glipizide has been researched along with Insulin Resistance in 28 studies
Glipizide: An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.
glipizide : An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy and long-term effects of glipizide treatment on glucose and insulin metabolism in individuals with impaired glucose tolerance (IGT)." | 9.12 | Long-term beneficial effects of glipizide treatment on glucose tolerance in subjects with impaired glucose tolerance. ( Ehrnström, B; Eriksson, JG; Groop, L; Lehtovirta, M; Salmela, S, 2006) |
| "Insulin-resistant, obesity-prone mice (KK strain) were treated with pioglitazone, placebo, or the sulfonylurea compound, glipizide, for 2." | 7.73 | Pioglitazone protects against thrombosis in a mouse model of obesity and insulin resistance. ( Bodary, PF; Eitzman, DT; Jongeward, KL; King, SA; Vargas, FB; Wickenheiser, KJ, 2005) |
| "Studies in patients with insulin independent diabetes indicate that treatment with the second generation sulfonylurea glipizide results in partial amelioration of their insulin resistance and that this effect is significant in glipizide's antidiabetic action." | 7.66 | Insulin resistance in patients with insulin independent diabetes mellitus: partial amelioration by the sulfonylurea glipizide. ( Feinglos, MN; Lebovitz, H, 1979) |
| "To assess the efficacy and long-term effects of glipizide treatment on glucose and insulin metabolism in individuals with impaired glucose tolerance (IGT)." | 5.12 | Long-term beneficial effects of glipizide treatment on glucose tolerance in subjects with impaired glucose tolerance. ( Ehrnström, B; Eriksson, JG; Groop, L; Lehtovirta, M; Salmela, S, 2006) |
| "181 African American subjects with insulin resistance and normal glucose tolerance test were randomised to receive glipizide 5 mg/day (n = 25), metformin 500 mg/day (n = 59), or placebo (n = 97) for 24 months." | 5.11 | Long term cardiovascular effects of oral antidiabetic agents in non-diabetic patients with insulin resistance: double blind, prospective, randomised study. ( Boudoulas, H; Osei, K; Schuster, DP; Sparks, EA; Stakos, DA; Wooley, CF, 2005) |
| " Consequently, a four-phase (glipizide v insulin) cross-over design study was conducted to determine a better effect of glipizide treatment on insulin sensitivity and the effect this has on BP in 19 NIDDM patients." | 5.08 | Insulin versus glipizide treatment in patients with non-insulin-dependent diabetes mellitus. Effects on blood pressure and glucose tolerance. ( Grunberger, G; Levy, J; Vandenberg, M, 1995) |
| "BCAA/AAAs changed acutely during glipizide and metformin administration, and the magnitude and direction of change differed by the insulin resistance status of the individual and the intervention." | 3.79 | Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus. ( Ackerman, RJ; Altshuler, D; Billings, LK; Chamarthi, B; Clish, CB; Davis, J; Deik, A; Fanelli, RR; Florez, JC; Gerszten, RE; Grant, RW; Hernandez, AM; Huang, C; Hudson, MS; Khan, SQ; Littleton, KR; Lo, J; McCarthy, RM; Rhee, EP; Stolerman, E; Taylor, A; Walford, GA; Wang, TJ; Warner, AS, 2013) |
| "Insulin-resistant, obesity-prone mice (KK strain) were treated with pioglitazone, placebo, or the sulfonylurea compound, glipizide, for 2." | 3.73 | Pioglitazone protects against thrombosis in a mouse model of obesity and insulin resistance. ( Bodary, PF; Eitzman, DT; Jongeward, KL; King, SA; Vargas, FB; Wickenheiser, KJ, 2005) |
| "Insulin tolerance test was done to assess the insulin sensitivity in a group of untreated non insulin dependent diabetic subjects before and after sulfonylurea (tolbutamide, glibenclamide, glipizide) therapy." | 3.68 | Effect of sulphonylurea therapy on insulin sensitivity in non insulin dependent diabetics. ( Dash, RJ; Khandekar, S; Sethi, BK, 1990) |
| "The effect of glipizide treatment on diabetic control and on in vivo insulin secretion and action was studied in 20 patients with non-insulin-dependent diabetes mellitus (NIDDM)." | 3.66 | Effect of sulfonylurea treatment on in vivo insulin secretion and action in patients with non-insulin-dependent diabetes mellitus. ( Doberne, L; Greenfield, MS; Reaven, GM; Rosenthal, M; Schulz, B; Widstrom, A, 1982) |
| "Studies in patients with insulin independent diabetes indicate that treatment with the second generation sulfonylurea glipizide results in partial amelioration of their insulin resistance and that this effect is significant in glipizide's antidiabetic action." | 3.66 | Insulin resistance in patients with insulin independent diabetes mellitus: partial amelioration by the sulfonylurea glipizide. ( Feinglos, MN; Lebovitz, H, 1979) |
| " Post-dose glipizide concentrations were three times higher than those of glibenclamide, due to the incomplete bioavailability of the latter." | 2.66 | Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics. ( Fyhrqvist, F; Groop, L; Groop, PH; Melander, A; Tolppanen, EM; Tötterman, KJ; Wåhlin-Boll, E, 1985) |
| "Pheochromocytomas have been described to lead to hyperglycemia and diabetes, due to the suppression of insulin release and increased insulin resistance." | 1.37 | Resolution of insulin-requiring diabetes in a liver transplant recipient after treatment of a pheochromocytoma: case report and review of literature. ( Courgi, R; Gallagher, EJ; Heiba, S; Tamler, R, 2011) |
| "Nateglinide (Nateg) was administered to elicit only an early insulin secretory response and glipizide (Glip) to elicit a later but greater insulin secretory response." | 1.31 | Early insulin release effectively improves glucose tolerance: studies in two rodent models of type 2 diabetes mellitus. ( Chen, W; de Souza, CJ; Dragonas, N; Gagen, K, 2001) |
| "Glipizide therapy also was ineffective in improving plasma insulin levels, which were significantly depressed in the diabetic group." | 1.29 | Effects of chronic glipizide treatment on the NIDD heart. ( Schaffer, SW; Warner, BA; Wilson, GL, 1993) |
| "The effects of glipizide treatment on insulin sensitivity, glucose-mediated insulin secretion, and glucose utilization were measured in newly diagnosed or untreated patients with noninsulin-dependent diabetes mellitus." | 1.27 | Mechanism of action of the second-generation sulfonylurea glipizide. ( Feinglos, MN; Lebovitz, HE, 1983) |
| "Glipizide is a "second generation" sulfonylurea compound, and in this study the effects of several months of glipizide treatment on various aspects of glucose, insulin, and lipid metabolism were documented in 23 patients with noninsulin-dependent diabetes mellitus." | 1.27 | Effect of glipizide treatment on various aspects of glucose, insulin, and lipid metabolism in patients with noninsulin-dependent diabetes mellitus. ( Reaven, GM, 1983) |
| "Glipizide treatment did not significantly alter basal glucose turnover, Ra, mean glucose values, or mean insulin levels as determined by radioimmunoassay." | 1.26 | Selective potentiation of insulin-mediated glucose disposal in normal dogs by the sulfonylurea glipizide. ( Andersen, DK; Jones, RS; Lebovitz, HE; Putnam, WS, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (42.86) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Samms, RJ | 1 |
| Cheng, CC | 1 |
| Fourcaudot, M | 1 |
| Heikkinen, S | 1 |
| Khattab, A | 1 |
| Adams, J | 1 |
| Cersosimo, E | 1 |
| Triplitt, C | 1 |
| Puckett, C | 1 |
| Tsintzas, K | 1 |
| Adams, AC | 1 |
| Abdul-Ghani, MA | 1 |
| DeFronzo, RA | 1 |
| Norton, L | 1 |
| Campbell, JM | 1 |
| Adanichkin, N | 1 |
| Kurmis, R | 1 |
| Munn, Z | 1 |
| Walford, GA | 1 |
| Davis, J | 1 |
| Warner, AS | 1 |
| Ackerman, RJ | 1 |
| Billings, LK | 1 |
| Chamarthi, B | 1 |
| Fanelli, RR | 1 |
| Hernandez, AM | 1 |
| Huang, C | 1 |
| Khan, SQ | 1 |
| Littleton, KR | 1 |
| Lo, J | 1 |
| McCarthy, RM | 1 |
| Rhee, EP | 1 |
| Deik, A | 1 |
| Stolerman, E | 1 |
| Taylor, A | 1 |
| Hudson, MS | 1 |
| Wang, TJ | 1 |
| Altshuler, D | 1 |
| Grant, RW | 1 |
| Clish, CB | 1 |
| Gerszten, RE | 1 |
| Florez, JC | 1 |
| Agrawal, A | 1 |
| Gallagher, EJ | 1 |
| Courgi, R | 1 |
| Heiba, S | 1 |
| Tamler, R | 1 |
| Osei, K | 2 |
| Rhinesmith, S | 1 |
| Gaillard, T | 1 |
| Schuster, D | 1 |
| Stakos, DA | 1 |
| Schuster, DP | 1 |
| Sparks, EA | 1 |
| Wooley, CF | 1 |
| Boudoulas, H | 1 |
| Xiabo, C | 1 |
| Hui, W | 1 |
| Bodary, PF | 1 |
| Vargas, FB | 1 |
| King, SA | 1 |
| Jongeward, KL | 1 |
| Wickenheiser, KJ | 1 |
| Eitzman, DT | 1 |
| Rosenstock, J | 1 |
| Goldstein, BJ | 1 |
| Vinik, AI | 1 |
| O'neill, MC | 1 |
| Porter, LE | 1 |
| Heise, MA | 1 |
| Kravitz, B | 1 |
| Dirani, RG | 1 |
| Freed, MI | 1 |
| Eriksson, JG | 1 |
| Lehtovirta, M | 1 |
| Ehrnström, B | 1 |
| Salmela, S | 1 |
| Groop, L | 2 |
| Lebovitz, HE | 4 |
| Feinglos, MN | 4 |
| Shuman, CR | 1 |
| Reaven, GM | 2 |
| Greenfield, MS | 1 |
| Doberne, L | 1 |
| Rosenthal, M | 1 |
| Schulz, B | 1 |
| Widstrom, A | 1 |
| Putnam, WS | 1 |
| Andersen, DK | 1 |
| Jones, RS | 1 |
| Levy, J | 1 |
| Vandenberg, M | 1 |
| Grunberger, G | 1 |
| Schaffer, SW | 1 |
| Warner, BA | 1 |
| Wilson, GL | 1 |
| de Souza, CJ | 1 |
| Gagen, K | 1 |
| Chen, W | 1 |
| Dragonas, N | 1 |
| Manohar, V | 1 |
| Talpur, NA | 1 |
| Echard, BW | 1 |
| Lieberman, S | 1 |
| Preuss, HG | 1 |
| Lebovitz, H | 1 |
| Patsch, W | 1 |
| Sailer, S | 1 |
| Braunsteiner, H | 1 |
| Khandekar, S | 1 |
| Sethi, BK | 1 |
| Dash, RJ | 1 |
| Shank, WA | 1 |
| Morrison, AD | 1 |
| Bolinder, J | 1 |
| Ostman, J | 1 |
| Arner, P | 1 |
| Wåhlin-Boll, E | 1 |
| Groop, PH | 1 |
| Tötterman, KJ | 1 |
| Melander, A | 1 |
| Tolppanen, EM | 1 |
| Fyhrqvist, F | 1 |
2 reviews available for glipizide and Insulin Resistance
| Article | Year |
|---|---|
Intensive insulin therapy, insulin sensitisers and insulin secretagogues for burns: A systematic review of effectiveness and safety.
Topics: Burns; Dipeptidyl-Peptidase IV Inhibitors; Disease Management; Exenatide; Glipizide; Humans; Hypergl | 2018 |
Oral sulfonylureas for the treatment of type II diabetes: an update.
Topics: Administration, Oral; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Hypersensitivity; Glipizide; G | 1986 |
9 trials available for glipizide and Insulin Resistance
| Article | Year |
|---|---|
FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Exenatide; Fibroblast Growth Factors; Glipizide; Glycated | 2022 |
Metabolic effects of chronic glipizide gastrointestinal therapeutic system on serum glucose, insulin secretion, insulin sensitivity, and hepatic insulin extraction in glucose-tolerant, first-degree relatives of African American patients with type 2 diabet
Topics: Adult; Black People; Blood Glucose; C-Peptide; Delayed-Action Preparations; Diabetes Mellitus, Type | 2003 |
Long term cardiovascular effects of oral antidiabetic agents in non-diabetic patients with insulin resistance: double blind, prospective, randomised study.
Topics: Administration, Oral; Adult; Aorta; Blood Flow Velocity; Blood Glucose; Blood Pressure; Double-Blind | 2005 |
Effect of jiang zhuo mixture on blood glucose level and insulin resistance in diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Drugs, Chinese Herbal; Fe | 2005 |
Effect of early addition of rosiglitazone to sulphonylurea therapy in older type 2 diabetes patients (>60 years): the Rosiglitazone Early vs. SULphonylurea Titration (RESULT) study.
Topics: Age Factors; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Disease Progression; Double-Blin | 2006 |
Long-term beneficial effects of glipizide treatment on glucose tolerance in subjects with impaired glucose tolerance.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Disease Progression; Double-Blind Method; Fam | 2006 |
Glipizide: an overview.
Topics: Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Glipizide; Half-Life; Humans; In | 1983 |
Insulin versus glipizide treatment in patients with non-insulin-dependent diabetes mellitus. Effects on blood pressure and glucose tolerance.
Topics: Adult; Aged; Blood Glucose; Blood Pressure; C-Peptide; Cholesterol; Cross-Over Studies; Diabetes Mel | 1995 |
Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics.
Topics: Aged; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus, Type 2; Double-Blind Method; Erythro | 1985 |
17 other studies available for glipizide and Insulin Resistance
| Article | Year |
|---|---|
Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus.
Topics: Aged; Amino Acids, Aromatic; Amino Acids, Branched-Chain; Biomarkers; Blood Glucose; Diabetes Mellit | 2013 |
Effectiveness of the early addition of rosiglitazone to control hyperglycemia after unsuccessful submaximal sulphonylurea monotherapy: the Rosiglitazone Early Versus SULphonylurea Titration (RESULT) Study.
Topics: Age Factors; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Disease Progression; Double-Blin | 2009 |
Resolution of insulin-requiring diabetes in a liver transplant recipient after treatment of a pheochromocytoma: case report and review of literature.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Diabetes Mellitus, Type 2; Female; Glipizide; Glucocorticoid | 2011 |
Pioglitazone protects against thrombosis in a mouse model of obesity and insulin resistance.
Topics: Animals; Carotid Arteries; Disease Models, Animal; Drug Evaluation, Preclinical; Glipizide; Insulin | 2005 |
Mechanism of action of the second-generation sulfonylurea glipizide.
Topics: Animals; Binding Sites; Diabetes Mellitus, Type 2; Dogs; Drug Synergism; Female; Glipizide; Glucose; | 1983 |
Long-term safety and efficacy of glipizide.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Female; Glipizide; Glucose Tolerance Test; Humans; Insulin | 1983 |
Effect of glipizide treatment on various aspects of glucose, insulin, and lipid metabolism in patients with noninsulin-dependent diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type | 1983 |
Effect of sulfonylurea treatment on in vivo insulin secretion and action in patients with non-insulin-dependent diabetes mellitus.
Topics: Aged; Blood Glucose; Diabetes Mellitus; Female; Glipizide; Humans; Insulin; Insulin Resistance; Insu | 1982 |
Sulfonylurea treatment of insulin-independent diabetes mellitus.
Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diet, Diabetic; Glipizide; Humans; Hypoglycemic Agent | 1980 |
Selective potentiation of insulin-mediated glucose disposal in normal dogs by the sulfonylurea glipizide.
Topics: Animals; Dogs; Glipizide; Glucose; Insulin; Insulin Resistance; Liver; Sulfonylurea Compounds | 1981 |
Effects of chronic glipizide treatment on the NIDD heart.
Topics: Animals; Animals, Newborn; Blood Glucose; Cardiac Output, Low; Diabetes Mellitus, Experimental; Diab | 1993 |
Early insulin release effectively improves glucose tolerance: studies in two rodent models of type 2 diabetes mellitus.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Dietary Fats; Gastric Emptying; Gli | 2001 |
Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice.
Topics: Agaricales; Animals; Blood Glucose; Diabetes Mellitus; Glipizide; Glucans; Hypoglycemic Agents; Insu | 2002 |
Insulin resistance in patients with insulin independent diabetes mellitus: partial amelioration by the sulfonylurea glipizide.
Topics: Blood Glucose; Diabetes Mellitus; Diet, Diabetic; Glipizide; Glucose; Glucose Tolerance Test; Humans | 1979 |
[The effect of Glipizide on the blood glucose and insulin in non-ketotic diabetes mellitus (author's transl)].
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus; Glipizide; Humans; Hyperlipidemias; Insulin; Insulin | 1976 |
Effect of sulphonylurea therapy on insulin sensitivity in non insulin dependent diabetics.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glipizide; Glyburide; Humans; Insulin Resistance; Middle A | 1990 |
Reversal of insulin resistance in adipose tissue of non-insulin-dependent diabetics by treatment with diet and sulphonylurea.
Topics: Adipose Tissue; Diabetes Mellitus, Type 2; Female; Glipizide; Glucose; Glyburide; Humans; Insulin; I | 1985 |