| Assay ID | Title | Year | Journal | Article |
|---|
| AID483127 | Binding affinity to human serum albumin | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Glycine amides as PPARalpha agonists. |
| AID483122 | Agonist activity at Gal4-fused human PPARgamma | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Glycine amides as PPARalpha agonists. |
| AID141913 | Agonist activity for murine PPAR gamma receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
| The PPARs: from orphan receptors to drug discovery. |
| AID677052 | Selectivity ratio for EC50 for human PPARgamma to EC50 for human PPARalpha | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. |
| AID156464 | Cotransfection activity of compound against human Peroxisome proliferator activated receptor alpha was determined | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. |
| AID483126 | Agonist activity at Gal4-fused mouse PPARdelta | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Glycine amides as PPARalpha agonists. |
| AID483128 | Aqueous solubility of the compound | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Glycine amides as PPARalpha agonists. |
| AID156932 | Cotransfection activity of compound against human Peroxisome proliferator activated receptor gamma was determined | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. |
| AID483124 | Agonist activity at Gal4-fused mouse PPARalpha | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Glycine amides as PPARalpha agonists. |
| AID311964 | Agonist activity at PPARgamma expressed in HEK293 cells assessed as aP2 gene induction relative to BRL-49653 | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24
| Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. |
| AID311961 | Agonist activity at PPARdelta expressed in HEK293 cells by GAL4 transactivation assay | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24
| Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. |
| AID483121 | Agonist activity at Gal4-fused human PPARalpha | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Glycine amides as PPARalpha agonists. |
| AID677054 | Agonist activity at human PPARalpha | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. |
| AID289934 | Agonist activity at human PPARalpha in HepG2 cells by PPAR-GAL4 transactivation assay | 2007 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
| Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists. |
| AID483125 | Agonist activity at Gal4-fused mouse PPARgamma | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Glycine amides as PPARalpha agonists. |
| AID677053 | Selectivity ratio for EC50 for human PPARbeta/gamma to EC50 for human PPARalpha | 2012 | Journal of medicinal chemistry, May-10, Volume: 55, Issue:9
| Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators. |
| AID156469 | Compound was tested for agonist activity on human Peroxisome proliferator activated receptor delta-GAL4 chimeric receptor in transfected CV-1 cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
| AID311946 | Agonist activity at rat PPARalpha in rat H4IIE cells assessed as gene induction | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24
| Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. |
| AID156780 | Cotransfection activity of compound against human Peroxisome proliferator activated receptor delta was determined; Not determined | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. |
| AID185029 | Minimum effective dose producing a 40-60% decrease in serum TLDL cholesterol in rats relative to vehicle -treated controls | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
| AID156785 | Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor delta-GAL4 chimeric receptor in transfected CV-1 cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
| AID91237 | Agonist activity for Human PPAR alpha receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
| The PPARs: from orphan receptors to drug discovery. |
| AID311960 | Agonist activity at PPARalpha expressed in HEK293 cells by GAL4 transactivation assay | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24
| Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. |
| AID91246 | Agonist activity for Human PPAR gamma receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
| The PPARs: from orphan receptors to drug discovery. |
| AID417012 | Agonist activity at PPARgamma ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
| Selective, potent PPARgamma agonists with cyclopentenone core structure. |
| AID157279 | Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV-1 cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
| AID156450 | Inhibitory activity of compound against the binding of human Peroxisome proliferator activated receptor delta was determined; Not determined | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. |
| AID141903 | Agonist activity for murine PPAR alpha receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
| The PPARs: from orphan receptors to drug discovery. |
| AID141908 | Agonist activity for murine PPAR delta receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
| The PPARs: from orphan receptors to drug discovery. |
| AID156453 | Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
| AID156137 | In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
| AID156937 | In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
| AID417010 | Agonist activity at PPARalpha ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
| Selective, potent PPARgamma agonists with cyclopentenone core structure. |
| AID483123 | Agonist activity at Gal4-fused human PPARdelta | 2010 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 20, Issue:11
| Glycine amides as PPARalpha agonists. |
| AID156801 | Compound was tested for agonist activity on human Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV-1 cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
| AID156283 | Inhibitory activity against human Peroxisome proliferator activated receptor alpha | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. |
| AID417011 | Agonist activity at PPARdelta ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7
| Selective, potent PPARgamma agonists with cyclopentenone core structure. |
| AID156956 | Inhibitory activity of compound against the binding of human Peroxisome proliferator activated receptor gamma was determined | 2003 | Journal of medicinal chemistry, Nov-20, Volume: 46, Issue:24
| Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist. |
| AID84143 | In vivo triglyceride lowering activity in fat-fed hamsters at a dose of 3 mg/kg, po for 7 days | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
| AID311962 | Agonist activity at PPARgamma expressed in HEK293 cells by GAL4 transactivation assay | 2007 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 17, Issue:24
| Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. |
| AID156123 | Compound was tested for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected CV-1 cells | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
| AID91241 | Agonist activity for Human PPAR delta receptor in transcriptional activation assay | 2000 | Journal of medicinal chemistry, Feb-24, Volume: 43, Issue:4
| The PPARs: from orphan receptors to drug discovery. |
| AID156359 | In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
| AID1346733 | Human Peroxisome proliferator-activated receptor-alpha (1C. Peroxisome proliferator-activated receptors) | 1999 | Journal of medicinal chemistry, Sep-23, Volume: 42, Issue:19
| A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. |
| AID1346733 | Human Peroxisome proliferator-activated receptor-alpha (1C. Peroxisome proliferator-activated receptors) | 1999 | Diabetes, Jul, Volume: 48, Issue:7
| A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. |
| AID1346733 | Human Peroxisome proliferator-activated receptor-alpha (1C. Peroxisome proliferator-activated receptors) | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
| AID1346800 | Human Peroxisome proliferator-activated receptor-gamma (1C. Peroxisome proliferator-activated receptors) | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
| AID1346790 | Human Peroxisome proliferator-activated receptor-beta/delta (1C. Peroxisome proliferator-activated receptors) | 2001 | Bioorganic & medicinal chemistry letters, May-07, Volume: 11, Issue:9
| Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. |
| AID1798927 | Cell-Based Transcription Assay from Article 10.1016/j.bmcl.2006.11.050: \\Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists.\\ | 2007 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
| Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |