Compounds > bis(2,3-dibromo-4,5-dihydroxybenzyl) ether
Page last updated: 2024-11-12

bis(2,3-dibromo-4,5-dihydroxybenzyl) ether

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

bis(2,3-dibromo-4,5-dihydroxybenzyl) ether: inhibits alpha-glucosidase; has antibacterial, antifungal, and cytotoxic activities; isolated from several red algae; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10053921
CHEMBL ID491516
MeSH IDM000610711

Synonyms (9)

Synonym
3,4-dibromo-5-[(2,3-dibromo-4,5-dihydroxy-phenyl)methoxymethyl]benzene-1,2-diol
CHEMBL491516 ,
bis(2,3-dibromo-4,5-dihydroxybenzyl)ether
bdbm50329701
bis(2, 3-dibromo-4,5-dihydroxybenzyl) ether
74849-07-3
bis(2,3-dibromo-4,5-dihydroxybenzyl) ether
DTXSID10434771
3,4-dibromo-5-[(2,3-dibromo-4,5-dihydroxyphenyl)methoxymethyl]benzene-1,2-diol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Isocitrate lyaseCandida albicansIC50 (µMol)28.06006.00007.50009.0000AID527628
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID527633Antimicrobial activity against Salmonella Typhimurium ATCC 14028 after 24 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID333360Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay2004Journal of natural products, Oct, Volume: 67, Issue:10
Dibenzyl bromophenols with diverse dimerization patterns from the brown alga Leathesia nana.
AID379864Inhibition of yeast alpha-glucosidase by colorimetric method1999Journal of natural products, Jun, Volume: 62, Issue:6
Two new bromophenols from the red alga odonthalia corymbifera
AID333363Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay2004Journal of natural products, Oct, Volume: 67, Issue:10
Dibenzyl bromophenols with diverse dimerization patterns from the brown alga Leathesia nana.
AID527634Antimicrobial activity against Candida albicans ATCC 10231 after 48 to 72 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID527628Inhibition of Candida albicans ATCC 10231 isocitrate lyase2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID527636Antimicrobial activity against Trichophyton rubrum IFO 9185 after 48 to 72 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID333362Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay2004Journal of natural products, Oct, Volume: 67, Issue:10
Dibenzyl bromophenols with diverse dimerization patterns from the brown alga Leathesia nana.
AID527637Antimicrobial activity against Trichophyton mentagrophytes IFO 40996 after 48 to 72 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID527631Antimicrobial activity against Micrococcus luteus IFO 12708 after 24 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID333361Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay2004Journal of natural products, Oct, Volume: 67, Issue:10
Dibenzyl bromophenols with diverse dimerization patterns from the brown alga Leathesia nana.
AID527630Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID333359Cytotoxicity against human A549 cells after 96 hrs by MTT assay2004Journal of natural products, Oct, Volume: 67, Issue:10
Dibenzyl bromophenols with diverse dimerization patterns from the brown alga Leathesia nana.
AID527629Antimicrobial activity against Staphylococcus aureus ATCC 6538p after 24 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID527635Antimicrobial activity against Aspergillus fumigatus HIC 6094 after 48 to 72 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
AID527632Antimicrobial activity against Proteus vulgaris ATCC 3851 after 24 hrs by broth dilution method2010Bioorganic & medicinal chemistry letters, Nov-15, Volume: 20, Issue:22
Bromophenols as Candida albicans isocitrate lyase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
3-nitropropionic acid
3-nitropropionic acid: succinate dehydrogenase inactivator; biosynthesized by FABACEAE plants from ASPARAGINE. 3-nitropropanoic acid : A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.		2.0510C-nitro compoundantimycobacterial drug;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mycotoxin;
neurotoxin
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.0510beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
2,4-dibromophenol
2,4-dibromophenol : A bromophenol that is phenol in which the hydrogens at positions 2 and 4 have been replaced by bromines.		2.0510brominated flame retardant;
bromophenol;
dibromobenzene		marine metabolite
lanosol
2,3-dibromo-4,5-dihydroxybenzyl alcohol: an antibacterial isolated from red sea algae		210catechols
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0510antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Insulin Sensitivity
[description not available]		02.1310
Insulin Resistance
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.		02.1310