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phosphotyrosine and Insulin Resistance

phosphotyrosine has been researched along with Insulin Resistance in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	20 (36.36)	18.2507
2000's	29 (52.73)	29.6817
2010's	6 (10.91)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Davis, RJ; Flavell, RA; Jung, DY; Kant, S; Kim, JK; Morel, C; Standen, CL; Swat, W	1
AbouBechara, D; Bakke, J; Bettaieb, A; Bremer, A; Cantley, LC; Cummings, B; Graham, J; Haj, FG; Havel, PJ; Liu, S; Lyssiotis, CA; Matsuo, K; Melhem, R; Nagata, N; Stanhope, K; Xi, Y; Zhang, S; Zhang, ZY	1
Dong, H; Gong, YL; Lu, FE; Wang, JH; Xu, LJ; Zou, X	1
Chao, H; Grande, R; Harris, TE; Li, C; Li, H; Lira, V; Yan, Z	1
Daniel, H; Ecker, J; Giesbertz, P; Höfle, AS; Padberg, I; Rein, D; Spanier, B	1
Imaizumi, T; Koga, H; Matsui, T; Nakamura, K; Sata, M; Takeuchi, M; Ueno, T; Yamagishi, S; Yoshida, T	1
Baculikova, M; Fiala, R; Jezova, D; Macho, L; Zorad, S	1
Hashiramoto, M; Iwamoto, K; Kasuga, M; Miyake, K; Mori, H; Ogawa, W; Sakaguchi, K	1
Dey, CS; Gupta, A	1
Dao-Feng, B; Wei, D; Xin-Long, C; Zhao-Fan, X	1
Carvalho, CR; Lima, MH; Rocha, EM; Saad, MJ; Thirone, AC; Ueno, M	1
Brozinick, JT; Dohm, GL; Roberts, BR	1
Abella, A; Camps, M; Carpéné, C; Claret, M; Fernández-Alvarez, J; Gomis, R; Gumà, A; Marti, L; Palacín, M; Testar, X; Viguerie, N; Zorzano, A	1
Liu, G	1
D'Haens, E; Féry, F; Kayserilli, H; Kleijer, WJ; Maassen, JA; Tobias, ES; Tukel, T; van der Zon, GC; Yuksel-Apak, M	1
Haj, FG; Kahn, BB; Kim, HJ; Kim, JK; Kim, YB; Neel, BG; Shulman, GI; Zabolotny, JM	1
Igarashi, Y; Inokuchi, J; Kabayama, K; Kang, BW; Kitamura, F; Sato, T; Uemura, S	1
Burks, D; Carter, EA; Fischman, AJ; Tompkins, RG; White, M	1
Hernández-Cruz, JM; Pariente, JA; Redondo, PC; Rosado, JA; Saavedra, FR; Salido, GM	1
Boura-Halfon, S; Herschkovitz, A; Leroith, D; Liu, YF; Paz, K; Ronen, D; Zick, Y	1
Hodgkinson, CP; Mander, A; Sale, GJ	1
Gao, J; Hasegawa, Y; Imai, J; Ishibashi, S; Ishigaki, Y; Kanzaki, M; Katagiri, H; Ogihara, T; Oka, Y; Uno, K; Yamada, T; Yamamoto, TT	1
Berti, L; Häring, H; Kellerer, M; Kiehn, R; Kroder, G; Mosthaf, L; Tippmer, S	1
Budavari, A; Hotamisligil, GS; Murray, D; Spiegelman, BM	1
Gorden, P; Levy-Toledano, R; Roach, P; Taouis, M; Taylor, SI	1
Araki, E; Brüning, JC; Haag, B; Johnson, RS; Kahn, CR; Lipes, MA; Patti, ME	1
Egawa, K; Hasegawa, M; Ide, R; Iwanishi, M; Kashiwagi, A; Kikkawa, R; Maegawa, H; Shigeta, Y; Ugi, S	1
Danielsen, AG; Hosomi, Y; Liu, F; Roth, RA; Shii, K	1
Goldfine, ID; Maddux, BA; Moller, DE; Reaven, GM; Sbraccia, P	1
Backer, JM; Folli, F; Kahn, CR; Saad, MJ	1
Le Marchand-Brustel, Y; Ricort, JM; Tanti, JF; Van Obberghen, E	1
Ikezu, T; Martyn, JA; Okamoto, T; Tompkins, RG; Yonezawa, K	1
Bedol, D; Ernsberger, P; Farrell, CJ; Friedman, JE; Ishizuka, T; Kaung, HL; Koletsky, RJ; Liu, S	1
Begum, N; Ragolia, L	1
Chi, MM; Heimberg, H; Hresko, RC; Mueckler, M	1
Accili, D; Brüning, JC; Goodyear, LJ; Hayashi, T; Hörsch, D; Kahn, CR; Michael, MD; Winnay, JN	1
Klein, HH; Müller, R; Pedersen, O; Vestergaard, H	1
Chan, CC; Cheng, A; Collins, S; Cromlish, W; Elchebly, M; Gresser, MJ; Himms-Hagen, J; Kennedy, BP; Loy, AL; Michaliszyn, E; Normandin, D; Payette, P; Ramachandran, C; Tremblay, ML	1
Noguchi, Y; Satoh, S; Yoshikawa, T	1
Le Marchand-Brustel, Y	1
Busch, AK; Hansen, LL; Ikeda, Y; Mosthaf, L; Olsen, GS	1
Eckel, J; Till, M; Uphues, I	1
Anai, M; Asano, T; Fujishiro, M; Fukushima, Y; Funaki, M; Inukai, K; Katagiri, H; Kikuchi, M; Ogihara, T; Oka, Y; Onishi, Y; Ono, H; Sakoda, H	1
Berg, AH; Engelman, JA; Lewis, RY; Lisanti, MP; Scherer, PE	1
Janez, A; Olefsky, JM; Worrall, DS	1
Fantus, IG; Goldstein, BJ; Lai, R; Le-Tien, H; Shin, P; Tang, S	1
Hirose, M; Ibebunjo, C; Iebunjo, C; Kaneki, M; Martyn, JA; Sugita, H; Yasuhara, S	1
Boss, O; Kahn, BB; Kamatkar, S; Kim, JK; Kim, YB; Klaman, LD; Neel, BG; Pani, MA; Peroni, OD; Shulman, GI; Zabolotny, JM	1
Haruta, T; Ishibashi, O; Iwata, M; Kawahara, J; Kobayashi, M; Sasaoka, T; Takano, A; Takata, Y; Ueno, E; Uno, T; Usui, I	1
Haruta, T; Iwata, M; Kawahara, J; Kobayashi, M; Sasaoka, T; Takano, A; Ueno, E; Uno, T; Usui, I	1
Hirata, AE; Rojas, FA; Saad, MJ	1
Björnholm, M; Jensen, CB; Madsbad, S; Song, XM; Storgaard, H; Vaag, A; Zierath, JR	1
Dagou, C; Delarue, J; Durand, G; Pinault, M; Ster, C; Taouis, M	1
Hevener, A; Janez, A; Olefsky, J; Reichart, D	1
Grunberger, G; Levy, J; Nagy, K	1

Reviews

2 review(s) available for phosphotyrosine and Insulin Resistance

Article	Year
Protein tyrosine phosphatase 1B inhibition: opportunities and challenges. Current medicinal chemistry, 2003, Volume: 10, Issue:15 Topics: Acetates; Animals; Benzoates; Enzyme Inhibitors; Humans; Hydroquinones; Insulin Resistance; Molecular Mimicry; Oligonucleotides, Antisense; Organophosphonates; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Salicylates; Structure-Activity Relationship	2003
Molecular mechanisms of insulin action in normal and insulin-resistant states. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1999, Volume: 107, Issue:2 Topics: Animals; Aurothioglucose; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Mice; Obesity; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine	1999

Article

Year

Protein tyrosine phosphatase 1B inhibition: opportunities and challenges.

Current medicinal chemistry, 2003, Volume: 10, Issue:15

Topics: Acetates; Animals; Benzoates; Enzyme Inhibitors; Humans; Hydroquinones; Insulin Resistance; Molecular Mimicry; Oligonucleotides, Antisense; Organophosphonates; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Salicylates; Structure-Activity Relationship

2003

Molecular mechanisms of insulin action in normal and insulin-resistant states.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 1999, Volume: 107, Issue:2

Topics: Animals; Aurothioglucose; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Mice; Obesity; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine

1999

Other Studies

53 other study(ies) available for phosphotyrosine and Insulin Resistance

Article	Year
A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell reports, 2017, Sep-19, Volume: 20, Issue:12 Topics: Adaptor Proteins, Signal Transducing; Animals; Diet, High-Fat; Enzyme Activation; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Male; Membrane Microdomains; Mice, Inbred C57BL; Palmitates; Phosphorylation; Phosphotyrosine; Protein Domains; src-Family Kinases; Stress, Physiological	2017
Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of biological chemistry, 2013, Jun-14, Volume: 288, Issue:24 Topics: 3T3-L1 Cells; Adipose Tissue, Brown; Adult; Aged; Amino Acid Substitution; Animals; Diet, High-Fat; Energy Metabolism; Gene Knockdown Techniques; Glucose Intolerance; Humans; Insulin Resistance; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Phosphorylation; Phosphotyrosine; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Pyruvate Kinase; Signal Transduction	2013
Jiaotai Pill enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats. Chinese journal of integrative medicine, 2013, Volume: 19, Issue:9 Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Glucose Tolerance Test; Glucose Transporter Type 4; Homeostasis; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Subunits; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction	2013
Involvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells. Molecular endocrinology (Baltimore, Md.), 2015, Volume: 29, Issue:6 Topics: Adenylyl Cyclases; Animals; Cell Differentiation; Cell Line; Deoxyglucose; Disease Models, Animal; Gene Knockdown Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice, Obese; Models, Biological; Muscle Cells; Muscle Fibers, Skeletal; Muscle, Skeletal; Phosphorylation; Phosphotyrosine; Physical Conditioning, Animal; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Receptors, Corticotropin-Releasing Hormone; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Urocortins	2015
Metabolite profiling in plasma and tissues of ob/ob and db/db mice identifies novel markers of obesity and type 2 diabetes. Diabetologia, 2015, Volume: 58, Issue:9 Topics: 3-Hydroxybutyric Acid; Adipose Tissue; Animals; Diabetes Mellitus, Type 2; Fatty Acids; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Glyoxylates; Insulin Resistance; Leptin; Liver; Lysine; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; Obesity; Phosphotyrosine; Signal Transduction; Sorbitol	2015
Pigment epithelium-derived factor (PEDF) ameliorates advanced glycation end product (AGE)-induced hepatic insulin resistance in vitro by suppressing Rac-1 activation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2008, Volume: 40, Issue:9 Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Enzyme Activation; Eye Proteins; Genes, Dominant; Glycation End Products, Advanced; Glycogen; Hepatocytes; Humans; I-kappa B Kinase; I-kappa B Proteins; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; JNK Mitogen-Activated Protein Kinases; Models, Biological; Nerve Growth Factors; NF-KappaB Inhibitor alpha; Phosphoproteins; Phosphotyrosine; rac1 GTP-Binding Protein; Serpins; Signal Transduction	2008
Rats with monosodium glutamate-induced obesity and insulin resistance exhibit low expression of Galpha(i2) G-protein. General physiology and biophysics, 2008, Volume: 27, Issue:3 Topics: Adipocytes; Animals; Cell Membrane; Down-Regulation; GTP-Binding Protein alpha Subunit, Gi2; Insulin Resistance; Male; Obesity; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Sodium Glutamate	2008
Two related cases of type A insulin resistance with compound heterozygous mutations of the insulin receptor gene. Diabetes research and clinical practice, 2009, Volume: 83, Issue:3 Topics: Adolescent; Amino Acid Substitution; Aspartic Acid; Female; Genetic Carrier Screening; Genetic Variation; Glucose Intolerance; Glycine; Heterozygote; Humans; Insulin Resistance; Mutation; Phenotype; Phosphotyrosine; Receptor, Insulin; Siblings	2009
PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase. Molecular and cellular endocrinology, 2009, Oct-15, Volume: 309, Issue:1-2 Topics: Animals; Cell Differentiation; Cell Line; Deoxyglucose; Down-Regulation; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Inositol Polyphosphate 5-Phosphatases; Insulin; Insulin Resistance; Mice; Muscle, Skeletal; Mutation; Phosphatidylinositol 3-Kinases; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotyrosine; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; RNA, Small Interfering	2009
mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine(307) residues after burn. Burns : journal of the International Society for Burn Injuries, 2011, Volume: 37, Issue:1 Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Burns; C-Peptide; Disease Models, Animal; Glucose Clamp Technique; Immunohistochemistry; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Muscle, Skeletal; Phosphorylation; Phosphoserine; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Serine; Sirolimus; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha	2011
Regulation of IRS-1/SHP2 interaction and AKT phosphorylation in animal models of insulin resistance. Endocrine, 2002, Volume: 18, Issue:1 Topics: Aging; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Epinephrine; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar	2002
Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. Diabetes, 2003, Volume: 52, Issue:4 Topics: Adult; Body Mass Index; Deoxyglucose; Enzyme Activation; Epidermal Growth Factor; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Obesity; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction	2003
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats. Diabetes, 2003, Volume: 52, Issue:4 Topics: Adipocytes; Amine Oxidase (Copper-Containing); Animals; Benzylamines; Biological Transport; Blood Glucose; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucose; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Muscle, Skeletal; Peroxides; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; Recombinant Proteins; Vanadates	2003
Identification and functional assessment of novel and known insulin receptor mutations in five patients with syndromes of severe insulin resistance. The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:9 Topics: Adolescent; Animals; Blotting, Western; Cells, Cultured; CHO Cells; Codon, Nonsense; Cricetinae; DNA; Female; Fibroblasts; Humans; Hypoglycemic Agents; Infant; Insulin; Insulin Resistance; Mutation; Mutation, Missense; Phenotype; Phosphotyrosine; Receptor, Insulin; Signal Transduction	2003
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. The Journal of biological chemistry, 2004, Jun-04, Volume: 279, Issue:23 Topics: Animals; Fatty Acids; Genotype; Glucose; HLA Antigens; Humans; Insulin; Insulin Resistance; Isoenzymes; Male; Mice; Mice, Transgenic; Muscles; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Isoforms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptor, Insulin; Signal Transduction; Transgenes; Tyrosine	2004
TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3. Glycobiology, 2005, Volume: 15, Issue:1 Topics: Adipocytes; Animals; Cell Line; Ceramides; Detergents; Enzyme Activation; G(M3) Ganglioside; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Membrane Microdomains; Mice; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphotyrosine; Tumor Necrosis Factor-alpha	2005
Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue. International journal of molecular medicine, 2004, Volume: 14, Issue:4 Topics: Adipose Tissue; Animals; Burns; C-Peptide; Glucose; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Membranes; Muscle, Skeletal; Phosphoproteins; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Temperature	2004
Reduced plasma membrane Ca2+-ATPase function in platelets from patients with non-insulin-dependent diabetes mellitus. Haematologica, 2004, Volume: 89, Issue:9 Topics: Adult; Blood Platelets; Calcium; Calcium-Transporting ATPases; Cation Transport Proteins; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Ionomycin; Male; Phosphorylation; Phosphotyrosine; Plasma Membrane Calcium-Transporting ATPases; Platelet Activation; Protein Processing, Post-Translational; Thapsigargin	2004
Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance. Molecular and cellular biology, 2004, Volume: 24, Issue:21 Topics: Adenoviridae; Animals; Binding Sites; Cell Line; Cricetinae; Enzyme Activation; Gene Expression Regulation, Viral; Genes, myc; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mitogen-Activated Protein Kinases; Mutation; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine	2004
Knock-down of LAR protein tyrosine phosphatase induces insulin resistance. FEBS letters, 2005, Jun-06, Volume: 579, Issue:14 Topics: Cell Line; Humans; Insulin; Insulin Resistance; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor-Like Protein Tyrosine Phosphatases, Class 4; Receptor, Insulin; Receptors, Cell Surface; RNA, Small Interfering; Signal Transduction; Substrate Specificity	2005
Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. Diabetes, 2007, Volume: 56, Issue:1 Topics: Adipose Tissue; Animals; Apolipoproteins E; Body Weight; Cystinyl Aminopeptidase; Insulin Resistance; Mice; Mice, Knockout; Mice, Obese; Phosphotyrosine; Triglycerides	2007
Troglitazone prevents glucose-induced insulin resistance of insulin receptor in rat-1 fibroblasts. Diabetes, 1994, Volume: 43, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Line; Chromans; Fibroblasts; Glucose; Humans; Hypoglycemic Agents; Immunoblotting; Immunosorbent Techniques; Insulin Resistance; Isoquinolines; Kinetics; Phosphorylation; Phosphotyrosine; Piperazines; Rats; Receptor, Insulin; Thiazoles; Thiazolidinediones; Troglitazone; Tyrosine	1994
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. The Journal of clinical investigation, 1994, Volume: 94, Issue:4 Topics: Adipose Tissue; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Immunoglobulin G; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Muscles; Neutralization Tests; Obesity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Zucker; Receptor, Insulin; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Specific Pathogen-Free Organisms; Tumor Necrosis Factor-alpha; Tyrosine	1994
Rescue and activation of a binding-deficient insulin receptor. Evidence for intermolecular transphosphorylation. The Journal of biological chemistry, 1994, Nov-04, Volume: 269, Issue:44 Topics: 3T3 Cells; Animals; Enzyme Activation; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Mutagenesis, Site-Directed; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Receptor, Insulin; Structure-Activity Relationship; Transfection; Tyrosine	1994
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature, 1994, Nov-10, Volume: 372, Issue:6502 Topics: Animals; Blood Glucose; Female; Growth; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tyrosine	1994
Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities. The Journal of biological chemistry, 1995, Mar-31, Volume: 270, Issue:13 Topics: Aminoisobutyric Acids; Animals; Biological Transport; Blotting, Western; Cell Line; Cytosol; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Kinetics; Macromolecular Substances; Phosphotyrosine; Pioglitazone; Protein Tyrosine Phosphatases; Raffinose; Rats; Receptor, Insulin; Recombinant Proteins; Swine; Thiazoles; Thiazolidinediones; Transfection; Tyrosine	1995
Activation of protein kinase C alpha inhibits signaling by members of the insulin receptor family. The Journal of biological chemistry, 1995, Sep-15, Volume: 270, Issue:37 Topics: Amino Acid Sequence; Animals; Cattle; Cell Division; CHO Cells; Cricetinae; Drosophila; Enzyme Activation; GTPase-Activating Proteins; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Isoenzymes; Kinetics; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Protein Kinase C; Proteins; Receptor, IGF Type 1; Receptor, Insulin; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrosine	1995
Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insulin resistance. The Journal of clinical endocrinology and metabolism, 1993, Volume: 77, Issue:1 Topics: Adolescent; Adult; Blood Glucose; Cells, Cultured; Fasting; Female; Fibroblasts; Food; Humans; Immunosorbent Techniques; Insulin; Insulin Resistance; Male; Phosphotyrosine; Protein-Tyrosine Kinases; Receptor, Insulin; Tyrosine	1993
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus. The Journal of clinical investigation, 1993, Volume: 92, Issue:4 Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Macromolecular Substances; Mice; Mice, Obese; Muscles; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Tyrosine	1993
Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes. Diabetologia, 1995, Volume: 38, Issue:10 Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin	1995
Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. The Journal of biological chemistry, 1997, Oct-03, Volume: 272, Issue:40 Topics: Alkaline Phosphatase; Animals; Burns; Fasting; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Phosphotyrosine; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Recombinant Proteins; Reference Values	1997
Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat. The American journal of physiology, 1997, Volume: 273, Issue:5 Topics: 3-O-Methylglucose; Animals; Blood Glucose; Crosses, Genetic; Female; Glucose Tolerance Test; Glucose Transporter Type 4; Homozygote; Humans; Hypertension; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Obesity; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction	1997
Altered regulation of insulin signaling components in adipocytes of insulin-resistant type II diabetic Goto-Kakizaki rats. Metabolism: clinical and experimental, 1998, Volume: 47, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Glucose Transporter Type 4; GRB2 Adaptor Protein; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Monosaccharide Transport Proteins; Muscle Proteins; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Phosphatase 1; Proteins; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction	1998
Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. The Journal of biological chemistry, 1998, Aug-07, Volume: 273, Issue:32 Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Cell Fractionation; Deoxyglucose; Glucosamine; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Inosine; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptor, Insulin; Sodium Azide	1998
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Molecular cell, 1998, Volume: 2, Issue:5 Topics: Animals; Blood Glucose; Body Weight; Cells, Cultured; Cholesterol; Creatine Kinase; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Integrases; Isoenzymes; Lipids; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Muscle, Skeletal; Phosphotyrosine; Receptor, Insulin; Signal Transduction; Viral Proteins	1998
Implications of compound heterozygous insulin receptor mutations in congenital muscle fibre type disproportion myopathy for the receptor kinase activation. Diabetologia, 1999, Volume: 42, Issue:2 Topics: Adult; Antibodies; Enzyme Activation; Erythrocytes; Heterozygote; Humans; Insulin; Insulin Resistance; Male; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Diseases; Mutation; Phosphotyrosine; Point Mutation; Receptor, Insulin	1999
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (New York, N.Y.), 1999, Mar-05, Volume: 283, Issue:5407 Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fats; Gene Targeting; Glucose Tolerance Test; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; Mice; Mice, Knockout; Muscle, Skeletal; Obesity; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Receptor, Insulin; Signal Transduction	1999
Inhibition of IRS-1 phosphorylation and the alterations of GLUT4 in isolated adipocytes from cachectic tumor-bearing rats. Biochemical and biophysical research communications, 1999, Mar-24, Volume: 256, Issue:3 Topics: Adipocytes; Animals; Biological Transport; Body Weight; Cachexia; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Eating; Glucose; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Male; Microsomes; Monosaccharide Transport Proteins; Muscle Proteins; Organ Size; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Inbred F344; Receptor, Insulin; Sarcoma, Experimental	1999
Insulin signaling is inhibited by micromolar concentrations of H(2)O(2). Evidence for a role of H(2)O(2) in tumor necrosis factor alpha-mediated insulin resistance. The Journal of biological chemistry, 1999, Aug-27, Volume: 274, Issue:35 Topics: Calcium-Calmodulin-Dependent Protein Kinases; Catalase; Cell Line; Enzyme Inhibitors; Glucose; Humans; Hydrogen Peroxide; Hyperglycemia; Insulin; Insulin Resistance; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Protein Kinase C; Receptor, Insulin; Signal Transduction; Tumor Necrosis Factor-alpha; Vanadates	1999
Cardiac insulin resistance is associated with an impaired recruitment of phosphatidylinositol 3-kinase to GLUT4 vesicles. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000, Volume: 24 Suppl 2 Topics: Animals; Glucose Transporter Type 4; Heart; Immunosorbent Techniques; Insulin; Insulin Resistance; Monosaccharide Transport Proteins; Muscle Proteins; Myocardium; Obesity; Phosphatidylinositol 3-Kinases; Phosphotyrosine; Rats; Rats, Zucker	2000
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Diabetes, 2000, Volume: 49, Issue:10 Topics: 3T3 Cells; Adipocytes; Aminoimidazole Carboxamide; Animals; Biological Transport; Dexamethasone; Enzyme Activation; Gene Expression; Glucocorticoids; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Osmotic Pressure; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Receptor, Insulin; Ribonucleotides; Signal Transduction	2000
Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Molecular endocrinology (Baltimore, Md.), 2000, Volume: 14, Issue:10 Topics: 3T3 Cells; Adipocytes; Animals; Anisomycin; Cell Differentiation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphoserine; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Tumor Necrosis Factor-alpha	2000
Insulin-mediated cellular insulin resistance decreases osmotic shock-induced glucose transport in 3T3-L1 adipocytes. Endocrinology, 2000, Volume: 141, Issue:12 Topics: 3T3 Cells; Actins; Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Biological Transport; Cell Membrane; Enzyme Activation; Glucose; Glucose Transporter Type 4; Insulin; Insulin Resistance; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Osmotic Pressure; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Signal Transduction	2000
Decreased in situ insulin receptor dephosphorylation in hyperglycemia-induced insulin resistance in rat adipocytes. Diabetes, 2001, Volume: 50, Issue:1 Topics: Adipocytes; Animals; Deoxyglucose; Hyperglycemia; Immunoblotting; Insulin Resistance; Male; Phosphorylation; Phosphotyrosine; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Tyrosine	2001
Long-term denervation impairs insulin receptor substrate-1-mediated insulin signaling in skeletal muscle. Metabolism: clinical and experimental, 2001, Volume: 50, Issue:2 Topics: Animals; Denervation; Enzyme Activation; Hindlimb; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Time Factors	2001
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proceedings of the National Academy of Sciences of the United States of America, 2001, Apr-24, Volume: 98, Issue:9 Topics: Animals; Blood Glucose; Body Composition; Creatine Kinase; Creatine Kinase, MM Form; Fatty Acids, Nonesterified; Humans; Insulin; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Isoenzymes; Mice; Mice, Transgenic; Muscles; Organ Specificity; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Signal Transduction	2001
Pioglitazone ameliorates tumor necrosis factor-alpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator--activated receptor-gamma. Diabetes, 2001, Volume: 50, Issue:5 Topics: 3T3 Cells; Adipocytes; Animals; Cell Differentiation; Cell Line; Deoxyglucose; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Mice; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Transforming Growth Factor alpha	2001
Growth hormone induces cellular insulin resistance by uncoupling phosphatidylinositol 3-kinase and its downstream signals in 3T3-L1 adipocytes. Diabetes, 2001, Volume: 50, Issue:8 Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Cell Line; Cytosol; Deoxyglucose; Human Growth Hormone; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Insulin-Like Growth Factor I; Janus Kinase 2; Kinetics; MAP Kinase Signaling System; Mice; Microsomes; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Signal Transduction; Swine; Transfection	2001
Regulation of IRS-2 tyrosine phosphorylation in fasting and diabetes. Molecular and cellular endocrinology, 2001, Oct-25, Volume: 183, Issue:1-2 Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Signal Transduction	2001
Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected]. Diabetes, 2001, Volume: 50, Issue:12 Topics: Adult; Biopsy; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Glucose Clamp Technique; Glucose Intolerance; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Peroxidation; Male; Middle Aged; Muscle, Skeletal; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction	2001
N-3 polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle. American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:3 Topics: Adipose Tissue; Animals; Blood Glucose; Dietary Fats; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Glucose Transporter Type 4; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Leptin; Lipids; Liver; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar; Receptor, Insulin; RNA, Messenger; Signal Transduction	2002
Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes, 2002, Volume: 51, Issue:6 Topics: Animals; Blood Glucose; Emulsions; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Kinetics; Lecithins; Male; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Rats; Rats, Wistar; Safflower Oil; Sex Characteristics; Soybean Oil	2002
High-fat feeding induces tissue-specific alteration in proportion of activated insulin receptors in rats. Acta endocrinologica, 1990, Volume: 122, Issue:3 Topics: Animals; Cell Membrane; Dietary Fats; Insulin; Insulin Resistance; Kidney; Liver; Male; Muscles; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains; Receptor, Insulin; Tyrosine	1990