metribolone and Insulin-Resistance

Synthetic radioinert androgen methyltrienolone administered daily for 2 weeks to male rats with severe diabetes led to a sharp increase in blood testosterone and was accompanied by reduction in glucose level due to an increase in tissue sensitivity to insulin. Normalization of plasma testosterone concentration contributed to saturation of active androgen receptors in the myocardium with testosterone; the number of free receptors decreased by 1.8 times. Testosterone that diminishes the catabolic effects of glucocorticoids improved the state of the myocardium, which was confirmed by activation of DNA and RNA synthesis.

Topics: Anabolic Agents; Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental; DNA Replication; Estradiol; Growth Hormone; Heart; Insulin; Insulin Resistance; Male; Metribolone; Myocardium; Rats; Receptors, Androgen; RNA; Testosterone; Tissue Distribution