clonidine has been researched along with Insulin Resistance in 13 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our aim was to investigate whether insulin sensitivity, leptin, androgen or estradiol levels are associated with disturbed GH response to clonidine in lean patients with polycystic ovary syndrome." | 7.73 | Influence of leptin, androgens and insulin sensitivity on increased GH response to clonidine in lean patients with polycystic ovary syndrome. ( Capp, E; Comim, FV; D'Avila, A; Spritzer, PM, 2005) |
| "The role that the central sympathetic nervous system plays in the development of obesity hypertension and insulin was evaluated by feeding dogs a high fat diet with or without clonidine treatment." | 7.70 | Clonidine prevents insulin resistance and hypertension in obese dogs. ( Babu, K; Mao, HZ; Marker, P; Rocchini, AJ; Rocchini, AP, 1999) |
| "The I1-imidazoline receptor is a specific high-affinity binding site corresponding to a functional cell-surface receptor mediating the antihypertensive actions of moxonidine and other second-generation centrally-acting agents, and may play a role in countering insulin resistance in an animal model of metabolic syndrome X." | 4.79 | The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease. ( Ernsberger, P; Friedman, JE; Koletsky, RJ, 1997) |
| "Our aim was to investigate whether insulin sensitivity, leptin, androgen or estradiol levels are associated with disturbed GH response to clonidine in lean patients with polycystic ovary syndrome." | 3.73 | Influence of leptin, androgens and insulin sensitivity on increased GH response to clonidine in lean patients with polycystic ovary syndrome. ( Capp, E; Comim, FV; D'Avila, A; Spritzer, PM, 2005) |
| "The role that the central sympathetic nervous system plays in the development of obesity hypertension and insulin was evaluated by feeding dogs a high fat diet with or without clonidine treatment." | 3.70 | Clonidine prevents insulin resistance and hypertension in obese dogs. ( Babu, K; Mao, HZ; Marker, P; Rocchini, AJ; Rocchini, AP, 1999) |
| "This study aimed to develop a novel type 2 diabetes model designated the HND (Horio-Niki diabetic) mouse, by transferring diabetogenic genes from wild castaneus mice (Mus musculus castaneus) captured in the Philippines into laboratory mice (C57BL/6J:B6)." | 1.33 | The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion. ( Anunciado, RV; Horio, F; Imamura, T; Kobayashi, M; Namikawa, T; Niki, I; Teradaira, S, 2005) |
| "Only clonidine treatment totally prevented the development of insulin resistance, and high-dose aspirin, known to prevent insulin resistance by inhibition of the activity of IkappaB kinase-beta, decreased the degree of insulin resistance by almost 70%." | 1.32 | Hypertension and insulin resistance are not directly related in obese dogs. ( Gokee, A; Rocchini, AP; Yang, JQ, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 6 (46.15) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peltonen, GL | 1 |
| Scalzo, RL | 1 |
| Schweder, MM | 1 |
| Larson, DG | 1 |
| Luckasen, GJ | 1 |
| Irwin, D | 1 |
| Hamilton, KL | 1 |
| Schroeder, T | 1 |
| Bell, C | 1 |
| Rocchini, AP | 2 |
| Yang, JQ | 1 |
| Gokee, A | 1 |
| Spritzer, PM | 1 |
| Comim, FV | 1 |
| Capp, E | 1 |
| D'Avila, A | 1 |
| Roos, M | 1 |
| Horio, F | 1 |
| Teradaira, S | 1 |
| Imamura, T | 1 |
| Anunciado, RV | 1 |
| Kobayashi, M | 1 |
| Namikawa, T | 1 |
| Niki, I | 1 |
| Mayer, MA | 1 |
| Höcht, C | 1 |
| Opezzo, JA | 1 |
| Taira, CA | 1 |
| Fernández, BE | 1 |
| Puyó, AM | 1 |
| Reynisdottir, S | 1 |
| Ellerfeldt, K | 1 |
| Wahrenberg, H | 1 |
| Lithell, H | 1 |
| Arner, P | 1 |
| Ernsberger, P | 1 |
| Friedman, JE | 1 |
| Koletsky, RJ | 1 |
| Mao, HZ | 1 |
| Babu, K | 1 |
| Marker, P | 1 |
| Rocchini, AJ | 1 |
| Almqvist, EG | 1 |
| Groop, LC | 1 |
| Manhem, PJ | 1 |
| Wajnrajch, MP | 1 |
| Gertner, JM | 1 |
| Huma, Z | 1 |
| Popovic, J | 1 |
| Lin, K | 1 |
| Verlander, PC | 1 |
| Batish, SD | 1 |
| Giampietro, PF | 1 |
| Davis, JG | 1 |
| New, MI | 1 |
| Auerbach, AD | 1 |
| Saperstein, R | 1 |
| Chapin, EW | 1 |
| Brady, EJ | 1 |
| Slater, EE | 1 |
| Hwang, IS | 1 |
| Ho, H | 1 |
| Hoffman, BB | 1 |
| Reaven, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for clonidine and Insulin Resistance
| Article | Year |
|---|---|
The I1-imidazoline receptor: from binding site to therapeutic target in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Binding Sites; Clonidine; Humans; Hypertension; Imidazoles; Imidaz | 1997 |
1 trial available for clonidine and Insulin Resistance
| Article | Year |
|---|---|
Sympathetic inhibition attenuates hypoxia induced insulin resistance in healthy adult humans.
Topics: Adult; Blood Glucose; Clonidine; Humans; Hypoxia; Insulin Resistance; Male; Sympathetic Nervous Syst | 2012 |
11 other studies available for clonidine and Insulin Resistance
| Article | Year |
|---|---|
Hypertension and insulin resistance are not directly related in obese dogs.
Topics: Adrenergic beta-Antagonists; Animals; Aspirin; Atenolol; Blood Glucose; Clonidine; Diet, Sodium-Rest | 2004 |
Influence of leptin, androgens and insulin sensitivity on increased GH response to clonidine in lean patients with polycystic ovary syndrome.
Topics: Adrenergic alpha-Agonists; Adult; Androgens; Body Mass Index; Clonidine; Dose-Response Relationship, | 2005 |
[With diabetes into the mountains. The metabolism derails faster].
Topics: Acclimatization; Antihypertensive Agents; Blood Glucose; Clonidine; Diabetes Mellitus; Heart Disease | 2005 |
The HND mouse, a nonobese model of type 2 diabetes mellitus with impaired insulin secretion.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Wild; Blood Glucose; Clonidine; Crosses, | 2005 |
High fructose diet increases anterior hypothalamic alpha 2-adrenoceptors responsiveness.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Diet; Fructose; Hypertension; Hypotha | 2007 |
Multiple lipolysis defects in the insulin resistance (metabolic) syndrome.
Topics: Adipose Tissue; Aged; Clonidine; Dose-Response Relationship, Drug; Humans; Insulin Resistance; Isopr | 1994 |
Clonidine prevents insulin resistance and hypertension in obese dogs.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Body Weight; Cardiac Output; Clonid | 1999 |
Growth hormone response to the insulin tolerance and clonidine tests in type 1 diabetes.
Topics: Adult; Case-Control Studies; Clonidine; Diabetes Mellitus, Type 1; Female; Growth Hormone; Humans; I | 1999 |
Evaluation of growth and hormonal status in patients referred to the International Fanconi Anemia Registry.
Topics: Adolescent; Adult; Anthropometry; Body Height; Child; Child, Preschool; Clonidine; Diabetes Mellitus | 2001 |
Effects of an alpha 2-adrenoceptor antagonist on glucose tolerance in the genetically obese mouse (C57BL/6J ob/ob).
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Clonidine; Diaphragm; Gl | 1990 |
Fructose-induced insulin resistance and hypertension in rats.
Topics: Animals; Blood Glucose; Clonidine; Fatty Acids, Nonesterified; Fructose; Hypertension; Insulin; Insu | 1987 |