4-hydroxyestradiol has been researched along with Insulin-Resistance* in 1 studies
1 other study(ies) available for 4-hydroxyestradiol and Insulin-Resistance
Article | Year |
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Estrogenization of insulin by catecholestrogen produced high affinity autoantibodies and altered the normal function of insulin in type 1 diabetes.
Insulin (Ins) covalently modified by catecholestrogens (CEs) was commonly found in diabetic patients who have developed insulin resistance. Estrogenization of insulin altered its molecular function and effect carbohydrates metabolisms in these patients. Insulin resistance is a common phenomenon in diabetes but the exact mechanism remains unknown. In this study, binding specificity and affinity of autoantibodies against estrogenized insulin (4-hydroxyestradiol-insulin; 4-OHE. Specificity and affinity of autoantibodies from the sera of 66 T1D patients and 41 controls were analyzed by direct binding, competition ELISA and quantitative precipitin titration. Insulin was also estimated in the serum of T1D patients by ELISA.. Estrogenized insulin (4-OHE. Estrogenization of insulin by catecholestrogen makes these molecules highly antigenic and produced high-affinity autoantibodies in T1D patients. As a result, patients develop insulin resistance and presented this molecule as a potential biomarker for T1D. Topics: Adult; Autoantibodies; Biomarkers; Blood Glucose; Blood Specimen Collection; Competitive Bidding; Diabetes Mellitus, Type 1; Enzyme-Linked Immunosorbent Assay; Estrogens, Catechol; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Receptor, Insulin; Sensitivity and Specificity | 2020 |