phosphoserine has been researched along with Insulin Resistance in 29 studies
Phosphoserine: The phosphoric acid ester of serine.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased flux through the hexosamine biosynthetic pathway and increased O-linked glycosylation (N-acetylglucosamine [O-GlcNAc]) of proteins have been implicated in insulin resistance." | 3.72 | Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle. ( Arias, EB; Cartee, GD; Kim, J, 2004) |
| "Insulin resistance is a hallmark of Type II diabetes." | 2.43 | Modulation of insulin signalling by insulin sensitizers. ( Jiang, G; Zhang, BB, 2005) |
| "Insulin resistance is characterised by a decrease in insulin effect on glucose transport in muscle and adipose tIssue." | 2.42 | Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling. ( Barrès, R; Gonzalez, T; Grémeaux, T; Gual, P; Le Marchand-Brustel, Y; Tanti, JF, 2004) |
| "Insulin resistance was then induced in adipocytes using dexamethasone, and DHM was shown to dose and time dependently promote glucose uptake in the dexamethasone-treated adipocytes." | 1.48 | Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPARγ in 3T3-L1 cells. ( Lang, H; Liu, L; Mi, M; Zhou, M; Zhou, Y, 2018) |
| "While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder." | 1.38 | Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. ( Arnold, SE; Arvanitakis, Z; Bakshi, KP; Bennett, DA; Fuino, RL; Han, LY; Kawaguchi, KR; Kazi, H; Samoyedny, AJ; Schneider, JA; Stucky, A; Talbot, K; Trojanowski, JQ; Wang, HY; Wilson, RS; Wolf, BA, 2012) |
| "Obesity is associated with insulin resistance and a state of abnormal inflammatory response." | 1.34 | Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. ( Araújo, EP; Carvalheira, JB; Carvalho-Filho, MA; Curi, R; Hirabara, SM; Prada, PO; Saad, MJ; Schenka, AA; Tsukumo, DM; Vassallo, J; Velloso, LA, 2007) |
| "We conclude that obesity is associated with increased intramyocellular ceramide content." | 1.32 | Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. ( Adams, JM; Berria, R; DeFronzo, RA; Mandarino, LJ; Pratipanawatr, T; Sullards, MC; Wang, E, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 18 (62.07) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Den Hartogh, DJ | 1 |
| Vlavcheski, F | 1 |
| Giacca, A | 1 |
| MacPherson, REK | 1 |
| Tsiani, E | 1 |
| Merz, KE | 1 |
| Hwang, J | 1 |
| Zhou, C | 1 |
| Veluthakal, R | 1 |
| McCown, EM | 1 |
| Hamilton, A | 1 |
| Oh, E | 1 |
| Dai, W | 1 |
| Fueger, PT | 1 |
| Jiang, L | 1 |
| Huss, JM | 1 |
| Thurmond, DC | 1 |
| Hong, CT | 1 |
| Chen, KY | 1 |
| Wang, W | 1 |
| Chiu, JY | 1 |
| Wu, D | 1 |
| Chao, TY | 1 |
| Hu, CJ | 1 |
| Chau, KD | 1 |
| Bamodu, OA | 1 |
| Liu, L | 1 |
| Zhou, M | 1 |
| Lang, H | 1 |
| Zhou, Y | 1 |
| Mi, M | 1 |
| Salinari, S | 1 |
| Debard, C | 1 |
| Bertuzzi, A | 1 |
| Durand, C | 1 |
| Zimmet, P | 1 |
| Vidal, H | 1 |
| Mingrone, G | 1 |
| de Matos, MA | 1 |
| Ottone, Vde O | 1 |
| Duarte, TC | 1 |
| Sampaio, PF | 1 |
| Costa, KB | 1 |
| Fonseca, CA | 1 |
| Neves, MP | 1 |
| Schneider, SM | 1 |
| Moseley, P | 1 |
| Coimbra, CC | 1 |
| Magalhães, Fde C | 1 |
| Rocha-Vieira, E | 1 |
| Amorim, FT | 1 |
| Kim, B | 1 |
| Figueroa-Romero, C | 1 |
| Pacut, C | 1 |
| Backus, C | 1 |
| Feldman, EL | 1 |
| Li, L | 1 |
| Thompson, LH | 1 |
| Zhao, L | 1 |
| Messina, JL | 1 |
| Wang, C | 1 |
| Liu, M | 1 |
| Riojas, RA | 1 |
| Xin, X | 1 |
| Gao, Z | 2 |
| Zeng, R | 1 |
| Wu, J | 1 |
| Dong, LQ | 1 |
| Liu, F | 1 |
| Xin-Long, C | 1 |
| Zhao-Fan, X | 1 |
| Dao-Feng, B | 1 |
| Wei, D | 1 |
| Talbot, K | 1 |
| Wang, HY | 1 |
| Kazi, H | 1 |
| Han, LY | 1 |
| Bakshi, KP | 1 |
| Stucky, A | 1 |
| Fuino, RL | 1 |
| Kawaguchi, KR | 1 |
| Samoyedny, AJ | 1 |
| Wilson, RS | 1 |
| Arvanitakis, Z | 1 |
| Schneider, JA | 1 |
| Wolf, BA | 1 |
| Bennett, DA | 1 |
| Trojanowski, JQ | 1 |
| Arnold, SE | 1 |
| Potashnik, R | 2 |
| Bloch-Damti, A | 2 |
| Bashan, N | 2 |
| Rudich, A | 2 |
| Adams, JM | 1 |
| Pratipanawatr, T | 1 |
| Berria, R | 1 |
| Wang, E | 1 |
| DeFronzo, RA | 1 |
| Sullards, MC | 1 |
| Mandarino, LJ | 1 |
| Arias, EB | 1 |
| Kim, J | 1 |
| Cartee, GD | 1 |
| Tanti, JF | 2 |
| Gual, P | 2 |
| Grémeaux, T | 1 |
| Gonzalez, T | 1 |
| Barrès, R | 1 |
| Le Marchand-Brustel, Y | 2 |
| Zhang, X | 1 |
| Zuberi, A | 1 |
| Hwang, D | 1 |
| Quon, MJ | 1 |
| Lefevre, M | 1 |
| Ye, J | 1 |
| Liu, YF | 1 |
| Herschkovitz, A | 1 |
| Boura-Halfon, S | 1 |
| Ronen, D | 1 |
| Paz, K | 1 |
| Leroith, D | 1 |
| Zick, Y | 1 |
| Morisco, C | 1 |
| Condorelli, G | 2 |
| Trimarco, V | 1 |
| Bellis, A | 1 |
| Marrone, C | 1 |
| Sadoshima, J | 1 |
| Trimarco, B | 1 |
| Tian, R | 1 |
| Ueno, M | 1 |
| Carvalheira, JB | 2 |
| Tambascia, RC | 1 |
| Bezerra, RM | 1 |
| Amaral, ME | 1 |
| Carneiro, EM | 1 |
| Folli, F | 1 |
| Franchini, KG | 1 |
| Saad, MJ | 2 |
| Jiang, G | 1 |
| Zhang, BB | 1 |
| Draznin, B | 1 |
| Tsukumo, DM | 1 |
| Carvalho-Filho, MA | 1 |
| Prada, PO | 1 |
| Hirabara, SM | 1 |
| Schenka, AA | 1 |
| Araújo, EP | 1 |
| Vassallo, J | 1 |
| Curi, R | 1 |
| Velloso, LA | 1 |
| Dunaif, A | 1 |
| Xia, J | 1 |
| Book, CB | 1 |
| Schenker, E | 1 |
| Tang, Z | 1 |
| Yu, ZW | 1 |
| Wickman, A | 1 |
| Eriksson, JW | 1 |
| Engelman, JA | 1 |
| Berg, AH | 1 |
| Lewis, RY | 1 |
| Lisanti, MP | 1 |
| Scherer, PE | 1 |
| Nelson, BA | 1 |
| Robinson, KA | 1 |
| Buse, MG | 1 |
| Berg, CE | 1 |
| Lavan, BE | 1 |
| Rondinone, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A HIIT to Improve Metabolic Health in Obese Adults With Insulin Resistance[NCT04075799] | 18 participants (Actual) | Interventional | 2022-01-01 | Completed | |||
| An Open Label, Single Site, 48 Week, Randomised Controlled Trial Evaluating the Safety and Efficacy of Exenatide Once-weekly in the Treatment of Patients With Multiple System Atrophy[NCT04431713] | Phase 2 | 50 participants (Anticipated) | Interventional | 2020-09-16 | Recruiting | ||
| Muscle Insulin Resistance In Aging[NCT02230839] | 200 participants (Anticipated) | Interventional | 2014-06-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phosphoserine and Insulin Resistance
| Article | Year |
|---|---|
Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Homeostasis; Humans; Insulin; Insulin | 2004 |
Modulation of insulin signalling by insulin sensitizers.
Topics: Animals; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Phosphoproteins; | 2005 |
Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin.
Topics: Animals; Enzyme Activation; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance | 2006 |
1 trial available for phosphoserine and Insulin Resistance
| Article | Year |
|---|---|
Exercise reduces cellular stress related to skeletal muscle insulin resistance.
Topics: Adult; Exercise; Fasting; Female; HSP70 Heat-Shock Proteins; Humans; Insulin; Insulin Receptor Subst | 2014 |
25 other studies available for phosphoserine and Insulin Resistance
| Article | Year |
|---|---|
Carnosic Acid Attenuates the Free Fatty Acid-Induced Insulin Resistance in Muscle Cells and Adipocytes.
Topics: 3T3-L1 Cells; Abietanes; Adipocytes; AMP-Activated Protein Kinases; Animals; Cell Line; Fatty Acids, | 2022 |
Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1.
Topics: Adenylate Kinase; Animals; Cell Respiration; Citric Acid Cycle; Cyclic AMP-Dependent Protein Kinases | 2022 |
Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
Topics: alpha-Synuclein; Animals; Diabetes Mellitus, Type 2; Disease Progression; Dopaminergic Neurons; Geno | 2020 |
Dihydromyricetin enhances glucose uptake by inhibition of MEK/ERK pathway and consequent down-regulation of phosphorylation of PPARγ in 3T3-L1 cells.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adiponectin; Anilides; Animals; Cell Survival; Dexamethasone | 2018 |
Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance.
Topics: Adult; Animals; Cell Differentiation; Culture Media, Conditioned; Deoxyglucose; Diabetes Mellitus, E | 2013 |
Insulin Resistance Prevents AMPK-induced Tau Dephosphorylation through Akt-mediated Increase in AMPKSer-485 Phosphorylation.
Topics: Adenylate Kinase; Alzheimer Disease; Animals; Cell Line; Diabetes Complications; Diet, High-Fat; Hum | 2015 |
Tissue-specific difference in the molecular mechanisms for the development of acute insulin resistance after injury.
Topics: Acute Disease; Animals; Corticosterone; Fatty Acids, Nonesterified; Hemorrhage; Hormone Antagonists; | 2009 |
Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Cell Line; Cricetinae; Enzyme Activation; Ins | 2009 |
mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine(307) residues after burn.
Topics: Animals; Anti-Bacterial Agents; Blotting, Western; Burns; C-Peptide; Disease Models, Animal; Glucose | 2011 |
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Brain; Cerebellar Cortex; Cognition D | 2012 |
IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.
Topics: 3T3 Cells; Animals; Antioxidants; Biomarkers; Cycloheximide; Cysteine Endopeptidases; Glucose Oxidas | 2003 |
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
Topics: Adult; Blood Glucose; Ceramides; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Humans | 2004 |
Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle.
Topics: Acetylglucosamine; Animals; Biological Transport; Glucose; Glycosylation; Insulin; Insulin Resistanc | 2004 |
Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.
Topics: Adipocytes; Adipose Tissue; Animal Feed; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; F | 2004 |
Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.
Topics: Adenoviridae; Animals; Binding Sites; Cell Line; Cricetinae; Enzyme Activation; Gene Expression Regu | 2004 |
Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.
Topics: Adrenergic beta-Agonists; Amino Acid Substitution; Animals; Animals, Newborn; Cells, Cultured; Cycli | 2005 |
Another role for the celebrity: Akt and insulin resistance.
Topics: Adrenergic beta-Agonists; Animals; Deoxyglucose; Enzyme Activation; Humans; Insulin Resistance; Isop | 2005 |
Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.
Topics: Adipose Tissue; Animals; Body Weight; Energy Intake; Epididymis; Glucose Clamp Technique; Glycolysis | 2005 |
Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Inhibitors; Hydrogen Peroxide; Insulin | 2006 |
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.
Topics: Adipose Tissue; Animal Feed; Animals; Blood Glucose; Body Weight; Cell Shape; Dietary Fats; Enzyme A | 2007 |
Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.
Topics: Adult; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Fibroblasts; Humans; Insul | 1995 |
Cryptic receptors for insulin-like growth factor II in the plasma membrane of rat adipocytes--a possible link to cellular insulin resistance.
Topics: Adipocytes; Animals; Bucladesine; Cell Membrane; Enzyme Inhibitors; Ethers, Cyclic; Insulin; Insulin | 1996 |
Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Anisomycin; Cell Differentiation; Enzyme Inhibitors; Epidermal Growt | 2000 |
Defective Akt activation is associated with glucose- but not glucosamine-induced insulin resistance.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Electrophoresis, Polyacrylamide Gel; Enzyme Ac | 2002 |
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment.
Topics: Adipocytes; Animals; Biological Transport; Cell Line; Glucose; Insulin; Insulin Antagonists; Insulin | 2002 |