Page last updated: 2024-08-23

mifepristone and Insulin Resistance

mifepristone has been researched along with Insulin Resistance in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.00)18.2507
2000's6 (30.00)29.6817
2010's9 (45.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Andrews, ZB; Cowley, MA; Dodd, GT; Eramo, M; Henry, BA; Mitchell, CA; Tiganis, T; Xirouchaki, CE1
Datta, K; Kumar, S; Saha, P; Tyagi, RK1
Grewal, S; Gubbi, S; McGlotten, R; Muniyappa, R; Nieman, LK; Sharma, ST1
Chadarevian, R; Debono, M; Eastell, R; Newell-Price, J; Ross, RJ1
Colleran, K; Gross, C; Molitch, ME; Purnell, JQ; Wallia, A1
Bae, JH; Cho, YS; Park, SY1
Hasan, AU; Hashimoto, T; Igarashi, J; Kohno, M; Kosaka, H; Nagai, Y; Ohmori, K; Yamashita, T1
Akiyama, N; Akiyama, Y; Asakura, K; Hanasaki, K; Imagawa, K; Kato, H; Kuroda, T; Murayama, T; Ono, T; Shinosaki, T1
Beaudry, JL; Belanoff, JK; Dunford, EC; Hunt, H; Riddell, MC; Teich, T; Zaharieva, D1
Beaudry, JL; Belanoff, JK; Dunford, EC; Hunt, H; Pivovarov, JA; Porras, DP; Riddell, MC; Teich, T1
Anuradha, CV; Priyadarshini, E1
Li, L; Messina, JL; Thompson, LH; Zhao, L1
Auwerx, J; Lydon, J; O'Malley, BW; Picard, F; Schoonjans, K; Wanatabe, M1
Ishizawa, M; Ishizuka, T; Kajita, K; Kawai, Y; Miura, A; Morita, H; Natsume, Y; Uno, Y; Yasuda, K1
Andrew, R; Homer, NZ; Karpe, F; Stimson, RH; Tan, GD; Wake, DJ; Walker, BR1
Cooney, GJ; Hara, T; Kusunoki, M; Storlien, LH1
Alam, T; Chen, L; McCorkle, K; McGarry, JD; Ogawa, A; Ohneda, M; Pieber, TR; Stein, DT; Unger, RH1
Ishizawa, M; Ishizuka, T; Itaya, S; Kajita, K; Kanoh, Y; Miura, A; Murase, H; Nagashima, T; Yamamoto, M; Yasuda, K1
Anil Kumar, KL; Marita, AR1
Bitar, MS1

Trials

3 trial(s) available for mifepristone and Insulin Resistance

ArticleYear
Mifepristone Improves Adipose Tissue Insulin Sensitivity in Insulin Resistant Individuals.
    The Journal of clinical endocrinology and metabolism, 2021, 04-23, Volume: 106, Issue:5

    Topics: Adipose Tissue; Adult; Aged; Cross-Over Studies; Double-Blind Method; Female; Glucose Intolerance; Humans; Insulin Resistance; Insulin Secretion; Male; Middle Aged; Mifepristone; Obesity; Overweight; Prediabetic State; United States

2021
Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol: a pilot study.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Adrenal Gland Neoplasms; Aged; Biomarkers, Tumor; Female; Humans; Hydrocortisone; Hypothalamus; Insulin Resistance; Male; Middle Aged; Mifepristone; Pilot Projects; Pituitary-Adrenal System; Safety

2013
Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1 in subcutaneous adipose tissue in men.
    The Journal of clinical endocrinology and metabolism, 2007, Volume: 92, Issue:5

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adult; Aged; Cortisone; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Fenofibrate; Gas Chromatography-Mass Spectrometry; Hormone Antagonists; Humans; Hydrocortisone; Hypolipidemic Agents; Insulin Resistance; Kinetics; Liver; Male; Metyrapone; Microdialysis; Middle Aged; Mifepristone; Obesity; PPAR alpha; PPAR gamma; Rosiglitazone; Subcutaneous Fat; Thiazolidinediones

2007

Other Studies

17 other study(ies) available for mifepristone and Insulin Resistance

ArticleYear
Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.
    Cell reports, 2019, Sep-10, Volume: 28, Issue:11

    Topics: Adipose Tissue, White; Administration, Intranasal; Animals; Blood-Brain Barrier; Cholestanes; Diet, High-Fat; Feeding Behavior; Gliosis; Glucocorticoids; Hypothalamus; Insulin Resistance; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mifepristone; Obesity; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 2; Spermine; Weight Loss

2019
Upsurge in autophagy, associated with mifepristone-treated polycystic ovarian condition, is reversed upon thymoquinone treatment.
    The Journal of steroid biochemistry and molecular biology, 2021, Volume: 208

    Topics: Androgens; Animals; Autophagy; Beclin-1; Benzoquinones; Disease Models, Animal; eIF-2 Kinase; Female; Gene Expression Regulation; Granulosa Cells; Humans; Insulin Resistance; Mifepristone; Ovary; Ovulation; Polycystic Ovary Syndrome; Rats; Receptors, Androgen

2021
Improvement in insulin sensitivity during mifepristone treatment of Cushing syndrome: early and late effects.
    Diabetes care, 2013, Volume: 36, Issue:9

    Topics: Cushing Syndrome; Glucose Tolerance Test; Hormone Antagonists; Humans; Insulin Resistance; Mifepristone

2013
Cortisone induces insulin resistance in C2C12 myotubes through activation of 11beta-hydroxysteroid dehydrogenase 1 and autocrinal regulation.
    Cell biochemistry and function, 2014, Volume: 32, Issue:3

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Autocrine Communication; Cell Line; Cortisone; Glucocorticoids; Glucose; Glycyrrhetinic Acid; Humans; Hydrocortisone; Insulin; Insulin Resistance; Mifepristone; Muscle Fibers, Skeletal; Receptors, Glucocorticoid

2014
Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: 3T3-L1 Cells; Adiponectin; Adipose Tissue; Animals; Cell Differentiation; Diet, High-Fat; Disease Models, Animal; Insulin Resistance; Male; Mice; Mifepristone; Obesity

2013
Pharmacological evaluation of adipose dysfunction via 11β-hydroxysteroid dehydrogenase type 1 in the development of diabetes in diet-induced obese mice with cortisone pellet implantation.
    The Journal of pharmacology and experimental therapeutics, 2014, Volume: 349, Issue:1

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adipose Tissue; Animals; Cortisone; Diabetes Mellitus, Experimental; Diet, High-Fat; Glucocorticoids; Glucose; Insulin Resistance; Mice; Mice, Inbred C57BL; Mifepristone; Obesity; Receptors, Glucocorticoid; Up-Regulation

2014
Effects of selective and non-selective glucocorticoid receptor II antagonists on rapid-onset diabetes in young rats.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Animals; Blood Glucose; Body Weight; Corticosterone; Diabetes Mellitus, Experimental; Diet, High-Fat; Hormone Antagonists; Insulin; Insulin Resistance; Male; Mifepristone; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Small Molecule Libraries

2014
Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction.
    American journal of physiology. Endocrinology and metabolism, 2016, 07-01, Volume: 311, Issue:1

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adiposity; Animals; Blood Glucose; Blotting, Western; Body Weight; Caloric Restriction; Gluconeogenesis; Glucose Intolerance; Glucose Tolerance Test; Glycogen; Glycogenolysis; Hormone Antagonists; Insulin; Insulin Resistance; Intra-Abdominal Fat; Lipolysis; Liver; Male; Mifepristone; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid

2016
Glucocorticoid Antagonism Reduces Insulin Resistance and Associated Lipid Abnormalities in High-Fructose-Fed Mice.
    Canadian journal of diabetes, 2017, Volume: 41, Issue:1

    Topics: Animals; Fatty Acids, Nonesterified; Fructose; Glucocorticoids; Insulin Resistance; Lipid Metabolism; Lipids; Male; Mice; Mifepristone; Receptors, Glucocorticoid; Triglycerides

2017
Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury.
    Endocrinology, 2009, Volume: 150, Issue:1

    Topics: Acute Disease; Animals; Corticosterone; Fatty Acids, Nonesterified; Hemorrhage; Hormone Antagonists; Insulin; Insulin Resistance; Liver; Male; Metyrapone; Mifepristone; Muscle, Skeletal; Phosphoserine; Rats; Rats, Sprague-Dawley; Signal Transduction; Wounds and Injuries

2009
Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Nov-26, Volume: 99, Issue:24

    Topics: Animals; Blood Glucose; Cell Count; Cell Division; Cell Size; Diabetes Mellitus, Experimental; Diabetes, Gestational; Female; Glucose; Glucose Tolerance Test; Homeostasis; Hormone Antagonists; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mifepristone; Organ Size; Pregnancy; Progesterone; Receptors, Progesterone; Sex Characteristics; Signal Transduction

2002
Inhibition of PKCbeta improves glucocorticoid-induced insulin resistance in rat adipocytes.
    IUBMB life, 2002, Volume: 54, Issue:6

    Topics: Adipocytes; Animals; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Dominant; Glucocorticoids; Hormone Antagonists; Insulin Resistance; Male; Mifepristone; Protein Kinase C; Protein Kinase C beta; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, Glucocorticoid; Time Factors; Transfection

2002
Amelioration of high-fat feeding-induced insulin resistance in skeletal muscle with the antiglucocorticoid RU486.
    Diabetes, 1995, Volume: 44, Issue:6

    Topics: Animals; Blood Glucose; Dietary Fats; Glucose; Glucose Clamp Technique; Insulin; Insulin Resistance; Male; Mifepristone; Muscle, Skeletal; Rats; Rats, Wistar

1995
Amylin-insulin relationships in insulin resistance with and without diabetic hyperglycemia.
    The American journal of physiology, 1993, Volume: 265, Issue:3 Pt 1

    Topics: Amyloid; Animals; Dexamethasone; Diabetes Mellitus, Type 2; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Islet Amyloid Polypeptide; Male; Mifepristone; Obesity; Pancreas; Rats; Rats, Wistar; Rats, Zucker; Receptors, Glucocorticoid; RNA, Messenger; Somatostatin

1993
Effect of glucocorticoid receptor antagonist RU 38486 on acute glucocorticoid-induced insulin resistance in rat adipocytes.
    Metabolism: clinical and experimental, 1997, Volume: 46, Issue:9

    Topics: Adipocytes; Animals; Biological Transport; Brain; Deoxyglucose; Dexamethasone; Glucocorticoids; Hormone Antagonists; Insulin; Insulin Resistance; Isoenzymes; Male; Mifepristone; Muscle Proteins; Muscle, Skeletal; Prednisolone; Protein Kinase C; Rats; Rats, Wistar; Receptors, Glucocorticoid; Time Factors

1997
Troglitazone prevents and reverses dexamethasone induced insulin resistance on glycogen synthesis in 3T3 adipocytes.
    British journal of pharmacology, 2000, Volume: 130, Issue:2

    Topics: 3T3 Cells; Abortifacient Agents, Steroidal; Adipocytes; Animals; Binding Sites; Chromans; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Glucocorticoids; Glycogen; Hypoglycemic Agents; Insulin; Insulin Resistance; Iodine Radioisotopes; Mice; Mifepristone; Thiazoles; Thiazolidinediones; Troglitazone

2000
Co-administration of etomoxir and RU-486 mitigates insulin resistance in hepatic and muscular tissues of STZ-induced diabetic rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2001, Volume: 33, Issue:10

    Topics: Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Enzyme Inhibitors; Epoxy Compounds; Fatty Acids, Nonesterified; Glucose; Hormone Antagonists; Insulin Resistance; Liver; Male; Mifepristone; Mitochondria; Muscle, Skeletal; Rats; Rats, Wistar

2001