Page last updated: 2024-11-13
amorfrutin b
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
amorfrutin B: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 24739090 |
| CHEMBL ID | 2337127 |
| SCHEMBL ID | 10039861 |
| MeSH ID | M0586594 |
Synonyms (11)
| Synonym |
|---|
| amorfrutin b |
| bdbm50428826 |
| CHEMBL2337127 , |
| SCHEMBL10039861 |
| amorfrutin b, >=85% (nmr) |
| 78916-42-4 |
| 3-[(2e)-3,7-dimethylocta-2,6-dien-1-yl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)benzoic acid |
| Q27467732 |
| 3-[(2e)-3,7-dimethyl-2,6-octadien-1-yl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)-benzoicacid |
| 3-[(2e)-3,7-dimethylocta-2,6-dienyl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)benzoic acid |
| AKOS040734349 |
Research Excerpts
Overview
Amorfrutin B is a selective modulator of the PPARγ receptor. It protects brain neurons from hypoxic and ischemic damage.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Amorfrutin B is a selective modulator of the PPARγ receptor, which has recently been identified as an effective neuroprotective compound that protects brain neurons from hypoxic and ischemic damage. " | ( Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation. Beyer, C; Kajta, M; Przepiórska, K; Wnuk, A, 2023) | 3.8 |
Treatment
| Excerpt | Reference | Relevance |
|---|---|---|
| "Amorfrutin B treatment did not induce weight gain and furthermore showed liver-protecting properties." | ( Amorfrutin B is an efficient natural peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent glucose-lowering properties. Freiwald, A; Kawamoto, K; Kliem, M; Müller-Kuhrt, L; Sauer, S; Schroeder, FC; Siems, K; Weidner, C; Witzke, A; Wowro, SJ, 2013) | 2.55 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Protein Targets (3)
Activation Measurements
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 (µMol) | 0.0615 | 0.0000 | 0.9922 | 10.0000 | AID1231734; AID731518 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Kd | 0.0190 | 0.0012 | 0.9531 | 4.9800 | AID731519 |
| Peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Kd | 1.8000 | 0.0004 | 0.6256 | 1.8000 | AID731520 |
| Peroxisome proliferator-activated receptor alpha | Homo sapiens (human) | Kd | 2.6000 | 0.0010 | 0.4686 | 2.6000 | AID731521 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
Biological Processes (135)
Molecular Functions (42)
Ceullar Components (7)
Bioassays (37)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1231746 | Agonist activity at PPARgamma in human HT29 cells assessed as reduction in in TNFalpha-induced GROalpha gene expression at 1 uM after 48 hrs by real-time qPCR analysis | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1231748 | Agonist activity at PPARgamma in human HT29 cells assessed as reduction in in TNFalpha-induced MIP3alpha gene expression at 1 uM after 48 hrs by real-time qPCR analysis | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1585345 | Inhibition of RhlA quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as reduction in rhamnolipid production at 10 to 50 uM after 20 hrs | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID731518 | Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ. |
| AID1286295 | Antiproliferative activity against human PC3 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
| AID1585343 | Inhibition of lasB quorum sensing system in Pseudomonas aeruginosa PAO1 harboring mini-ctx-lasB-lacZ after 24 hrs by beta-galactosidase reporter gene assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1286291 | Antiproliferative activity against human HT-29 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
| AID1286292 | Antiproliferative activity against human HT-29 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay relative to control | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
| AID1585341 | Inhibition of RhlA quorum sensing system in Pseudomonas aeruginosa PAO1 harboring mini-ctx-RhlA-lacZ at 50 uM after 24 hrs by beta-galactosidase reporter gene assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1231735 | Reduction in TNFalpha-induced PPARgamma expression in human HT-29 cells after 48 hrs by Western blotting analysis | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1286286 | Antiproliferative activity against human PC3 cells assessed as cellular DNA content after 72 hrs by CyQUANT NF fluorescence assay relative to control | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
| AID1231734 | Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1585342 | Inhibition of RhlA quorum sensing system in Pseudomonas aeruginosa PAO1 harboring mini-ctx-RhlA-lacZ at 2.5 to 20 uM after 24 hrs by beta-galactosidase reporter gene assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1585347 | Inhibition of pqsA quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as reduction in pyocyanin release at 10 uM after 20 hrs relative to control | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1585349 | Inhibition of pqsA quorum sensing system in Pseudomonas aeruginosa PAO1 harboring mini-ctx-pqsA-lacZ at 50 uM in presence of PQS by beta-galactosidase reporter gene assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1286290 | Antiproliferative activity against human MCF7 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
| AID1231747 | Agonist activity at PPARgamma in human HT29 cells assessed as reduction in in TNFalpha-induced IL8 gene expression at 1 uM after 48 hrs by real-time qPCR analysis | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID731520 | Binding affinity to human PPARdelta (unknown origin) by competitive TR-FRET assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ. |
| AID1585344 | Inhibition of pqsA quorum sensing system in Pseudomonas aeruginosa PAO1 harboring mini-ctx-pqsA-lacZ after 24 hrs by beta-galactosidase reporter gene assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1286296 | Antiproliferative activity against human MCF7 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay relative to control | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
| AID1231737 | Cytotoxicity against human HT-29 cells assessed as cell viability up to 5 uM after 54 hrs by CytoTox-Glo assay | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1231751 | Agonist activity at PPARgamma in human HT29 cells assessed as reduction in in TNFalpha-induced MIP2 gene expression at 1 uM after 48 hrs by real-time qPCR analysis | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1286294 | Antiproliferative activity against human T84 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay relative to control | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
| AID731521 | Binding affinity to human PPARalpha (unknown origin) by competitive TR-FRET assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ. |
| AID1231745 | Agonist activity at PPARgamma in human HT29 cells assessed as reduction in in TNFalpha-induced COX2 gene expression at 1 uM after 48 hrs by real-time qPCR analysis | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1585348 | Inhibition of lasB quorum sensing system in Pseudomonas aeruginosa PAO1 harboring mini-ctx-lasB-lacZ at 50 uM in presence of ODdHL by beta-galactosidase reporter gene assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID731519 | Binding affinity to human PPARgamma (unknown origin) by competitive TR-FRET assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ. |
| AID1585337 | Anti-biofilm activity against Pseudomonas aeruginosa PAO1 at 1 to 50 uM after 24 hrs by crystal violet staining based assay relative to control | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID731517 | Agonist at human PPARgamma LBD expressed in human HEK293 cells cotransfected with GAL4-Luc assessed as transcriptional activation by luciferase reporter gene assay relative to rosiglitazone | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4 | Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ. |
| AID1585336 | Anti-biofilm activity against Pseudomonas aeruginosa PAO1 at 50 uM after 24 hrs by crystal violet staining based assay relative to control | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1585340 | Toxicity in Pseudomonas aeruginosa PAO1 harboring mini-ctx-lacZ assessed as effect on beta-galactosidase activity at 2.5 to 50 uM beta-galactosidase reporter gene assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1585339 | Toxicity in Pseudomonas aeruginosa PAO1 assessed as growth inhibition at 1 to 50 uM after 2 to 16 hrs | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1231749 | Agonist activity at PPARgamma in human HT29 cells assessed as reduction in in TNFalpha-induced GROgamma gene expression at 1 uM after 48 hrs by real-time qPCR analysis | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1231750 | Agonist activity at PPARgamma in human HT29 cells assessed as reduction in in TNFalpha-induced IL-1beta gene expression at 1 uM after 48 hrs by real-time qPCR analysis | 2015 | Journal of natural products, May-22, Volume: 78, Issue:5 | Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties. |
| AID1585346 | Inhibition of lasB quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as reduction in elastase release at 10 uM after 24 hrs relative to control | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1585338 | Anti-biofilm activity against Pseudomonas aeruginosa PAO1 after 24 hrs by crystal violet staining based assay | 2018 | Journal of natural products, 12-28, Volume: 81, Issue:12 | Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A and B as Inhibitors of the Pseudomonas aeruginosa Quorum Sensing System. |
| AID1286293 | Antiproliferative activity against human T84 cells assessed as cellular DNA content after 96 hrs by CyQUANT NF fluorescence assay | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (9)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 19.88
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (19.88) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||