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lg 100268 and Insulin Resistance

lg 100268 has been researched along with Insulin Resistance in 6 studies

LG 100268: a retinoid X receptor (RXR) selective compound; structure given in first source

Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.

Research Excerpts

ExcerptRelevanceReference
"Chronic administration of retinoid X receptor agonists LG 100268 and LG 100324 to Zucker fa/fa rats reduces food intake and body weight gain, lowers plasma insulin concentrations while maintaining normoglycaemia, indicating an improvement of insulin sensitivity."3.70Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats. ( Cawthorne, MA; Crombie, DL; Heyman, RA; Hislop, DC; Liu, YL; Sennitt, MV, 2000)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Michellys, PY1
Ardecky, RJ1
Chen, JH1
Crombie, DL3
Etgen, GJ1
Faul, MM1
Faulkner, AL1
Grese, TA1
Heyman, RA4
Karanewsky, DS1
Klausing, K2
Leibowitz, MD2
Liu, S1
Mais, DA1
Mapes, CM1
Marschke, KB1
Reifel-Miller, A1
Ogilvie, KM1
Rungta, D2
Thompson, AW1
Tyhonas, JS1
Boehm, MF2
Mukherjee, R1
Davies, PJ2
Bischoff, ED1
Cesario, RM2
Jow, L1
Hamann, LG1
Mondon, CE1
Nadzan, AM1
Paterniti, JR1
Liu, YL1
Sennitt, MV1
Hislop, DC1
Cawthorne, MA1
Razzaghi, H1
Crombie, D1
Lala, DS1
Yamauchi, T1
Waki, H1
Kamon, J1
Murakami, K1
Motojima, K1
Komeda, K1
Miki, H1
Kubota, N1
Terauchi, Y1
Tsuchida, A1
Tsuboyama-Kasaoka, N1
Yamauchi, N1
Ide, T1
Hori, W1
Kato, S1
Fukayama, M1
Akanuma, Y1
Ezaki, O1
Itai, A1
Nagai, R1
Kimura, S1
Tobe, K1
Kagechika, H1
Shudo, K1
Kadowaki, T1
Shen, Q1
Cline, GW1
Shulman, GI1

Other Studies

6 other studies available for lg 100268 and Insulin Resistance

ArticleYear
Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.
    Journal of medicinal chemistry, 2003, Jun-19, Volume: 46, Issue:13

    Topics: Animals; Blood Glucose; Caprylates; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Insulin Resistan

2003
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists.
    Nature, 1997, Mar-27, Volume: 386, Issue:6623

    Topics: Animals; Bexarotene; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glucose Tole

1997
Retinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2000, Volume: 24, Issue:8

    Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Eating; Hypoglycemic Agents; Insulin; Ins

2000
The rexinoid LG100754 is a novel RXR:PPARgamma agonist and decreases glucose levels in vivo.
    Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:8

    Topics: 3T3 Cells; Adipocytes; Animals; Blood Glucose; Cell Differentiation; Diabetes Mellitus; Dimerization

2001
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
    The Journal of clinical investigation, 2001, Volume: 108, Issue:7

    Topics: 3T3 Cells; Adipose Tissue; Animals; Benzhydryl Compounds; Benzoates; Biphenyl Compounds; Diabetes Me

2001
Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice.
    The Journal of biological chemistry, 2004, May-07, Volume: 279, Issue:19

    Topics: Acyl Coenzyme A; Animals; Anticholesteremic Agents; Biological Transport; Blotting, Western; Body We

2004