Page last updated: 2024-11-12

pancreastatin

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Description

pancreastatin: A 49 residue post-translational fragment of chromogranin A that inhibits insulin secretion; amino acid sequence given in first source; the 49-amino acid peptide is from pig; human pancreastatin has 52 amino acids (hCgA 250-310) ; see also record for human pancreastatin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID16132402
MeSH IDM0144953

Synonyms (5)

Synonym
106477-83-2
pancreastatin, pig
pancreastatin (pig)
pancreastatin
DTXSID80147609

Research Excerpts

Overview

Pancreastatin (PST) is a crucial bioactive peptide derived from chromogranin A (CHGA) proprotein that exhibits an anti-insulin effect on adipocytes. Pancreastsatin is a 49 amino acid peptide with a C-terminal glycine amide originally isolated from porcine pancreas.

ExcerptReferenceRelevance
"Pancreastatin (PST) is an endogenous bioactive peptide. "( Pancreastatin inhibitor PSTi8 balances energy homeostasis by attenuating adipose tissue inflammation in high fat diet fed mice.
Dadge, S; Garg, R; Gayen, JR; Goand, UK; Gupta, AP; Verma, S, 2023
)
3.8
"Pancreastatin (PST) is a crucial bioactive peptide derived from chromogranin A (CHGA) proprotein that exhibits an anti-insulin effect on adipocytes. "( Pancreastatin mediated regulation of UCP-1 and energy expenditure in high fructose fed perimenopausal rats.
Gayen, JR; Husain, A; Katekar, R; Reza, MI; Singh, P; Syed, AA, 2021
)
3.51
"Pancreastatin (PST) is an endogenous peptide which regulates glucose and lipid metabolism in liver and adipose tissues. "( Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus.
Chandra, S; Gayen, JR; Gupta, AP; Hossain, Z; Riyazuddin, M; Siddiqi, MI; Syed, AA; Valicherla, GR, 2018
)
2.29
"Pancreastatin is a derived peptide of chromogranin A (CgA). "( Serum pancreastatin: the next predictive neuroendocrine tumor marker.
Divino, CM; Rustagi, S; Warner, RR, 2013
)
2.31
"Pancreastatin (PST) is a regulatory peptide containing 49 amino acids, first isolated from porcine pancreas. "( Pancreastatin is an endogenous peptide that regulates glucose homeostasis.
Gayen, JR; Hossain, Z; Mahata, SK; Valicherla, GR, 2013
)
3.28
"Pancreastatin is a fragment of the chromogranin A (CgA) molecule. "( Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior.
Boudreaux, JP; Gandolfi, AE; Go, VL; Halfdanarson, T; Howe, JR; Joseph, S; Krutzik, SR; Lindholm, E; Mamikunian, G; O'Dorisio, MS; O'Dorisio, TM; Vinik, AI; Wang, YZ; Woltering, EA, 2010
)
2.04
"Pancreastatin is a 49 amino acid peptide with a C-terminal glycine amide originally isolated from porcine pancreas. "( Secretion of pancreastatins from isolated, perfused, porcine adrenal glands.
Fahrenkrug, J; Holst, JJ; Jensen, TD, 1994
)
2.1
"Pancreastatin is a carboxyl-terminal amidated peptide derived from chromogranin A (CgA) corresponding to porcine CgA residues 240-288 (CgA240-288). "( Pancreastatin, a chromogranin A-derived peptide, inhibits transcription of the parathyroid hormone and chromogranin A genes and decreases the stability of the respective messenger ribonucleic acids in parathyroid cells in culture.
Cohn, DV; Darling, DS; Fasciotto, BH; Zhang, JX, 1994
)
3.17
"Pancreastatin is a novel peptide, isolated from porcine pancreatic extracts, that is known to be derived from chromogranin A. "( Pancreastatin decreases plasma epinephrine levels in surgical stress in the rat.
Goberna, R; Sánchez-Margalet, V,
)
3.02
"Pancreastatin is a 49 amino acid peptide first isolated, purified and characterized from the porcine pancreas, and whose biological activity in different tissues can be assigned to the C-terminal part of the molecule. "( Pancreastatin: further evidence for its consideration as a regulatory peptide.
Goberna, R; Lucas, M; Sánchez-Margalet, V, 1996
)
3.18
"Pancreastatin is a 49 amino acid peptide first isolated, purified and characterized from porcine pancreas. "( Pancreastatin action in the liver: dual coupling to different G proteins.
Goberna, R; Lucas, M; Sánchez-Margalet, V, 1996
)
3.18
"Pancreastatin is a regulatory peptide known to inhibit insulin secretion and insulin action with a glycogenolytic effect in the liver. "( Normal pancreastatin-like and increased post-glucose insulin levels in young offspring of insulin-resistant non-obese essential hypertensive patients.
Goberna, R; Mateo, J; Oliván, J; Pérez-Cano, R; Ramos, E; Sánchez-Margalet, V, 1997
)
2.19
"Pancreastatin (PST) is an inhibitor of pancreatic exocrine secretion in vivo but not in vitro, which suggests that the inhibitory effect of PST is indirect, that is, not mediated by a specific receptor on pancreatic acinar cells. "( Effect of pancreastatin on cerulein-stimulated pancreatic blood flow and exocrine secretion in anaesthetized rats.
Goto, M; Ito, T; Migita, Y; Nakano, I; Nawata, H, 1999
)
2.15
"Pancreastatin is an amidated, biologically active peptide whose sequence is contained within CgA."( Pancreastatin and bovine parathyroid cell secretion.
Drees, BM; Hamilton, JW, 1992
)
2.45
"Pancreastatin is a 49 amino acid peptide with a C-terminal glycine amide originally isolated from porcine pancreas. "( Immunocytochemical localisation of pancreastatin and chromogranin A in porcine neuroendocrine tissues.
Fahrenkrug, J; Jensen, TB; Sundler, F, 1991
)
2
"Pancreastatin is a 49 amino acid peptide with a C-terminal glycine amide originally isolated from porcine pancreas. "( Characterization of immunoreactive pancreastatin in porcine tissues.
Børglum Jensen, TD; Fahrenkrug, J; Holst, JJ, 1991
)
2
"Pancreastatin is a 49 amino acid peptide originally isolated from porcine pancreas on the basis of its C-terminal glycinamide as isolation criterion. "( Pancreastatin--a novel regulatory peptide?
Creutzfeldt, W; Schmidt, WE, 1991
)
3.17
"Pancreastatin is a 49 amino acid peptide that occurs in pancreatic endocrine cells. "( Pancreastatin inhibits insulin secretion and exocrine pancreatic secretion in the pig.
Ahrén, B; Karlsson, B; Pierzynowski, SG; Weström, B, 1990
)
3.16
"Pancreastatin is a 49 amino acid comprising peptide isolated from porcine pancreas that is derived by proteolytic processing from chromogranin A. "( Light and electron microscopical immunocytochemical localization of pancreastatin-like immunoreactivity in porcine tissues.
Creutzfeldt, W; Lamberts, R; Schmidt, WE, 1990
)
1.96
"Pancreastatin is a novel 49-amino acid peptide with a C-terminal glycine amide. "( Glycogenolytic effect of pancreastatin in the rat.
Calvo, JR; Goberna, R; Sanchez, V, 1990
)
2.03
"Pancreastatin is a recently isolated pancreatic peptide which has been shown to be a potent inhibitor of insulin release in a perfused rat pancreas assay (1). "( Characterization and regulation of a cDNA clone for rat pancreastatin.
Abood, ME; Eberwine, JH, 1990
)
1.97
"Pancreastatin is a potent inhibitor of parathyroid gland secretion, and it and chromogranin-A inhibit glucose-stimulated insulin release by the pancreas."( Autocrine regulation of parathyroid secretion: inhibition of secretion by chromogranin-A (secretory protein-I) and potentiation of secretion by chromogranin-A and pancreastatin antibodies.
Bourdeau, AM; Cohn, DV; Fasciotto, BH; Gorr, SU, 1990
)
1.2
"Pancreastatin is a novel peptide that was recently purified from extracts of the porcine pancreas. "( Effect of pancreastatin on pancreatic endocrine and exocrine secretion.
Asada, I; Greeley, GH; Ishizuka, J; Lluis, F; Poston, GJ; Tatemoto, K; Thompson, JC, 1989
)
2.12
"Pancreastatin is a 49-amino acid straight chain molecule isolated from porcine pancreatic extracts. "( Pancreastatin inhibits insulin secretion as induced by glucagon, vasoactive intestinal peptide, gastric inhibitory peptide, and 8-cholecystokinin in the perfused rat pancreas.
Marco, J; Miralles, P; Peiró, E; Silvestre, RA; Villanueva, ML, 1989
)
3.16
"Pancreastatin is a novel peptide, isolated from porcine pancreatic extracts, which has been shown to inhibit glucose-induced insulin release "in vitro". "( Effects of pancreastatin on insulin, glucagon and somatostatin secretion by the perfused rat pancreas.
Marco, J; Miralles, P; Peiró, E; Silvestre, RA; Villanueva, ML, 1988
)
2.11
"Pancreastatin is a peptide isolated from the porcine pancreas and shown to inhibit insulin release. "( Localization of pancreastatin immunoreactivity in porcine endocrine cells.
Efendic, S; Hutton, JC; Orci, L; Ostenson, CG; Ravazzola, M; Tatemoto, K, 1988
)
2.06
"Pancreastatin is a recently identified 49-amino-acid peptide found in gastrointestinal tract and gastric mucosa. "( Pancreastatin: a novel peptide inhibitor of parietal cell secretion.
Adrian, TE; Lewis, JJ; Modlin, IM; Zdon, MJ, 1988
)
3.16
"Pancreastatin is a peptide isolated from porcine pancreas which has insulin-suppressive actions in vitro and sequence homology with chromogranin A. "( Pancreastatin distribution and plasma levels in the pig.
Bishop, AE; Bretherton-Watt, D; Facer, P; Fahey, M; Ghatei, MA; Hedges, M; Roth, K; Tatemoto, K; Valentino, KL; Williams, G,
)
3.02

Effects

Pancreastatin has a prohormonal precursor, chromogranin A (CGA), which is a glycoprotein present in neuroendocrine cells, including the endocrine pancreas.

ExcerptReferenceRelevance
"Pancreastatin has a prohormonal precursor, chromogranin A (CGA), which is a glycoprotein present in neuroendocrine cells, including the endocrine pancreas."( Pancreastatin: further evidence for its consideration as a regulatory peptide.
Goberna, R; Lucas, M; Sánchez-Margalet, V, 1996
)
2.46
"Pancreastatin has a prohormonal precursor, chromogranin A, which is a glycoprotein present in neuroendocrine cells, including the endocrine pancreas."( Pancreastatin action in the liver: dual coupling to different G proteins.
Goberna, R; Lucas, M; Sánchez-Margalet, V, 1996
)
2.46
"Pancreastatin has been found to be a potent inhibitor of glucose-stimulated insulin release."( Pancreastatin, a presumed product of chromogranin-A (secretory protein-I) processing, inhibits secretion from porcine parathyroid cells in culture.
Cohn, DV; DeFranco, DJ; Fasciotto, BH; Gorr, SU; Levine, MA, 1989
)
2.44

Actions

Pancreastatin plays important physiological role in potentiating the metabolic effects of catecholamines. It may also play a pathophysiological role in insulin resistance states with increased sympathetic activity.

ExcerptReferenceRelevance
"Pancreastatin plays important physiological role in potentiating the metabolic effects of catecholamines, and may also play a pathophysiological role in insulin resistance states with increased sympathetic activity."( Metabolic effects and mechanism of action of the chromogranin A-derived peptide pancreastatin.
González-Yanes, C; Najib, S; Sánchez-Margalet, V; Santos-Alvarez, J, 2010
)
1.31
"Pancreastatin can still produce a stimulatory effect when added 18 h after incubation of cultures with concanavalin A and apparently uses a diacylglycerol independent mechanism."( Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49).
Banfic, H; De Clerck, LS; De Potter, W; Haberstock-Debic, H; Stevens, WJ; Wechsung, E,
)
1.12
"pancreastatin did inhibit the i.v."( Effects of pancreastatin on insulin and pancreatic polypeptide secretion in the dog.
Baba, S; Inoue, T; Inui, A; Morioka, H; Oimomi, M; Okita, M; Oya, M; Sakatani, N; Tatemoto, K, 1989
)
1.39
"Pancreastatin did not increase glucose in vivo."( Effects of systemic pancreastatin on memory retention.
Flood, JF; Morley, JE; Tatemoto, K,
)
1.18

Pharmacokinetics

ExcerptReferenceRelevance
" This study investigates the pharmacokinetic (PK) properties of PSTi8 in Sprague Dawley rats, for the first time."( Evaluation of the Pharmacokinetics of the Pancreastatin Inhibitor PSTi8 Peptide in Rats: Integration of In Vitro and In Vivo Findings.
Dadge, S; Gayen, JR; Husain, A; Katekar, RA; Riyazuddin, M; Singh, SK; Syed, AA; Valicherla, GR; Wahajuddin, M, 2022
)
0.99

Bioavailability

ExcerptReferenceRelevance
" The bioavailability of PSTi8 after intraperitoneal and subcutaneous administration was found to be 95."( Evaluation of the Pharmacokinetics of the Pancreastatin Inhibitor PSTi8 Peptide in Rats: Integration of In Vitro and In Vivo Findings.
Dadge, S; Gayen, JR; Husain, A; Katekar, RA; Riyazuddin, M; Singh, SK; Syed, AA; Valicherla, GR; Wahajuddin, M, 2022
)
0.99

Dosage Studied

ExcerptRelevanceReference
" It produced a rightward shift of the gastrin dose-response curve, consistent with competitive inhibition."( Evaluation of three novel cholecystokinin-B/gastrin receptor antagonists: a study of their effects on rat stomach enterochromaffin-like cell activity.
Ding, XQ; Håkanson, R; Lindström, E, 1997
)
0.3
" These effects were observed in a wide range of insulin concentrations, leading to a shift to the right in the dose-response curve."( Pancreastatin inhibits insulin action in rat adipocytes.
González-Yanes, C; Sánchez-Margalet, V, 1998
)
1.74
" Gastrin dose-response curves were constructed in the absence or presence of increasing concentrations of antagonist."( Pharmacological analysis of CCK2 receptor antagonists using isolated rat stomach ECL cells.
Björkqvist, M; Håkanson, R; Lindström, E, 1999
)
0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (267)

TimeframeStudies, This Drug (%)All Drugs %
pre-199043 (16.10)18.7374
1990's143 (53.56)18.2507
2000's41 (15.36)29.6817
2010's25 (9.36)24.3611
2020's15 (5.62)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.17 (24.57)
Research Supply Index5.64 (2.92)
Research Growth Index4.87 (4.65)
Search Engine Demand Index45.70 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (1.44%)5.53%
Reviews27 (9.75%)6.00%
Case Studies3 (1.08%)4.05%
Observational0 (0.00%)0.25%
Other243 (87.73%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]