antroquinonol d profile

antroquinonol: isolated from Antrodia camphorata [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

antroquinonol : An enone that is cyclohex-2-en-1-one substituted by a hydroxy group at position 4, methoxy groups at positions 2 and 3, a methyl group at position 6 and a (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl group at position 5 (the 4R,5R,6R stereoisomer). It is isolated from the solid-state fermented mycelium of the fungus Antrodia camphorata and has been found to exhibit potent cytotoxicity against a number of human cancer cell lines. However, a synthesis-enabled biological re-examination published in 2016, revealed minimal in vitro and in vivo antitumour activity in preclinical models. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	24875259
CHEMBL ID	3235620
CHEBI ID	65415
SCHEMBL ID	16919581
MeSH ID	M000607680

Synonym
antroquinonol
(+)-antroquinonol a
antroquinonol d
antroquinonol a
(4r,5r,6r)-4-hydroxy-2,3-dimethoxy-6-methyl-5-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]cyclohex-2-en-1-one
CHEBI:65415 ,
j3.387.174k
hocena
CHEMBL3235620
(4r)-2,3-dimethoxy-4.alpha.-hydroxy-5.alpha.-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienyl)-6.beta.-methyl-2-cyclohexene-1-one
antroquinonol [who-dd]
2-cyclohexen-1-one, 4-hydroxy-2,3-dimethoxy-6-methyl-5-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl)-, (4r,5r,6r)-
AX9P92T7JZ ,
(+)-antroquinonol
1010081-09-0
unii-ax9p92t7jz
(4r)-2,3-dimethoxy-4alpha-hydroxy-5alpha-((2e,6e)-3,7,11-trimethyl-2,6,10-dodecatrienyl)-6beta-methyl-2-cyclohexene-1-one
SCHEMBL16919581
LJTSIMVOOOLKOL-FNRDIUJOSA-N
DB12326
Q27133859
(4r,5r,6r)-4-hydroxy-2,3-dimethoxy-6-methyl-5-((2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)cyclohex-2-enone
(4r,5r,6r)-4-hydroxy-2,3-dimethoxy-6-methyl-5-((2e,6e)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)cyclohex-2-en-1-one
(4r,5r,6r)-4-hydroxy-2,3-dimethoxy-6-methyl-5-[(2e,6e)-3,7,11-trimethyldodeca-2,6,10-trienyl]cyclohex-2-en-1-one
CS-0016956
HY-19893
AKOS040750532

Role	Description
antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.
fungal metabolite	Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
enone	An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
secondary alcohol	A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
enol ether	Ethers ROR' where R has a double bond adjacent to the oxygen of the ether linkage.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Protein farnesyltransferase subunit beta	Rattus norvegicus (Norway rat)	IC50 (µMol)	2.9860	0.0019	0.6507	2.9860	AID1415844
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Rattus norvegicus (Norway rat)	IC50 (µMol)	2.9860	0.0019	0.5451	2.9860	AID1415844
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID1129217	Drug excretion in Wistar rat urine assessed as (E)-6-((1R,2R,6R)-2-Hydroxy-3,4-dimethoxy-6-methyl-5-oxocyclo-hex-3-enyl)-4-methylhex-4-enoic acid level at 200 mg/kg, po administered via gavage measured after 24 hrs by HPLC-SPE-TT-NMR analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Metabolites of antroquinonol found in rat urine following oral administration.
AID1129219	Drug excretion in Wistar rat urine assessed as (E)-6-((1R,2R6R)-2,5-Dihy droxy-4-methoxy-6-methyl-3-oxocyclo-hex-4-enyl)-4-methylhex-3-enoic acid level at 200 mg/kg, po administered via gavage measured after 24 hrs by HPLC-SPE-TT-NMR analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Metabolites of antroquinonol found in rat urine following oral administration.
AID1129218	Drug excretion in Wistar rat urine assessed as (E)-6-((1R,2R,6R)-2-Hydroxy-3,4-dimethoxy-6-methyl-5-oxocyclo-hex-3-enyl)-4-methylhex-3-enoic acid level at 200 mg/kg, po administered via gavage measured after 24 hrs by HPLC-SPE-TT-NMR analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Metabolites of antroquinonol found in rat urine following oral administration.
AID1415844	Inhibition of recombinant rat FTase alpha/beta expressed in Escherichia coli using NBD-FPP/GST-tagged H-Ras as substrate incubated for 2 hrs by SDS-PAGE method	2017	MedChemComm, May-01, Volume: 8, Issue:5	New tricks for human farnesyltransferase inhibitor: cancer and beyond.
AID1501978	Growth inhibition of human A549 cells after 48 hrs by SRB assay	2017	Journal of natural products, 09-22, Volume: 80, Issue:9	Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea.
AID1501979	Growth inhibition of human PC3 cells after 48 hrs by SRB assay	2017	Journal of natural products, 09-22, Volume: 80, Issue:9	Meroterpenoids from a Medicinal Fungus Antrodia cinnamomea.
AID1129220	Drug excretion in Wistar rat urine assessed as (E)-6-((1R,2R6R)-2,5-Dihy droxy-4-methoxy-6-methyl-3-oxocyclo-hex-4-enyl)-4-methylhex-4-enoic acid level at 200 mg/kg, po administered via gavage measured after 24 hrs by HPLC-SPE-TT-NMR analysis	2014	Journal of natural products, Apr-25, Volume: 77, Issue:4	Metabolites of antroquinonol found in rat urine following oral administration.
AID1415843	Cytotoxicity against human A549 cells assessed as decrease in cell viability after 48 hrs by MTT assay	2017	MedChemComm, May-01, Volume: 8, Issue:5	New tricks for human farnesyltransferase inhibitor: cancer and beyond.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (2.44)	29.6817
2010's	32 (78.05)	24.3611
2020's	8 (19.51)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (4.88%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	39 (95.12%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	2.21	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
diphenyleneiodonium diphenyleneiodonium: structure in first source; NADPH oxidase inhibitor. dibenziodolium : An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.	2.15	1	organic cation
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.15	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
ubiquinone q1 Ubiquinone Q1: interacts with iron atom to form acceptor quinone complex. ubiquinone-1 : A compound composed of the standard 2,3-dimethoxy-5-methylbenzoquinone nucleus common to ubiquinones; and a side chain of a single isoprenoid unit.	2.21	1	ubiquinones
chloroform Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.	2.11	1	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.17	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
acetonitrile acetonitrile: RN given refers to unlabeled cpd. acetonitrile : A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group.	2.11	1	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent
propylparaben Parabens: Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)	2.21	1	benzoate ester; paraben; phenols	antifungal agent; antimicrobial agent
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	2.55	2	butan-4-olide	metabolite; neurotoxin
maleic anhydride Maleic Anhydrides: Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.. maleic anhydride : A cyclic dicarboxylic anhydride that is the cyclic anhydride of maleic acid.	2.25	1	cyclic dicarboxylic anhydride; furans	allergen
cyclohexanol Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.. cyclohexanols : An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.	2.11	1	cyclohexanols; secondary alcohol	solvent
thiazolidines Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.	2.31	1	thiazolidine
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.83	3	dialdehyde	biomarker
iridium Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.	2.11	1	cobalt group element atom; platinum group metal atom
tiletamine hydrochloride Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.	2.83	3
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.11	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
alkenes [no description available]	2.11	1
ng-nitroarginine methyl ester NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.	2.17	1	alpha-amino acid ester; L-arginine derivative; methyl ester; N-nitro compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor
orsellinic acid orsellinic acid: from the Sonoran desert endophytic fungus Chaetomium globosum; structure in first source. o-orsellinic acid : A dihydroxybenzoic acid that is 2,4-dihydroxybenzoic acid in which the hydrogen at position 6 is replaced by a methyl group.	2.55	2	dihydroxybenzoic acid; resorcinols	fungal metabolite; marine metabolite; metabolite
arginine methyl ester arginine methyl ester: RN given refers to (L)-isomer	2.17	1	alpha-amino acid ester
sesquiterpenes [no description available]	2.11	1
coenzyme q10 coenzyme Q10: Ubiquinone ring with a chain of 10 isoprene units; redox equilibrium with ubiqunol serving in mitochondrial inner membrane to transfer electrons; presence during reconstitution of acetylcholine receptor into phospholipid vesicles yields vesicles active in catalyzing carbamylcholine-sensitive Na+ flux; coenzyme Q10 depletion has been noted with use of statins. coenzyme Q10 : A ubiquinone having a side chain of 10 isoprenoid units. In the naturally occurring isomer, all isoprenyl double bonds are in the E- configuration.	2.25	1	ubiquinones	antioxidant; ferroptosis inhibitor; human metabolite
ubiquinone q3 [no description available]	2.15	1
glucagon-like peptide 1 Glucagon-Like Peptide 1: A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.	2.11	1
ubiquinone Ubiquinone: A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.	6.25	40
4-acetylantroquinonol b 4-acetylantroquinonol B: an antineoplastic agent isolated from Antrodia connamomea; structure in first source	2.55	2
lugdunin lugdunin: antibiotic from Staphylococcus lugdunensis. lugdunin : A thiazolidine-containing homodetic cyclic peptide that is isolated from human nasal bacteria. Exhibits bactericidal activity against many major pathogens including methicillin-resistant Staphylococcus aureus (MRSA).	2.31	1	homodetic cyclic peptide; indoles; macrocycle; peptide antibiotic; thiazolidines	human metabolite; rat metabolite

Condition	Indicated	Relationship Strength	Studies
Disbacteriosis [description not available]	0	2.25	1
Alcoholic Liver Diseases [description not available]	0	2.25	1
Liver Diseases, Alcoholic Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.	0	2.25	1
Alloxan Diabetes [description not available]	0	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	0	3.36	6
Breast Cancer [description not available]	0	2.54	2
Cancer of Lung [description not available]	0	3.74	3
Breast Neoplasms Tumors or cancer of the human BREAST.	0	2.54	2
Lung Neoplasms Tumors or cancer of the LUNG.	0	3.74	3
Blood Pressure, High [description not available]	0	2.17	1
Innate Inflammatory Response [description not available]	0	2.51	2
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	0	2.17	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	0	2.51	2
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	0	2.17	1
Berger Disease [description not available]	0	2.08	1
Glomerulonephritis, IGA A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.	0	2.08	1
Proteinuria The presence of proteins in the urine, an indicator of KIDNEY DISEASES.	0	2.08	1
Insulin Sensitivity [description not available]	0	2.11	1
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	0	2.11	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	0	2.11	1
Acute Confusional Senile Dementia [description not available]	0	2.11	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	0	2.11	1
Glial Cell Tumors [description not available]	0	2.11	1
Invasiveness, Neoplasm [description not available]	0	2.11	1
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	0	2.11	1
Cancer of Colon [description not available]	0	2.15	1
Colonic Neoplasms Tumors or cancer of the COLON.	0	2.15	1
Hepatocellular Carcinoma [description not available]	0	7.05	1
Cancer of Liver [description not available]	0	2.05	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	0	2.05	1
Liver Neoplasms Tumors or cancer of the LIVER.	0	2.05	1
Carcinoma, Non-Small Cell Lung [description not available]	0	2.06	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	1	4.06	1
Focal Epithelial Hyperplasia Hyperplasia of the mucous membrane of the lips, tongue, and less commonly, the buccal mucosa, floor of the mouth, and palate, presenting soft, painless, round to oval sessile papules about 1 to 4 mm in diameter. The condition usually occurs in children and young adults and has familial predilection, lasting for several months, sometimes years, before running its course. A viral etiology is suspected, the isolated organism being usually the human papillomavirus. (Jablonski, Illustrated Dictionary of Dentistry; Belshe, Textbook of Human Virology, 2d ed, p954)	0	2.06	1
Focal Segmental Glomerulosclerosis [description not available]	0	2.06	1
Sclerosis A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.	0	2.06	1
Glomerulosclerosis, Focal Segmental A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.	0	2.06	1
Acute Liver Injury, Drug-Induced [description not available]	0	2.06	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	0	2.06	1
Cancer of Pancreas [description not available]	0	2.07	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	1	4.07	1
Disease Exacerbation [description not available]	0	2.07	1
Glomerulonephritis, Lupus [description not available]	0	2.07	1
Lupus Nephritis Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).	0	7.07	1

antroquinonol d

Description

Cross-References

Synonyms (27)

Roles (2)

Drug Classes (3)

Protein Targets (2)

Inhibition Measurements

Bioassays (8)

Research

Studies (41)

Market Indicators

Research Demand Index: 12.43

Study Types