clozapine-n-oxide and Insulin-Resistance

clozapine-n-oxide has been researched along with Insulin-Resistance* in 1 studies

Other Studies

1 other study(ies) available for clozapine-n-oxide and Insulin-Resistance

ArticleYear
Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues.
    Diabetes, 2017, Volume: 66, Issue:9

    The ventromedial hypothalamus (VMH) regulates glucose and energy metabolism in mammals. Optogenetic stimulation of VMH neurons that express steroidogenic factor 1 (SF1) induces hyperglycemia. However, leptin acting via the VMH stimulates whole-body glucose utilization and insulin sensitivity in some peripheral tissues, and this effect of leptin appears to be mediated by SF1 neurons. We examined the effects of activation of SF1 neurons with DREADD (designer receptors exclusively activated by designer drugs) technology. Activation of SF1 neurons by an intraperitoneal injection of clozapine-

    Topics: Animals; Clozapine; Insulin; Insulin Resistance; Integrases; Mice; Mice, Transgenic; Neurons; RNA Splicing Factors; Ventromedial Hypothalamic Nucleus

2017