L 783281: structure in first source [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 3013166 |
| SCHEMBL ID | 304445 |
| MeSH ID | M0304948 |
| Synonym |
|---|
| HMS3268I16 |
| dmaq-b1 |
| 2-[2-(1,1-dimethylallyl)-1h-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1h-indol-3-yl]-1,4-benzoquinone |
| 2,5-cyclohexadiene-1,4-dione, 2-[2-(1,1-dimethyl-2-propenyl)-1h-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1h-indol-3-yl]- |
| NCGC00025307-01 |
| tocris-1819 |
| l-783,281 |
| daq b1 |
| demethylasterriquinone b1 |
| l 783281 |
| 2,5-dihydroxy-3-[2-(2-methylbut-3-en-2-yl)-1h-indol-3-yl]-6-[7-(3-methylbut-2-enyl)-1h-indol-3-yl]cyclohexa-2,5-diene-1,4-dione |
| l783281 |
| 78860-34-1 |
| l-783281 |
| SCHEMBL304445 |
| 2-[2-(1,1-dimethyl-2-propenyl)-1h-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1h-indol-3-yl]-2,5-cyclohexadiene-1,4-dione |
| AKOS024456800 |
| SR-01000597541-1 |
| sr-01000597541 |
| XMGNJVXBPZAETK-UHFFFAOYSA-N |
| 2,5-dihydroxy-3-(7-(3-methylbut-2-en-1-yl)-1h-indol-3-yl)-6-(2-(2-methylbut-3-en-2-yl)-1h-indol-3-yl)cyclohexa-2,5-diene-1,4-dione |
| demethylasterriquinone b 1; dimethylasterriquinone |
| EX-A4908 |
| unii-f6582h6jqw |
| AMY42295 |
| NCGC00025307-02 |
| 2566744-46-3 |
| 2,5-cyclohexadiene-1,4-dione, 2-(2-(1,1-dimethyl-2-propenyl)-1h-indol-3-yl)-3,6-dihydroxy-5-(7-(3-methyl-2-butenyl)-1h-indol-3-yl)- |
| F6582H6JQW , |
| dimethylasterriquinone |
| 2,5-cyclohexadiene-1,4-dione, 2-(2-(1,1-dimethyl-2-propen-1-yl)-1h-indol-3-yl)-3,6-dihydroxy-5-(7-(3-methyl-2-buten-1-yl)-1h-indol-3-yl)- |
| CS-0028912 |
| HY-107586 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Glyceraldehyde-3-phosphate dehydrogenase | Oryctolagus cuniculus (rabbit) | IC50 | 15.0000 | AID292160 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Glyceraldehyde-3-phosphate dehydrogenase | Homo sapiens (human) | Kd | 7.2000 | AID292161 |
| Insulin receptor | Homo sapiens (human) | EC50 | 5.0000 | AID91685 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1347163 | 384 well plate NINDS AMC confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347164 | 384 well plate NINDS Rhodamine confirmatory qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347167 | Vero cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 ISSN: 2211-1247 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347149 | Furin counterscreen qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347152 | Confirmatory screen NINDS AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347169 | Tertiary RLuc qRT-PCR qHTS assay for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347168 | HepG2 cells viability qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347161 | Confirmatory screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347153 | Confirmatory screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID93465 | Percent insulin like growth factor receptor(IGFIR) activity at 30 uM | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19 ISSN: 0022-2623 | Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. |
| AID155188 | Percent platelet derived growth factor receptor (PDGFR) activity at 30 uM | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19 ISSN: 0022-2623 | Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. |
| AID67287 | Percent epidermal growth factor receptor (EGFR) activity at 30 uM | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19 ISSN: 0022-2623 | Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. |
| AID93071 | Percent activation of insulin receptor in CHO cells by 10 uM of compound | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 ISSN: 0960-894X | The basal SAR of a novel insulin receptor activator. |
| AID93074 | Ability to activate the insulin receptor compared to that of lead structure 1 expressed as X/1 | 2000 | Bioorganic & medicinal chemistry letters, Jun-05, Volume: 10, Issue:11 ISSN: 0960-894X | The basal SAR of a novel insulin receptor activator. |
| AID292161 | Binding affinity to GAPDH in human erythrocytes | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15 ISSN: 0022-2623 | Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. |
| AID292160 | Binding affinity to GAPDH in rabbit muscle | 2007 | Journal of medicinal chemistry, Jul-26, Volume: 50, Issue:15 ISSN: 0022-2623 | Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. |
| AID91685 | Activation of human insulin receptor tyrosine kinase (IRTK) | 2000 | Journal of medicinal chemistry, Sep-21, Volume: 43, Issue:19 ISSN: 0022-2623 | Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 21 (70.00) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 4 (12.90%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 27 (87.10%) | 84.16% |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allergic Encephalomyelitis | 0 | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Alloxan Diabetes | 0 | 1999 | 2001 | 24.0 | low | 0 | 0 | 2 | 1 | 0 | 0 | |
| Autoimmune Diabetes | 0 | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| Blood Pressure, High | 0 | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Body Weight | 0 | 2005 | 2018 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 | |
| Cardiometabolic Syndrome | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Compensatory Hyperinsulinemia | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Congenital Zika Syndrome | 0 | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| Diabetes Mellitus | 0 | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 3 | 0 | 0 | |
| Diabetes Mellitus, Adult-Onset | 0 | 1999 | 2018 | 19.7 | medium | 0 | 0 | 3 | 2 | 2 | 0 | |
| Diabetes Mellitus, Type 1 | 0 | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| Diabetes Mellitus, Type 2 | 0 | 1999 | 2018 | 19.7 | medium | 0 | 0 | 3 | 2 | 2 | 0 | |
| Disease Models, Animal | 0 | 2001 | 2020 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 | |
| HIV Coinfection | 0 | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| HIV Infections | 0 | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Hyperglycemia | 0 | 1999 | 2011 | 20.7 | low | 0 | 0 | 2 | 0 | 1 | 0 | |
| Hyperglycemia, Postprandial | 0 | 1999 | 2011 | 20.7 | low | 0 | 0 | 2 | 0 | 1 | 0 | |
| Hyperinsulinism | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Hypertension | 0 | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Insulin Resistance | 0 | 2001 | 2018 | 16.6 | low | 0 | 0 | 0 | 3 | 2 | 0 | |
| Insulin Sensitivity | 0 | 2001 | 2018 | 16.6 | low | 0 | 0 | 0 | 3 | 2 | 0 | |
| Metabolic Syndrome | 0 | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Muscle Relaxation | 0 | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Nerve Degeneration | 0 | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 | |
| Obesity | 0 | 2005 | 2011 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 | |
| Zika Virus Infection | 0 | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Article | Year |
|---|---|
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, , Volume: 96, Issue:5 | 2019 |
| The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. Journal of neurochemistry, , Volume: 78, Issue:5 | 2001 |
| Article | Year |
|---|---|
| Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway. Toxicology letters, , Jun-15, Volume: 290 | 2018 |