chlorpropamide has been researched along with Insulin Resistance in 15 studies
Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)
chlorpropamide : An N-sulfonylurea that is urea in which a hydrogen attached to one of the nitrogens is substituted by 4-chlorobenzenesulfonyl group and a hydrogen attached to the other nitrogen is substituted by propyl group. Chlorpropamide is a hypoglycaemic agent used in the treatment of type 2 (non-insulin-dependent) diabetes mellitus not responding to dietary modification.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After the observation of decreasing insulin resistance in a diabetic patient during treatment with mebendazole for nematosis, we investigated the effect of mebendazole on metabolic control in six Type 1 (insulin-dependent) and six Type 2 (non-insulin-dependent) diabetic patients, eight of whom were chronically resistant to conventional treatment." | 3.67 | Improvement of metabolic control in diabetic patients during mebendazole administration: preliminary studies. ( Boden, G; Caprio, S; Dayal, VK; Hoeldtke, RD; Mozzoli, MA; Owen, OE; Ray, TK; Reichard, GA; Shuman, CR; Smith, RH, 1984) |
| "Treatment with chlorpropamide (one to three months, average dose equals 375 mg/day) was associated with a marked reduction in hyperglycemia and an increase toward normal in insulin binding to mononuclear cells." | 1.26 | Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients. ( Olefsky, JM; Reaven, GM, 1976) |
| "Chlorpropamide treatment reduced the insulin requirement to zero, which was unrelated to a change in insulin antibody concentration." | 1.25 | Sulphonylureas and insulin resistance. ( Lloyd, E; Vinik, AI, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| GARDNER, CT | 1 |
| JOHNSON, LF | 1 |
| TUCKER, HS | 1 |
| KODEJSZKO, E | 1 |
| CARLETTI, D | 1 |
| Caprio, S | 1 |
| Ray, TK | 1 |
| Boden, G | 1 |
| Reichard, GA | 1 |
| Shuman, CR | 1 |
| Smith, RH | 1 |
| Mozzoli, MA | 1 |
| Dayal, VK | 1 |
| Hoeldtke, RD | 1 |
| Owen, OE | 1 |
| Tattersall, RB | 1 |
| Leatherdale, BA | 1 |
| Ingram, DA | 1 |
| Dixon, K | 1 |
| Olefsky, JM | 1 |
| Reaven, GM | 1 |
| McMorrow, RG | 1 |
| McConnell, LH | 1 |
| Lloyd, E | 1 |
| Vinik, AI | 1 |
| Shank, WA | 1 |
| Morrison, AD | 1 |
| Owens, DR | 1 |
| Hosker, JP | 1 |
| Burnett, MA | 1 |
| Davies, EG | 1 |
| Harris, EA | 1 |
| Turner, RC | 1 |
| Lev-Ran, AS | 1 |
| de Assis, LM | 1 |
| Nicolau, W | 1 |
| Salomon, JB | 1 |
| de Cintra, AB | 1 |
| Pieroni, RR | 1 |
| Fineberg, SK | 1 |
3 reviews available for chlorpropamide and Insulin Resistance
| Article | Year |
|---|---|
[25 years of diabetic treatment by oral hypoglycemic agents: successes and failures].
Topics: Aged; Aging; Blood Glucose; Cardiovascular Diseases; Chlorpropamide; Diabetes Complications; Diabete | 1984 |
Oral sulfonylureas for the treatment of type II diabetes: an update.
Topics: Administration, Oral; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Hypersensitivity; Glipizide; G | 1986 |
Effects of oral sulfonylureas on the spectrum of defects in non-insulin-dependent diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Chlorpropamide; Clinical Trials as Topic; Combined Modality Therapy; Dia | 1985 |
1 trial available for chlorpropamide and Insulin Resistance
| Article | Year |
|---|---|
Effects of oral sulfonylureas on the spectrum of defects in non-insulin-dependent diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Chlorpropamide; Clinical Trials as Topic; Combined Modality Therapy; Dia | 1985 |
12 other studies available for chlorpropamide and Insulin Resistance
| Article | Year |
|---|---|
INSULIN RESISTANCE.
Topics: Chlorpropamide; Cortisone; Diabetes Mellitus; Insulin; Insulin Antibodies; Insulin Resistance | 1964 |
[CLINICAL PROBLEMS IN THE MATTER OF INSULIN RESISTANCE].
Topics: Adolescent; Chlorpropamide; Diabetes Mellitus; Diagnosis; Drug Tolerance; Hemagglutination; Humans; | 1964 |
[CHLORPROPAMIDE AND PHENETHYLBIGUANIDE ASSOCIATED WITH INSULIN THERAPY IN SOME CASES OF INSULIN RESISTANCE].
Topics: Antimalarials; Biguanides; Chlorpropamide; Diabetes Mellitus; Guanidine; Guanidines; Humans; Insulin | 1965 |
Improvement of metabolic control in diabetic patients during mebendazole administration: preliminary studies.
Topics: Adult; Benzimidazoles; Blood Glucose; C-Peptide; Chlorpropamide; Diabetes Mellitus, Type 1; Diabetes | 1984 |
Recurrent insulin resistance.
Topics: Chlorpropamide; Diabetes Mellitus; Female; Humans; Insulin; Insulin Resistance; Middle Aged; Prednis | 1980 |
Effects of sulfonylurea therapy on insulin binding to mononuclear leukocytes of diabetic patients.
Topics: Adult; Chlorpropamide; Diabetes Mellitus; Female; Humans; Hyperglycemia; Insulin; Insulin Resistance | 1976 |
Insulin hypersensitivity with insulin resistance.
Topics: Chlorpropamide; Diabetes Mellitus; Drug Hypersensitivity; Dyspnea; Female; Humans; Insulin; Insulin | 1976 |
Sulphonylureas and insulin resistance.
Topics: Chlorpropamide; Diabetes Mellitus; Female; Humans; Insulin; Insulin Antibodies; Insulin Resistance; | 1975 |
Sulphonylurea therapy doubles B-cell response to glucose in type 2 diabetic patients.
Topics: Aged; Blood Glucose; C-Peptide; Chlorpropamide; Diabetes Mellitus, Type 2; Glucose; Glyburide; Human | 1985 |
Treatment with chlorpropamide-phenformin combination in adult, obese, ketosis-resistant diabetics.
Topics: Age Factors; Aged; Chlorpropamide; Diabetes Complications; Diabetes Mellitus; Diabetic Ketoacidosis; | 1971 |
Immunobiological studies in two cases of insulin-resistant diabetes.
Topics: Adult; Chlorpropamide; Diabetes Insipidus; Diabetes Mellitus; Female; Humans; Insulin; Insulin Antib | 1970 |
Combinations of oral hypoglycemic drugs in obese, insulin-resistant diabetics.
Topics: Adult; Aged; Blood Glucose; Carbohydrate Metabolism; Chlorpropamide; Diabetes Mellitus; Drug Synergi | 1968 |