Peroxisomal sarcosine oxidase

A peroxisomal sarcosine oxidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P0Z9]

PSO;
EC 1.5.3.1;
EC 1.5.3.7;
L-pipecolate oxidase;
L-pipecolic acid oxidase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pipecolic acid	Homo sapiens (human)	Km	3,700.0000	1	1

This protein enables 4 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
sarcosine oxidase activity	molecular function	Catalysis of the reaction: H2O + O2 + sarcosine = formaldehyde + glycine + H2O2. [EC:1.5.3.1, RHEA:13313]
L-pipecolate oxidase activity	molecular function	Catalysis of the reaction: L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. [EC:1.5.3.7, RHEA:11992]
flavin adenine dinucleotide binding	molecular function	Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]

This protein is located in 3 target(s):

Target	Category	Definition
peroxisome	cellular component	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]
peroxisomal matrix	cellular component	The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. [GOC:curators, ISBN:0815316194]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 1 target(s):

Target	Category	Definition
peroxisome	cellular component	A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]

This protein is involved in 2 target(s):

Target	Category	Definition
lysine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. [GOC:go_curators]
L-lysine catabolic process to acetyl-CoA via L-pipecolate	biological process	The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate. [GOC:mah, MetaCyc:PWY-5283]