succinic acid has been researched along with Insulin Resistance in 8 studies
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Insulin sensitivity was determined with the isoglycaemic-hyperinsulinaemic clamp technique." | 1.37 | Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. ( Andersen, JL; Dela, F; Hansen, CN; Helge, JW; Hey-Mogensen, M; Larsen, S; Madsbad, S; Stride, N; Worm, D, 2011) |
| "Although obesity is a risk factor for development of type 2 diabetes and chemical modification of proteins by advanced glycoxidation and lipoxidation end products is implicated in the development of diabetic complications, little is known about the chemical modification of proteins in adipocytes or adipose tissue." | 1.34 | Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress. ( Baatz, JE; Baynes, JW; Bethard, J; Blatnik, M; Brock, JW; Frizzell, N; Nagai, R; Thorpe, SR; Walla, MD, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ives, SJ | 1 |
| Zaleski, KS | 1 |
| Slocum, C | 1 |
| Escudero, D | 1 |
| Sheridan, C | 1 |
| Legesse, S | 1 |
| Vidal, K | 1 |
| Lagalwar, S | 1 |
| Reynolds, TH | 1 |
| Hernández, MAG | 1 |
| Canfora, EE | 1 |
| Blaak, EE | 1 |
| Vasan, SK | 1 |
| Noordam, R | 1 |
| Gowri, MS | 1 |
| Neville, MJ | 1 |
| Karpe, F | 1 |
| Christodoulides, C | 1 |
| Gupte, AA | 1 |
| Minze, LJ | 1 |
| Reyes, M | 1 |
| Ren, Y | 1 |
| Wang, X | 1 |
| Brunner, G | 1 |
| Ghosn, M | 1 |
| Cordero-Reyes, AM | 1 |
| Ding, K | 1 |
| Pratico, D | 1 |
| Morrisett, J | 1 |
| Shi, ZZ | 1 |
| Hamilton, DJ | 1 |
| Lyon, CJ | 1 |
| Hsueh, WA | 1 |
| Gattu, AK | 1 |
| Birkenfeld, AL | 1 |
| Iwakiri, Y | 1 |
| Jay, S | 1 |
| Saltzman, M | 1 |
| Doll, J | 1 |
| Protiva, P | 1 |
| Samuel, VT | 1 |
| Crawford, SE | 1 |
| Chung, C | 1 |
| Larsen, S | 1 |
| Stride, N | 1 |
| Hey-Mogensen, M | 1 |
| Hansen, CN | 1 |
| Andersen, JL | 1 |
| Madsbad, S | 1 |
| Worm, D | 1 |
| Helge, JW | 1 |
| Dela, F | 1 |
| Cloarec, O | 1 |
| Dumas, ME | 1 |
| Craig, A | 1 |
| Barton, RH | 1 |
| Trygg, J | 1 |
| Hudson, J | 1 |
| Blancher, C | 1 |
| Gauguier, D | 1 |
| Lindon, JC | 1 |
| Holmes, E | 1 |
| Nicholson, J | 1 |
| Nagai, R | 1 |
| Brock, JW | 1 |
| Blatnik, M | 1 |
| Baatz, JE | 1 |
| Bethard, J | 1 |
| Walla, MD | 1 |
| Thorpe, SR | 1 |
| Baynes, JW | 1 |
| Frizzell, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| LIFESTAT - Living With Statins, a Cross Sectional Study on the Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02250677] | 75 participants (Actual) | Observational | 2014-04-30 | Completed | |||
| Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02796378] | Phase 4 | 30 participants (Anticipated) | Interventional | 2016-06-30 | Active, not recruiting | ||
| Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being[NCT02255682] | Phase 4 | 35 participants (Actual) | Interventional | 2015-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for succinic acid and Insulin Resistance
| Article | Year |
|---|---|
The effect of succinic acid on the metabolic profile in high-fat diet-induced obesity and insulin resistance.
Topics: Animals; Body Weight; Diet, High-Fat; Energy Metabolism; Insulin Resistance; Male; Metabolome; Mice; | 2020 |
Faecal microbial metabolites of proteolytic and saccharolytic fermentation in relation to degree of insulin resistance in adult individuals.
Topics: Adult; Aged; Blood Glucose; Body Weights and Measures; Cross-Sectional Studies; Fatty Acids, Noneste | 2021 |
The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study.
Topics: Adipocytes; Adipose Tissue, Brown; Adiposity; Adult; Body Mass Index; Cross-Sectional Studies; Energ | 2019 |
High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance.
Topics: Age Factors; Animals; Atherosclerosis; Blotting, Western; Diet, High-Fat; Fatty Liver; Glucose; Glut | 2013 |
Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
Topics: Adipocytes; Animals; Eye Proteins; Gene Expression Regulation; Glucose Tolerance Test; Hepatocytes; | 2014 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes.
Topics: Carnitine; Case-Control Studies; Cell Respiration; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; | 2011 |
Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.
Topics: Amines; Animals; Biomarkers; Citric Acid; Creatine; Creatinine; Dietary Carbohydrates; Discriminant | 2005 |
Succination of protein thiols during adipocyte maturation: a biomarker of mitochondrial stress.
Topics: 3T3 Cells; Adipocytes; Adipogenesis; Adipose Tissue; Animals; Biomarkers; Cell Differentiation; Citr | 2007 |