protocatechuic acid has been researched along with Insulin Resistance in 10 studies
protocatechuic acid: RN given refers to parent cpd; structure
3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.
Insulin Resistance: Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Protocatechuic acid (PCA), a polyphenol, exerts beneficial effects on insulin resistance and diabetes." | 8.31 | The Muscle-Conditioned Medium Containing Protocatechuic Acid Improves Insulin Resistance by Modulating Muscle Communication with Liver and Adipose Tissue. ( Al-Hassan, N; Alketbi, M; Hussein, H; Kizhakkayil, J; Platat, C; Shakoor, H, 2023) |
| "Insulin resistance is a common feature of obesity and type 2 diabetes and partly results from an imbalance between food intake and energy expenditure." | 5.91 | Protocatechuic Acid Ameliorates High Fat Diet-Induced Obesity and Insulin Resistance in Mice. ( Han, S; Han, Y; Huang, R; Li, Z; Qin, X; Wang, T; Wang, X; Wang, Y; Wu, J; Xia, B; Xiang, Y; Yang, G, 2023) |
| "Hydrogen-rich water has a significant protective effect on OGD/R-causing HT22 cell injury, and the mechanism may be related to the inhibition of autophagy." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| "Age, APACHE score at ICU admission, neurological disease, sepsis and duration of mechanical ventilation were all independent risk factors for the development of delirium in ICU patients." | 4.40 | Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19. ( , 2023) |
| " Protocatechuic acid (PCA), a polyphenol, exerts beneficial effects on insulin resistance and diabetes." | 4.31 | The Muscle-Conditioned Medium Containing Protocatechuic Acid Improves Insulin Resistance by Modulating Muscle Communication with Liver and Adipose Tissue. ( Al-Hassan, N; Alketbi, M; Hussein, H; Kizhakkayil, J; Platat, C; Shakoor, H, 2023) |
| "This study investigated the influence of caffeic, ferulic, gallic and protocatechuic acids on high-fructose diet-induced metabolic syndrome in rats." | 3.88 | Dietary phenolic acids reverse insulin resistance, hyperglycaemia, dyslipidaemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats. ( Ajiboye, TO; Ibitoye, OB, 2018) |
| " It has been demonstrated that anthocyanins and one of their representative metabolites, protocatechuic acid (PCA), ameliorate hyperglycemia, and insulin sensitivity." | 3.81 | Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity. ( D'Archivio, M; Del Gaudio, I; Filesi, C; Galvano, F; Giovannini, C; Iacovelli, A; Masella, R; Pluchinotta, FR; Santangelo, C; Scazzocchio, B; Varì, R, 2015) |
| "Insulin resistance is a common feature of obesity and type 2 diabetes and partly results from an imbalance between food intake and energy expenditure." | 1.91 | Protocatechuic Acid Ameliorates High Fat Diet-Induced Obesity and Insulin Resistance in Mice. ( Han, S; Han, Y; Huang, R; Li, Z; Qin, X; Wang, T; Wang, X; Wang, Y; Wu, J; Xia, B; Xiang, Y; Yang, G, 2023) |
| "Protocatechuic acid (PCA) has a protective effect on alcoholic liver injury, but the role of PCA in type 2 diabetes-induced liver injury is not well known." | 1.91 | Hepatoprotective effect of protocatechuic acid against type 2 diabetes-induced liver injury. ( Chen, S; Feng, Q; Lu, G; Wang, Y; Xu, K, 2023) |
| "Insulin resistance was induced in male Wistar rats by a 7-day treatment with dexamethasone (DEX) (1 mg/kg/day, i." | 1.51 | Protocatechuic acid exhibits hepatoprotective, vasculoprotective, antioxidant and insulin-like effects in dexamethasone-induced insulin-resistant rats. ( El-Sonbaty, YA; Gameil, NM; Megahed, N; Suddek, GM, 2019) |
| "Decreasing insulin resistance is a most desirable aim to be reached for an effective therapeutic/preventive action against metabolic syndrome and type 2 diabetes." | 1.42 | Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity. ( D'Archivio, M; Del Gaudio, I; Filesi, C; Galvano, F; Giovannini, C; Iacovelli, A; Masella, R; Pluchinotta, FR; Santangelo, C; Scazzocchio, B; Varì, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 5 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiang, Y | 1 |
| Huang, R | 1 |
| Wang, Y | 2 |
| Han, S | 1 |
| Qin, X | 1 |
| Li, Z | 1 |
| Wang, X | 1 |
| Han, Y | 1 |
| Wang, T | 1 |
| Xia, B | 1 |
| Wu, J | 1 |
| Yang, G | 1 |
| Xu, K | 1 |
| Lu, G | 1 |
| Feng, Q | 1 |
| Chen, S | 1 |
| Shakoor, H | 1 |
| Hussein, H | 1 |
| Al-Hassan, N | 1 |
| Alketbi, M | 1 |
| Kizhakkayil, J | 1 |
| Platat, C | 1 |
| El-Sonbaty, YA | 1 |
| Suddek, GM | 2 |
| Megahed, N | 1 |
| Gameil, NM | 1 |
| Abdelmageed, ME | 1 |
| Shehatou, GSG | 1 |
| Salem, HA | 1 |
| Ibitoye, OB | 1 |
| Ajiboye, TO | 1 |
| Ormazabal, P | 1 |
| Scazzocchio, B | 2 |
| Varì, R | 2 |
| Santangelo, C | 2 |
| D'Archivio, M | 2 |
| Silecchia, G | 1 |
| Iacovelli, A | 2 |
| Giovannini, C | 2 |
| Masella, R | 2 |
| Rebollo-Hernanz, M | 1 |
| Zhang, Q | 1 |
| Aguilera, Y | 1 |
| Martín-Cabrejas, MA | 1 |
| de Mejia, EG | 1 |
| Filesi, C | 1 |
| Del Gaudio, I | 1 |
| Galvano, F | 1 |
| Pluchinotta, FR | 1 |
1 review available for protocatechuic acid and Insulin Resistance
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
1 trial available for protocatechuic acid and Insulin Resistance
| Article | Year |
|---|---|
Effect of 12-week of aerobic exercise on hormones and lipid profile status in adolescent girls with polycystic ovary syndrome: A study during COVID-19.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenosine Triphosp | 2023 |
9 other studies available for protocatechuic acid and Insulin Resistance
| Article | Year |
|---|---|
Protocatechuic Acid Ameliorates High Fat Diet-Induced Obesity and Insulin Resistance in Mice.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Insulin; Insulin Resistance; Lipids; Male; Mice; | 2023 |
Hepatoprotective effect of protocatechuic acid against type 2 diabetes-induced liver injury.
Topics: Animals; beta Catenin; Chemical and Drug Induced Liver Injury, Chronic; Diabetes Mellitus, Type 2; I | 2023 |
The Muscle-Conditioned Medium Containing Protocatechuic Acid Improves Insulin Resistance by Modulating Muscle Communication with Liver and Adipose Tissue.
Topics: 3T3-L1 Cells; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Culture Media, Conditioned; Gl | 2023 |
Protocatechuic acid exhibits hepatoprotective, vasculoprotective, antioxidant and insulin-like effects in dexamethasone-induced insulin-resistant rats.
Topics: Animals; Antioxidants; Cardiotonic Agents; Dietary Supplements; Disease Models, Animal; Dyslipidemia | 2019 |
Protocatechuic acid improves hepatic insulin resistance and restores vascular oxidative status in type-2 diabetic rats.
Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glycation End | 2021 |
Dietary phenolic acids reverse insulin resistance, hyperglycaemia, dyslipidaemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats.
Topics: Animals; Anti-Obesity Agents; Antioxidants; Biomarkers; Caffeic Acids; Coumaric Acids; Cytokines; Di | 2018 |
Effect of protocatechuic acid on insulin responsiveness and inflammation in visceral adipose tissue from obese individuals: possible role for PTP1B.
Topics: Adult; Aged; Case-Control Studies; Female; Humans; Hydroxybenzoates; Inflammation; Insulin; Insulin | 2018 |
Cocoa Shell Aqueous Phenolic Extract Preserves Mitochondrial Function and Insulin Sensitivity by Attenuating Inflammation between Macrophages and Adipocytes In Vitro.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Biflavonoids; Cacao; Catechin; Glucose Transporter Type 4; Hydrox | 2019 |
Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity.
Topics: Absorption, Physiological; AMP-Activated Protein Kinases; Cells, Cultured; Dietary Supplements; Enzy | 2015 |