Compounds > methacycline
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methacycline and Insulin Resistance

methacycline has been researched along with Insulin Resistance in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.00)18.2507
2000's0 (0.00)29.6817
2010's17 (68.00)24.3611
2020's7 (28.00)2.80

Authors

AuthorsStudies
Bikopoulos, G; Ceddia, RB; Da Eira, D; de Pinho, RA; Hadday, I; Jani, S; Mohasses, A1
Ikeda, SI; Kaga, N; Kakehi, S; Kawamori, R; Kubota, A; Sakuraba, K; Shiuchi, T; Taka, H; Tamura, Y; Ueno, N; Watada, H1
Li, P; Liu, HL; Liu, RZ; Liu, WP; Shi, MY; Xu, YY; Yang, H; Zhang, C; Zhang, XY; Zhang, Y; Zhang, YP; Zheng, ZG1
Barac, M; Bogdanović Radović, I; Hadžija, M; Popović Hadžija, M; Siketić, Z1
Bhanot, S; Blume, N; Bogan, JS; Cline, GW; Gaspar, RC; Hirabara, SM; Kahn, M; Lee, S; Luukkonen, PK; Lyu, K; Rasch, MG; Rinehart, J; Rodrigues, MRS; Samuel, VT; Serlie, MJ; Shulman, GI; Ter Horst, KW; Zhang, D; Zhang, Y1
Bergman, BC; Harrison, K; Kahn, D; Kerege, A; Macias, E; Newsom, SA; Perreault, L; Snell-Bergeon, J; Strauss, A; Zarini, S1
Li, X; Lyu, K; Perry, RJ; Samuel, VT; Shulman, GI; Song, J; Zhang, D1
Benziane, B; Björnholm, M; Borg, ML; Chibalin, AV; Gilbert, M; Massart, J; Riedl, I; Tom, RZ; Zierath, JR1
Bergman, BC; D'Alessandro, A; Harrison, KA; Jackman, MR; Kahn, DE; Kerege, A; MacLean, PS; Nemkov, T; Newsom, SA; Perreault, L; Snell-Bergeon, JK; Strauss, A1
Baranowski, M; Dela, F; Greve Dideriksen, S; Larsen, S; Munk Scheuer, C; Søgaard, D; Taulo Lund, M; Vestergaard Abildskov, C; Wulff Helge, J1
Bonen, A; Chabowski, A; Han, XX; Holloway, GP; Jain, SS1
Perry, RJ; Petersen, KF; Samuel, VT; Shulman, GI1
Fayyaz, S; Japtok, L; Kleuser, B1
Bruce, CR; Burch, ML; Febbraio, MA; Frank, M; Genders, AJ; Jackowski, S; Kowalski, GM; Lamon, S; Lee-Young, RS; McGee, SL; Meikle, PJ; Risis, S; Russell, AP; Selathurai, A; Sepulveda, P; Watt, MJ1
Abudukadier, A; Akgul, EO; Bhanot, S; Guigni, B; Jornayvaz, FR; Jurczak, MJ; Kanda, S; Majumdar, SK; Manchem, VP; Petersen, KF; Popov, VB; Samuel, VT; Shulman, GI; Zhang, D1
Alsted, TJ; Holm, C; Jordy, AB; Kiens, B; Schjerling, P; Serup, AK1
Correia, JC; Hunerdosse, DM; Louie, SM; Massart, J; Näslund, E; Nomura, DK; Ruas, JL; Ruby, MA; Schönke, M; Zierath, JR1
Choi, CS; Christianson, J; Dong, J; Liu, ZX; Neschen, S; Shulman, GI; Tian, L; Wood, PA; Zhang, D1
Boon, W; De Vogel-van den Bosch, J; Hesselink, MK; Hoeks, J; Houten, SM; Kersten, S; Schaart, G; Schrauwen, P; Timmers, S; Van Beurden, D; van Dijk, PJ; Voshol, PJ; Wanders, RJ1
Hajduch, E; Turban, S1
Aerts, JM; De Baets, MH; de Vogel-van den Bosch, J; Ferraz, MJ; Hesselink, MK; Losen, M; Martinez-Martinez, P; Schaart, G; Schrauwen, P; Timmers, S; van Beurden, D1
Amati, F; Coen, P; Dubé, JJ; Goodpaster, BH; Rossi, A; Stefanovic-Racic, M; Toledo, FG1
Belury, MA; Liu, LF; Stout, MB1
Jornayvaz, FR; Shulman, GI1
Baldo, G; Basso, D; Brigato, L; Ceolotto, G; Plebani, M; Tiengo, A; Valerio, A1

Reviews

4 review(s) available for methacycline and Insulin Resistance

ArticleYear
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes.
    Nature, 2014, Jun-05, Volume: 510, Issue:7503

    Topics: Animals; Diabetes Mellitus, Type 2; Diglycerides; Fatty Liver; Humans; Hyperglycemia; Insulin Resistance; Lipid Metabolism; Lipids; Lipodystrophy; Lipogenesis; Liver; Muscle, Skeletal; Non-alcoholic Fatty Liver Disease; Triglycerides

2014
Divergent role of sphingosine 1-phosphate on insulin resistance.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2014, Volume: 34, Issue:1

    Topics: Ceramides; Diabetes Mellitus, Type 2; Diglycerides; Fatty Acids, Nonesterified; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Lysophospholipids; Muscle, Skeletal; Signal Transduction; Sphingosine

2014
Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance.
    FEBS letters, 2011, Jan-21, Volume: 585, Issue:2

    Topics: Ceramides; Diglycerides; Humans; Insulin Resistance; Lipid Metabolism; Protein Isoforms; Protein Kinase C

2011
Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance.
    Cell metabolism, 2012, May-02, Volume: 15, Issue:5

    Topics: Animals; Diabetes Mellitus, Type 2; Diglycerides; Fatty Liver; Humans; Insulin Resistance; Liver; Mice; Non-alcoholic Fatty Liver Disease; Protein Kinase C-epsilon

2012

Trials

2 trial(s) available for methacycline and Insulin Resistance

ArticleYear
Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle.
    JCI insight, 2018, 02-08, Volume: 3, Issue:3

    Topics: Adult; Biopsy; Blood Glucose; Cross-Sectional Studies; Cytosol; Diabetes Mellitus, Type 2; Diglycerides; Endoplasmic Reticulum; Female; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Insulin Resistance; Male; Middle Aged; Mitochondria; Muscle, Skeletal; Obesity; Sarcolemma; Sphingolipids

2018
Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide.
    Diabetologia, 2011, Volume: 54, Issue:5

    Topics: Aged; Body Composition; Ceramides; Diet, Reducing; Diglycerides; Exercise; Female; Humans; Insulin Resistance; Male; Middle Aged; Muscle, Skeletal; Triglycerides; Weight Loss

2011

Other Studies

19 other study(ies) available for methacycline and Insulin Resistance

ArticleYear
Distinct mechanisms involving diacylglycerol, ceramides, and inflammation underlie insulin resistance in oxidative and glycolytic muscles from high fat-fed rats.
    Scientific reports, 2021, 09-27, Volume: 11, Issue:1

    Topics: Animals; Ceramides; Diet, High-Fat; Dietary Sucrose; Diglycerides; Disease Models, Animal; Glycolysis; Humans; Inflammation; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Obesity; Oxidative Stress; Rats

2021
Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation.
    American journal of physiology. Endocrinology and metabolism, 2021, 12-01, Volume: 321, Issue:6

    Topics: Adult; Animals; Casts, Surgical; Diglycerides; Hindlimb Suspension; Humans; Insulin; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Phosphatidate Phosphatase; Sedentary Behavior; Signal Transduction; Time Factors; Young Adult

2021
Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis.
    Cell metabolism, 2023, 01-03, Volume: 35, Issue:1

    Topics: Diabetes Mellitus, Type 2; Diglycerides; Humans; Insulin Resistance; Obesity; Protein Kinase C-epsilon

2023
Study of the diacylglycerol composition in the liver and serum of mice with prediabetes and diabetes using MeV TOF-SIMS.
    Diabetes research and clinical practice, 2020, Volume: 159

    Topics: Animals; Blood Chemical Analysis; Diabetes Mellitus, Experimental; Diglycerides; Fatty Acids; Female; Insulin Resistance; Lipid Metabolism; Lipids; Liver; Male; Mice; Mice, Inbred NOD; Prediabetic State; Spectrometry, Mass, Secondary Ion

2020
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance.
    Cell metabolism, 2020, 10-06, Volume: 32, Issue:4

    Topics: Animals; Cell Membrane; Diglycerides; Humans; Insulin Resistance; Liver; Male; Phosphorylation; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptor, Insulin

2020
Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans.
    Diabetologia, 2021, Volume: 64, Issue:1

    Topics: Adult; Athletes; Cell Nucleus; Cytosol; Diabetes Mellitus, Type 2; Dietary Fats; Diglycerides; Endoplasmic Reticulum; Female; Humans; Insulin Resistance; Male; Middle Aged; Mitochondria, Muscle; Muscle, Skeletal; Obesity; Physical Endurance; Sarcolemma; Triglycerides

2021
Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation.
    JCI insight, 2021, 02-22, Volume: 6, Issue:4

    Topics: Adipose Tissue, White; Animals; Antigens, CD; Diet, High-Fat; Dietary Fats; Diglycerides; Glucose; Humans; Insulin; Insulin Resistance; Lipolysis; Liver; Male; Mice; Overnutrition; Phosphorylation; Protein Kinase C-epsilon; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction

2021
DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism.
    Journal of lipid research, 2017, Volume: 58, Issue:12

    Topics: Animals; Biological Transport; Diacylglycerol Kinase; Diet, High-Fat; Diglycerides; Energy Metabolism; Gene Expression; Glucose; Homeostasis; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Knockout; Muscle, Skeletal; Obesity

2017
Muscle-Saturated Bioactive Lipids Are Increased with Aging and Influenced by High-Intensity Interval Training.
    International journal of molecular sciences, 2019, Mar-12, Volume: 20, Issue:5

    Topics: Adult; Aging; Blood Glucose; Ceramides; Diglycerides; Exercise; Fatty Acids; Female; Glucose; High-Intensity Interval Training; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Lipids; Male; Middle Aged; Muscle, Skeletal; Obesity; Overweight

2019
Chronic muscle stimulation improves insulin sensitivity while increasing subcellular lipid droplets and reducing selected diacylglycerol and ceramide species in obese Zucker rats.
    Diabetologia, 2014, Volume: 57, Issue:4

    Topics: Animals; Ceramides; Diglycerides; Female; Insulin; Insulin Resistance; Muscle Contraction; Muscle, Skeletal; Obesity; Rats; Rats, Zucker; Triglycerides

2014
The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity.
    Cell metabolism, 2015, May-05, Volume: 21, Issue:5

    Topics: Animals; Cytidine Diphosphate; Diglycerides; Ethanolamines; Glucose; Insulin Resistance; Lipid Metabolism; Mice; Mice, Knockout; Muscle, Skeletal; Obesity; Organelle Biogenesis; RNA Nucleotidyltransferases

2015
Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016, Volume: 30, Issue:3

    Topics: Adipose Tissue, White; Animals; beta Catenin; Dietary Fats; Diglycerides; Fatty Acids; Fatty Liver; Glucose; Insulin; Insulin Resistance; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Oligonucleotides, Antisense; Protective Agents; Triglycerides

2016
Partial Disruption of Lipolysis Increases Postexercise Insulin Sensitivity in Skeletal Muscle Despite Accumulation of DAG.
    Diabetes, 2016, Volume: 65, Issue:10

    Topics: Animals; Biological Transport; Diglycerides; Glucose; Insulin; Insulin Resistance; Lipolysis; Mice; Mice, Knockout; Muscle, Skeletal; Physical Conditioning, Animal; Sterol Esterase

2016
Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.
    Cell reports, 2017, 01-17, Volume: 18, Issue:3

    Topics: Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Cells, Cultured; Diet, High-Fat; Diglycerides; Endoplasmic Reticulum Stress; Genetic Vectors; Glucose; Glucose Intolerance; Hepatocytes; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Obesity; TOR Serine-Threonine Kinases

2017
Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency.
    Cell metabolism, 2010, May-05, Volume: 11, Issue:5

    Topics: Acyl-CoA Dehydrogenase, Long-Chain; AMP-Activated Protein Kinase Kinases; Animals; Dietary Fats; Diglycerides; Humans; Insulin; Insulin Resistance; Isoenzymes; Liver; Male; Mice; Mice, Knockout; Mitochondria; Obesity; PPAR alpha; Protein Kinase C; Protein Kinase C-epsilon; Protein Kinase C-theta; Protein Kinases

2010
The effects of long- or medium-chain fat diets on glucose tolerance and myocellular content of lipid intermediates in rats.
    Obesity (Silver Spring, Md.), 2011, Volume: 19, Issue:4

    Topics: Analysis of Variance; Animals; Blood Glucose; Blotting, Western; Body Weight; Carnitine; Dietary Fats; Diglycerides; Energy Metabolism; Fatty Acids; Glucose Intolerance; Glucose Tolerance Test; Insulin; Insulin Resistance; Lipid Peroxidation; Male; Muscle, Skeletal; Rats; Rats, Wistar; Triglycerides

2011
Paradoxical increase in TAG and DAG content parallel the insulin sensitizing effect of unilateral DGAT1 overexpression in rat skeletal muscle.
    PloS one, 2011, Jan-14, Volume: 6, Issue:1

    Topics: Animals; Diacylglycerol O-Acyltransferase; Diglycerides; Electroporation; Gene Expression; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Rats; Triglycerides

2011
Hepatic steatosis by dietary-conjugated linoleic acid is accompanied by accumulation of diacylglycerol and increased membrane-associated protein kinase C ε in mice.
    Molecular nutrition & food research, 2011, Volume: 55, Issue:7

    Topics: Animals; Diet; Diglycerides; Fatty Liver; Glucose; Glucose-6-Phosphatase; Hyperglycemia; Insulin Resistance; Linoleic Acids, Conjugated; Liver; Male; Mice; Mice, Inbred C57BL; Phosphoenolpyruvate Carboxykinase (ATP); Protein Kinase C-epsilon; Triglycerides

2011
Glucose metabolic alterations in isolated and perfused rat hepatocytes induced by pancreatic cancer conditioned medium: a low molecular weight factor possibly involved.
    Biochemical and biophysical research communications, 1999, Apr-13, Volume: 257, Issue:2

    Topics: Animals; Biological Factors; Cell Membrane; Cells, Cultured; Culture Media, Conditioned; Cytosol; Diglycerides; Epidermal Growth Factor; Glucose; Humans; Insulin Resistance; Interleukins; Lactic Acid; Liver; Male; Molecular Weight; Pancreatic Neoplasms; Perfusion; Protein Kinase C; Rats; Rats, Wistar; Transforming Growth Factor beta; Tumor Cells, Cultured

1999