urea has been researched along with Insulin Resistance in 45 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " RESULTS In the mouse model of NAFLD, RKI-1447 reduced insulin resistance and the levels of alanine aminotransferase (ALT), aspartate transaminase (AST), total cholesterol, triglyceride, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), and superoxide dismutase (SOD)." | 7.96 | The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid. ( Jiang, W; Wang, J, 2020) |
| "Measurement of urinary electrolytes and urea revealed that an osmotic diuresis induced by urea derived principally by breakdown of endogenous protein was causative." | 7.79 | Severe hypernatremia from a urea-induced diuresis due to body protein wasting in an insulin-resistant type 2 diabetic patient. ( Anderson, A; Barrett, EJ, 2013) |
| "1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea 14a (AR9281), a potent and selective soluble epoxide hydrolase inhibitor, was recently tested in a phase 2a clinical setting for its effectiveness in reducing blood pressure and improving insulin resistance in pre-diabetic patients." | 7.77 | 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. ( Aavula, BR; Anandan, SK; Cases, S; Chen, D; Cheng, Y; Do, ZN; Gless, R; Hammock, BD; Jones, PD; MacIntyre, DE; Mehra, U; Patel, DV; Sabry, J; Tran, V; Vincelette, J; Wang, YX; Waszczuk, J; Webb, HK; Whitcomb, R; White, K; Wong, KR; Zhang, LN, 2011) |
| "The study evaluates the effect of genistein, a soy isoflavone, on insulin sensitivity and renal functional and structural injury in rats rendered insulin-resistant by feeding on a high-fructose diet for 60 days." | 7.74 | Effect of genistein, a soy isoflavone, on whole body insulin sensitivity and renal damage induced by a high-fructose diet. ( Anuradha, CV; Palanisamy, N; Viswanathan, P, 2008) |
| " Furthermore, glycine could be linked to metabolic health and insulin sensitivity through the betaine osmolyte." | 5.22 | Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance. ( Astrup, A; Carayol, J; Charon, C; Fazelzadeh, P; Hager, J; Lefebvre, G; Matone, A; Morine, M; Saris, WH; Scott-Boyer, MP; Valsesia, A; Vervoort, J, 2016) |
| " RESULTS In the mouse model of NAFLD, RKI-1447 reduced insulin resistance and the levels of alanine aminotransferase (ALT), aspartate transaminase (AST), total cholesterol, triglyceride, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), and superoxide dismutase (SOD)." | 3.96 | The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid. ( Jiang, W; Wang, J, 2020) |
| "Measurement of urinary electrolytes and urea revealed that an osmotic diuresis induced by urea derived principally by breakdown of endogenous protein was causative." | 3.79 | Severe hypernatremia from a urea-induced diuresis due to body protein wasting in an insulin-resistant type 2 diabetic patient. ( Anderson, A; Barrett, EJ, 2013) |
| "1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea 14a (AR9281), a potent and selective soluble epoxide hydrolase inhibitor, was recently tested in a phase 2a clinical setting for its effectiveness in reducing blood pressure and improving insulin resistance in pre-diabetic patients." | 3.77 | 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia. ( Aavula, BR; Anandan, SK; Cases, S; Chen, D; Cheng, Y; Do, ZN; Gless, R; Hammock, BD; Jones, PD; MacIntyre, DE; Mehra, U; Patel, DV; Sabry, J; Tran, V; Vincelette, J; Wang, YX; Waszczuk, J; Webb, HK; Whitcomb, R; White, K; Wong, KR; Zhang, LN, 2011) |
| " There was no significant effect of insulin resistance and NASH on whole body rate of protein turnover [phenylalanine Ra (rate of appearance)] and on the rate of urea synthesis." | 3.77 | Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine. ( Bennett, C; Dasarathy, S; Duenas, C; Edmison, J; Gruca, LL; Kalhan, SC; Lopez, R; Marczewski, S, 2011) |
| " In the sub-chronic study, the effect of CS-extract and GLB (at the above doses) on body weight (BW), plasma glucose, insulin, TC, LDL-cholesterol, HDL-cholesterol, TG, urea and creatinine was determined in normal and OHH rats; insulin resistance (IR as HOMA-IR), atherosclerotic and cardioprotective indices were calculated." | 3.77 | Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats. ( Aissaoui, A; Israili, ZH; Lyoussi, B; Zizi, S, 2011) |
| " In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially C-reactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis." | 3.76 | Relationship between insulin resistance and inflamation markers in hemodialysis patients. ( Binici, DN; Borazan, A, 2010) |
| " Glycerol in T2DM microdialysate (but not in T1DM) was higher than in healthy volunteers, which is likely explained by sc insulin resistance (insulin is a potent antilipolytic hormone)." | 3.76 | Analyte flux at a biomaterial-tissue interface over time: implications for sensors for type 1 and 2 diabetes mellitus. ( Adamson, U; Brismar, K; Ekberg, NR; Hedblad, MA; Malmstedt, J; Ungerstedt, U; Wisniewski, N, 2010) |
| "The study evaluates the effect of genistein, a soy isoflavone, on insulin sensitivity and renal functional and structural injury in rats rendered insulin-resistant by feeding on a high-fructose diet for 60 days." | 3.74 | Effect of genistein, a soy isoflavone, on whole body insulin sensitivity and renal damage induced by a high-fructose diet. ( Anuradha, CV; Palanisamy, N; Viswanathan, P, 2008) |
| " In extract treated (500 mg/kg) diabetic rats serum and urinary glucose, urinary urea, food and fluid intake were decreased, while body weight gain was increased, all of which indicate an improvement in diabetic state (p<0." | 3.74 | Antidiabetic activity of Vatairea macrocarpa extract in rats. ( dos Santos, MP; Grigulo, R; Kawashita, NH; Lima, JC; Lima, LL; Lopes, CF; Martins, DT; Oliveira, HC; Stoppiglia, LF, 2008) |
| "Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and is associated with overweight and insulin resistance (IR)." | 1.72 | Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease. ( Berndt, N; Bufler, P; Eckstein, J; Henning, S; Holzhütter, HG; Hudert, CA; Loddenkemper, C; Meierhofer, D; Sack, I; Wallach, I; Wiegand, S, 2022) |
| "Patients with NAFLD had hyperglucagonemia and increased levels of glucagonotropic amino acids, including alanine in particular." | 1.56 | Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis. ( Andersen, DB; Bisgaard, HC; Dall, M; Eriksen, PL; Galsgaard, KD; Gillum, MP; Gluud, LL; Hassing, AS; Holst, JJ; Hunt, JE; Jepsen, SL; Kjeldsen, SAS; Knop, FK; Kuhre, RE; Pedersen, J; Santos, A; Sulek, K; Torekov, SS; Trammell, SAJ; Treebak, JT; Vasilopoulou, CG; Vilstrup, H; Werge, MP; Wewer Albrechtsen, NJ; Windeløv, JA; Winther-Sørensen, M; Ørskov, C, 2020) |
| "Hyperglycemia in type 2 diabetes mellitus has been linked to non-alcoholic fatty liver disease, which can progress to inflammation, fibrosis/cirrhosis, and hepatocellular carcinoma." | 1.43 | Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes. ( Ballinger, KR; Davidson, MD; Khetani, SR, 2016) |
| "It suggests that the HFS diet-induced hyperinsulinemia is responsible for the decrease in the circulating levels of urea, creatinine, and many amino acids, despite an increase in serum glucose levels." | 1.39 | Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats. ( de la Garza, AL; Etxeberria, U; Martínez, JA; Milagro, FI, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (17.78) | 18.7374 |
| 1990's | 2 (4.44) | 18.2507 |
| 2000's | 9 (20.00) | 29.6817 |
| 2010's | 20 (44.44) | 24.3611 |
| 2020's | 6 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fuglsang-Nielsen, R | 1 |
| Rakvaag, E | 1 |
| Vestergaard, P | 1 |
| Hermansen, K | 1 |
| Gregersen, S | 1 |
| Starup-Linde, J | 1 |
| Berndt, N | 1 |
| Hudert, CA | 1 |
| Eckstein, J | 1 |
| Loddenkemper, C | 1 |
| Henning, S | 1 |
| Bufler, P | 1 |
| Meierhofer, D | 1 |
| Sack, I | 1 |
| Wiegand, S | 1 |
| Wallach, I | 1 |
| Holzhütter, HG | 1 |
| Wahba, NS | 1 |
| Abdel-Ghany, RH | 1 |
| Ghareib, SA | 1 |
| Abdel-Aal, M | 1 |
| Alsemeh, AE | 1 |
| Wang, J | 1 |
| Jiang, W | 1 |
| Winther-Sørensen, M | 1 |
| Galsgaard, KD | 1 |
| Santos, A | 1 |
| Trammell, SAJ | 1 |
| Sulek, K | 1 |
| Kuhre, RE | 1 |
| Pedersen, J | 1 |
| Andersen, DB | 1 |
| Hassing, AS | 1 |
| Dall, M | 1 |
| Treebak, JT | 1 |
| Gillum, MP | 1 |
| Torekov, SS | 1 |
| Windeløv, JA | 1 |
| Hunt, JE | 1 |
| Kjeldsen, SAS | 1 |
| Jepsen, SL | 1 |
| Vasilopoulou, CG | 1 |
| Knop, FK | 1 |
| Ørskov, C | 1 |
| Werge, MP | 1 |
| Bisgaard, HC | 1 |
| Eriksen, PL | 1 |
| Vilstrup, H | 1 |
| Gluud, LL | 1 |
| Holst, JJ | 1 |
| Wewer Albrechtsen, NJ | 1 |
| Abdel-Latif, RG | 1 |
| Ahmed, AF | 1 |
| Heeba, GH | 1 |
| Palau-Rodriguez, M | 1 |
| Tulipani, S | 1 |
| Marco-Ramell, A | 1 |
| Miñarro, A | 1 |
| Jáuregui, O | 1 |
| Sanchez-Pla, A | 1 |
| Ramos-Molina, B | 1 |
| Tinahones, FJ | 1 |
| Andres-Lacueva, C | 1 |
| Anderson, A | 1 |
| Barrett, EJ | 1 |
| Roche, C | 1 |
| Besnier, M | 1 |
| Cassel, R | 1 |
| Harouki, N | 1 |
| Coquerel, D | 1 |
| Guerrot, D | 1 |
| Nicol, L | 1 |
| Loizon, E | 1 |
| Remy-Jouet, I | 1 |
| Morisseau, C | 1 |
| Mulder, P | 1 |
| Ouvrard-Pascaud, A | 1 |
| Madec, AM | 1 |
| Richard, V | 1 |
| Bellien, J | 1 |
| White, PA | 1 |
| Araújo, JM | 1 |
| Cercato, LM | 1 |
| Souza, LA | 1 |
| Barbosa, AP | 1 |
| Quintans-Junior, LJ | 1 |
| Machado, UF | 1 |
| Camargo, EA | 1 |
| Brito, LC | 1 |
| Santos, MR | 1 |
| Matone, A | 1 |
| Scott-Boyer, MP | 1 |
| Carayol, J | 1 |
| Fazelzadeh, P | 1 |
| Lefebvre, G | 1 |
| Valsesia, A | 1 |
| Charon, C | 1 |
| Vervoort, J | 1 |
| Astrup, A | 1 |
| Saris, WH | 1 |
| Morine, M | 1 |
| Hager, J | 1 |
| Abbas, SY | 1 |
| Basyouni, WM | 1 |
| El-Bayouki, KA | 1 |
| Abdel-Rahman, RF | 1 |
| Davidson, MD | 1 |
| Ballinger, KR | 1 |
| Khetani, SR | 1 |
| Lau, WL | 1 |
| Vaziri, ND | 1 |
| Palanisamy, N | 1 |
| Viswanathan, P | 1 |
| Anuradha, CV | 3 |
| Ka, T | 1 |
| Inokuchi, T | 1 |
| Tamada, D | 1 |
| Suda, M | 1 |
| Tsutsumi, Z | 1 |
| Okuda, C | 1 |
| Yamamoto, A | 1 |
| Takahashi, S | 1 |
| Moriwaki, Y | 1 |
| Yamamoto, T | 1 |
| D'Apolito, M | 1 |
| Du, X | 1 |
| Zong, H | 1 |
| Catucci, A | 1 |
| Maiuri, L | 1 |
| Trivisano, T | 1 |
| Pettoello-Mantovani, M | 1 |
| Campanozzi, A | 1 |
| Raia, V | 1 |
| Pessin, JE | 1 |
| Brownlee, M | 1 |
| Giardino, I | 1 |
| Borazan, A | 1 |
| Binici, DN | 1 |
| Ekberg, NR | 1 |
| Brismar, K | 1 |
| Malmstedt, J | 1 |
| Hedblad, MA | 1 |
| Adamson, U | 1 |
| Ungerstedt, U | 1 |
| Wisniewski, N | 1 |
| Anandan, SK | 1 |
| Webb, HK | 1 |
| Chen, D | 1 |
| Wang, YX | 1 |
| Aavula, BR | 1 |
| Cases, S | 1 |
| Cheng, Y | 1 |
| Do, ZN | 1 |
| Mehra, U | 1 |
| Tran, V | 1 |
| Vincelette, J | 1 |
| Waszczuk, J | 1 |
| White, K | 1 |
| Wong, KR | 1 |
| Zhang, LN | 1 |
| Jones, PD | 1 |
| Hammock, BD | 1 |
| Patel, DV | 1 |
| Whitcomb, R | 1 |
| MacIntyre, DE | 1 |
| Sabry, J | 1 |
| Gless, R | 1 |
| Kalhan, SC | 2 |
| Edmison, J | 1 |
| Marczewski, S | 1 |
| Dasarathy, S | 1 |
| Gruca, LL | 1 |
| Bennett, C | 1 |
| Duenas, C | 1 |
| Lopez, R | 1 |
| Aissaoui, A | 1 |
| Zizi, S | 1 |
| Israili, ZH | 1 |
| Lyoussi, B | 1 |
| Hou, SZ | 1 |
| Chen, SX | 1 |
| Huang, S | 1 |
| Jiang, DX | 1 |
| Zhou, CJ | 1 |
| Chen, CQ | 1 |
| Liang, YM | 1 |
| Lai, XP | 1 |
| Porcelli, L | 1 |
| Gilardi, F | 1 |
| Laghezza, A | 1 |
| Piemontese, L | 1 |
| Mitro, N | 1 |
| Azzariti, A | 1 |
| Altieri, F | 1 |
| Cervoni, L | 1 |
| Fracchiolla, G | 1 |
| Giudici, M | 1 |
| Guerrini, U | 1 |
| Lavecchia, A | 1 |
| Montanari, R | 1 |
| Di Giovanni, C | 1 |
| Paradiso, A | 1 |
| Pochetti, G | 1 |
| Simone, GM | 1 |
| Tortorella, P | 1 |
| Crestani, M | 1 |
| Loiodice, F | 1 |
| Fernández-Fígares, I | 1 |
| Lachica, M | 1 |
| Martín, A | 1 |
| Nieto, R | 1 |
| González-Valero, L | 1 |
| Rodríguez-López, JM | 1 |
| Aguilera, JF | 1 |
| Etxeberria, U | 1 |
| de la Garza, AL | 1 |
| Martínez, JA | 1 |
| Milagro, FI | 1 |
| Vidyashankar, S | 1 |
| Sandeep Varma, R | 1 |
| Patki, PS | 1 |
| BELLENS, R | 1 |
| DE MEUTTER, R | 1 |
| CONARD, V | 1 |
| RIESER, P | 1 |
| RIESER, CH | 1 |
| Thirunavukkarasu, V | 1 |
| Anitha Nandhini, AT | 1 |
| Hamrin, K | 2 |
| Henriksson, J | 2 |
| Kok, P | 1 |
| Roelfsema, F | 1 |
| Frölich, M | 1 |
| van Pelt, J | 1 |
| Stokkel, MP | 1 |
| Meinders, AE | 1 |
| Pijl, H | 1 |
| Pazarloglou, M | 1 |
| Spaia, S | 1 |
| Pagkalos, E | 1 |
| Ioannidis, H | 1 |
| Askepidis, N | 1 |
| Varyemezis, V | 1 |
| Smith, RN | 1 |
| Mann, NJ | 1 |
| Braue, A | 1 |
| Mäkeläinen, H | 1 |
| Varigos, GA | 1 |
| Oliveira, HC | 1 |
| dos Santos, MP | 1 |
| Grigulo, R | 1 |
| Lima, LL | 1 |
| Martins, DT | 1 |
| Lima, JC | 1 |
| Stoppiglia, LF | 1 |
| Lopes, CF | 1 |
| Kawashita, NH | 1 |
| Mitch, WE | 1 |
| Clark, AS | 1 |
| Brissot, P | 1 |
| Simon, P | 1 |
| Meyrier, A | 1 |
| Balakrishnan, SD | 1 |
| Devapatla, S | 1 |
| Weisshaar, E | 1 |
| Bonnekoh, B | 1 |
| Franke, I | 1 |
| Gollnick, H | 1 |
| Ostman, J | 1 |
| Bolinder, J | 1 |
| Gunnarsson, R | 1 |
| Brattström, C | 1 |
| Tydén, G | 1 |
| Wahren, J | 1 |
| Groth, CG | 1 |
| Devlin, JT | 1 |
| Horton, ES | 2 |
| Hinton, P | 1 |
| Allison, SP | 1 |
| Littlejohn, S | 1 |
| Lloyd, J | 1 |
| Johnson, C | 1 |
| Lebovitz, HE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Whey Protein and Dietary Fibers on Risk Markers of the Metabolic Syndrome and Bone Health[NCT02931630] | 72 participants (Actual) | Interventional | 2016-05-31 | Completed | |||
| Open-label, Flexible-dose Adjunctive Bromocriptine for Patients With Schizophrenia and Impaired Glucose Tolerance[NCT03575000] | Phase 4 | 20 participants (Anticipated) | Interventional | 2023-11-01 | Not yet recruiting | ||
| [NCT01969175] | 60 participants (Anticipated) | Interventional | 2013-10-31 | Recruiting | |||
| Glargine Dosing in Hospitalized Patients With Type 2 Diabetes and Renal Insufficiency[NCT00911625] | Phase 4 | 114 participants (Actual) | Interventional | 2009-01-21 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants have their blood glucose measured daily for six days. The average blood glucose measure over all six days is compared between the two treatment cohorts. (NCT00911625)
Timeframe: 6 Days
| Intervention | milligrams per deciliter (Mean) |
|---|---|
| 0.5 Units/kg | 174 |
| 0.25 Units/kg | 174.5 |
4 reviews available for urea and Insulin Resistance
| Article | Year |
|---|---|
Urea, a true uremic toxin: the empire strikes back.
Topics: Animals; Diet, Protein-Restricted; Humans; Insulin Resistance; Proteins; Renal Insufficiency, Chroni | 2017 |
Muscle protein turnover in uremia.
Topics: Amino Acids; Animals; Dietary Proteins; Fasting; Glucose; Humans; In Vitro Techniques; Insulin; Insu | 1983 |
Uremia and the liver. III. Uremia and hepatic metabolism of carbohydrates, lipids, and proteins.
Topics: Amino Acids; Animals; Carbohydrate Metabolism; Cholesterol; Glucagon; Gluconeogenesis; Glucose Toler | 1981 |
Pregnancy, insulin resistance and nitrogen accretion.
Topics: Female; Humans; Insulin Resistance; Leucine; Nitrogen; Pregnancy; Urea | 1999 |
6 trials available for urea and Insulin Resistance
| Article | Year |
|---|---|
The Effects of 12-Weeks Whey Protein Supplements on Markers of Bone Turnover in Adults With Abdominal Obesity - A
Topics: Adult; Biomarkers; Bone Remodeling; Calcium; Diabetes Mellitus, Type 2; Dietary Fiber; Humans; Insul | 2022 |
Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance.
Topics: Adult; Ammonia; Betaine; Caloric Restriction; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosp | 2016 |
Impact of dietary betaine and conjugated linoleic acid on insulin sensitivity, protein and fat metabolism of obese pigs.
Topics: Analysis of Variance; Animal Nutritional Physiological Phenomena; Animals; Betaine; Dietary Proteins | 2012 |
Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women.
Topics: Adult; Blood Glucose; Bromocriptine; Calorimetry, Indirect; Circadian Rhythm; Cross-Over Studies; Do | 2006 |
A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial.
Topics: Acne Vulgaris; Adolescent; Adult; Blood Glucose; Dietary Carbohydrates; Glycemic Index; Humans; Insu | 2007 |
Insulin and glucose to reduce catabolic response to injury in burned patients.
Topics: Adult; Blood Glucose; Blood Urea Nitrogen; Burns; Child; Clinical Trials as Topic; Glucose; Glycosur | 1971 |
35 other studies available for urea and Insulin Resistance
| Article | Year |
|---|---|
Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease.
Topics: Ammonia; Carbohydrates; Child; Glutamine; Humans; Insulin Resistance; Lipids; Liver; Non-alcoholic F | 2022 |
Vitamin D3 potentiates the renoprotective effects of vildagliptin in a rat model of fructose/salt-induced insulin resistance.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Cholecalciferol; Creatinine; Dipeptidyl-Pepti | 2020 |
The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cholesterol; | 2020 |
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis.
Topics: Adult; Amino Acids; Animals; Blood Glucose; Fatty Liver; Female; Glucagon; Glucagon-Secreting Cells; | 2020 |
Low-dose lixisenatide protects against early-onset nephropathy induced in diabetic rats.
Topics: Animals; Antioxidants; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet, Hi | 2020 |
Metabotypes of response to bariatric surgery independent of the magnitude of weight loss.
Topics: Adult; Anthropometry; Bariatric Surgery; C-Reactive Protein; Chromatography, Liquid; Female; Follow- | 2018 |
Severe hypernatremia from a urea-induced diuresis due to body protein wasting in an insulin-resistant type 2 diabetic patient.
Topics: Diabetes Mellitus, Type 2; Diuresis; Electrolytes; Glucocorticoids; Humans; Hypernatremia; Hypertens | 2013 |
Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice.
Topics: Animals; Benzoates; Blood Glucose; Coronary Vessels; Disease Models, Animal; Dose-Response Relations | 2015 |
Chrysobalanus icaco L. Leaves Normalizes Insulin Sensitivity and Blood Glucose and Inhibits Weight Gain in High-Fat Diet-Induced Obese Mice.
Topics: Adipose Tissue; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Blood Gluc | 2016 |
Synthesis and Evaluation of 1-Substituted-Biguanide Derivatives as Anti-Diabetic Agents for Type II Diabetes Insulin Resistant.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biguanides; Blood Glucose; Cholesterol; | 2016 |
Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes.
Topics: 3T3 Cells; Albumins; Animals; Blood Glucose; Cell Line; Coculture Techniques; Cytochrome P-450 CYP1A | 2016 |
Effect of genistein, a soy isoflavone, on whole body insulin sensitivity and renal damage induced by a high-fructose diet.
Topics: Acute Kidney Injury; Analysis of Variance; Animals; Biopsy, Needle; Blood Glucose; Creatinine; Dieta | 2008 |
Relationship between plasma uridine and urinary urea excretion.
Topics: Adult; Creatinine; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Gout; Homeostasis; H | 2010 |
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.
Topics: 3T3-L1 Cells; Animals; Blood Glucose; Glucose; Glucose Intolerance; Insulin Receptor Substrate Prote | 2010 |
Relationship between insulin resistance and inflamation markers in hemodialysis patients.
Topics: Albumins; Analysis of Variance; Biomarkers; Blood Glucose; C-Reactive Protein; Female; Fibrinogen; H | 2010 |
Analyte flux at a biomaterial-tissue interface over time: implications for sensors for type 1 and 2 diabetes mellitus.
Topics: Adult; Aged; Biocompatible Materials; Biopsy; Biosensing Techniques; Diabetes Mellitus, Type 1; Diab | 2010 |
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.
Topics: Adamantane; Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Blood Glucose; D | 2011 |
Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine.
Topics: Adipokines; Adult; Aged; Calorimetry, Indirect; Case-Control Studies; Cysteine; Fatty Liver; Female; | 2011 |
Hypoglycemic and hypolipidemic effects of Coriandrum sativum L. in Meriones shawi rats.
Topics: Administration, Oral; Animals; Atherosclerosis; Biomarkers; Blood Glucose; Body Weight; Coriandrum; | 2011 |
The hypoglycemic activity of Lithocarpus polystachyus Rehd. leaves in the experimental hyperglycemic rats.
Topics: Animals; Blood Glucose; Blood Proteins; C-Reactive Protein; Cholesterol; Creatinine; Diabetes Mellit | 2011 |
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.
Topics: Adipocytes; Animals; Antineoplastic Agents; Benzoxazoles; Body Weight; Calorimetry; Cell Differentia | 2012 |
Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats.
Topics: Amino Acids; Animals; Creatinine; Diet, High-Fat; Fatty Acids, Unsaturated; Hyperglycemia; Hyperinsu | 2013 |
Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells.
Topics: Alanine Transaminase; Albumins; Antioxidants; Cytokines; DNA Fragmentation; Fatty Liver; Glucose; Gl | 2013 |
[Effects of single dose of BZ 55 on glucose concentration and insulin sensitivity of normal rats].
Topics: Animals; Blood Glucose; Hematologic Tests; Insulin; Insulin Resistance; Rats; Sulfanilamide; Sulfani | 1956 |
REVERSAL OF INSULIN RESISTANCE IN RED CELL SUGAR TRANSPORT.
Topics: Arabinose; Biological Transport; Carbohydrate Metabolism; Chymotrypsin; Erythrocytes; Fructose; Gala | 1964 |
Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats.
Topics: Animals; Biological Transport; Blood Glucose; Blood Pressure; Calcium-Transporting ATPases; Creatine | 2004 |
Local effect of vanadate on interstitial glucose and lactate concentrations in human skeletal muscle.
Topics: Adult; Aged; Catheterization; Glucose; Humans; Insulin; Insulin Resistance; Lactic Acid; Leg; Male; | 2005 |
Evaluation of insulin resistance and sodium sensitivity in normotensive offspring of hypertensive individuals.
Topics: Adult; Blood Pressure; Child; Child of Impaired Parents; Cholesterol; Female; Genetic Predisposition | 2007 |
Antidiabetic activity of Vatairea macrocarpa extract in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Brazil; Diabetes Mellitus, Experimental; Disease Model | 2008 |
Interstitial glucose concentration in insulin-resistant human skeletal muscle: influence of one bout of exercise and of local perfusion with insulin or vanadate.
Topics: Bicycling; Exercise; Extracellular Fluid; Glucose; Heart Rate; Humans; Hypoglycemic Agents; Infusion | 2008 |
Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance.
Topics: Animals; Blood Glucose; Blood Pressure; Creatinine; Disease Models, Animal; Fructose; Glucose Tolera | 1999 |
[Successful symptomatic tazarotene treatment of juvenile acanthosis nigricans of the familial obesity-associated type in insulin resistance].
Topics: Acanthosis Nigricans; Administration, Topical; Child; Diabetes Mellitus; Diabetes Mellitus, Type 2; | 2001 |
Effects of pancreas transplantation on metabolic and hormonal profiles in IDDM patients.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Circadian Rhythm; Creatinine; Diabetes Mellitus, Type 1 | 1989 |
Effects of prior high-intensity exercise on glucose metabolism in normal and insulin-resistant men.
Topics: Adult; Blood Glucose; C-Peptide; Glucose; Glucose Tolerance Test; Glycogen; Glycogen Synthase; Human | 1985 |
Carbohydrate metabolism in uremia.
Topics: Adipose Tissue; Adolescent; Adult; Aged; Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes M | 1968 |