l-796449 has been researched along with Insulin-Resistance* in 1 studies
1 other study(ies) available for l-796449 and Insulin-Resistance
Article | Year |
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Phenylacetic acid derivatives as hPPAR agonists.
Beginning with the weakly active lead structure 1, a new series of hPPAR agonists was developed. In vivo glucose and triglyceride lowering activity was obtained by homologation and oxamination to 3, then conversion to substituted benzisoxazoles 4 and 5. Further manipulation afforded benzofurans 6 and 7. Compound 7 was of comparable potency as a glucose and triglyceride lowering agent in insulin resistant rodents to BRL 49653. Topics: Animals; Blood Glucose; Dose-Response Relationship, Drug; Drug Design; Hypoglycemic Agents; Insulin Resistance; Male; Mice; Phenylacetates; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides | 2003 |