6-deoxy-6-fluoroglucose profile

6-deoxy-6-fluoroglucose, also known as 6-fluoroglucose or 6-FG, is a glucose analog that is used as a PET tracer. It is synthesized by fluorination of glucose and is important for its ability to be readily taken up by cells via glucose transporters. This is because 6-FG is structurally similar to glucose, but the fluorine atom prevents it from being metabolized further. 6-FG accumulates in tissues that are metabolically active, such as tumors, allowing them to be visualized through PET scans. 6-FG is studied to detect and monitor cancer, monitor glucose metabolism in the brain, and assess the effectiveness of cancer therapies.'

6-deoxy-6-fluoroglucose: RN given refers to (D)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	120673
SCHEMBL ID	2952274
MeSH ID	M0108299

Synonym
(3r,4s,5s,6s)-6-(fluoromethyl)tetrahydropyran-2,3,4,5-tetrol
6-deoxy-6-fluoroglucose
(3r,4s,5s,6s)-6-(fluoromethyl)oxane-2,3,4,5-tetrol
A822108
(2r,3r,4r,5s,6r)-6-(fluoromethyl)tetrahydropyran-2,3,4,5-tetrol
A826671
(3r,4s,5s,6s)-6-(fluoromethyl)tetrahydro-2h-pyran-2,3,4,5-tetraol
34168-77-9
AKOS006240258
glucose, 6-fluorohydrin
6-deoxy-6-fluoro-glucopyranose
6-desoxy-6-fluoro-d-glucopyranose
SCHEMBL2952274
6-fluoro-6-deoxy-d-glucopyranose
mfcd00064096
CS-0362885
6-fluoro-6-deoxyglucose

Excerpt	Reference	Relevance
" We then assessed the bio-distribution and pharmacokinetic properties of 6-FDG-GNPs in vivo using a murine model."	( Pharmacokinetic and toxicological evaluation of multi-functional thiol-6-fluoro-6-deoxy-D-glucose gold nanoparticles in vivo. Chen, J; Kong, B; Roa, W; Song, K; Wilson, J; Xing, JZ; Xiong, Y; Yang, X, 2012)	0.38

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (35.71)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (28.57)	29.6817
2010's	5 (35.71)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
choline [no description available]	2.96	1	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.06	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	2	1	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	2.07	1	copper group element atom; elemental gold
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.96	1	benzenes; phenyl acetates
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
fluorodeoxyglucose f18 Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)	4.23	6	2-deoxy-2-((18)F)fluoro-D-glucose; 2-deoxy-2-fluoro-aldehydo-D-glucose
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	4.91	14
3-deoxy-3-fluoro-d-glucose [no description available]	2.07	1
glycogen glycogen : A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.	2.07	1
carbon-11 acetate carbon-11 acetate: a tracer of myocardial oxygen consumption	2.96	1
D-fructopyranose [no description available]	1.93	1	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent
acebutolol alpha-D-glucosyl-(1->4)-alpha-D-mannose : An alpha-D-glucosyl-(1->4)-D-mannopyranose in which the anomeric hydroxy group has alpha configuration.	2.07	1	alpha-D-glucosyl-(1->4)-D-mannopyranose

Condition	Relationship Strength	Studies
Insulin Sensitivity [description not available]	2.1	1
Insulin Resistance Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.	2.1	1
Hepatocellular Carcinoma [description not available]	2.96	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.96	1
Adenocarcinoma, Basal Cell [description not available]	2.07	1
Breast Cancer [description not available]	2.07	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.07	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.07	1
Hyperglycemia, Postprandial Abnormally high BLOOD GLUCOSE level after a meal.	2.07	1
Hyperglycemia Abnormally high BLOOD GLUCOSE level.	2.07	1
Acute Confusional Senile Dementia [description not available]	1.96	1
Amentia [description not available]	1.96	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	1.96	1
Dementia An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.	1.96	1
Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.	1.96	1

6-deoxy-6-fluoroglucose

Description

Cross-References

Synonyms (17)

Research Excerpts

Pharmacokinetics

Research

Studies (14)

Market Indicators

Research Demand Index: 11.62

Study Types