Compounds > letrozole
Page last updated: 2024-10-30

letrozole and Insulin Resistance

letrozole has been researched along with Insulin Resistance in 44 studies

Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.

Research Excerpts

ExcerptRelevanceReference
"This study aims to investigate the effects of a high-fat, high-fructose (HF/HFr) diet on metabolic/endocrine dysregulations associated with letrozole (LET)-induced Polycystic Ovarian Syndrome (PCOS) in prepubertal female mice."8.12The Role of a High-Fat, High-Fructose Diet on Letrozole-Induced Polycystic Ovarian Syndrome in Prepubertal Mice. ( Bajerska, J; Kołodziejski, PA; Pieczyńska, JM; Pruszyńska-Oszmałek, E; Łukomska, A, 2022)
" Liraglutide has favourable neuroprotective effects that may protect against the possible cognitive dysfunction in PCOS."8.02Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome. ( Abdel Salam, RM; Ahmed, MAE; Eltarzy, MA; Saad, MA, 2021)
"The beneficial effects of metformin, especially its capacity to ameliorate insulin resistance (IR) in polycystic ovary syndrome (PCOS), explains why it is widely prescribed."8.02Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance. ( Li, S; Xiao, L; Xie, Y, 2021)
" deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats."8.02Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats. ( Goh, YM; Hashim, N; Haslan, MA; Samsulrizal, N; Shirazi, FH; Zin, NSNM, 2021)
"BACKGROUND The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model."7.96Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways. ( Dun, J; Huang, L; Huang, M; Ji, F; Lin, Q; Lin, Y; Xu, J; Yang, J; You, X; Zhang, J, 2020)
"Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat."7.85Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome. ( Benrick, A; Carlström, M; Cushman, SW; Fornes, R; Hu, M; Ivarsson, N; Maciel, GAR; Maliqueo, M; Marcondes, RR; Stener-Victorin, E; Stenkula, KG, 2017)
" The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance."7.85Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. ( Afsar, T; Almajwal, A; Jahan, S; Pirzada, M; Rauf, N; Razak, S; Ullah, A; Ullah, H, 2017)
"Icariin-treated rats had lower weight gain and reduced triglycerides, fasting insulin, HOMA-IR, TNF-α, and interleukin-6 with higher high-density lipoprotein cholesterol levels than PCOS rats."5.91Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome. ( Hai, Y; Huang, X; Ke, X; Li, P; Li, X; Ren, L; Tian, J; Wang, J; Wang, M; Zhang, R; Zuo, B; Zuo, L, 2023)
"The letrozole-treated mice showed a disrupted estrous cycle and were arrested in the diestrus phase."5.62Cysteine-Cysteine Motif Chemokine Receptor 5 Expression in Letrozole-Induced Polycystic Ovary Syndrome Mice. ( Chen, CW; Chen, KH; Chen, LK; Ho, CH; Hwang, JL; Juan, CC; Liu, PS; Seow, KM; Wang, PH, 2021)
"A rat model of PCOS-IR was established using a high-fat diet (49 d) combined with letrozole (1 mg/kg·d, for 28 d)."5.62Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet. ( Li, CX; Li, M; Miao, MS; Peng, MF; Ren, Z; Song, YG; Tian, S, 2021)
" The methods for establishing PCOS-IR animal model include using dehydroepiandrosterone (DHEA) and sodium prasterone sulfate subcutaneous injection, testosterone propionate combined with high-fat diet, and so on."5.56A Rat Model of Polycystic Ovary Syndrome with Insulin Resistance Induced by Letrozole Combined with High Fat Diet. ( Wang, MX; Xu, X; Yin, Q, 2020)
"We also investigated whether hyperinsulinemia occurs secondary to weight gain and insulin resistance in this model or if it can occur independently."5.46Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance. ( Anvar, AR; Hernández-Carretero, A; Rivera, AJ; Skarra, DV; Thackray, VG, 2017)
" In contrast, in the testosterone-plus-letrozole-treated group, the concentration decreased during letrozole treatment, indicating improved insulin sensitivity."5.10The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor. ( Dunkel, L; Saukkonen, T; Wickman, S, 2002)
"This study aims to investigate the effects of a high-fat, high-fructose (HF/HFr) diet on metabolic/endocrine dysregulations associated with letrozole (LET)-induced Polycystic Ovarian Syndrome (PCOS) in prepubertal female mice."4.12The Role of a High-Fat, High-Fructose Diet on Letrozole-Induced Polycystic Ovarian Syndrome in Prepubertal Mice. ( Bajerska, J; Kołodziejski, PA; Pieczyńska, JM; Pruszyńska-Oszmałek, E; Łukomska, A, 2022)
" deltoidea at the dose of 500 and 1000 mg/kg/day reduced insulin resistance, obesity indices, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL), malondialdehyde (MDA), testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) to near-normal levels in PCOS rats."4.02Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats. ( Goh, YM; Hashim, N; Haslan, MA; Samsulrizal, N; Shirazi, FH; Zin, NSNM, 2021)
" Liraglutide has favourable neuroprotective effects that may protect against the possible cognitive dysfunction in PCOS."4.02Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome. ( Abdel Salam, RM; Ahmed, MAE; Eltarzy, MA; Saad, MA, 2021)
"To assess the characteristics of intestinal flora in PCOS and explore whether abnormal intestinal flora can affect insulin resistance and promote PCOS and whether chenodeoxycholic acid (CDCA) can activate intestinal farnesoid X receptor (FXR), improving glucose metabolism in PCOS."4.02Intestinal Flora is a Key Factor in Insulin Resistance and Contributes to the Development of Polycystic Ovary Syndrome. ( He, Y; Huang, QF; Li, ZW; Tang, WL; Wang, ZW; Wu, S; Yang, YL; Zhou, HW; Zhou, WW; Zhou, ZY, 2021)
"The beneficial effects of metformin, especially its capacity to ameliorate insulin resistance (IR) in polycystic ovary syndrome (PCOS), explains why it is widely prescribed."4.02Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance. ( Li, S; Xiao, L; Xie, Y, 2021)
"A PCOS with insulin resistance rat model was created by administering letrozole and a high-fat diet."3.96MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance. ( Li, K; Lin, Z; Ma, H; Pan, H; Yu, C; Zhang, C, 2020)
"BACKGROUND The aim of this study was to explore whether letrozole and high-fat diets (HFD) can induce obese insulin-resistant polycystic ovary syndrome (PCOS) with all reproductive and metabolic phenotypes in a rat model."3.96Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways. ( Dun, J; Huang, L; Huang, M; Ji, F; Lin, Q; Lin, Y; Xu, J; Yang, J; You, X; Zhang, J, 2020)
" In addition, the minimal weight gain and lack of insulin resistance in adult female mice after letrozole treatment indicates that this model may be useful for investigating the effects of hyperandrogenemia on the hypothalamic-pituitary-gonadal axis and the periphery without the influence of substantial metabolic dysregulation."3.91Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice. ( Anvar, AR; Ho, BS; Kelley, ST; Sau, L; Skarra, DV; Thackray, VG; Torres, PJ, 2019)
"To evaluate the effect of metformin and pioglitazone on leutinizing hormone and follicle stimulating hormone receptor mRNA expression, hyperandrogenism and insulin resistance in high fat diet induced and letrozole induced PCOS in rats."3.88Insulin Sensitizers Modulate GnRH Receptor Expression in PCOS Rats. ( Patel, R; Shah, G, 2018)
"Here we hypothesized that exercise in dihydrotestosterone (DHT) or letrozole (LET)-induced polycystic ovary syndrome mouse models improves impaired insulin and glucose metabolism, adipose tissue morphology, and expression of genes related to adipogenesis, lipid metabolism, Notch pathway and browning in inguinal and mesenteric fat."3.85Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome. ( Benrick, A; Carlström, M; Cushman, SW; Fornes, R; Hu, M; Ivarsson, N; Maciel, GAR; Maliqueo, M; Marcondes, RR; Stener-Victorin, E; Stenkula, KG, 2017)
" The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance."3.85Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. ( Afsar, T; Almajwal, A; Jahan, S; Pirzada, M; Rauf, N; Razak, S; Ullah, A; Ullah, H, 2017)
"Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator."2.87Insulin resistance is associated with depression risk in polycystic ovary syndrome. ( Cedars, MI; Eisenberg, E; Greenwood, EA; Huddleston, HG; Legro, RS; Pasch, LA, 2018)
"Insulin sensitivity was quantified by the Matsuda index."2.82Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men. ( Amory, JK; Chao, J; Kratz, M; Matsumoto, AM; Page, ST; Rubinow, KB, 2016)
"Obesity is also a feature of this syndrome and contributes to associated metabolic abnormalities."2.48Polycystic ovarian syndrome management options. ( Bates, GW; Propst, AM, 2012)
"Icariin-treated rats had lower weight gain and reduced triglycerides, fasting insulin, HOMA-IR, TNF-α, and interleukin-6 with higher high-density lipoprotein cholesterol levels than PCOS rats."1.91Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome. ( Hai, Y; Huang, X; Ke, X; Li, P; Li, X; Ren, L; Tian, J; Wang, J; Wang, M; Zhang, R; Zuo, B; Zuo, L, 2023)
"Although insulin resistance was not due to an impairment of fetal or offspring growth, nor to an alteration in adipose or hepatic sensitivity to insulin, skeletal muscle microvacularization critical for delivery of nutrients/insulin was significantly reduced in fetuses and offspring deprived of estrogen in utero."1.72Estrogen promotes fetal skeletal muscle myofiber development important for insulin sensitivity in offspring. ( Albrecht, ED; Kim, SO; Pepe, GJ, 2022)
"The letrozole-treated mice showed a disrupted estrous cycle and were arrested in the diestrus phase."1.62Cysteine-Cysteine Motif Chemokine Receptor 5 Expression in Letrozole-Induced Polycystic Ovary Syndrome Mice. ( Chen, CW; Chen, KH; Chen, LK; Ho, CH; Hwang, JL; Juan, CC; Liu, PS; Seow, KM; Wang, PH, 2021)
"A rat model of PCOS-IR was established using a high-fat diet (49 d) combined with letrozole (1 mg/kg·d, for 28 d)."1.62Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet. ( Li, CX; Li, M; Miao, MS; Peng, MF; Ren, Z; Song, YG; Tian, S, 2021)
"Polycystic ovary syndrome is a common reproductive disorder in the female of reproductive age, which is characterized by hyperandrogenism, insulin resistance, cystic ovary and infertility."1.62Inhibition of visfatin by FK866 mitigates pathogenesis of cystic ovary in letrozole-induced hyperandrogenised mice. ( Annie, L; Gurusubramanian, G; Roy, VK, 2021)
"Treatment with quercetin improved the PCOS related disturbances in estrous cycle, lipid profile, serum levels of testosterone, estradiol and progesterone, and IR."1.62Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis. ( Khadem-Ansari, MH; Mihanfar, A; Nouri, M; Roshangar, L, 2021)
" The methods for establishing PCOS-IR animal model include using dehydroepiandrosterone (DHEA) and sodium prasterone sulfate subcutaneous injection, testosterone propionate combined with high-fat diet, and so on."1.56A Rat Model of Polycystic Ovary Syndrome with Insulin Resistance Induced by Letrozole Combined with High Fat Diet. ( Wang, MX; Xu, X; Yin, Q, 2020)
"We also investigated whether hyperinsulinemia occurs secondary to weight gain and insulin resistance in this model or if it can occur independently."1.46Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance. ( Anvar, AR; Hernández-Carretero, A; Rivera, AJ; Skarra, DV; Thackray, VG, 2017)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (9.09)29.6817
2010's17 (38.64)24.3611
2020's23 (52.27)2.80

Authors

AuthorsStudies
Xie, Y1
Xiao, L1
Li, S1
Haslan, MA1
Samsulrizal, N1
Hashim, N1
Zin, NSNM1
Shirazi, FH1
Goh, YM1
Seow, KM1
Liu, PS1
Chen, KH1
Chen, CW1
Chen, LK1
Ho, CH1
Hwang, JL1
Wang, PH1
Juan, CC1
Wu, YY2
Li, SY1
Zhu, HQ1
Zhuang, ZM1
Shao, M1
Chen, FL1
Liu, CS1
Tang, QF1
Albrecht, ED4
Aberdeen, GW2
Babischkin, JS1
Prior, SJ1
Lynch, TJ3
Baranyk, IA1
Pepe, GJ4
Kim, SO3
Pieczyńska, JM1
Pruszyńska-Oszmałek, E1
Kołodziejski, PA1
Łukomska, A1
Bajerska, J1
Olaniyi, KS3
Areloegbe, SE3
Wang, Y2
Chen, J1
Dong, H1
Ma, R1
Zou, Y1
Wang, W1
Zheng, Q1
Feng, Y1
Tan, Z1
Zeng, X1
Zhao, Y1
Deng, Y1
Gu, B1
Sun, A1
Rabah, HM1
Mohamed, DA1
Mariah, RA1
Abd El-Khalik, SR1
Khattab, HA1
AbuoHashish, NA1
Abdelsattar, AM1
Raslan, MA1
Farghal, EE1
Eltokhy, AK1
Panchal, D1
Pandya, T1
Kevlani, V1
Shah, S1
Acharya, S1
Zuo, L1
Hai, Y1
Zhang, R1
Zuo, B1
Tian, J1
Li, P1
Ke, X1
Wang, M1
Ren, L1
Li, X1
Huang, X1
Wang, J1
Gao, Y1
Mo, S1
Cao, H1
Zhi, Y1
Ma, X1
Huang, Z1
Li, B3
Wu, J2
Zhang, K1
Jin, L1
Wang, MX1
Yin, Q1
Xu, X1
Xu, J1
Dun, J1
Yang, J2
Zhang, J4
Lin, Q1
Huang, M1
Ji, F1
Huang, L1
You, X1
Lin, Y1
Zhang, C2
Yu, C1
Lin, Z1
Pan, H1
Li, K1
Ma, H2
Saad, MA1
Eltarzy, MA1
Abdel Salam, RM1
Ahmed, MAE1
Peng, MF1
Tian, S1
Song, YG1
Li, CX1
Miao, MS1
Ren, Z1
Li, M1
Annie, L1
Gurusubramanian, G1
Roy, VK1
Mihanfar, A1
Nouri, M1
Roshangar, L1
Khadem-Ansari, MH1
Yang, YL1
Zhou, WW1
Wu, S1
Tang, WL1
Wang, ZW1
Zhou, ZY1
Li, ZW1
Huang, QF1
He, Y1
Zhou, HW1
Hansda, SR1
Haldar, C1
Marcondes, RR2
Maliqueo, M2
Fornes, R1
Benrick, A2
Hu, M1
Ivarsson, N1
Carlström, M1
Cushman, SW1
Stenkula, KG1
Maciel, GAR1
Stener-Victorin, E3
Skarra, DV2
Hernández-Carretero, A1
Rivera, AJ1
Anvar, AR2
Thackray, VG2
Ullah, A1
Jahan, S1
Razak, S1
Pirzada, M1
Ullah, H1
Almajwal, A1
Rauf, N1
Afsar, T1
Greenwood, EA1
Pasch, LA1
Cedars, MI1
Legro, RS2
Eisenberg, E1
Huddleston, HG1
Patel, R1
Shah, G1
Winiczenko, R1
Górnicki, K1
Kaleta, A1
Janaszek-Mańkowska, M1
Khan, ZA1
Singh, C1
Khan, T1
Ganguly, M1
Bradsher, C1
Goodwin, P1
Petty, JT1
Sandau, C1
Bove, DG1
Marsaa, K1
Bekkelund, CS1
Lindholm, MG1
Salazar, J1
Bermúdez, V1
Olivar, LC1
Torres, W1
Palmar, J1
Añez, R1
Ordoñez, MG1
Rivas, JR1
Martínez, MS1
Hernández, JD1
Graterol, M1
Rojas, J1
Mubarak, Z1
Humaira, A1
Gani, BA1
Muchlisin, ZA1
Gremillet, C1
Jakobsson, JG1
Gomila, A1
Shaw, E1
Carratalà, J1
Leibovici, L1
Tebé, C1
Wiegand, I1
Vallejo-Torres, L1
Vigo, JM1
Morris, S1
Stoddart, M1
Grier, S1
Vank, C1
Cuperus, N1
Van den Heuvel, L1
Eliakim-Raz, N1
Vuong, C1
MacGowan, A1
Addy, I1
Pujol, M1
Cobb, A1
Rieger, E1
Bell, J1
Mallik, S1
Zhao, Z1
Szécsényi, Á1
Li, G1
Gascon, J1
Pidko, EA1
Zhang, GR1
Wolker, T1
Sandbeck, DJS1
Munoz, M1
Mayrhofer, KJJ1
Cherevko, S1
Etzold, BJM1
Lukashuk, L1
Yigit, N1
Rameshan, R1
Kolar, E1
Teschner, D1
Hävecker, M1
Knop-Gericke, A1
Schlögl, R1
Föttinger, K1
Rupprechter, G1
Franconieri, F1
Deshayes, S1
de Boysson, H1
Trad, S1
Martin Silva, N1
Terrier, B1
Bienvenu, B1
Galateau-Sallé, F1
Emile, JF1
Johnson, AC1
Aouba, A1
Vogt, TJ1
Gevensleben, H1
Dietrich, J1
Kristiansen, G1
Bootz, F1
Landsberg, J1
Goltz, D1
Dietrich, D1
Idorn, M1
Skadborg, SK1
Kellermann, L1
Halldórsdóttir, HR1
Holmen Olofsson, G1
Met, Ö1
Thor Straten, P1
Johnson, LE1
Brockstedt, D1
Leong, M1
Lauer, P1
Theisen, E1
Sauer, JD1
McNeel, DG1
Morandi, F1
Marimpietri, D1
Horenstein, AL1
Bolzoni, M1
Toscani, D1
Costa, F1
Castella, B1
Faini, AC1
Massaia, M1
Pistoia, V1
Giuliani, N1
Malavasi, F1
Qiu, J1
Peng, S1
Yang, A1
Ma, Y1
Han, L1
Cheng, MA1
Farmer, E1
Hung, CF1
Wu, TC1
Modak, S1
Le Luduec, JB1
Cheung, IY1
Goldman, DA1
Ostrovnaya, I1
Doubrovina, E1
Basu, E1
Kushner, BH1
Kramer, K1
Roberts, SS1
O'Reilly, RJ1
Cheung, NV1
Hsu, KC1
Salgarello, T1
Giudiceandrea, A1
Calandriello, L1
Marangoni, D1
Colotto, A1
Caporossi, A1
Falsini, B1
Lefrançois, P1
Xie, P1
Wang, L2
Tetzlaff, MT1
Moreau, L1
Watters, AK1
Netchiporouk, E1
Provost, N1
Gilbert, M1
Ni, X1
Sasseville, D1
Wheeler, DA1
Duvic, M1
Litvinov, IV1
O'Connor, BJ1
Fryda, NJ1
Ranglack, DH1
Yang, Y2
Zhang, X2
Grün, AL1
Emmerling, C1
Aumeeruddy-Elalfi, Z1
Ismaël, IS1
Hosenally, M1
Zengin, G1
Mahomoodally, MF1
Dotsenko, A1
Gusakov, A1
Rozhkova, A1
Sinitsyna, O1
Shashkov, I1
Sinitsyn, A1
Hong, CE1
Kim, JU1
Lee, JW1
Lee, SW1
Jo, IH1
Pandiyarajan, S1
Premasudha, P1
Kadirvelu, K1
Wang, B1
Luo, L1
Wang, D1
Ding, R1
Hong, J1
Caviezel, D1
Maissen, S1
Niess, JH1
Kiss, C1
Hruz, P1
Pockes, S1
Wifling, D1
Keller, M1
Buschauer, A1
Elz, S1
Santos, AF1
Ferreira, IP1
Pinheiro, CB1
Santos, VG1
Lopes, MTP1
Teixeira, LR1
Rocha, WR1
Rodrigues, GLS1
Beraldo, H1
Lohar, S1
Dhara, K1
Roy, P1
Sinha Babu, SP1
Chattopadhyay, P1
Sukwong, P1
Sunwoo, IY1
Lee, MJ1
Ra, CH1
Jeong, GT1
Kim, SK2
Huvinen, E1
Eriksson, JG1
Stach-Lempinen, B1
Tiitinen, A1
Koivusalo, SB1
Malhotra, M1
Suresh, S1
Garg, A1
Wei, L1
Jiang, Y2
Zhou, W1
Liu, S1
Liu, Y1
Rausch-Fan, X1
Liu, Z1
Marques, WL1
van der Woude, LN1
Luttik, MAH1
van den Broek, M1
Nijenhuis, JM1
Pronk, JT1
van Maris, AJA1
Mans, R1
Gombert, AK1
Xu, A1
Sun, J1
Li, J2
Chen, W2
Zheng, R1
Han, Z1
Ji, L1
Shen, WQ1
Bao, LP1
Hu, SF1
Gao, XJ1
Xie, YP1
Gao, XF1
Huang, WH1
Lu, X1
Gostin, PF1
Addison, O1
Morrell, AP1
Zhang, Y2
Cook, AJMC1
Liens, A1
Stoica, M1
Ignatyev, K1
Street, SR1
Chiu, YL1
Davenport, AJ1
Qiu, Z1
Shu, J1
Tang, D1
Gao, X1
Huang, K1
Wai, H1
Du, K1
Anesini, J1
Kim, WS1
Eastman, A1
Micalizio, GC1
Liang, JH1
Huo, XK1
Cheng, ZB1
Sun, CP1
Zhao, JC1
Kang, XH1
Zhang, TY1
Chen, ZJ1
Yang, TM1
Deng, XP1
Zhang, YX1
Salem, HF1
Kharshoum, RM1
Abou-Taleb, HA1
AbouTaleb, HA1
AbouElhassan, KM1
Ohata, C1
Ohyama, B1
Kuwahara, F1
Katayama, E1
Nakama, T1
Kobayashi, S1
Kashiwagi, T1
Kimura, J1
Lin, JD1
Liou, MJ1
Hsu, HL1
Leong, KK1
Chen, YT1
Wang, YR1
Hung, WS1
Lee, HY1
Tsai, HJ1
Tseng, CP1
Alten, B1
Yesiltepe, M1
Bayraktar, E1
Tas, ST1
Gocmen, AY1
Kursungoz, C1
Martinez, A1
Sara, Y1
Huang, S2
Adams, E1
Van Schepdael, A1
Wang, Q1
Chung, CY1
Yang, W1
Yang, G1
Chough, S1
Chen, Y1
Yin, B1
Bhattacharya, R1
Hu, Y1
Saeui, CT1
Yarema, KJ1
Betenbaugh, MJ1
Zhang, H1
Patik, JC1
Tucker, WJ1
Curtis, BM1
Nelson, MD1
Nasirian, A1
Park, S1
Brothers, RM1
Dohlmann, TL1
Hindsø, M1
Dela, F1
Helge, JW1
Larsen, S1
Gayani, B1
Dilhari, A1
Wijesinghe, GK1
Kumarage, S1
Abayaweera, G1
Samarakoon, SR1
Perera, IC1
Kottegoda, N1
Weerasekera, MM1
Nardi, MV1
Timpel, M1
Ligorio, G1
Zorn Morales, N1
Chiappini, A1
Toccoli, T1
Verucchi, R1
Ceccato, R1
Pasquali, L1
List-Kratochvil, EJW1
Quaranta, A1
Dirè, S1
Heo, K1
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Kang, DH1
Kim, JH1
Park, JH1
Akhtar, N1
Saha, A1
Kumar, V1
Pradhan, N1
Panda, S1
Morla, S1
Kumar, S1
Manna, D1
Wang, H1
Xu, E1
Yu, S1
Li, D1
Quan, J1
Xu, L1
Saslow, SA1
Um, W1
Pearce, CI1
Bowden, ME1
Engelhard, MH1
Lukens, WL1
Kim, DS1
Schweiger, MJ1
Kruger, AA1
Adair, LS1
Kuzawa, C1
McDade, T1
Carba, DB1
Borja, JB1
Liang, X2
Song, W1
Wang, K1
Zhang, B1
Peele, ME1
Luo, HR1
Chen, ZY1
Fei, JJ1
Du, ZJ1
Yi, KJ1
Im, WT1
Kim, DW1
Ji, X1
Xu, Z1
Ding, Y1
Song, Q1
Zhao, H1
Lee, DW1
Lee, H1
Kwon, BO1
Khim, JS1
Yim, UH1
Park, H1
Park, B1
Choi, IG1
Kim, BS1
Kim, JJ1
Wang, JJ1
Chen, Q1
Li, YZ1
Sakai, M1
Yamaguchi, M1
Nagao, Y1
Kawachi, N1
Kikuchi, M1
Torikai, K1
Kamiya, T1
Takeda, S1
Watanabe, S1
Takahashi, T1
Arakawa, K1
Nakano, T1
Rufo, S1
Continentino, MA1
Nikolaou, V1
Plass, F1
Planchat, A1
Charisiadis, A1
Charalambidis, G1
Angaridis, PA1
Kahnt, A1
Odobel, F1
Coutsolelos, AG1
Fuentes, I1
García-Mendiola, T1
Sato, S1
Pita, M1
Nakamura, H1
Lorenzo, E1
Teixidor, F1
Marques, F1
Viñas, C1
Liu, F1
Qi, P1
Zhang, L1
Torres, PJ1
Ho, BS1
Sau, L1
Kelley, ST1
Rocha, AL1
Oliveira, FR1
Azevedo, RC1
Silva, VA1
Peres, TM1
Candido, AL1
Gomes, KB1
Reis, FM1
Adeyanju, OA1
Falodun, TO1
Fabunmi, OA1
Olatunji, LA1
Soladoye, AO1
Maniu, A2
Nadler, JL1
Quon, MJ1
Chao, J1
Rubinow, KB1
Kratz, M1
Amory, JK1
Matsumoto, AM1
Page, ST1
Aberdeen, G1
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Saukkonen, T1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Combined Resveratrol and Myo-inositol on Altered Metabolic, Endocrine Parameters and Perceived Stress in Patients With Polycystic Ovarian Syndrome[NCT04867252]Phase 288 participants (Actual)Interventional2021-05-03Completed
Androgen-mediated Pathways in the Regulation of Insulin Sensitivity in Men[NCT01686828]Phase 1/Phase 253 participants (Actual)Interventional2013-06-30Completed
Effect of Acupuncture Pre-treatment Combined With Letrozole on Live Birth in Infertile Women With Polycystic Ovary Syndrome[NCT02491320]Phase 3384 participants (Actual)Interventional2015-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Changes in Adipose Tissue Gene Expression

We examined whether differences in lipoprotein lipase expression would be evident across study treatment groups. RNA was isolated from whole adipose tissue gene expression, and complementary DNA (cDNA) was synthesized from 1.5 ug of RNA per sample. Gene expression was measured by polymerase chain reaction (PCR) using predesigned TaqMan® Gene Expression Assays. Standard curves were included on each plate, so Ct values were converted to copy numbers of the target gene. Expression values were normalized to the geometric mean of the housekeeping genes phosphoglycerate kinase and 18s. (NCT01686828)
Timeframe: 4 weeks

Interventiongene copy number per ng RNA (Mean)
Acyline + Placebo Gel + Placebo Pills7493
Acyline + Testosterone Gel (1.25g/d) + Placebo Pills8224
Acyline + Testosterone Gel (5g/d) + Placebo Pills7885
Acyline + Testosterone Gel (5g/d) + Letrozole8320

Insulin Sensitivity Quantified by Matsuda Index

Whole body insulin sensitivity as quantified by Matsuda Index at the end of the treatment period, calculated by the following equation: 10,000/square root of(FPG*FI)*(FPG+PG30*2+PG60*2+PG90*2+PG120)/8*(FPI+PI30*2+PI60*2+PI90*2+PI)/8). FPG=fasting plasma glucose level; FPI=fasting plasma insulin level; PG30,60,90, and 120=plasma glucose levels sampled at 30,60,90, and 120 minutes after oral glucose load; PI30,60,90, and 120=plasma insulin levels sampled at 30,60,90, and 120 minutes after the oral glucose load (NCT01686828)
Timeframe: 4 weeks

Interventionunits on a scale (Median)
Acyline & Placebo Gel & Placebo Pill5.0
Acyline & Testosterone Gel 1.25g/d & Placebo Pill9.4
Acyline & Testosterone Gel 5g/d & Placebo Pill7.2
Acyline & Testosterone Gel & Letrozole7.3

Changes in Body Composition

Fat mass and lean mass were measured by dual energy X-ray absorptiometry (DEXA) at baseline and at the end of the 4 week treatment period (NCT01686828)
Timeframe: 4 weeks

,,,
Interventionkg (Mean)
Change in fat massChange in lean mass
Acyline & Placebo Gel & Placebo Pill1.1-1.2
Acyline & Testosterone Gel & Letrozole0.5-0.3
Acyline & Testosterone Gel 1.25g/d & Placebo Pill0.7-1.4
Acyline & Testosterone Gel 5g/d & Placebo Pill-0.40.0

Reviews

4 reviews available for letrozole and Insulin Resistance

ArticleYear
Recent advances in the understanding and management of polycystic ovary syndrome.
    F1000Research, 2019, Volume: 8

    Topics: Aromatase Inhibitors; Clomiphene; Female; Humans; Insulin Resistance; Letrozole; Obesity; Polycystic

2019
Ovulation induction in polycystic ovary syndrome: Current options.
    Best practice & research. Clinical obstetrics & gynaecology, 2016, Volume: 37

    Topics: Anovulation; Anti-Obesity Agents; Aromatase Inhibitors; Bariatric Surgery; Clomiphene; Diet Therapy;

2016
Polycystic ovarian syndrome management options.
    Obstetrics and gynecology clinics of North America, 2012, Volume: 39, Issue:4

    Topics: Clomiphene; Contraceptives, Oral, Hormonal; Estrogen Antagonists; Exercise; Female; Humans; Infertil

2012
Ovulation induction in polycystic ovary syndrome.
    Minerva ginecologica, 2008, Volume: 60, Issue:1

    Topics: Adult; Anovulation; Aromatase Inhibitors; Body Mass Index; Clomiphene; Diathermy; Female; Fertility

2008

Trials

7 trials available for letrozole and Insulin Resistance

ArticleYear
Insulin resistance is associated with depression risk in polycystic ovary syndrome.
    Fertility and sterility, 2018, 07-01, Volume: 110, Issue:1

    Topics: Adult; Clomiphene; Depression; Female; Humans; Infertility, Female; Insulin Resistance; Letrozole; P

2018
    Neural computing & applications, 2018, Volume: 30, Issue:6

    Topics: Activities of Daily Living; Acute Disease; Adalimumab; Adaptation, Physiological; Adenosine Triphosp

2018
Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men.
    The Journal of clinical endocrinology and metabolism, 2016, Volume: 101, Issue:10

    Topics: Adiposity; Adult; Androgens; Aromatase Inhibitors; Blood Glucose; Double-Blind Method; Estradiol; Go

2016
Comparison of acupuncture pretreatment followed by letrozole versus letrozole alone on live birth in anovulatory infertile women with polycystic ovary syndrome: a study protocol for a randomised controlled trial.
    BMJ open, 2016, 10-07, Volume: 6, Issue:10

    Topics: Acupuncture Therapy; Adult; Aromatase Inhibitors; Birth Rate; Clinical Protocols; Electroacupuncture

2016
Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men.
    Diabetes care, 2010, Volume: 33, Issue:8

    Topics: Adult; Aromatase Inhibitors; Estradiol; Fasting; Gastric Inhibitory Polypeptide; Humans; Insulin Res

2010
Blockade of oestrogen biosynthesis in peripubertal boys: effects on lipid metabolism, insulin sensitivity, and body composition.
    European journal of endocrinology, 2006, Volume: 155, Issue:3

    Topics: Adolescent; Apolipoprotein A-I; Apolipoproteins B; Aromatase Inhibitors; Body Composition; Body Heig

2006
The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.
    European journal of endocrinology, 2002, Volume: 146, Issue:3

    Topics: Adolescent; Aromatase Inhibitors; Body Composition; Body Height; Body Weight; Double-Blind Method; E

2002

Other Studies

33 other studies available for letrozole and Insulin Resistance

ArticleYear
Effects of Metformin on Reproductive, Endocrine, and Metabolic Characteristics of Female Offspring in a Rat Model of Letrozole-Induced Polycystic Ovarian Syndrome With Insulin Resistance.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: Animals; Animals, Newborn; Antineoplastic Agents; Female; Hyperinsulinism; Hypoglycemic Agents; Insu

2021
Ficus deltoidea ameliorates biochemical, hormonal, and histomorphometric changes in letrozole-induced polycystic ovarian syndrome rats.
    BMC complementary medicine and therapies, 2021, Nov-29, Volume: 21, Issue:1

    Topics: Animals; Antioxidants; Blood Glucose; Corpus Luteum; Disease Models, Animal; Endometrium; Female; Fi

2021
Cysteine-Cysteine Motif Chemokine Receptor 5 Expression in Letrozole-Induced Polycystic Ovary Syndrome Mice.
    International journal of molecular sciences, 2021, Dec-23, Volume: 23, Issue:1

    Topics: Animals; Cysteine; Diabetes Mellitus, Type 2; Diestrus; Disease Models, Animal; Estrous Cycle; Femal

2021
Network pharmacology integrated with experimental validation reveals the regulatory mechanism of action of Hehuan Yin decoction in polycystic ovary syndrome with insulin resistance.
    Journal of ethnopharmacology, 2022, May-10, Volume: 289

    Topics: Animals; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Female; Insulin Resistance;

2022
Estrogen Promotes Microvascularization in the Fetus and Thus Vascular Function and Insulin Sensitivity in Offspring.
    Endocrinology, 2022, 05-01, Volume: 163, Issue:5

    Topics: Animals; Estradiol; Estrogens; Female; Fetus; Glucose; Insulin; Insulin Resistance; Letrozole; Nitri

2022
Estrogen promotes fetal skeletal muscle myofiber development important for insulin sensitivity in offspring.
    Endocrine, 2022, Volume: 78, Issue:1

    Topics: Animals; Aromatase Inhibitors; Estrogens; Fetal Development; Fetus; Insulin; Insulin Resistance; Let

2022
The Role of a High-Fat, High-Fructose Diet on Letrozole-Induced Polycystic Ovarian Syndrome in Prepubertal Mice.
    Nutrients, 2022, Jun-15, Volume: 14, Issue:12

    Topics: Animals; Diet, High-Fat; Female; Fructose; Insulin Resistance; Letrozole; Mice; Mice, Inbred C57BL;

2022
Acetate: A therapeutic candidate against renal disorder in a rat model of polycystic ovarian syndrome.
    The Journal of steroid biochemistry and molecular biology, 2023, Volume: 225

    Topics: Animals; Disease Models, Animal; Female; Insulin Resistance; Kidney Diseases; Letrozole; NF-kappa B;

2023
The Disparity in the Management of Polycystic Ovary Syndrome between Obstetrician-Gynecologists in Different-Level Hospitals under the Hierarchical Medical System.
    BioMed research international, 2022, Volume: 2022

    Topics: Androgens; Blood Glucose; Female; Hospitals; Humans; Insulin Resistance; Letrozole; Lipids; Metformi

2022
Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
    Nutrition (Burbank, Los Angeles County, Calif.), 2023, Volume: 107

    Topics: Acetates; Animals; Female; Humans; Inflammasomes; Insulin; Insulin Resistance; Letrozole; Muscle, Sk

2023
Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
    Nutrition (Burbank, Los Angeles County, Calif.), 2023, Volume: 107

    Topics: Acetates; Animals; Female; Humans; Inflammasomes; Insulin; Insulin Resistance; Letrozole; Muscle, Sk

2023
Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
    Nutrition (Burbank, Los Angeles County, Calif.), 2023, Volume: 107

    Topics: Acetates; Animals; Female; Humans; Inflammasomes; Insulin; Insulin Resistance; Letrozole; Muscle, Sk

2023
Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3.
    Nutrition (Burbank, Los Angeles County, Calif.), 2023, Volume: 107

    Topics: Acetates; Animals; Female; Humans; Inflammasomes; Insulin; Insulin Resistance; Letrozole; Muscle, Sk

2023
Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue.
    Redox report : communications in free radical research, 2023, Volume: 28, Issue:1

    Topics: Animals; Female; Humans; Insulin Resistance; Letrozole; Lipids; Metformin; Mitochondria; Nanoparticl

2023
Development and evaluation of novel krill oil-based clomiphene microemulsion as a therapeutic strategy for PCOS treatment.
    Drug delivery and translational research, 2023, Volume: 13, Issue:9

    Topics: Animals; Clomiphene; Euphausiacea; Female; Humans; Infertility, Female; Insulin Resistance; Letrozol

2023
Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome.
    European journal of pharmacology, 2023, Aug-15, Volume: 953

    Topics: Animals; Cytokine Receptor gp130; Diet, High-Fat; Female; Gonadal Steroid Hormones; Humans; Insulin

2023
The efficacy and mechanism of Angelica sinensis (Oliv.) Diels root aqueous extract based on RNA sequencing and 16S rDNA sequencing in alleviating polycystic ovary syndrome.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 120

    Topics: AMP-Activated Protein Kinases; Angelica sinensis; Animals; DNA, Ribosomal; Eosine Yellowish-(YS); Fe

2023
A Rat Model of Polycystic Ovary Syndrome with Insulin Resistance Induced by Letrozole Combined with High Fat Diet.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, May-25, Volume: 26

    Topics: Animals; Diet, High-Fat; Disease Models, Animal; Female; Follicle Stimulating Hormone; Insulin; Insu

2020
Letrozole Rat Model Mimics Human Polycystic Ovarian Syndrome and Changes in Insulin Signal Pathways.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, Jul-08, Volume: 26

    Topics: Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Estrous Cycle; Female; Insulin; Insuli

2020
MiRNAs expression profiling of rat ovaries displaying PCOS with insulin resistance.
    Archives of gynecology and obstetrics, 2020, Volume: 302, Issue:5

    Topics: Animals; Biomarkers; Down-Regulation; Female; Gene Expression Profiling; Gene Ontology; High-Through

2020
Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome.
    Life sciences, 2021, Jan-15, Volume: 265

    Topics: Animals; Blood Glucose; Cognitive Dysfunction; Disease Models, Animal; Estradiol; Female; Gene Expre

2021
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
    Journal of ethnopharmacology, 2021, Jun-12, Volume: 273

    Topics: Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Eucommiaceae; Female; Flavonoids; Gona

2021
Inhibition of visfatin by FK866 mitigates pathogenesis of cystic ovary in letrozole-induced hyperandrogenised mice.
    Life sciences, 2021, Jul-01, Volume: 276

    Topics: Acrylamides; Androgens; Animals; Blood Glucose; Cytokines; Disease Models, Animal; Female; Hyperandr

2021
Therapeutic potential of quercetin in an animal model of PCOS: Possible involvement of AMPK/SIRT-1 axis.
    European journal of pharmacology, 2021, Jun-05, Volume: 900

    Topics: Adiponectin; AMP-Activated Protein Kinases; Animals; Estrous Cycle; Female; Hormones; Insulin Resist

2021
Intestinal Flora is a Key Factor in Insulin Resistance and Contributes to the Development of Polycystic Ovary Syndrome.
    Endocrinology, 2021, 10-01, Volume: 162, Issue:10

    Topics: Animals; Bacteroides; Biomarkers; Case-Control Studies; Chenodeoxycholic Acid; Female; Fibroblast Gr

2021
Uterine anomalies in cell proliferation, energy homeostasis and oxidative stress in PCOS hamsters, M. auratus: Therapeutic potentials of melatonin.
    Life sciences, 2021, Sep-15, Volume: 281

    Topics: Animals; Aromatase Inhibitors; Blood Glucose; Cell Proliferation; Cricetinae; Disease Models, Animal

2021
Exercise differentially affects metabolic functions and white adipose tissue in female letrozole- and dihydrotestosterone-induced mouse models of polycystic ovary syndrome.
    Molecular and cellular endocrinology, 2017, 06-15, Volume: 448

    Topics: Adipocytes; Adipogenesis; Adipose Tissue, White; Animals; Body Composition; Body Weight; Cell Size;

2017
Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance.
    Endocrinology, 2017, 09-01, Volume: 158, Issue:9

    Topics: Animals; Eating; Energy Metabolism; Female; Glucose; Hyperandrogenism; Hyperinsulinism; Insulin Resi

2017
Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats.
    Journal of ovarian research, 2017, Sep-15, Volume: 10, Issue:1

    Topics: Androgen Antagonists; Animals; Blood Glucose; Body Weight; Catalase; Estradiol; Female; gamma-Aminob

2017
Insulin Sensitizers Modulate GnRH Receptor Expression in PCOS Rats.
    Archives of medical research, 2018, Volume: 49, Issue:3

    Topics: Animals; Body Weight; Carboxymethylcellulose Sodium; Diet, High-Fat; Female; Glucose Tolerance Test;

2018
Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice.
    BMC microbiology, 2019, 03-12, Volume: 19, Issue:1

    Topics: Age Factors; Animals; Aromatase Inhibitors; Disease Models, Animal; Female; Gastrointestinal Microbi

2019
Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by suppressing elevated circulating testosterone.
    Chemico-biological interactions, 2019, Sep-01, Volume: 310

    Topics: Androgen Antagonists; Animals; Female; Insulin Resistance; Letrozole; Luteinizing Hormone; Mineraloc

2019
Estrogen deprivation in primate pregnancy leads to insulin resistance in offspring.
    The Journal of endocrinology, 2016, Volume: 230, Issue:2

    Topics: Animals; Blood Glucose; Estradiol; Female; Fetal Development; Insulin; Insulin Resistance; Insulin S

2016
Insulin resistance elicited in postpubertal primate offspring deprived of estrogen in utero.
    Endocrine, 2016, Volume: 54, Issue:3

    Topics: Animals; Aromatase Inhibitors; Estradiol; Female; Glucose Tolerance Test; Insulin Resistance; Letroz

2016
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome.
    Experimental physiology, 2017, 01-01, Volume: 102, Issue:1

    Topics: Acupuncture Therapy; Adipose Tissue; Animals; Aromatase; Aromatase Inhibitors; Cytochrome P-450 Enzy

2017
[Correlation of hormone-metabolic status in breast cancer and effectiveness of adjuvant hormone therapy].
    Voprosy onkologii, 2006, Volume: 52, Issue:2

    Topics: Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; C-Peptide; Chemotherapy,

2006