4-phenylbutyric acid has been researched along with Insulin Resistance in 12 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Min, BK | 1 |
| Kang, HJ | 1 |
| Choi, BJ | 1 |
| Jeon, YH | 1 |
| Cho, JY | 1 |
| Lee, IK | 1 |
| Kim, DW | 1 |
| Crossland, H | 1 |
| Smith, K | 1 |
| Idris, I | 1 |
| Phillips, BE | 1 |
| Atherton, PJ | 1 |
| Wilkinson, DJ | 1 |
| Liu, Y | 2 |
| Chen, Y | 1 |
| Zhang, J | 1 |
| Zhang, Y | 1 |
| Su, Z | 1 |
| Townsend, LK | 1 |
| Medak, KD | 1 |
| Peppler, WT | 1 |
| Meers, GM | 1 |
| Rector, RS | 1 |
| LeBlanc, PJ | 1 |
| Wright, DC | 1 |
| Vella, RE | 1 |
| Pillon, NJ | 1 |
| Zarrouki, B | 1 |
| Croze, ML | 1 |
| Koppe, L | 1 |
| Guichardant, M | 1 |
| Pesenti, S | 1 |
| Chauvin, MA | 1 |
| Rieusset, J | 1 |
| Géloën, A | 1 |
| Soulage, CO | 1 |
| Guridi, M | 1 |
| Tintignac, LA | 1 |
| Lin, S | 1 |
| Kupr, B | 1 |
| Castets, P | 1 |
| Rüegg, MA | 1 |
| Cao, AL | 1 |
| Wang, L | 1 |
| Chen, X | 1 |
| Wang, YM | 1 |
| Guo, HJ | 1 |
| Chu, S | 1 |
| Liu, C | 1 |
| Zhang, XM | 1 |
| Peng, W | 1 |
| Guo, Q | 1 |
| Xu, L | 1 |
| Li, H | 1 |
| Sun, H | 1 |
| Liu, J | 1 |
| Wu, S | 1 |
| Zhou, B | 1 |
| Xu, TY | 1 |
| Chen, RH | 1 |
| Wang, P | 1 |
| Zhang, RY | 1 |
| Ke, SF | 1 |
| Miao, CY | 1 |
| Nogueira, TC | 1 |
| Lellis-Santos, C | 1 |
| Jesus, DS | 1 |
| Taneda, M | 1 |
| Rodrigues, SC | 1 |
| Amaral, FG | 1 |
| Lopes, AM | 1 |
| Cipolla-Neto, J | 1 |
| Bordin, S | 1 |
| Anhê, GF | 1 |
| Ozcan, U | 2 |
| Yilmaz, E | 2 |
| Ozcan, L | 2 |
| Furuhashi, M | 1 |
| Vaillancourt, E | 1 |
| Smith, RO | 1 |
| Görgün, CZ | 1 |
| Hotamisligil, GS | 2 |
| Düvel, K | 1 |
| Sahin, M | 1 |
| Manning, BD | 1 |
12 other studies available for 4-phenylbutyric acid and Insulin Resistance
| Article | Year |
|---|---|
Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity via Brown Adipose Tissue Activation.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Anti-Obesity Agents; Diet, High-Fat; Disease Models, Ani | 2019 |
Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach.
Topics: Amino Acids, Branched-Chain; Animals; Cell Line; Glycogen; Insulin; Insulin Receptor Substrate Prote | 2020 |
Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress.
Topics: 3T3-L1 Cells; Adipocytes, White; Animals; Anti-Obesity Agents; Benzamides; Endoplasmic Reticulum Str | 2017 |
High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.
Topics: Animals; Diet, High-Fat; Dietary Fats; Endoplasmic Reticulum Stress; Glucose; Glucose Intolerance; H | 2019 |
Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation.
Topics: Acetylcysteine; Animals; Anthracenes; Bronchoalveolar Lavage Fluid; Cell Line; Enzyme Activation; In | 2015 |
Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.
Topics: Animals; Endoplasmic Reticulum Stress; Fatty Acids; Female; Fibroblast Growth Factors; Glucose; Insu | 2015 |
Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy.
Topics: Albuminuria; Animals; Apoptosis; Autophagy; Cells, Cultured; Diabetic Nephropathies; Endoplasmic Ret | 2016 |
Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Autophagy; Autophagy-Related Protein 7; eIF-2 Kinase; Endopla | 2017 |
4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2010 |
Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response.
Topics: Adiposity; Animals; Body Weight; Circadian Rhythm; Eating; Gluconeogenesis; Immunoblotting; Insulin | 2011 |
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, | 2006 |
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Cell Line; Child, P | 2008 |