acetylcarnitine has been researched along with Insulin Resistance in 19 studies
Acetylcarnitine: An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Angiotensin II promotes insulin resistance." | 7.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Here, we investigate whether angiotensin II-induced insulin resistance in skeletal muscle is associated with Sirtuin3 dysregulation and whether pharmacological manipulation of Sirtuin3 confers protection." | 7.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Parental and GLUT4-myc L6 rat skeletal muscle cells exposed to angiotensin II are used as in vitro models of insulin resistance." | 7.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Angiotensin II promotes insulin resistance in skeletal muscle cells via mitochondrial oxidative stress, resulting in a two-fold increase in superoxide generation." | 7.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Our data demonstrate that angiotensin II-induced insulin resistance fosters mitochondrial superoxide generation, in turn leading to Sirtuin3 dysfunction." | 7.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "We conclude that addition of ALC therapy is superior to metformin plus pioglitazone in ameliorating insulin resistance, polycystic ovaries, menstrual irregularities, and hypoadiponectinemia in women with PCOS." | 5.41 | Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial. ( Badshah, H; Ehtesham, E; Habib, SH; Israr, M; Malik, MO; Rauf, B; Raza, MA; Shah, FA; Shah, I; Shah, M; Tauqir, S; Usman, M, 2021) |
| "In boys, the BCAA score corresponded with decreasing C-peptide, C-peptide-based insulin resistance (CP-IR), total cholesterol (TC), and low-density-lipoprotein cholesterol (LDL)." | 3.91 | Metabolomic profiles and development of metabolic risk during the pubertal transition: a prospective study in the ELEMENT Project. ( Cantoral, A; Perng, W; Peterson, KE; Song, PXK; Tang, L; Tellez-Rojo, MM, 2019) |
| "Angiotensin II promotes insulin resistance." | 3.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Here, we investigate whether angiotensin II-induced insulin resistance in skeletal muscle is associated with Sirtuin3 dysregulation and whether pharmacological manipulation of Sirtuin3 confers protection." | 3.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Parental and GLUT4-myc L6 rat skeletal muscle cells exposed to angiotensin II are used as in vitro models of insulin resistance." | 3.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Angiotensin II promotes insulin resistance in skeletal muscle cells via mitochondrial oxidative stress, resulting in a two-fold increase in superoxide generation." | 3.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Our data demonstrate that angiotensin II-induced insulin resistance fosters mitochondrial superoxide generation, in turn leading to Sirtuin3 dysfunction." | 3.81 | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. ( Benigni, A; Buelli, S; Cassis, P; Longaretti, L; Macconi, D; Morigi, M; Perico, L; Perico, N; Remuzzi, G, 2015) |
| "Animal models suggest that acetylcarnitine production is essential for maintaining metabolic flexibility and insulin sensitivity." | 3.80 | Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. ( Brouwers, B; Hesselink, MK; Hoeks, J; Kooi, ME; Koves, T; Lindeboom, L; Muoio, DM; Nabuurs, CI; Phielix, E; Schrauwen, P; Schrauwen-Hinderling, VB; Stevens, RD; Wildberger, JE, 2014) |
| "Insulin resistance was calculated by Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)." | 3.01 | Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial. ( Badshah, H; Ehtesham, E; Habib, SH; Israr, M; Malik, MO; Rauf, B; Raza, MA; Shah, FA; Shah, I; Shah, M; Tauqir, S; Usman, M, 2021) |
| "Type 2 diabetes mellitus is an independent risk factor for the development of cardiovascular disease." | 2.47 | Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. ( Alvarez de Sotomayor, M; Herrera, MD; Justo, ML; Mingorance, C; Rodríguez-Rodríguez, R, 2011) |
| " The inhibition of TNF-alpha could be improved by ALC and in a dose-response relation." | 1.36 | [Effect of acetyl-L-carnitine on the insulin resistance of L6 cells induced by tumor necrosis factor-alpha]. ( Dai, X; Ding, Y; Li, Y; Wang, J; Zhang, Z; Zhao, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, H | 1 |
| Wang, Y | 1 |
| Zhang, X | 1 |
| Li, P | 1 |
| Shang, L | 1 |
| Chen, X | 1 |
| Zeng, J | 1 |
| Tauqir, S | 1 |
| Israr, M | 1 |
| Rauf, B | 1 |
| Malik, MO | 1 |
| Habib, SH | 1 |
| Shah, FA | 1 |
| Usman, M | 1 |
| Raza, MA | 1 |
| Shah, I | 1 |
| Badshah, H | 1 |
| Ehtesham, E | 1 |
| Shah, M | 1 |
| Perng, W | 1 |
| Tang, L | 1 |
| Song, PXK | 1 |
| Tellez-Rojo, MM | 1 |
| Cantoral, A | 1 |
| Peterson, KE | 1 |
| Kathirvel, E | 1 |
| Morgan, K | 1 |
| French, SW | 1 |
| Morgan, TR | 1 |
| Lindeboom, L | 1 |
| Nabuurs, CI | 1 |
| Hoeks, J | 1 |
| Brouwers, B | 1 |
| Phielix, E | 1 |
| Kooi, ME | 1 |
| Hesselink, MK | 1 |
| Wildberger, JE | 1 |
| Stevens, RD | 2 |
| Koves, T | 1 |
| Muoio, DM | 2 |
| Schrauwen, P | 1 |
| Schrauwen-Hinderling, VB | 1 |
| Macconi, D | 1 |
| Perico, L | 1 |
| Longaretti, L | 1 |
| Morigi, M | 1 |
| Cassis, P | 1 |
| Buelli, S | 1 |
| Perico, N | 1 |
| Remuzzi, G | 3 |
| Benigni, A | 1 |
| Samms, RJ | 1 |
| Murphy, M | 1 |
| Fowler, MJ | 1 |
| Cooper, S | 1 |
| Emmerson, P | 1 |
| Coskun, T | 1 |
| Adams, AC | 1 |
| Kharitonenkov, A | 1 |
| Ebling, FJ | 1 |
| Tsintzas, K | 2 |
| Zhang, Z | 2 |
| Zhao, M | 2 |
| Li, Q | 1 |
| Zhao, H | 1 |
| Wang, J | 2 |
| Li, Y | 2 |
| Ruggenenti, P | 2 |
| Cattaneo, D | 1 |
| Loriga, G | 1 |
| Ledda, F | 1 |
| Motterlini, N | 1 |
| Gherardi, G | 1 |
| Orisio, S | 1 |
| Whaley-Connell, A | 1 |
| Sowers, JR | 1 |
| van der Meer, IM | 1 |
| Ding, Y | 1 |
| Dai, X | 1 |
| Mingorance, C | 1 |
| Rodríguez-Rodríguez, R | 1 |
| Justo, ML | 1 |
| Alvarez de Sotomayor, M | 1 |
| Herrera, MD | 1 |
| Ringseis, R | 1 |
| Mooren, FC | 1 |
| Keller, J | 1 |
| Couturier, A | 1 |
| Wen, G | 1 |
| Hirche, F | 1 |
| Stangl, GI | 1 |
| Eder, K | 1 |
| Krüger, K | 1 |
| Noland, RC | 1 |
| Kovalik, JP | 1 |
| Seiler, SE | 1 |
| Davies, MN | 1 |
| DeBalsi, KL | 1 |
| Ilkayeva, OR | 1 |
| Kheterpal, I | 1 |
| Zhang, J | 1 |
| Covington, JD | 1 |
| Bajpeyi, S | 1 |
| Ravussin, E | 1 |
| Kraus, W | 1 |
| Koves, TR | 1 |
| Mynatt, RL | 1 |
| Ferreira, MR | 1 |
| Camberos, Mdel C | 1 |
| Selenscig, D | 1 |
| Martucci, LC | 1 |
| Chicco, A | 1 |
| Lombardo, YB | 1 |
| Cresto, JC | 1 |
| Chokkalingam, K | 1 |
| Jewell, K | 1 |
| Norton, L | 1 |
| Macdonald, IA | 1 |
| Constantin-Teodosiu, D | 1 |
| Shen, W | 1 |
| Liu, K | 1 |
| Tian, C | 1 |
| Yang, L | 1 |
| Li, X | 1 |
| Ren, J | 1 |
| Packer, L | 1 |
| Cotman, CW | 1 |
| Liu, J | 1 |
| Fisher, JS | 1 |
| Gao, J | 1 |
| Han, DH | 1 |
| Holloszy, JO | 1 |
| Nolte, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress Response in Patients With PCOS: A Double Blind Randomized Clinical Trial[NCT04113889] | Phase 2 | 147 participants (Actual) | Interventional | 2019-10-15 | Completed | ||
| The Effects of Acetyl L--Carnitine and Myo/Chiro-Inositol on Improving Ovulation, Pregnancy Rate, Ovarian Function and Perceived Stress Response in Patients With PCOS[NCT05767515] | 120 participants (Anticipated) | Interventional | 2023-04-15 | Not yet recruiting | |||
| Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients[NCT03670693] | 45 participants (Actual) | Interventional | 2018-08-01 | Completed | |||
| A Pilot Study to Evaluate the Short-term Effects of Acetyl-carnitine on Insulin Resistance and the Metabolic Syndrome in Patients at Increased Risk of Type 2 Diabetes: Acetyl-carnitine in Insulin Resistance[NCT00393770] | Phase 2 | 43 participants (Actual) | Interventional | 2004-02-29 | Completed | ||
| Effects of Acute and Chronic Exercise on Myeloid-Derived Suppressor Cells in Melanoma Patients[NCT05615883] | 20 participants (Anticipated) | Interventional | 2020-01-20 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for acetylcarnitine and Insulin Resistance
| Article | Year |
|---|---|
Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders.
Topics: Acetylcarnitine; Animals; Cardiovascular Agents; Cardiovascular Diseases; Carnitine; Diabetes Mellit | 2011 |
3 trials available for acetylcarnitine and Insulin Resistance
| Article | Year |
|---|---|
Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Topics: Acetylcarnitine; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycy | 2021 |
Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Topics: Acetylcarnitine; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycy | 2021 |
Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Topics: Acetylcarnitine; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycy | 2021 |
Acetyl-L-Carnitine Ameliorates Metabolic and Endocrine Alterations in Women with PCOS: A Double-Blind Randomized Clinical Trial.
Topics: Acetylcarnitine; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Metformin; Polycy | 2021 |
Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy.
Topics: Acetylcarnitine; Adiponectin; Administration, Oral; Adult; Blood Glucose; Blood Pressure; Cardiovasc | 2009 |
Elevated free fatty acids attenuate the insulin-induced suppression of PDK4 gene expression in human skeletal muscle: potential role of intramuscular long-chain acyl-coenzyme A.
Topics: Acetylcarnitine; Acyl Coenzyme A; Adult; Carbohydrate Metabolism; Fat Emulsions, Intravenous; Fatty | 2007 |
15 other studies available for acetylcarnitine and Insulin Resistance
| Article | Year |
|---|---|
Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice.
Topics: Acetyl Coenzyme A; Acetylcarnitine; Animals; Diabetes Mellitus, Experimental; Fatty Acids; Fatty Liv | 2023 |
Metabolomic profiles and development of metabolic risk during the pubertal transition: a prospective study in the ELEMENT Project.
Topics: Acetylcarnitine; Adolescent; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Asparagine; Biomark | 2019 |
Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease.
Topics: Acetylcarnitine; Adipose Tissue; Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransfe | 2013 |
Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection.
Topics: Acetylcarnitine; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Male; M | 2014 |
Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II.
Topics: Acetylcarnitine; Angiotensin II; Animals; Cell Line; Insulin Resistance; Mitochondria; Muscle, Skele | 2015 |
Dual effects of fibroblast growth factor 21 on hepatic energy metabolism.
Topics: Acetyl-CoA Carboxylase; Acetylcarnitine; Animals; Carbohydrate Metabolism; Energy Metabolism; Fibrob | 2015 |
Acetyl-l-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells.
Topics: Acetylcarnitine; AMP-Activated Protein Kinases; Animals; Cell Line; Glucose; Insulin; Insulin Recept | 2009 |
Hypertension and insulin resistance.
Topics: Acetylcarnitine; Administration, Oral; Blood Pressure; Cardiovascular Diseases; Endothelial Cells; H | 2009 |
Oral acetyl-L-carnitine therapy and insulin resistance.
Topics: Acetylcarnitine; Administration, Oral; Animals; Blood Glucose; Cardiovascular Diseases; Diabetes Mel | 2010 |
[Effect of acetyl-L-carnitine on the insulin resistance of L6 cells induced by tumor necrosis factor-alpha].
Topics: Acetylcarnitine; Animals; Cell Line; Disease Models, Animal; Insulin Receptor Substrate Proteins; In | 2010 |
Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet.
Topics: Acetylcarnitine; Animals; Body Weight; Carnitine; Diet, High-Fat; Fatty Acids; Gene Expression Regul | 2011 |
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.
Topics: Acetyl Coenzyme A; Acetylcarnitine; Animals; Carbon; Carnitine; Carnitine O-Acetyltransferase; Cells | 2012 |
Changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis induced by an acetyl-L-carnitine and nicotinamide treatment in dyslipidaemic insulin-resistant rats.
Topics: Acetyl-CoA Carboxylase; Acetylcarnitine; Animals; Body Weight; Carnitine O-Palmitoyltransferase; Dis | 2013 |
R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Acetylcarnitine; Adipocytes; Animals; Carnitine O-Palmitoyltransferase; DNA, Mitochond | 2008 |
Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin.
Topics: Acetylcarnitine; Adenylate Kinase; Animals; Biological Transport; Cycloheximide; Enzyme Activation; | 2002 |