diethylnitrosamine has been researched along with Insulin Resistance in 11 studies
Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 5.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "These data indicate that dietary sugar intake contributes to liver tumor burden independent of excess adiposity or insulin resistance in mice treated with diethylnitrosamine." | 3.81 | Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. ( Breen, DS; Byrne, FL; Caldwell, SH; Chow, JD; Healy, ME; Hoehn, KL; Lackner, C; Leitinger, N; Li, C, 2015) |
| " Metformin, which is widely used in the treatment of diabetes, ameliorates insulin sensitivity." | 3.81 | Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. ( Baba, A; Kochi, T; Kubota, M; Moriwaki, H; Ohno, T; Shimizu, M; Shirakami, Y; Tanaka, T; Tsurumi, H, 2015) |
| " The serum levels of glucose and leptin decreased by dietary BCAA, whereas the value of the quantitative insulin sensitivity check index increased by this agent, indicating the improvement of insulin resistance and hyperleptinemia." | 3.76 | Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. ( Iwasa, J; Moriwaki, H; Sakai, H; Shimizu, M; Shirakami, Y; Shiraki, M; Takai, K; Tanaka, T; Terakura, Y; Tsurumi, H, 2010) |
| "Several animal models of nonalcoholic steatohepatitis have been developed to facilitate its study; however, few fully recapitulate all its clinical features, which include insulin resistance, inflammation, fibrosis, and carcinogenesis." | 1.43 | Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine. ( Abe, Y; Aiura, K; Hibi, T; Itano, O; Kishida, N; Kitagawa, Y; Kitago, M; Masugi, Y; Matsuda, S; Sakamoto, M; Shinoda, M; Yagi, H, 2016) |
| "Many animal models of nonalcoholic steatohepatitis have been reported." | 1.43 | A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis. ( Ejima, C; Ishizaki, S; Kuroda, H, 2016) |
| "The current epidemics of type 2 diabetes mellitus (T2DM), non-alcoholic steatohepatitis (NASH), and Alzheimer's disease (AD) all represent insulin-resistance diseases." | 1.35 | Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease. ( de la Monte, SM; Lawton, M; Longato, L; Neusner, A; Tong, M; Wands, JR, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Mello, T | 1 |
| Materozzi, M | 1 |
| Zanieri, F | 1 |
| Simeone, I | 1 |
| Ceni, E | 1 |
| Bereshchenko, O | 1 |
| Polvani, S | 1 |
| Tarocchi, M | 1 |
| Marroncini, G | 1 |
| Nerlov, C | 1 |
| Guasti, D | 1 |
| Bani, D | 1 |
| Pinzani, M | 1 |
| Galli, A | 1 |
| Healy, ME | 1 |
| Chow, JD | 1 |
| Byrne, FL | 1 |
| Breen, DS | 1 |
| Leitinger, N | 1 |
| Li, C | 1 |
| Lackner, C | 1 |
| Caldwell, SH | 1 |
| Hoehn, KL | 1 |
| Ohno, T | 1 |
| Shimizu, M | 4 |
| Shirakami, Y | 4 |
| Baba, A | 1 |
| Kochi, T | 2 |
| Kubota, M | 3 |
| Tsurumi, H | 3 |
| Tanaka, T | 4 |
| Moriwaki, H | 4 |
| Miyazaki, T | 1 |
| Ideta, T | 1 |
| Sakai, H | 3 |
| Kishida, N | 1 |
| Matsuda, S | 1 |
| Itano, O | 1 |
| Shinoda, M | 1 |
| Kitago, M | 1 |
| Yagi, H | 1 |
| Abe, Y | 1 |
| Hibi, T | 1 |
| Masugi, Y | 1 |
| Aiura, K | 1 |
| Sakamoto, M | 1 |
| Kitagawa, Y | 1 |
| Ejima, C | 1 |
| Kuroda, H | 1 |
| Ishizaki, S | 1 |
| Kaji, K | 1 |
| Yoshiji, H | 1 |
| Kitade, M | 1 |
| Ikenaka, Y | 1 |
| Noguchi, R | 1 |
| Yoshii, J | 1 |
| Yanase, K | 1 |
| Namisaki, T | 1 |
| Yamazaki, M | 1 |
| Moriya, K | 1 |
| Tsujimoto, T | 1 |
| Kawaratani, H | 1 |
| Akahane, T | 1 |
| Uemura, M | 1 |
| Fukui, H | 1 |
| Iwasa, J | 2 |
| Shiraki, M | 1 |
| Terakura, Y | 1 |
| Takai, K | 2 |
| Tong, M | 1 |
| Neusner, A | 1 |
| Longato, L | 1 |
| Lawton, M | 1 |
| Wands, JR | 1 |
| de la Monte, SM | 1 |
| Yasuda, Y | 1 |
| Lagopoulos, L | 1 |
| Sunahara, GI | 1 |
| Würzner, H | 1 |
| Dombrowsky, I | 1 |
| Stalder, R | 1 |
11 other studies available for diethylnitrosamine and Insulin Resistance
| Article | Year |
|---|---|
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carcinogenesis; Carcinoma, Hepatocellu | 2020 |
Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine.
Topics: Adipokines; Adiposity; Animals; Carcinogens; Diet, Ketogenic; Diet, Western; Dietary Carbohydrates; | 2015 |
Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice.
Topics: Adipokines; Animals; Animals, Newborn; Carcinogenesis; Diabetes Mellitus, Experimental; Diethylnitro | 2015 |
Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice.
Topics: Alginates; Animals; Cell Transformation, Neoplastic; Diabetes Mellitus, Experimental; Diethylnitrosa | 2016 |
Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine.
Topics: Animals; Biomarkers; Body Weight; Carcinoma, Hepatocellular; Choline Deficiency; Diet, High-Fat; Die | 2016 |
A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis.
Topics: Animals; Cholesterol; Diet, High-Fat; Diethylnitrosamine; Disease Models, Animal; Fibrosis; Insulin | 2016 |
Impact of insulin resistance on the progression of chronic liver diseases.
Topics: Animals; Cell Proliferation; Chronic Disease; Collagen; Diethylnitrosamine; Disease Progression; Glu | 2008 |
Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.
Topics: Alanine Transaminase; Amino Acids, Branched-Chain; Animals; Diabetes Complications; Dietary Suppleme | 2010 |
Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steatohepatitis, and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; | 2009 |
Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cytokines; Diabetes Complications; Diabetes Melli | 2011 |
The effects of alternating dietary restriction and ad libitum feeding of mice on the development of diethylnitrosamine-induced liver tumours and its correlation to insulinaemia.
Topics: Adenoma; Animals; Body Weight; Carcinoma, Hepatocellular; Diet; Diethylnitrosamine; Eating; Female; | 1991 |