glycine has been researched along with Insulin Resistance in 61 studies
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " By combining the benefits of glycine, NAC and GSH, GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans." | 9.69 | Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. ( Hsu, JW; Jahoor, F; Kumar, P; Liu, C; Minard, CG; Muthupillai, R; Sekhar, RV; Suliburk, J; Taffet, GE, 2023) |
| "The metabolic signature associated with obesity is characterized by a decrease in plasma glycine concentration, a feature closely associated with insulin resistance and highly predictive of the risk of developing chronic metabolic diseases." | 9.41 | Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances. ( Alves, A; Morio, B, 2023) |
| "This work identifies 2 novel findings in older HIV-infected patients: 1) diminished synthesis due to decreased availability of cysteine and glycine contributes to GSH deficiency and can be rapidly corrected by dietary supplementation of these precursors and 2) correction of GSH deficiency is associated with improvement of mitochondrial fat and carbohydrate oxidation in both fasted and fed states and with improvements in insulin sensitivity, body composition, and muscle strength." | 9.19 | Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. ( Hsu, JW; Jahoor, F; Nguyen, D; Sekhar, RV, 2014) |
| "Plasma glycine level is low in patients with obesity or diabetes and the improvement of insulin resistance increases plasma glycine concentration." | 8.98 | Insulin resistance and glycine metabolism in humans. ( Adeva-Andany, M; Ameneiros-Rodríguez, E; Domínguez-Montero, A; Donapetry-García, C; Fernández-Fernández, C; Souto-Adeva, G, 2018) |
| "Maternal exposure to glyphosate affected insulin sensitivity and caused hepatic inflammation in adult F1 mice offspring." | 8.12 | Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring. ( Alegre-Maller, ACP; Amorim, JPA; Balbo, SL; Bonfleur, ML; Gomes, ECZ; Teleken, JL; Vargas, R, 2022) |
| " In addition, the plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance." | 8.12 | Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis. ( Alves, A; Bassot, A; Bloise, AMNLG; Chanon, S; Drevet Mulard, E; Godet, M; Lamarche, F; Lefebvre, R; Loizon, E; Morio, B; Panthu, B; Pinteur, C; Rautureau, GJP, 2022) |
| "Metformin had differential effects on fasting insulin levels, insulin resistance as demonstrated by homeostasis model assessment (HOMA), LH, total testosterone, dehydroepiandrosterone sulphate and free testosterone index on the basis of IRS genotype." | 7.73 | The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome. ( Aktas, A; Dilek, S; Erdal, EM; Ertunc, D; Tok, EC, 2005) |
| " By combining the benefits of glycine, NAC and GSH, GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans." | 5.69 | Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. ( Hsu, JW; Jahoor, F; Kumar, P; Liu, C; Minard, CG; Muthupillai, R; Sekhar, RV; Suliburk, J; Taffet, GE, 2023) |
| "The metabolic signature associated with obesity is characterized by a decrease in plasma glycine concentration, a feature closely associated with insulin resistance and highly predictive of the risk of developing chronic metabolic diseases." | 5.41 | Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances. ( Alves, A; Morio, B, 2023) |
| "Hyperuricemia is associated with cardiovascular risk." | 5.33 | Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity. ( Fu, Y; Katsuya, T; Masuo, K; Ogihara, T; Rakugi, H; Tuck, ML, 2005) |
| "Obesity is associated with insulin resistance and other major cardiovascular risk factors." | 5.30 | Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1. ( Breban, D; Hell, E; Krempler, F; Patsch, W; Winkler, C, 1998) |
| " Furthermore, glycine could be linked to metabolic health and insulin sensitivity through the betaine osmolyte." | 5.22 | Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance. ( Astrup, A; Carayol, J; Charon, C; Fazelzadeh, P; Hager, J; Lefebvre, G; Matone, A; Morine, M; Saris, WH; Scott-Boyer, MP; Valsesia, A; Vervoort, J, 2016) |
| "The molecular mechanisms by which muraglitazar (peroxisome proliferator-activated receptor γ/α agonist) improves insulin sensitivity in Type 2 diabetes mellitus are not fully understood." | 5.20 | The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo. ( Cersosimo, E; Coletta, DK; DeFronzo, RA; Fernandez, M; Gastaldelli, A; Musi, N, 2015) |
| "This work identifies 2 novel findings in older HIV-infected patients: 1) diminished synthesis due to decreased availability of cysteine and glycine contributes to GSH deficiency and can be rapidly corrected by dietary supplementation of these precursors and 2) correction of GSH deficiency is associated with improvement of mitochondrial fat and carbohydrate oxidation in both fasted and fed states and with improvements in insulin sensitivity, body composition, and muscle strength." | 5.19 | Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. ( Hsu, JW; Jahoor, F; Nguyen, D; Sekhar, RV, 2014) |
| "Muraglitazar (i) improves glycaemic control by enhancing insulin sensitivity and β cell function in T2DM subjects, (ii) improves multiple cardiovascular risk factors, (iii) reduces muscle, visceral and hepatic fat content in T2DM subjects." | 5.15 | Metabolic effects of muraglitazar in type 2 diabetic subjects. ( Casolaro, A; Cersosimo, E; DeFronzo, RA; Fernandez, M; Ferrannini, E; Gastaldelli, A; Hardies, J; Musi, N; Petz, R; Tantiwong, P; Triplitt, C, 2011) |
| "Plasma glycine level is low in patients with obesity or diabetes and the improvement of insulin resistance increases plasma glycine concentration." | 4.98 | Insulin resistance and glycine metabolism in humans. ( Adeva-Andany, M; Ameneiros-Rodríguez, E; Domínguez-Montero, A; Donapetry-García, C; Fernández-Fernández, C; Souto-Adeva, G, 2018) |
| "Maternal exposure to glyphosate affected insulin sensitivity and caused hepatic inflammation in adult F1 mice offspring." | 4.12 | Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring. ( Alegre-Maller, ACP; Amorim, JPA; Balbo, SL; Bonfleur, ML; Gomes, ECZ; Teleken, JL; Vargas, R, 2022) |
| " In addition, the plasma level of glycine is decreased in obesity, and the decrease is strongly correlated with the severity of insulin resistance." | 4.12 | Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis. ( Alves, A; Bassot, A; Bloise, AMNLG; Chanon, S; Drevet Mulard, E; Godet, M; Lamarche, F; Lefebvre, R; Loizon, E; Morio, B; Panthu, B; Pinteur, C; Rautureau, GJP, 2022) |
| " Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity." | 3.81 | Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. ( Amin, SG; Bisson, WH; Brocker, CN; Desai, D; Gavrilova, O; Gonzalez, FJ; Jiang, C; Krausz, KW; Li, J; Liu, Y; Lv, Y; Patterson, AD; Shi, J; Xie, C, 2015) |
| "Metformin had differential effects on fasting insulin levels, insulin resistance as demonstrated by homeostasis model assessment (HOMA), LH, total testosterone, dehydroepiandrosterone sulphate and free testosterone index on the basis of IRS genotype." | 3.73 | The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome. ( Aktas, A; Dilek, S; Erdal, EM; Ertunc, D; Tok, EC, 2005) |
| " Oral administration of pioglitazone (20 mg/kg twice daily or 40 mg/kg/day for 4 weeks), an agent known to ameliorate insulin sensitivity, significantly decreased plasma glucose levels during the treatment period." | 3.69 | KB-R7785, a novel matrix metalloproteinase inhibitor, exerts its antidiabetic effect by inhibiting tumor necrosis factor-alpha production. ( Morimoto, Y; Nishikawa, K; Ohashi, M, 1997) |
| "The onset and/or progression of type 2 diabetes (T2D) can be prevented if intervention is early enough." | 2.55 | Impaired "Glycine"-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis. ( MacDonald, PE; Yan-Do, R, 2017) |
| "Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme, and glutathione biosynthesis." | 1.72 | Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. ( Butte, NF; Cole, SA; Comuzzie, AG; Haack, K; Hou, R; Krupenko, SA; Laston, S; Mehta, NR; Voruganti, VS, 2022) |
| "NAFLD and liver fibrosis were diagnosed using transient elastography and subjects were divided into three groups: normal, NAFLD, and liver fibrosis." | 1.56 | Changed Amino Acids in NAFLD and Liver Fibrosis: A Large Cross-Sectional Study without Influence of Insulin Resistance. ( Endo, T; Fukuda, S; Hasegawa, T; Iino, C; Kimura, M; Mikami, K; Nakaji, S; Sawada, N, 2020) |
| "Fasting glucose and insulin resistance are risk factors for premature death and other adverse outcomes." | 1.48 | Altered Plasma Amino Acids and Lipids Associated With Abnormal Glucose Metabolism and Insulin Resistance in Older Adults. ( Carlson, OD; Chia, CW; Fabbri, E; Ferrucci, L; Gonzalez-Freire, M; Khadeer, M; Moaddel, R; Salem, N; Semba, RD; Sun, K; Zhang, P, 2018) |
| "Metabolomic discovery of biomarkers of type 2 diabetes (T2D) risk may reveal etiological pathways and help to identify individuals at risk for disease." | 1.39 | Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. ( Adamski, J; Boeing, H; Drogan, D; Floegel, A; Fritsche, A; Häring, HU; Hrabě de Angelis, M; Illig, T; Joost, HG; Mühlenbruch, K; Peters, A; Pischon, T; Prehn, C; Roden, M; Schulze, MB; Stefan, N; Wang-Sattler, R; Yu, Z, 2013) |
| "Hydrogen sulfide (H(2)S) has been traditionally known for its toxic effects on living organisms." | 1.35 | Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats. ( Cao, K; Duridanova, D; Jia, X; Wang, R; Wu, L; Yang, G; Yang, W, 2009) |
| "Hyperuricemia is associated with cardiovascular risk." | 1.33 | Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity. ( Fu, Y; Katsuya, T; Masuo, K; Ogihara, T; Rakugi, H; Tuck, ML, 2005) |
| "Insulin resistance was evaluated with fasting insulin, fasting glucose/insulin ratio, and homeostasis model assessment index for insulin resistance (HOMAIR)." | 1.33 | Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism. ( Gong, KB; Ku, DC; Kuo, TC; Liang, SF; Lin, TC; Wu, MJ; Yen, JM, 2006) |
| "Insulin resistance is associated with hypertension, obesity, dyslipidemia, and type 2 diabetes." | 1.31 | Effect of TNF-alpha--converting enzyme inhibitor on insulin resistance in fructose-fed rats. ( Higashiura, K; Murakami, H; Shimamoto, K; Togashi, N; Ura, N, 2002) |
| "Obesity is associated with insulin resistance and other major cardiovascular risk factors." | 1.30 | Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1. ( Breban, D; Hell, E; Krempler, F; Patsch, W; Winkler, C, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.28) | 18.7374 |
| 1990's | 8 (13.11) | 18.2507 |
| 2000's | 17 (27.87) | 29.6817 |
| 2010's | 24 (39.34) | 24.3611 |
| 2020's | 10 (16.39) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, Z | 1 |
| Zhang, C | 1 |
| Wang, S | 2 |
| Zhang, Y | 2 |
| Li, R | 1 |
| Zhao, Y | 1 |
| Qiao, J | 1 |
| Krupenko, SA | 1 |
| Cole, SA | 1 |
| Hou, R | 1 |
| Haack, K | 1 |
| Laston, S | 1 |
| Mehta, NR | 1 |
| Comuzzie, AG | 1 |
| Butte, NF | 1 |
| Voruganti, VS | 1 |
| Gomes, ECZ | 1 |
| Teleken, JL | 1 |
| Vargas, R | 1 |
| Alegre-Maller, ACP | 1 |
| Amorim, JPA | 1 |
| Bonfleur, ML | 1 |
| Balbo, SL | 1 |
| Kumar, P | 2 |
| Liu, C | 2 |
| Suliburk, J | 1 |
| Hsu, JW | 3 |
| Muthupillai, R | 1 |
| Jahoor, F | 3 |
| Minard, CG | 1 |
| Taffet, GE | 1 |
| Sekhar, RV | 4 |
| Alves, A | 2 |
| Morio, B | 2 |
| Lamarche, F | 1 |
| Lefebvre, R | 1 |
| Drevet Mulard, E | 1 |
| Bassot, A | 1 |
| Chanon, S | 1 |
| Loizon, E | 1 |
| Pinteur, C | 1 |
| Bloise, AMNLG | 1 |
| Godet, M | 1 |
| Rautureau, GJP | 1 |
| Panthu, B | 1 |
| Yun, JH | 1 |
| Lee, HS | 1 |
| Yu, HY | 1 |
| Kim, YJ | 1 |
| Jeon, HJ | 1 |
| Oh, T | 1 |
| Kim, BJ | 1 |
| Choi, HJ | 1 |
| Kim, JM | 1 |
| Cerón, E | 1 |
| Bernal-Alcántara, D | 1 |
| Vanda, B | 1 |
| Sommer, B | 1 |
| Gonzalez-Trujano, E | 1 |
| Alvarado-Vásquez, N | 1 |
| Hasegawa, T | 1 |
| Iino, C | 1 |
| Endo, T | 1 |
| Mikami, K | 1 |
| Kimura, M | 1 |
| Sawada, N | 1 |
| Nakaji, S | 1 |
| Fukuda, S | 1 |
| Kale, OE | 1 |
| Vongdip, M | 1 |
| Ogundare, TF | 1 |
| Osilesi, O | 1 |
| Chacko, S | 1 |
| Minard, C | 1 |
| Yan-Do, R | 1 |
| MacDonald, PE | 1 |
| Adeva-Andany, M | 1 |
| Souto-Adeva, G | 1 |
| Ameneiros-Rodríguez, E | 1 |
| Fernández-Fernández, C | 1 |
| Donapetry-García, C | 1 |
| Domínguez-Montero, A | 1 |
| Vandenbeek, R | 1 |
| Khan, NP | 1 |
| Estall, JL | 1 |
| El-Hafidi, M | 1 |
| Franco, M | 1 |
| Ramírez, AR | 1 |
| Sosa, JS | 1 |
| Flores, JAP | 1 |
| Acosta, OL | 1 |
| Salgado, MC | 1 |
| Cardoso-Saldaña, G | 1 |
| Semba, RD | 1 |
| Gonzalez-Freire, M | 1 |
| Moaddel, R | 1 |
| Sun, K | 1 |
| Fabbri, E | 1 |
| Zhang, P | 1 |
| Carlson, OD | 1 |
| Khadeer, M | 1 |
| Chia, CW | 1 |
| Salem, N | 1 |
| Ferrucci, L | 1 |
| Nguyen, D | 2 |
| Samson, SL | 1 |
| Reddy, VT | 1 |
| Gonzalez, EV | 1 |
| Geng, B | 1 |
| Cai, B | 1 |
| Liao, F | 1 |
| Zheng, Y | 1 |
| Zeng, Q | 1 |
| Fan, X | 1 |
| Gong, Y | 1 |
| Yang, J | 1 |
| Cui, QH | 1 |
| Tang, C | 1 |
| Xu, GH | 1 |
| Lustgarten, MS | 1 |
| Price, LL | 1 |
| Phillips, EM | 1 |
| Fielding, RA | 1 |
| Cao, D | 1 |
| Ouyang, S | 1 |
| Liu, Z | 1 |
| Ma, F | 1 |
| Wu, J | 1 |
| Coletta, DK | 1 |
| Fernandez, M | 2 |
| Cersosimo, E | 2 |
| Gastaldelli, A | 2 |
| Musi, N | 2 |
| DeFronzo, RA | 2 |
| Glynn, EL | 1 |
| Piner, LW | 1 |
| Huffman, KM | 1 |
| Slentz, CA | 1 |
| Elliot-Penry, L | 1 |
| AbouAssi, H | 1 |
| White, PJ | 1 |
| Bain, JR | 1 |
| Muehlbauer, MJ | 1 |
| Ilkayeva, OR | 1 |
| Stevens, RD | 1 |
| Porter Starr, KN | 1 |
| Bales, CW | 1 |
| Volpi, E | 1 |
| Brosnan, MJ | 1 |
| Trimmer, JK | 1 |
| Rolph, TP | 1 |
| Newgard, CB | 1 |
| Kraus, WE | 1 |
| Xu, Q | 1 |
| Shu, G | 1 |
| Wang, L | 1 |
| Gao, P | 1 |
| Xi, Q | 1 |
| Jiang, Q | 1 |
| Zhu, X | 1 |
| Jiang, C | 1 |
| Xie, C | 1 |
| Lv, Y | 1 |
| Li, J | 1 |
| Krausz, KW | 1 |
| Shi, J | 1 |
| Brocker, CN | 1 |
| Desai, D | 1 |
| Amin, SG | 1 |
| Bisson, WH | 1 |
| Liu, Y | 1 |
| Gavrilova, O | 1 |
| Patterson, AD | 1 |
| Gonzalez, FJ | 1 |
| Matone, A | 1 |
| Scott-Boyer, MP | 1 |
| Carayol, J | 1 |
| Fazelzadeh, P | 1 |
| Lefebvre, G | 1 |
| Valsesia, A | 1 |
| Charon, C | 1 |
| Vervoort, J | 1 |
| Astrup, A | 1 |
| Saris, WH | 1 |
| Morine, M | 1 |
| Hager, J | 1 |
| Pérez-Torres, I | 1 |
| Zuniga-Munoz, AM | 1 |
| Guarner-Lans, V | 1 |
| Wu, L | 1 |
| Yang, W | 1 |
| Jia, X | 1 |
| Yang, G | 1 |
| Duridanova, D | 1 |
| Cao, K | 1 |
| Wang, R | 1 |
| Ogawa, W | 1 |
| Iwamoto, K | 1 |
| Mori, H | 1 |
| Hashiramoto, M | 1 |
| Miyake, K | 1 |
| Sakaguchi, K | 1 |
| Kasuga, M | 1 |
| Dravecká, I | 1 |
| Lazúrová, I | 1 |
| Habalová, V | 1 |
| Triplitt, C | 1 |
| Hardies, J | 1 |
| Casolaro, A | 1 |
| Petz, R | 1 |
| Tantiwong, P | 1 |
| Ferrannini, E | 2 |
| Floegel, A | 1 |
| Stefan, N | 1 |
| Yu, Z | 1 |
| Mühlenbruch, K | 1 |
| Drogan, D | 1 |
| Joost, HG | 1 |
| Fritsche, A | 1 |
| Häring, HU | 1 |
| Hrabě de Angelis, M | 1 |
| Peters, A | 1 |
| Roden, M | 1 |
| Prehn, C | 1 |
| Wang-Sattler, R | 1 |
| Illig, T | 1 |
| Schulze, MB | 1 |
| Adamski, J | 1 |
| Boeing, H | 1 |
| Pischon, T | 1 |
| Rosenson, RS | 1 |
| Wright, RS | 1 |
| Farkouh, M | 1 |
| Plutzky, J | 1 |
| Keung, W | 1 |
| Ussher, JR | 1 |
| Jaswal, JS | 1 |
| Raubenheimer, M | 1 |
| Lam, VH | 1 |
| Wagg, CS | 1 |
| Lopaschuk, GD | 1 |
| Chan, SH | 1 |
| Chen, JH | 1 |
| Li, YH | 1 |
| Tsai, LM | 1 |
| Xie, W | 1 |
| Wood, AR | 1 |
| Lyssenko, V | 1 |
| Weedon, MN | 1 |
| Knowles, JW | 1 |
| Alkayyali, S | 1 |
| Assimes, TL | 1 |
| Quertermous, T | 1 |
| Abbasi, F | 1 |
| Paananen, J | 1 |
| Häring, H | 1 |
| Hansen, T | 1 |
| Pedersen, O | 1 |
| Smith, U | 1 |
| Laakso, M | 1 |
| Dekker, JM | 1 |
| Nolan, JJ | 1 |
| Groop, L | 1 |
| Adam, KP | 1 |
| Gall, WE | 1 |
| Frayling, TM | 1 |
| Walker, M | 1 |
| Ikarashi, T | 1 |
| Hanyu, O | 1 |
| Maruyama, S | 1 |
| Souda, S | 1 |
| Kobayashi, C | 1 |
| Abe, E | 1 |
| Ukisu, J | 1 |
| Naganuma, K | 1 |
| Suzuki, A | 1 |
| Toya, M | 1 |
| Kaneko, S | 1 |
| Suzuki, K | 1 |
| Nakagawa, O | 1 |
| Aizawa, Y | 1 |
| D'Adamo, M | 1 |
| Perego, L | 1 |
| Cardellini, M | 1 |
| Marini, MA | 1 |
| Frontoni, S | 1 |
| Andreozzi, F | 1 |
| Sciacqua, A | 1 |
| Lauro, D | 1 |
| Sbraccia, P | 1 |
| Federici, M | 1 |
| Paganelli, M | 1 |
| Pontiroli, AE | 1 |
| Lauro, R | 1 |
| Perticone, F | 1 |
| Folli, F | 1 |
| Sesti, G | 1 |
| Sir-Petermann, T | 1 |
| Angel, B | 1 |
| Maliqueo, M | 1 |
| Santos, JL | 1 |
| Riesco, MV | 1 |
| Toloza, H | 1 |
| Pérez-Bravo, F | 1 |
| Nakashima, T | 1 |
| Sumida, Y | 1 |
| Mitsuyoshi, H | 1 |
| Okanoue, T | 1 |
| Ertunc, D | 1 |
| Tok, EC | 1 |
| Aktas, A | 1 |
| Erdal, EM | 1 |
| Dilek, S | 1 |
| Masuo, K | 1 |
| Katsuya, T | 1 |
| Fu, Y | 1 |
| Rakugi, H | 1 |
| Ogihara, T | 1 |
| Tuck, ML | 1 |
| Fanelli, M | 1 |
| Filippi, E | 1 |
| Sentinelli, F | 1 |
| Romeo, S | 1 |
| Fallarino, M | 1 |
| Buzzetti, R | 1 |
| Leonetti, F | 1 |
| Baroni, MG | 1 |
| Liu, W | 1 |
| Liu, M | 1 |
| Fan, W | 1 |
| Nawata, H | 1 |
| Yanase, T | 1 |
| Lin, TC | 1 |
| Yen, JM | 1 |
| Gong, KB | 1 |
| Kuo, TC | 1 |
| Ku, DC | 1 |
| Liang, SF | 1 |
| Wu, MJ | 1 |
| Pyrzak, B | 1 |
| Wiśniewska, A | 1 |
| Rymkiewicz-Kluczyńska, B | 1 |
| Bayazit, YA | 1 |
| Erdal, ME | 1 |
| Yilmaz, M | 1 |
| Ciftci, TU | 1 |
| Soylemez, F | 1 |
| Gokdoğan, T | 1 |
| Kokturk, O | 1 |
| Kemaloglu, YK | 1 |
| Koybasioglu, A | 1 |
| Moseley, RH | 1 |
| Orho, M | 1 |
| Nikula-Ijäs, P | 1 |
| Schalin-Jäntti, C | 1 |
| Permutt, MA | 1 |
| Groop, LC | 1 |
| Wertheimer, E | 1 |
| Barbetti, F | 1 |
| Muggeo, M | 1 |
| Roth, J | 1 |
| Taylor, SI | 1 |
| Ivy, JL | 1 |
| Cortez, MY | 1 |
| Chandler, RM | 1 |
| Byrne, HK | 1 |
| Miller, RH | 1 |
| Nozaki, O | 1 |
| Suzuki, Y | 1 |
| Shimada, F | 1 |
| Hashimoto, N | 1 |
| Taira, M | 1 |
| Hatanaka, Y | 1 |
| Notoya, Y | 1 |
| Kanashiro, O | 1 |
| Makino, H | 1 |
| Yoshida, S | 1 |
| Morimoto, Y | 1 |
| Nishikawa, K | 1 |
| Ohashi, M | 1 |
| Krempler, F | 1 |
| Hell, E | 1 |
| Winkler, C | 1 |
| Breban, D | 1 |
| Patsch, W | 1 |
| González-Ortiz, M | 1 |
| Medina-Santillán, R | 1 |
| Martínez-Abundis, E | 1 |
| von Drateln, CR | 1 |
| Siani, A | 1 |
| Iacone, R | 1 |
| Russo, O | 1 |
| Barba, G | 1 |
| Russo, P | 1 |
| Cappuccio, FP | 1 |
| Galletti, F | 1 |
| Strazzullo, P | 1 |
| Togashi, N | 1 |
| Ura, N | 1 |
| Higashiura, K | 1 |
| Murakami, H | 1 |
| Shimamoto, K | 1 |
| Gourley, DR | 1 |
| van der Vorm, ER | 1 |
| van der Zon, GC | 1 |
| Möller, W | 1 |
| Krans, HM | 1 |
| Lindhout, D | 1 |
| Maassen, JA | 1 |
| Yamamoto, R | 1 |
| Shiba, T | 1 |
| Tobe, K | 1 |
| Shibasaki, Y | 1 |
| Koshio, O | 1 |
| Izumi, T | 1 |
| Odawara, M | 1 |
| Mikami, Y | 1 |
| Matsuura, N | 1 |
| Akanuma, Y | 1 |
| Felig, P | 1 |
| Marliss, E | 1 |
| Cahill, GF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Glutathione and Fuel Oxidation in Aging[NCT01870193] | Early Phase 1 | 36 participants (Anticipated) | Interventional | 2013-04-23 | Completed | ||
| The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters: A Clinical and Ex-vivo Study.[NCT03850314] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2019-03-31 | Not yet recruiting | ||
| Regulation of Branched-chain Amino Acid Metabolism in Pre-Diabetes: Responses to Exercise Training and Gastric Bypass Surgery[NCT01786941] | 132 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| Effect of Insulin Resistance on Branched Chain Amino Acid Metabolism.[NCT04886973] | 40 participants (Actual) | Interventional | 2022-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for glycine and Insulin Resistance
| Article | Year |
|---|---|
Alterations in glycine metabolism in obesity and chronic metabolic diseases - an update on new advances.
Topics: Amino Acids, Branched-Chain; Diet; Glycine; Humans; Insulin Resistance; Metabolic Diseases; Obesity | 2023 |
Impaired "Glycine"-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis.
Topics: Animals; Bariatric Surgery; Diabetes Mellitus, Type 2; Glucose; Glycine; Homeostasis; Humans; Insuli | 2017 |
Insulin resistance and glycine metabolism in humans.
Topics: Diabetes Mellitus, Type 2; Glycine; Humans; Insulin Resistance; Models, Biological | 2018 |
Linking Metabolic Disease With the PGC-1α Gly482Ser Polymorphism.
Topics: Amino Acid Substitution; Diabetes Mellitus, Type 2; Genetic Linkage; Genetic Predisposition to Disea | 2018 |
Association of the ADIPOQ T45G polymorphism with insulin resistance and blood glucose: a meta-analysis.
Topics: Adiponectin; Amino Acid Substitution; Blood Glucose; Case-Control Studies; Cross-Sectional Studies; | 2014 |
Beneficial Effects of the Amino Acid Glycine.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Glycine; Humans; Insulin Resistance; Kidney; Liver | 2017 |
Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects.
Topics: Alkanesulfonates; Diabetic Angiopathies; Glycine; Humans; Hypoglycemic Agents; Insulin Resistance; L | 2012 |
[Treatment of nonalcoholic steatohepatitis (NASH)].
Topics: Cysteine; Diet; Drug Combinations; Fatty Liver; Glycine; Hepatitis; Humans; Insulin Resistance; Live | 2004 |
Isolation and characterization of membrane drug receptors.
Topics: Animals; Drug Tolerance; gamma-Aminobutyric Acid; Glucagon; Glycine; Humans; Insulin; Insulin Resist | 1976 |
6 trials available for glycine and Insulin Resistance
| Article | Year |
|---|---|
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial.
Topics: Acetylcysteine; Aged; Aging; Animals; Dietary Supplements; Glutathione; Glycine; Health Promotion; H | 2023 |
Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients.
Topics: Age Factors; Anti-HIV Agents; Body Composition; Cysteine; Dietary Supplements; Glutathione; Glycine; | 2014 |
The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo.
Topics: Adiponectin; AMP-Activated Protein Kinases; Biopsy; Blood Glucose; Diabetes Mellitus, Type 2; Fatty | 2015 |
Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.
Topics: Adult; Ammonia; Betaine; Caloric Restriction; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosp | 2016 |
Metabolic effects of muraglitazar in type 2 diabetic subjects.
Topics: Body Mass Index; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; Glucose Tolerance Test; | 2011 |
Effect of glycine on insulin secretion and action in healthy first-degree relatives of type 2 diabetes mellitus patients.
Topics: Administration, Oral; Adolescent; Adult; Diabetes Mellitus, Type 2; Family Health; Female; Glycine; | 2001 |
46 other studies available for glycine and Insulin Resistance
| Article | Year |
|---|---|
Amino acid signatures in relation to polycystic ovary syndrome and increased risk of different metabolic disturbances.
Topics: Alanine; Amino Acids; Body Mass Index; Female; Glycine; Humans; Insulin Resistance; Lysine; Metaboli | 2022 |
Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children.
Topics: Child; Genome-Wide Association Study; Glycine; Glycine Dehydrogenase (Decarboxylating); Hispanic or | 2022 |
Exposure to glyphosate-based herbicide during early stages of development increases insulin sensitivity and causes liver inflammation in adult mice offspring.
Topics: Animals; Female; Glucose; Glycine; Glyphosate; Herbicides; Humans; Inflammation; Insulin; Insulin Re | 2022 |
Glycine Supplementation in Obesity Worsens Glucose Intolerance through Enhanced Liver Gluconeogenesis.
Topics: Animals; Diet, High-Fat; Dietary Supplements; Gluconeogenesis; Glucose Intolerance; Glycine; Insulin | 2022 |
Metabolomics profiles associated with HbA1c levels in patients with type 2 diabetes.
Topics: Aged; Amino Acids; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucose; Glycated H | 2019 |
Glycine supplementation during six months does not alter insulin, glucose or triglyceride plasma levels in healthy rats.
Topics: Animals; Blood Glucose; Dietary Supplements; Glucose; Glycine; Insulin; Insulin Resistance; Rats; Ra | 2021 |
Changed Amino Acids in NAFLD and Liver Fibrosis: A Large Cross-Sectional Study without Influence of Insulin Resistance.
Topics: Adult; Aged; Aged, 80 and over; Amino Acids; Cross-Sectional Studies; Female; Glutamic Acid; Glycine | 2020 |
The use of combined high-fructose diet and glyphosate to model rats type 2 diabetes symptomatology.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Fructose; Glycine; | 2021 |
Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Re
Topics: Acetylcysteine; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Cognition; Dietary Supplements; | 2021 |
Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance.
Topics: Animals; Catalase; Glutamate-Cysteine Ligase; Glutathione; Glycine; Insulin; Insulin Resistance; Mal | 2018 |
Altered Plasma Amino Acids and Lipids Associated With Abnormal Glucose Metabolism and Insulin Resistance in Older Adults.
Topics: Aged; Aged, 80 and over; Amino Acids; Biomarkers; Blood Glucose; Fasting; Female; Glucose Tolerance | 2018 |
Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione.
Topics: Aging; Animals; Antioxidants; Body Composition; Cholesterol, LDL; Cholesterol, VLDL; Cysteine; Fatty | 2013 |
Increase or decrease hydrogen sulfide exert opposite lipolysis, but reduce global insulin resistance in high fatty diet induced obese mice.
Topics: Adipocytes; Alkynes; Animals; Blood Glucose; Carrier Proteins; Cystathionine gamma-Lyase; Cysteine; | 2013 |
Serum glycine is associated with regional body fat and insulin resistance in functionally-limited older adults.
Topics: Adipose Tissue; Adiposity; Adult; Aged; Biomarkers; Chromatography, Liquid; Female; Gas Chromatograp | 2013 |
Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans.
Topics: Adult; Amino Acids, Branched-Chain; Blood Glucose; Exercise; Glucose Clamp Technique; Glycine; Human | 2015 |
N-Oleoyl glycine, a lipoamino acid, stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Androstadienes; Animals; Cell Differentiation; Dose-Response | 2015 |
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
Topics: Adolescent; Adult; Aged; Animals; Ceramides; Cholic Acids; Diet, High-Fat; Fatty Liver; Female; Glyc | 2015 |
Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats.
Topics: Alkynes; Animals; Blood Glucose; Catalysis; Cystathionine gamma-Lyase; Diabetes Mellitus; Glycine; H | 2009 |
Two related cases of type A insulin resistance with compound heterozygous mutations of the insulin receptor gene.
Topics: Adolescent; Amino Acid Substitution; Aspartic Acid; Female; Genetic Carrier Screening; Genetic Varia | 2009 |
The prevalence of Gly972Arg and C825T polymorphisms in Slovak women with polycystic ovary syndrome and their relation to the metabolic syndrome.
Topics: Adult; Blood Glucose; Body Mass Index; Female; Genotype; Glycine; Heterotrimeric GTP-Binding Protein | 2010 |
Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach.
Topics: Adult; Biomarkers; Diabetes Mellitus, Type 2; Female; Glycine; Hexoses; Humans; Insulin; Insulin Res | 2013 |
Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.
Topics: Animals; Anti-Obesity Agents; Carbohydrate Metabolism; Carnitine O-Palmitoyltransferase; Cell Membra | 2013 |
Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population.
Topics: Aged; Alleles; Asian People; Coronary Angiography; Coronary Artery Disease; Female; Gene Frequency; | 2012 |
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
Topics: Adult; Betaine; Diabetes Mellitus, Type 2; Female; Glycine; Humans; Insulin Resistance; Male; Middle | 2013 |
Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients.
Topics: Aged; Arginine; Diabetes Mellitus, Type 2; Fasting; Female; Genotype; Glucose; Glucose Tolerance Tes | 2004 |
The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes.
Topics: Adipose Tissue; Adult; Alanine; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Genotype; G | 2004 |
Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load.
Topics: Adolescent; Adult; Amino Acid Substitution; Area Under Curve; Arginine; Blood Glucose; Chile; Codon; | 2004 |
The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome.
Topics: Adult; Androgens; Arginine; Female; Glycine; Humans; Hypoglycemic Agents; Insulin Receptor Substrate | 2005 |
Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity.
Topics: Adult; Alleles; Asparagine; Gene Frequency; Genotype; Glycine; Homeostasis; Humans; Hyperuricemia; I | 2005 |
The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) gene associates with reduced insulin sensitivity in normal and glucose-intolerant obese subjects.
Topics: Adult; Amino Acid Substitution; Female; Genetic Predisposition to Disease; Glucose Intolerance; Glyc | 2005 |
The Gly146Ala variation in human SF-1 gene: its association with insulin resistance and type 2 diabetes in Chinese.
Topics: Alanine; Chi-Square Distribution; China; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genetic | 2006 |
Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism.
Topics: Adolescent; Adult; Alanine; Amino Acid Substitution; Arginine; Diabetes Mellitus; Female; Glucose In | 2006 |
[The influence of polymorphism the Gly972Arg variant insulin receptor substrate-1 (IRS-1) gene, and G-308A TNF-alpha gene on obesity and insulin resistance in children with obesity].
Topics: Adolescent; Arginine; Child; Female; Gene Frequency; Glycine; Humans; Insulin Receptor Substrate Pro | 2006 |
Insulin receptor substrate gene polymorphism is associated with obstructive sleep apnea syndrome in men.
Topics: Adult; Arginine; Female; Genetic Predisposition to Disease; Glycine; Humans; Insulin Receptor Substr | 2006 |
Therapy for nonalcoholic fatty liver disease.
Topics: Animals; Antioxidants; Cholagogues and Choleretics; Disease Models, Animal; Fatty Liver; Glycine; Hu | 2008 |
Isolation and characterization of the human muscle glycogen synthase gene.
Topics: Adult; Amino Acid Sequence; Animals; Base Sequence; Deoxyribonucleases, Type II Site-Specific; Diabe | 1995 |
Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Conserved Sequence; Gl | 1994 |
Effects of pyruvate on the metabolism and insulin resistance of obese Zucker rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Cholesterol; Energy Metabolism; Female; G | 1994 |
A glycine-1008 to valine mutation in the insulin receptor in a woman with type A insulin resistance.
Topics: Adult; Female; Glucose Tolerance Test; Glycine; Humans; Insulin; Insulin Resistance; Japan; Mutation | 1993 |
KB-R7785, a novel matrix metalloproteinase inhibitor, exerts its antidiabetic effect by inhibiting tumor necrosis factor-alpha production.
Topics: Animals; Blood Glucose; Body Weight; Glycine; Hydroxamic Acids; Hypoglycemic Agents; Insulin; Insuli | 1997 |
Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1.
Topics: Adult; Amino Acid Substitution; Arginine; Blood Glucose; Case-Control Studies; Codon; Female; Genoty | 1998 |
Gly40Ser polymorphism of the glucagon receptor gene is associated with central adiposity in men.
Topics: Adipose Tissue; Adult; Aged; Body Composition; Body Constitution; Body Mass Index; Energy Metabolism | 2001 |
Effect of TNF-alpha--converting enzyme inhibitor on insulin resistance in fructose-fed rats.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Blood Glucose; Blood Pressure; Body Weight; Diet; Fasting; F | 2002 |
An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport.
Topics: Alleles; Animals; Arginine; Base Sequence; CHO Cells; Cricetinae; Cross-Linking Reagents; Electropho | 1992 |
Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.
Topics: Acanthosis Nigricans; Adenosine Triphosphate; Adolescent; Alleles; B-Lymphocytes; Binding Sites; Cel | 1990 |
Plasma amino acid levels and insulin secretion in obesity.
Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Fasting; Feedback; Female; Glucose; Glycine; Humans; | 1969 |