Compounds > ponicidin
Page last updated: 2024-11-13

ponicidin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ponicidin: from the stems and leaves of Rabdosa nervosa [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID70698029
CHEBI ID67671
MeSH IDM0238767

Synonyms (4)

Synonym
ponicidin
52617-37-5
CHEBI:67671
Q27136143

Research Excerpts

Overview

Ponicidin is a diterpenoid compound extracted and purified from the traditional Chinese herb Rabdosia rubescens. It showed promising anti-cancer effects in a variety of tumors.

ExcerptReferenceRelevance
"Ponicidin is a diterpenoid isolated from a Chinese traditional herb (Rabdosia rubescens) and demonstrates the various pharmacological effects."( Neuroprotective Effect of Ponicidin Alleviating the Diabetic Cognitive Impairment: Regulation of Gut Microbiota.
Cao, D; Guo, F; Kumar, P; Li, X; Yan, Y; Zhang, K; Zhang, N; Zhang, X, 2023)		1.93
"Ponicidin is a diterpenoid compound extracted and purified from the traditional Chinese herb Rabdosia rubescens, and showed promising anti-cancer effects in a variety of tumors."( Ponicidin inhibited gallbladder cancer proliferation and metastasis by decreasing MAGEB2 expression through FOXO4.
Dong, P; Liu, SL; Mei, JW; Pan, LJ; Shi, LQ; Shu, YJ; Xiang, SS; Yang, ZY; Zhang, J; Zhang, Y; Zhao, C, 2023)		3.07
"Ponicidin is an active natural ent-kaurane diterpenoid ingredient originating from many Isondon herbs and is expected to become a new anticancer agent. "( A practical strategy for the characterization of ponicidin metabolites in vivo and in vitro by UHPLC-Q-TOF-MS based on nontargeted SWATH data acquisition.
Du, Y; Hou, L; Jin, Y; Ma, Y; Xie, W; Xu, H; Zhang, K; Zhang, L, 2017)		2.15
"Ponicidin is a diterpenoid extracted from the Chinese herb Isodon adenolomus, which has been reported as a therapeutic cytotoxic drug that may be used to treat various types of human cancer. "( Ponicidin suppresses HT29 cell growth via the induction of G1 cell cycle arrest and apoptosis.
Chen, C; Du, J; Sun, Y; Wang, W; Zheng, L, 2015)		3.3

Effects

ExcerptReferenceRelevance
"Ponicidin has a variety of biological effects such as immunoregulatory and anti-inflammatory functions as well as anti-viral functions especially in the upper respiratory tract infection. "( Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma.
Chen, WX; Kong, WM; Liao, XH; Liu, Y; Liu, YF; Lu, YM; Qu, GQ, 2015)		3.3
"Ponicidin has been reported to have anti-tumor effects on a large variety of malignant diseases."( Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro.
Chen, F; Hou, M; Huang, RW; Lin, DJ; Lin, Q; Liu, JJ; Pan, X; Peng, J; Song, YQ; Wu, XY; Zhang, MH, 2005)		1.34

Actions

ExcerptReferenceRelevance
"Ponicidin could inhibit the growth of QGY-7701 and HepG-2 cells significantly by induction of apoptosis. "( Ponicidin inhibits cell growth on hepatocellular carcinoma cells by induction of apoptosis.
Cai, CJ; Chen, GH; Li, H; Liu, PQ; Lu, MQ; Yang, Y; Zhang, JF, 2007)		3.23

Treatment

The ponicidin treatment effectively decreased the body weight, food intake, HOMA-IR, and HbAlc levels in the DN animals. PonicidIn treatment of lung cancer cells caused downregulation of anti-apoptotic protein Bcl-2 and survivin as well as upregulaton of pro-ap Optic protein Bax.

ExcerptReferenceRelevance
"The ponicidin treatment effectively decreased the body weight, food intake, HOMA-IR, and HbAlc levels in the DN animals."( Ponicidin attenuates streptozotocin-induced diabetic nephropathy in rats via modulating hyperlipidemia, oxidative stress, and inflammatory markers.
An, S; Jia, X; Li, Y; Xue, W; Yang, Y, 2022)		2.64
"The ponicidin treatment remarkably improved the proliferation of MG-63 cells."( Ponicidin Treatment Improved the Cell Proliferation, Differentiation, and Calcium Mineralization on the Osteoblast-Like MG-63 Cells.
Hao, P; Li, H; Miao, B; Zhang, Y, 2022)		2.64
"Ponicidin-treated MCF-7 cells expressed reduced levels of cyclin B1, cdc2, transcription factor E2F, and Rb including phosphorylation at S780."( Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens.
Gunatilaka, AL; Hsieh, TC; Liang, JY; Wijeratne, EK; Wu, JM, 2005)		1.25
"Ponicidin treatment of lung cancer cells caused downregulation of anti-apoptotic protein Bcl-2 and survivin as well as upregulaton of pro-apoptotic protein Bax in a time dependent manner when apoptosis ocurred."( Ponicidin, an ent-kaurane diterpenoid derived from a constituent of the herbal supplement PC-SPES, Rabdosia rubescens, induces apoptosis by activation of caspase-3 and mitochondrial events in lung cancer cells in vitro.
Chen, F; Hou, M; Huang, RW; Lin, DJ; Lin, Q; Liu, JJ; Pan, X; Peng, J; Wu, XY; Zhang, M, 2006)		2.5
"Treatment with ponicidin significantly suppressed HT29 cell growth by inducing G1 cell cycle arrest and apoptosis."( Ponicidin suppresses HT29 cell growth via the induction of G1 cell cycle arrest and apoptosis.
Chen, C; Du, J; Sun, Y; Wang, W; Zheng, L, 2015)		2.2

Bioavailability

ExcerptReferenceRelevance
" The method was sensitive and reliable and was successfully applied to a pharmacokinetic and bioavailability study of Herba Isodi Rubescentis extract in rats."( Simultaneous determination of oridonin, ponicidin and rosmarinic acid from Herba Isodi Rubescentis extract by LC-MS-MS in rat plasma.
Li, J; Liu, Y; Ma, B; Wang, Y; Xu, Q; Ying, H; Zhang, Q, )		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
dioxanes
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (25)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (4.00)18.2507
2000's8 (32.00)29.6817
2010's10 (40.00)24.3611
2020's6 (24.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.41 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index5.11 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (3.70%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other26 (96.30%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bisbenzimidazole
Bisbenzimidazole: A benzimidazole antifilarial agent; it is fluorescent when it binds to certain nucleotides in DNA, thus providing a tool for the study of DNA replication; it also interferes with mitosis.		2.0210bibenzimidazole;
N-methylpiperazine		anthelminthic drug;
fluorochrome
sulfamethoxazole
Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208). sulfamethoxazole : An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.		2.0510isoxazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide		antibacterial agent;
antiinfective agent;
antimicrobial agent;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
epitope;
P450 inhibitor;
xenobiotic
enmein
enmein: structure		2.3110delta-lactonemetabolite
lasiokaurin
lasiokaurin: kaurene-type diterpenoid from Isodon species; structure		1.9810kaurane diterpenoidmetabolite
oridonin
[no description available]		3.2860
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		7.01102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ganciclovir
[no description available]		2.41202-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.920
Diabetic Glomerulosclerosis
[description not available]		02.920
Hyperlipemia
[description not available]		02.4110
Innate Inflammatory Response
[description not available]		02.4110
Insulin Sensitivity
[description not available]		02.4110
Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.		02.920
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.		02.920
Hyperlipidemias
Conditions with excess LIPIDS in the blood.		02.4110
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.4110
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.		02.4110
Age-Related Osteoporosis
[description not available]		02.4110
Osteoporosis
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.		02.4110
Cancer of Gallbladder
[description not available]		02.610
Gallbladder Neoplasms
Tumors or cancer of the gallbladder.		02.610
Malignant Melanoma
[description not available]		02.610
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		07.610
Cancer of Liver
[description not available]		02.4920
Metastase
[description not available]		02.2110
Colorectal Cancer
[description not available]		07.2110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.4920
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.2110
Colorectal Neoplasms
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.		02.2110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.4820
Cancer of Stomach
[description not available]		02.1110
Stomach Neoplasms
Tumors or cancer of the STOMACH.		02.1110
Cancer of Prostate
[description not available]		02.0210
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0210
Granulocytic Leukemia
[description not available]		02.0210
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		02.0210
Breast Cancer
[description not available]		07.0210
Carcinoma, Anaplastic
[description not available]		02.0210
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.0210
Carcinoma
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.		02.0210
Cancer of Lung
[description not available]		02.0310
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0310
Hepatocellular Carcinoma
[description not available]		07.0310
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.0310
Herpes Simplex Virus Infection
[description not available]		02.0110
Herpes Simplex
A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)		07.0110