| Assay ID | Title | Year | Journal | Article |
|---|
| AID453381 | Agonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP accumulation | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. |
| AID1451010 | Displacement of [3H]CCPA from human A1 receptor expressed in CHO cell membranes after 60 mins by gamma counting method | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID453379 | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. |
| AID1650496 | Induction of adipogenesis in human MSC incubated for 5 days cotreated with IDX by ELISA | 2020 | Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
| Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. |
| AID1650493 | Binding affinity to GST-tagged human PPARalpha LBD up to 30 uM incubated for 2 to 6 hrs by TR-FRET assay | 2020 | Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
| Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. |
| AID391161 | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
| Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. |
| AID1650500 | Competitive binding affinity to GST-tagged human PPARdelta LBD incubated for 1 to 6 hrs by TR-FRET assay | 2020 | Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
| Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. |
| AID317750 | Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists. |
| AID391434 | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
| Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. |
| AID642995 | Binding affinity to human adenosine A3 receptor | 2012 | Journal of medicinal chemistry, Jan-12, Volume: 55, Issue:1
| Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands. |
| AID34711 | Binding affinity for human Adenosine A3 receptor in CHO cells using [125I]-iodo-AB-MECA | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor. |
| AID1650504 | Antagonist activity at PPARdelta LBD (unknown origin) assessed as increase in recruitment of SMRT ID2 corepressor peptide by TR-FRET assay | 2020 | Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
| Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. |
| AID259409 | Maximal agonistic effect at human adenosine A3 receptor in CHO cells at 10 uM by inhibition of forskolin-stimulated cAMP production | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor. |
| AID1451011 | Displacement of [3H]CGS21680 from human A2A adenosine receptor expressed in HEK293 cell membranes after 60 mins by gamma counting method | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID1443904 | Cytotoxicity against Sprague-Dawley rat microglial cells assessed as effect on cell viability up to 50 uM after 24 hrs by presto blue assay | | | |
| AID317751 | Displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in CHO cells | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists. |
| AID1650502 | Partial agonist at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 by TR-FRET assay relative to control | 2020 | Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
| Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. |
| AID34241 | Binding affinity for human adenosine A2A receptor in CHO cells using [3H]CGS-21680 | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor. |
| AID32866 | Binding affinity for rat adenosine A2A receptor of CHO cells using [3H]CGS-21680 | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor. |
| AID1451009 | Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cell membranes after 60 mins by gamma counting method | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID453374 | Binding affinity to human adenosine A3 receptor | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. |
| AID515857 | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed CHO cells after 60 mins by gamma counting | 2010 | Bioorganic & medicinal chemistry, Oct-01, Volume: 18, Issue:19
| Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors. |
| AID30449 | Binding affinity for human Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor. |
| AID1443903 | Antimigratory activity in Sprague-Dawley rat microglial cells assessed as inhibition of MCP-1 mediated cell migration at 100 nM after 20 mins by inverted confocal microscopy | | | |
| AID1650501 | Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 by TR-FRET assay | 2020 | Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
| Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. |
| AID424462 | Displacement of [3H]NECA from human recombinant adenosine A1 receptor expressed in CHO cells by liquid scintillation counting | 2009 | Bioorganic & medicinal chemistry, May-15, Volume: 17, Issue:10
| Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. |
| AID424463 | Displacement of [3H]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells by liquid scintillation counting | 2009 | Bioorganic & medicinal chemistry, May-15, Volume: 17, Issue:10
| Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. |
| AID259404 | Displacement of [3H]R-PIA from human adenosine A1 receptor transfected in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor. |
| AID453380 | Selectivity for human adenosine A3 receptor over human adenosine A1 receptor | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. |
| AID32038 | Binding affinity for rat Adenosine A1 receptor in CHO cells using [3H]N6-(R)-phenylisopropyladenosine | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor. |
| AID291340 | Activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production | 2007 | Journal of medicinal chemistry, Jul-12, Volume: 50, Issue:14
| Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists. |
| AID291333 | Displacement of [3H]CCPA from human adenosine A1 receptor in CHO cells | 2007 | Journal of medicinal chemistry, Jul-12, Volume: 50, Issue:14
| Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists. |
| AID391432 | Displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in HEK293 cells | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
| Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. |
| AID317752 | Displacement of [3H]ABMECA from human adenosine A3 receptor expressed in CHO cells | 2008 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 18, Issue:5
| Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists. |
| AID1451035 | Induction of adipogenesis in human bone marrow-derived mesenchymal stem cells assessed as adiponectin level at 4 uM measured on day 7 after 48 hrs by ELISA | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID424464 | Displacement of [3H]CGS21680 from human recombinant adenosine A2a receptor expressed in HEK293 cells by liquid scintillation counting | 2009 | Bioorganic & medicinal chemistry, May-15, Volume: 17, Issue:10
| Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists. |
| AID1451034 | Induction of adipogenesis in human bone marrow-derived mesenchymal stem cells assessed as adiponectin level at 20 uM measured on day 7 after 48 hrs by ELISA | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID1451022 | Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARgamma LBD by TR-FRET assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID291335 | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | 2007 | Journal of medicinal chemistry, Jul-12, Volume: 50, Issue:14
| Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists. |
| AID391436 | Displacement of [125I]I-AB-MECA from rat adenosine A3 receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Oct-23, Volume: 51, Issue:20
| Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists. |
| AID1451019 | Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARalpha LBD at 20 uM by TR-FRET assay relative to control | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID259406 | Displacement of [3H]CGS-21680 from human adenosine A2A receptor transfected in HEK293 cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor. |
| AID34427 | Inhibitory concentration against human Adenosine A3 receptor mediated inhibition of cyclic AMP in transfected CHO cells | 2003 | Journal of medicinal chemistry, Aug-28, Volume: 46, Issue:18
| N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor. |
| AID259408 | Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cells | 2006 | Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
| Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor. |
| AID1650505 | Antagonist at PPARdelta LBD (unknown origin) assessed as increase in recruitment of coactivator peptide C33 cotreated with PPARdelta agonist GW501516 by TR-FRET assay | 2020 | Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
| Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. |
| AID291334 | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in HEK293 cells | 2007 | Journal of medicinal chemistry, Jul-12, Volume: 50, Issue:14
| Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists. |
| AID1451024 | Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARdelta LBD by TR-FRET assay | 2017 | Journal of medicinal chemistry, 09-14, Volume: 60, Issue:17
| Polypharmacology of N |
| AID453377 | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. |
| AID453375 | Displacement of [3H]R-PIA from human adenosine A1 receptor expressed in CHO cells | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists. |
| AID1650499 | Competitive binding affinity to GST-tagged human PPARgamma LBD incubated for 1 to 6 hrs by TR-FRET assay | 2020 | Bioorganic & medicinal chemistry, 01-01, Volume: 28, Issue:1
| Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |