| Assay ID | Title | Year | Journal | Article |
|---|
| AID403097 | Displacement of [3H2]F3-methyl AA from human recombinant LXRbeta expressed in Escherichia coli BL21 cells | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID220386 | In vivo plasma triglyceride in db/db mouse after 11 days at 3 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID156132 | Transcriptional activation by human PPAR alpha | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID266372 | Inhibition of PPAR delta | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| SAR studies: designing potent and selective LXR agonists. |
| AID665203 | Agonist activity at PPARalpha | 2012 | Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11
| Activity landscape modeling of PPAR ligands with dual-activity difference maps. |
| AID12877 | Half-life was determined by iv administration (1.5 mg/kg) in fasted male Sprague-Dawley rats | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID240218 | Effective concentration for cofactor association with recombinant liver X receptor-alpha | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID665205 | Agonist activity at PPARgamma | 2012 | Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11
| Activity landscape modeling of PPAR ligands with dual-activity difference maps. |
| AID403095 | Displacement of [3H2]F3-methyl AA from human recombinant LXRalpha expressed in Escherichia coli BL21 cells | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID600728 | Displacement of radio-labeled full agonist from PPARgamma receptor | 2011 | European journal of medicinal chemistry, Jun, Volume: 46, Issue:6
| Discovery of new nanomolar peroxisome proliferator-activated receptor γ activators via elaborate ligand-based modeling. |
| AID174362 | In vivo plasma glucose in Zucker diabetic fatty rat after 11 days at 3 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID665204 | Agonist activity at PPARdelta | 2012 | Bioorganic & medicinal chemistry, Jun-01, Volume: 20, Issue:11
| Activity landscape modeling of PPAR ligands with dual-activity difference maps. |
| AID156607 | Transcriptional activation by human PPAR delta | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID220378 | In vivo plasma glucose in db/db mouse after 11 days at 10 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID175792 | In vivo plasma free fatty acid in Zucker diabetic fatty rat after 11 days at 3 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID1665619 | AUC (0.5 to 6 hrs) in C57BL/6 mouse serum at 9.14 umol/kg, ip by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
| A CNS-Targeting Prodrug Strategy for Nuclear Receptor Modulators. |
| AID240210 | Effective concentration for cofactor association with recombinant liver X receptor-beta | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID156933 | Transcriptional activation by human PPAR gamma | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID266373 | Inhibition of PPAR gamma | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| SAR studies: designing potent and selective LXR agonists. |
| AID266371 | Inhibition of PPAR alpha | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| SAR studies: designing potent and selective LXR agonists. |
| AID403364 | Activity of human recombinant LXRbeta ligand binding domain-mediated transcriptional activity in human HEK293 cells with Gal4 reporter plasmid by luciferase reporter assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID403099 | Agonist activity at human recombinant LXRalpha expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRalpha ligand binding domain by HTRF assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID266362 | Inhibition of LXR alpha | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| SAR studies: designing potent and selective LXR agonists. |
| AID156630 | In vitro binding affinity for human PPAR delta in SPA | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID11907 | Dose-normalized AUC was determined by po administration (10 mg/kg) in fasted male Sprague-Dawley rats | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID1665608 | AUC (0.5 to 6 hrs) in C57BL/6 mouse brain at 9.14 umol/kg, ip by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
| A CNS-Targeting Prodrug Strategy for Nuclear Receptor Modulators. |
| AID175941 | In vivo plasma triglyceride in Zucker diabetic fatty rat after 11 days at 3 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID174360 | In vivo plasma glucose in Zucker diabetic fatty rat after 11 days at 10 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID242554 | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID663659 | Binding affinity at human GST-tagged PPARdelta ligand binding domain after 1 hr by time-resolved FRET analysis | 2012 | European journal of medicinal chemistry, Jul, Volume: 53 | Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo. |
| AID220385 | In vivo plasma triglyceride in db/db mouse after 11 days at 30 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID243323 | Maximal induction of liver X receptor-beta receptor in transactivation assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID11213 | Clearance was determined by iv administration (1.5 mg/kg) in fasted male Sprague-Dawley rats | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID175791 | In vivo plasma free fatty acid in Zucker diabetic fatty rat after 11 days at 30 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID240151 | Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID403360 | Activity of human recombinant LXRalpha ligand binding domain-mediated transcriptional activity in human HEK293 cells with Gal4 reporter plasmid by luciferase reporter assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID266368 | Activity at LXR beta as beta-lactamase transactivation in CHO cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| SAR studies: designing potent and selective LXR agonists. |
| AID156955 | In vitro binding affinity for human PPAR gamma in SPA | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID174361 | In vivo plasma glucose in Zucker diabetic fatty rat after 11 days at 30 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID403100 | Agonist activity at human recombinant LXRbeta expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRbeta ligand binding domain by HTRF assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. |
| AID220383 | In vivo plasma triglyceride in db/db mouse after 11 days at 10 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID1665630 | Brain to serum concentration ratio, Kp of the compound in C57BL/6 mouse at 9.14 umol/kg, ip by LC-MS/MS analysis | 2020 | Journal of medicinal chemistry, 09-10, Volume: 63, Issue:17
| A CNS-Targeting Prodrug Strategy for Nuclear Receptor Modulators. |
| AID220380 | In vivo plasma glucose in db/db mouse after 11 days at 30 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID13633 | Oral bioavailability in rat (Sprague-Dawley) (fasted male) (dose 10 mg/kg) | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID266365 | Activity at LXR alpha as beta-lactamase transactivation in CHO cells | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| SAR studies: designing potent and selective LXR agonists. |
| AID175938 | In vivo plasma triglyceride in Zucker diabetic fatty rat after 11 days at 10 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID243328 | Maximal induction of liver X receptor-alpha receptor in transactivation assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID240148 | Effective concentration against liver X receptor-beta in HEK293 cell transactivation assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID266363 | Inhibition of LXR beta | 2006 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 16, Issue:11
| SAR studies: designing potent and selective LXR agonists. |
| AID156281 | In vitro binding affinity for human PPAR alpha in SPA | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID242413 | Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assay | 2005 | Bioorganic & medicinal chemistry letters, Jun-02, Volume: 15, Issue:11
| Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. |
| AID175789 | In vivo plasma free fatty acid in Zucker diabetic fatty rat after 11 days at 10 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID175940 | In vivo plasma triglyceride in Zucker diabetic fatty rat after 11 days at 30 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID220381 | In vivo plasma glucose in db/db mouse after 11 days at 3 mg/kg/day | 2003 | Bioorganic & medicinal chemistry letters, Apr-07, Volume: 13, Issue:7
| Phenylacetic acid derivatives as hPPAR agonists. |
| AID1346755 | Human Liver X receptor-alpha (1H. Liver X receptor-like receptors) | 2002 | Endocrinology, Jul, Volume: 143, Issue:7
| A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). |
| AID1346790 | Human Peroxisome proliferator-activated receptor-beta/delta (1C. Peroxisome proliferator-activated receptors) | 1999 | The Journal of biological chemistry, Mar-05, Volume: 274, Issue:10
| Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. |
| AID1346993 | Human Liver X receptor-beta (1H. Liver X receptor-like receptors) | 2002 | Endocrinology, Jul, Volume: 143, Issue:7
| A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). |
| AID1346800 | Human Peroxisome proliferator-activated receptor-gamma (1C. Peroxisome proliferator-activated receptors) | 1999 | The Journal of biological chemistry, Mar-05, Volume: 274, Issue:10
| Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |