; Mayurasakorn, K; Pojoga, LH; Rodi, NM; Romero, JR; Williams, GH; Yao, T1
Cui, J; Fan, R; Huang, Y; Qian, X; Ren, F; Wang, Q; Wei, L; Xiong, X; Zhao, B1
Gulshan, M; Hikosaka, K; Kitamura, T; Mahmood, A; Nakagawa, T; Okabe, K; Sasaki, T; Tobe, K; Usui, I; Yaku, K; Yamamoto, M1
Oxenkrug, G1
Imai, S; Yoshino, J1
Chi, Y; Sauve, AA1
Choi, JM; Kim, L; Lee, WY; Oh, KW; Park, CY; Park, SE; Park, SW; Rhee, EJ; Yang, SJ1
Alhonen, L; Asara, JM; Banks, AS; Bhanot, S; Cen, Y; Gong, F; Kahn, BB; Kong, D; Kraus, D; Monia, BP; Peroni, OD; Pirinen, E; Puigserver, P; Pulinilkunnil, TC; Rodgers, JT; Sauve, AA; Wang, YC; Yang, Q; Zhang, L1
Choo, HJ; Hong, J; Kim, BW; Ko, YG; Lee, H; Lee, JS; Park, JJ; Yi, JS; Yoon, GS; Yu, DM1
Ai, Y; Jia, SH; Marshall, JC; Parodo, J; Peng, Q1
Cui, J; Gong, H; Pang, J; Xi, C; Zhang, TM1
Corkey, BE; Jones Iv, AR; Kleckner, AS; Liesa, M; Nocito, L; Yoo, EJ1
Akie, TE; Cooper, MP; Lei, S; Liu, L; Nam, M1
Cho, JH; Chou, JY; Jun, HS; Kim, GY; Lee, YM; Mansfield, BC; Pan, CJ; Springer, DA1
Buzadzic, B; Daiber, A; Jankovic, A; Korac, A; Korac, B; Otasevic, V; Stancic, A1
Hakkarainen, A; Heinonen, S; Jukarainen, S; Kaprio, J; Lundbom, J; Lundbom, N; Muniandy, M; Pietiläinen, KH; Pirinen, E; Rämö, JT; Rappou, E; Rinnankoski-Tuikka, R; Rissanen, A; Tummers, M1
Ido, Y1
Hu, N; Ren, J; Zhang, Y1
Yamaguchi, S; Yoshino, J1
Imai, S; Kiess, W1
Fujie, H; Koike, K; Matsuura, Y; Miyamura, T; Miyoshi, H; Moriishi, K; Moriya, K; Shintani, Y; Shinzawa, S; Suzuki, T; Tsutsumi, T; Yotsuyanagi, H1
Azuma, K; Goodpaster, BH; Kelley, DE; Menshikova, EV; Ritov, VB; Ruderman, NB; Toledo, FG; Wood, R1
Baur, JA1
Kazdová, L; Kontrová, K; Mikulík, K; Pravenec, M; Sajdok, J; Skop, V; Zídek, V; Zídková, J1
Chung, JH; Foretz, M; Kang, H; Kim, MK; McBurney, MW; Park, SJ; Um, JH; Viollet, B; Yang, S1
Cheng, Z; White, MF1
Duarte, FV; Gomes, AP; Hubbard, BP; Jones, JG; Nunes, P; Palmeira, CM; Rolo, AP; Sinclair, DA; Teodoro, JS; Varela, AT1
Corkey, BE; Shirihai, O1
Berglund, ED; Coate, KC; Evans, RM; He, TT; Katafuchi, T; Kliewer, SA; Mangelsdorf, DJ; Potthoff, MJ; Wan, Y; Wei, W; Xiao, G; Xie, Y; Yu, RT; Zhang, Y1
Crescenzo, R; Iossa, S; Lionetti, L; Liverini, G; Mollica, MP; Tasso, R1
Gill, V; Singal, PK; Vasdev, S1
Kano, H; Kohno, M; Minami, M; Yasunari, K; Yokokawa, K; Yoshikawa, J1
Kadowaki, T1
Gawler, DJ; Houslay, MD; Milligan, G; Wilson, A1

Reviews

16 review(s) available for nad and Insulin Resistance

ArticleYear
The mechanisms of nucleotide actions in insulin resistance.
    Journal of genetics and genomics = Yi chuan xue bao, 2022, Volume: 49, Issue:4

    Topics: Adenosine Triphosphate; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin Resistance; NAD; Nucleotides

2022
Sirtuin deficiency and the adverse effects of fructose and uric acid synthesis.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2022, 05-01, Volume: 322, Issue:5

    Topics: Fructose; Humans; Insulin Resistance; NAD; Sirtuins; Uric Acid

2022
Mechanism of CD38 via NAD
    International journal of medical sciences, 2023, Volume: 20, Issue:2

    Topics: ADP-ribosyl Cyclase 1; Animals; Humans; Insulin Resistance; Lipids; Liver; Membrane Glycoproteins; Mice; NAD; Non-alcoholic Fatty Liver Disease

2023
SIRT1 Regulation in Ageing and Obesity.
    Mechanisms of ageing and development, 2020, Volume: 188

    Topics: Aging; Animals; Diabetes Mellitus, Type 2; DNA Damage; Exercise; Gene Expression Regulation; Humans; Hypoxia; Inflammation; Insulin Resistance; Metabolic Syndrome; Mice; NAD; Obesity; Oxidative Stress; Protein Domains; Protein Processing, Post-Translational; Risk; Sirtuin 1; Stress, Mechanical

2020
Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation.
    Molecular metabolism, 2021, Volume: 45

    Topics: Adipose Tissue; Animals; Epigenesis, Genetic; Humans; Insulin Resistance; Liver; NAD; Neoplasms; Niacinamide; Nicotinamide N-Methyltransferase; Obesity; S-Adenosylmethionine

2021
Cardiac Energy Metabolism in Heart Failure.
    Circulation research, 2021, 05-14, Volume: 128, Issue:10

    Topics: Adenosine Triphosphate; Amino Acids, Branched-Chain; Comorbidity; Diabetes Mellitus, Type 2; Energy Metabolism; Epigenesis, Genetic; Fatty Acids; Glucose; Glycolysis; Heart Failure; Humans; Insulin Resistance; Ketone Bodies; Mitochondria; Myocardium; NAD; Obesity; Oxidation-Reduction

2021
Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways.
    Molecular neurobiology, 2013, Volume: 48, Issue:2

    Topics: Biomarkers; Humans; Insulin Resistance; Kynurenine; Metabolic Networks and Pathways; NAD; Tryptophan

2013
The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing.
    Diabetes, obesity & metabolism, 2013, Volume: 15 Suppl 3

    Topics: Aging; Animals; Humans; Insulin; Insulin Resistance; Insulin Secretion; Metabolism; NAD; Nicotinamide Phosphoribosyltransferase; Nutritional Status; Sirtuin 1

2013
Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection.
    Current opinion in clinical nutrition and metabolic care, 2013, Volume: 16, Issue:6

    Topics: Alzheimer Disease; Animals; Brain; Disease Models, Animal; Energy Metabolism; Humans; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mitochondrial Turnover; Muscle, Skeletal; NAD; Neuroprotective Agents; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds

2013
Redox implications in adipose tissue (dys)function--A new look at old acquaintances.
    Redox biology, 2015, Volume: 6

    Topics: Adipocytes; Adipogenesis; Adipose Tissue; Diabetes Mellitus, Type 2; Energy Metabolism; Humans; Hydrogen Peroxide; Insulin Resistance; Metabolic Syndrome; Mitochondria; NAD; NADPH Oxidases; Obesity; Oxidation-Reduction

2015
Diabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3.
    Journal of diabetes investigation, 2016, Volume: 7, Issue:4

    Topics: Aging; AMP-Activated Protein Kinases; Animals; C-Peptide; Diabetes Complications; Diabetic Angiopathies; Disease Models, Animal; Epigenesis, Genetic; Feedback, Physiological; Forkhead Box Protein O3; Humans; Hypoxia; Insulin Resistance; NAD; Oxidation-Reduction; Oxidative Stress; Signal Transduction; Sirtuin 1

2016
Adipose tissue NAD
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2017, Volume: 39, Issue:5

    Topics: Adipose Tissue; Animals; Humans; Insulin Resistance; Models, Biological; NAD; Nicotinamide Phosphoribosyltransferase; Obesity; PPAR gamma; Protein Processing, Post-Translational; Sirtuin 1; Translational Research, Biomedical

2017
Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes.
    Frontiers in bioscience (Landmark edition), 2009, 01-01, Volume: 14, Issue:8

    Topics: Aging; Cytokines; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; NAD; Nicotinamide Phosphoribosyltransferase; Sirtuin 1; Sirtuins

2009
Biochemical effects of SIRT1 activators.
    Biochimica et biophysica acta, 2010, Volume: 1804, Issue:8

    Topics: Animals; Cardiotonic Agents; Energy Metabolism; Enzyme Activation; Heterocyclic Compounds, 4 or More Rings; Humans; Insulin Resistance; Learning; Longevity; Memory; Mice; Models, Biological; NAD; Neoplasms; Niacinamide; O-Acetyl-ADP-Ribose; Resveratrol; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 1; Stilbenes

2010
Beneficial effect of low ethanol intake on the cardiovascular system: possible biochemical mechanisms.
    Vascular health and risk management, 2006, Volume: 2, Issue:3

    Topics: Atherosclerosis; Cardiovascular Diseases; Cardiovascular System; Dyslipidemias; Endothelium, Vascular; Ethanol; Glycation End Products, Advanced; Humans; Hypertension; Insulin Resistance; NAD; Oxidative Stress

2006
[Molecular pathogenesis of type 2 diabetes mellitus].
    Seikagaku. The Journal of Japanese Biochemical Society, 1999, Volume: 71, Issue:11

    Topics: Animals; Diabetes Mellitus, Type 2; Environment; Glucokinase; Glucose; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Life Style; Liver; Mitochondria; NAD; Receptor, Insulin

1999

Trials

3 trial(s) available for nad and Insulin Resistance

ArticleYear
Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
    The Journal of clinical endocrinology and metabolism, 2023, Jul-14, Volume: 108, Issue:8

    Topics: Aged; Body Weight; Cholesterol; Humans; Insulin Resistance; Middle Aged; NAD; Nicotinamide Mononucleotide; Obesity; Overweight

2023
Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men.
    The Journal of physiology, 2020, Volume: 598, Issue:4

    Topics: Humans; Insulin Resistance; Male; Middle Aged; Mitochondria, Muscle; Muscle, Skeletal; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Obesity; Pyridinium Compounds

2020
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
    Science (New York, N.Y.), 2021, 06-11, Volume: 372, Issue:6547

    Topics: Aged; Body Composition; Dietary Supplements; Double-Blind Method; Female; Humans; Insulin; Insulin Resistance; Middle Aged; Mitochondria, Muscle; Muscle, Skeletal; NAD; Nicotinamide Mononucleotide; Obesity; Overweight; Postmenopause; Prediabetic State; RNA-Seq; Signal Transduction

2021

Other Studies

34 other study(ies) available for nad and Insulin Resistance

ArticleYear
Declining muscle NAD
    Molecular metabolism, 2022, Volume: 65

    Topics: Animals; Dihydrotestosterone; Female; Humans; Hyperandrogenism; Insulin Resistance; Lipids; Metabolic Syndrome; Mice; Muscle, Skeletal; NAD; Nicotinamide Mononucleotide; Obesity; Polycystic Ovary Syndrome

2022
Metabolomics Provides Insights into Renoprotective Effects of Semaglutide in Obese Mice.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Adenosine; Animals; Insulin Resistance; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Obese; NAD; Obesity

2022
Branched-chain amino acids alter cellular redox to induce lipid oxidation and reduce de novo lipogenesis in the liver.
    American journal of physiology. Endocrinology and metabolism, 2023, 04-01, Volume: 324, Issue:4

    Topics: Amino Acids, Branched-Chain; Animals; Insulin; Insulin Resistance; Lipid Metabolism; Lipids; Lipogenesis; Liver; Mice; Mice, Inbred C57BL; NAD; Oxidation-Reduction

2023
Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis.
    Theranostics, 2023, Volume: 13, Issue:11

    Topics: Adipose Tissue; Animals; Hyperglycemia; Insulin Resistance; Lipofuscin; Mice; NAD; Prediabetic State

2023
Vutiglabridin exerts anti-ageing effects in aged mice through alleviating age-related metabolic dysfunctions.
    Experimental gerontology, 2023, 10-01, Volume: 181

    Topics: Aging; Animals; Inflammation; Insulin Resistance; Mice; NAD; Reactive Oxygen Species

2023
D-Allulose Ameliorates Dysregulated Macrophage Function and Mitochondrial NADH Homeostasis, Mitigating Obesity-Induced Insulin Resistance.
    Nutrients, 2023, Sep-29, Volume: 15, Issue:19

    Topics: Adipose Tissue; Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Homeostasis; Humans; Inflammation; Insulin Resistance; Insulins; Macrophages; Mice; Mice, Inbred C57BL; Mitochondria; NAD; Obesity

2023
Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage.
    Nature communications, 2019, 09-20, Volume: 10, Issue:1

    Topics: Animals; Blood Glucose; Diet, High-Fat; Disease Models, Animal; DNA Damage; Gene Knockout Techniques; Genetic Predisposition to Disease; Glucose Intolerance; Hepatocytes; Insulin Resistance; Lipid Metabolism; Liver; Liver Diseases; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacinamide; Phosphotransferases (Alcohol Group Acceptor); Protective Agents; Pyridinium Compounds

2019
Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis.
    Molecular cell, 2020, 02-06, Volume: 77, Issue:3

    Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Apoptosis Regulatory Proteins; Diet; Energy Metabolism; Glucose; Glycolysis; HEK293 Cells; Humans; Insulin Resistance; Lipid Droplets; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Membranes; Mitochondrial Proteins; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Obesity; Oxidation-Reduction; Oxygen Consumption; Thermogenesis; Uncoupling Protein 1

2020
The therapeutic promises of NAD
    Cell metabolism, 2021, 07-06, Volume: 33, Issue:7

    Topics: Aging; Female; Humans; Insulin Resistance; Muscles; NAD; Prediabetic State

2021
Nicotinamide mononucleotide: a potential effective natural compound against insulin resistance.
    Signal transduction and targeted therapy, 2021, 08-19, Volume: 6, Issue:1

    Topics: Biological Products; Female; Humans; Insulin; Insulin Resistance; NAD; Nicotinamide Mononucleotide; Overweight; Randomized Controlled Trials as Topic

2021
Combined Salt and Caloric Restrictions: Potential Adverse Outcomes.
    Journal of the American Heart Association, 2017, Oct-11, Volume: 6, Issue:10

    Topics: Adiponectin; Aldosterone; Animal Nutritional Physiological Phenomena; Animals; Biomarkers; Blood Glucose; Blood Pressure; Caloric Restriction; Cardiovascular Diseases; Cytokines; Diet, Sodium-Restricted; Insulin; Insulin Resistance; Kidney; Male; NAD; Nicotinamide Phosphoribosyltransferase; Nutritional Status; Rats, Wistar; Renin; Renin-Angiotensin System; Risk Assessment; Risk Factors; Sodium, Dietary; Time Factors; Zona Glomerulosa

2017
Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance.
    Biochemical and biophysical research communications, 2018, 06-02, Volume: 500, Issue:2

    Topics: Aging; Animals; Diet, High-Fat; Fatty Liver; HEK293 Cells; Humans; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; NIH 3T3 Cells; Phosphotransferases (Alcohol Group Acceptor); Pyridinium Compounds; Triglycerides

2018
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance.
    Aging cell, 2018, Volume: 17, Issue:4

    Topics: Animals; Calorimetry; Cellular Senescence; Guanine Nucleotides; Insulin Resistance; Mice; Mice, Transgenic; Muscle, Skeletal; NAD; Nicotinamide-Nucleotide Adenylyltransferase; Reactive Oxygen Species

2018
Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.
    The Journal of nutritional biochemistry, 2014, Volume: 25, Issue:1

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; DNA, Mitochondrial; Energy Metabolism; Glucose; Glucose Tolerance Test; Insulin Resistance; Liver; Male; Mitochondrial Turnover; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Obesity; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Inbred OLETF; Signal Transduction; Sirtuin 1; Sirtuins; Transcription Factors

2014
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
    Nature, 2014, Apr-10, Volume: 508, Issue:7495

    Topics: Acetyltransferases; Adipocytes; Adipose Tissue; Adipose Tissue, White; Animals; Diabetes Mellitus, Type 2; Diet; Energy Metabolism; Fatty Liver; Gene Knockdown Techniques; Glucose Intolerance; Glucose Transporter Type 4; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Niacinamide; Nicotinamide N-Methyltransferase; Obesity; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; S-Adenosylmethionine; Sirtuin 1; Spermine; Thinness

2014
Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation.
    The Journal of biological chemistry, 2014, Jul-18, Volume: 289, Issue:29

    Topics: Animals; Cell Line; Electron Transport Complex I; Gene Knockdown Techniques; Insulin; Insulin Resistance; Mice; Mitochondrial Diseases; Models, Biological; Muscle Development; Muscle Fibers, Skeletal; Muscle, Skeletal; NAD; Oxidative Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RNA, Small Interfering; Signal Transduction; Sirtuin 1

2014
Pre-B cell colony enhancing factor induces Nampt-dependent translocation of the insulin receptor out of lipid microdomains in A549 lung epithelial cells.
    American journal of physiology. Endocrinology and metabolism, 2015, Feb-15, Volume: 308, Issue:4

    Topics: Acrylamides; Antigens, CD; Caveolin 1; Cell Line; Cytokines; Enzyme Inhibitors; Humans; Insulin; Insulin Resistance; Lung; Membrane Microdomains; NAD; Nicotinamide Phosphoribosyltransferase; Phosphorylation; Piperidines; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Recombinant Proteins; Respiratory Mucosa; Signal Transduction

2015
Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes.
    Journal of cellular physiology, 2015, Volume: 230, Issue:7

    Topics: Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Insulin; Insulin Resistance; Lipid Metabolism; NAD; Oleic Acid; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; Sirtuin 1

2015
The extracellular redox state modulates mitochondrial function, gluconeogenesis, and glycogen synthesis in murine hepatocytes.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Cysteine; Cystine; Diabetes Mellitus, Type 2; Gluconeogenesis; Glutathione; Glutathione Disulfide; Glycogen; Hepatocytes; Humans; Hydrogen Peroxide; Insulin Resistance; Mice; Mitochondria; NAD; Oxidation-Reduction; Respiration

2015
OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Animals; Diet, High-Fat; Fatty Acids; Gene Expression Regulation; Hepatocytes; Humans; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; NAD; Neoplasm Proteins; Non-alcoholic Fatty Liver Disease; Oxidation-Reduction; Oxidative Phosphorylation; Primary Cell Culture; Protein Kinase C-epsilon; Signal Transduction; Sirtuin 3

2015
Mice expressing reduced levels of hepatic glucose-6-phosphatase-α activity do not develop age-related insulin resistance or obesity.
    Human molecular genetics, 2015, Sep-15, Volume: 24, Issue:18

    Topics: AMP-Activated Protein Kinases; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Dependovirus; Disease Models, Animal; Energy Metabolism; Gene Expression; Genetic Therapy; Genetic Vectors; Glucose-6-Phosphatase; Glycogen Storage Disease Type I; Insulin Resistance; Liver; Mice; Mice, Knockout; NAD; Nuclear Proteins; Obesity; Signal Transduction; Sirtuin 1; Transcription Factors

2015
Obesity Is Associated With Low NAD(+)/SIRT Pathway Expression in Adipose Tissue of BMI-Discordant Monozygotic Twins.
    The Journal of clinical endocrinology and metabolism, 2016, Volume: 101, Issue:1

    Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Body Composition; Body Mass Index; Cohort Studies; Cross-Sectional Studies; Down-Regulation; Female; Finland; Glucose Tolerance Test; Humans; Insulin Resistance; Life Style; Male; NAD; Obesity; Sirtuins; Twins, Monozygotic

2016
Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α.
    Oncotarget, 2016, Nov-22, Volume: 7, Issue:47

    Topics: Aconitate Hydratase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Calcium; Cardiomyopathies; Echocardiography; Energy Metabolism; Glucose Tolerance Test; Heme Oxygenase-1; Insulin Resistance; Male; Mice; Mice, Transgenic; Mitochondria; Myocardium; Myocytes, Cardiac; NAD; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species

2016
Tacrolimus ameliorates metabolic disturbance and oxidative stress caused by hepatitis C virus core protein: analysis using mouse model and cultured cells.
    The American journal of pathology, 2009, Volume: 175, Issue:4

    Topics: Animals; Antioxidants; Cyclosporine; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Liver; Gene Expression Regulation; Glucose; Hep G2 Cells; Humans; Insulin Resistance; Lipid Metabolism; Liver; Mice; Mice, Transgenic; NAD; Oxidative Stress; Reactive Oxygen Species; RNA, Messenger; Tacrolimus; Viral Core Proteins

2009
Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity.
    American journal of physiology. Endocrinology and metabolism, 2010, Volume: 298, Issue:1

    Topics: 3-Hydroxyacyl CoA Dehydrogenases; Adult; Biopsy; Blood Glucose; Cardiolipins; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; DNA, Mitochondrial; Electron Transport; Humans; Insulin Resistance; Lipid Metabolism; Middle Aged; Mitochondria; Multienzyme Complexes; NAD; NADH, NADPH Oxidoreductases; Obesity; Oxidative Phosphorylation; Quadriceps Muscle; Trichloroacetic Acid

2010
Autocrine effects of visfatin on hepatocyte sensitivity to insulin action.
    Physiological research, 2010, Volume: 59, Issue:4

    Topics: Animals; Autocrine Communication; Biological Transport; Cell Line; Cytokines; Gene Expression Regulation, Enzymologic; Glucose; Hepatocytes; Insulin; Insulin Resistance; NAD; Nicotinamide Phosphoribosyltransferase; Rats; Rats, Inbred WKY; RNA Interference; RNA, Messenger

2010
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.
    Diabetes, 2010, Volume: 59, Issue:3

    Topics: AMP-Activated Protein Kinases; Animals; Cells, Cultured; Drug Resistance; Enzyme Inhibitors; Fibroblasts; Glucose Intolerance; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mitochondria; Muscle, Skeletal; NAD; Resveratrol; Sirtuin 1; Stilbenes; Weight Loss

2010
Foxo1 in hepatic lipid metabolism.
    Cell cycle (Georgetown, Tex.), 2010, Jan-15, Volume: 9, Issue:2

    Topics: Animals; Forkhead Box Protein O1; Forkhead Transcription Factors; Gluconeogenesis; Heme Oxygenase-1; Insulin Resistance; Lipid Metabolism; Liver; Membrane Proteins; Mice; NAD; Signal Transduction

2010
Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis.
    Biochimica et biophysica acta, 2012, Volume: 1822, Issue:2

    Topics: AMP-Activated Protein Kinases; Animals; Berberine; Cell Line; Diet, High-Fat; Glucose; Hormones; Hyperglycemia; Insulin Resistance; Male; Mice; Mitochondria; Mitochondria, Muscle; Muscle, Skeletal; Myoblasts; NAD; Obesity; Organelle Biogenesis; Phosphorylation; Rats; Rats, Sprague-Dawley; Sirtuin 1

2012
Metabolic master regulators: sharing information among multiple systems.
    Trends in endocrinology and metabolism: TEM, 2012, Volume: 23, Issue:12

    Topics: Adipose Tissue; Diabetes Mellitus, Type 2; Female; Homeostasis; Humans; Insulin Resistance; Lactic Acid; Liver; Metabolome; Mitochondria; Models, Biological; Muscles; NAD; NADP; Obesity; Oxidation-Reduction; Pyruvic Acid; Signal Transduction

2012
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.
    eLife, 2012, Oct-15, Volume: 1

    Topics: Adaptation, Physiological; Adenylate Kinase; Animals; Bone Resorption; Caloric Restriction; Fasting; Fatty Acids; Female; Fibroblast Growth Factors; Gene Expression Regulation; Growth Hormone; Insulin Resistance; Insulin-Like Growth Factor I; Ketone Bodies; Lipid Metabolism; Liver; Longevity; Male; Mice; Mice, Transgenic; NAD; Oxidation-Reduction; Signal Transduction; TOR Serine-Threonine Kinases; Transgenes

2012
A possible link between skeletal muscle mitochondrial efficiency and age-induced insulin resistance.
    Diabetes, 2004, Volume: 53, Issue:11

    Topics: Adult; Aged; Aging; Animals; Flavin-Adenine Dinucleotide; Humans; Insulin Resistance; Lipid Metabolism; Middle Aged; Mitochondria, Muscle; Models, Animal; Muscle, Skeletal; Myofibrils; NAD; Oxygen Consumption; Rats; Risk Factors; Sarcolemma

2004
Antioxidants improve impaired insulin-mediated glucose uptake and prevent migration and proliferation of cultured rabbit coronary smooth muscle cells induced by high glucose.
    Circulation, 1999, Mar-16, Volume: 99, Issue:10

    Topics: Animals; Antioxidants; Becaplermin; Biological Transport, Active; Cell Cycle; Cell Division; Cell Movement; Cells, Cultured; Coronary Vessels; Enzyme Activation; Enzyme Inhibitors; Flow Cytometry; Fructose; Glucose; Insulin; Insulin Resistance; Muscle, Smooth, Vascular; NAD; Naphthalenes; Oxidation-Reduction; Oxidative Stress; Phospholipase D; Platelet-Derived Growth Factor; Probucol; Protein Kinase C; Proto-Oncogene Proteins c-sis; Rabbits; Suramin; Vitamin E

1999
Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.
    Cellular signalling, 1989, Volume: 1, Issue:1

    Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Blotting, Western; Cell Membrane; Cholera Toxin; Colforsin; Diabetes Mellitus, Experimental; Glucagon; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Insulin Resistance; Liver; Male; NAD; Obesity; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Virulence Factors, Bordetella

1989